Cancer Currents: An NCI Cancer Research Blog
A blog featuring news and research updates from the National Cancer Institute. Learn more about Cancer Currents.
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Pump Up the Volume: “Priming Agents” May Improve Cancer Liquid BiopsiesUsing two different techniques, researchers showed they could temporarily boost ctDNA levels in the blood of mice with tumors. With more ctDNA in collected blood draws, a liquid biopsy could better detect cancer, the research team found.
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Repotrectinib Expands Treatment Options for Lung Cancers with ROS1 FusionsThe results of the clinical trial that led to FDA’s 2023 approval of repotrectinib (Augtyro) for lung cancers with ROS1 fusions have been published. The drug shrank tumors in 80% of people receiving the drug as an initial treatment.
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How a Simple Tool Is Saving Lives of Children with Cancer in Latin AmericaA system for catching treatment-related complications in children with cancer has proven to be highly effective in many Latin American hospitals. An NCI-funded study aims to help make these early warning systems sustainable.
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Manipulating an Immune Cell May Make Radiation Therapy More Effective, Study SuggestsIn a new study in mice, researchers showed they could enhance radiation therapy by boosting levels of the BAMBI protein in MDSC immune cells in the tumor microenvironment. After radiation, T cells flooded into the tumor and killed tumors elsewhere in the body.
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India’s First Homegrown CAR T-Cell Therapy Has Roots in NCI CollaborationTraining provided by NCI scientists helped researchers in India design an effective CAR-T cell therapy, NexCAR19, that can be manufactured in India, made available at a reasonable cost, and meet the needs of patients in India’s health care system.
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What Happens If More People Get Screened for Cancer?Researchers used computer modeling to estimate the number of deaths that could be prevented, and the harms caused, if more people used USPSTF-recommended cancer screening tests. The study’s lead investigator, Dr. Amy Knudsen, explains the findings.
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Can Some People with Breast Cancer Safely Skip Lymph Node Radiation?Some people with no evidence of cancer in nearby lymph nodes after presurgical chemotherapy can skip radiation to that area without increasing the risk of the cancer returning, a clinical trial found. But some experts caution that more details are needed.
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Trial Results Support Adding Daratumumab to Initial Treatment for Multiple MyelomaAdding daratumumab (Darzalex) to standard treatment helped people with newly diagnosed multiple myeloma live longer without their cancer getting worse or dying. People taking daratumumab were also more likely to have no detectable signs of cancer (minimal residual disease) after treatment.
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For People with Inherited Risk of Stomach Cancer, Gastrectomy Has Lasting ConsequencesIn a recent study, more than 90% of people who’d had their stomach surgically removed to prevent cancer experienced a least one chronic complication 2 years out from their surgery. For some, the complications are life altering.
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Enzalutamide Gets Added Approval for Prostate Cancer That Hasn’t SpreadUnder a new FDA approval, enzalutamide (Xtandi) can now be used alone, or in combination with leuprolide, to treat people with nonmetastatic prostate cancer that is at high risk of returning after surgery or radiation.
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Toripalimab Becomes First Immunotherapy Drug Approved for Nasopharyngeal CancerFDA approved toripalimab (Loqtorzi) based on the results of a large clinical trial showing that, when added to chemotherapy, the drug extended survival in people with nasopharyngeal cancer that returned after initial treatment or spread in the body.
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New on NCI’s Websites for December 2023NCI periodically provides updates on new websites and other online content of interest to the cancer community. See selected content that has been added as of December 2023.
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Following Abnormal Cancer Screening Results, Multi-Level Reminders May Increase Follow-UpIn a clinical trial, a simple letter and phone call helped increase the number of people who completed the recommended follow-up testing after an abnormal cancer screening result.
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Genetic Signature May Help Tailor Treatment for MeningiomaThe activity of 34 genes can accurately predict the aggressiveness of meningiomas, a new study shows. This gene expression signature may help oncologists select the best treatments for people with this common type of brain cancer than they can with current methods.
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Virtual Mind–Body Fitness Classes Show Unexpected Benefit in People with CancerIn a clinical trial, people being treated for cancer who participated in virtual mind–body fitness classes were less likely to be hospitalized, and had shorter stays when they were hospitalized, than people who did not take the classes.
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Antibody Drug Ejects Problematic Proteins from Cancer CellsAntibodies currently used in many cancer treatments have only been able to reach proteins outside of cancer cells. In a new study in mice, scientists found a way to target cancer-fueling KRAS and IDH1 proteins buried inside cancer cells.
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What Comes after NCI-MATCH? NCI’s New Precision Medicine Cancer TrialsNCI’s James H. Doroshow, M.D., reflects on the accomplishments of NCI-MATCH, a first-of-its-kind precision medicine cancer trial, and gives an overview of three new successor trials: ComboMATCH, MyeloMATCH, and iMATCH.
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Tarlatamab Shows Promise for Some People with Small Cell Lung CancerTarlatamab, a new type of targeted immunotherapy, shrank small cell lung cancer (SCLC) tumors in more than 30% of participants in an early-stage clinical trial. Participants had SCLC that had progressed after previous treatments with other drugs.
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Groundbreaking Trial Results Expand Treatment Options for Some People with Bladder CancerFor the first time in decades, people with advanced bladder cancer have more effective treatment options. New clinical trial results mark a pivotal moment following years of little progress, bladder cancer experts believe.
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Molecular Burglary: Cancer Cells Hijack Energy from Immune CellsA new study shows that, in some tumors, a subset of cancer cells can drain mitochondria, the tiny structures within cells that produce energy, from T cells and use them for their own energy needs.