COMETS Projects and Collaborations
The COnsortium of METabolomics Studies (COMETS) advances metabolomic epidemiology by facilitating collaborations among prospective cohort studies that perform metabolomic profiling of individuals. Collaborative metabolomics projects that have been proposed by COMETS members and approved by the COMETS Steering Committee are below.
List of COMETS Projects
| Focus* | Project | Lead Investigator(s) | Date Approved | Status |
|---|---|---|---|---|
| Health Outcomes | Blood metabolomic profiling in prostate cancer risk | Demetrius Albanes | 2017 Fall | Ongoing |
| Health Outcomes | Blood metabolites profiling in malignant glioma risk | Demetrius Albanes | 2017 Fall | Ongoing |
| Metabolit(s) - Focused |
Levels of trimethylamine metabolites and their associations with dietary and non-dietary factors |
Danxia Yu | 2017 Fall | Complete |
| Exposures and Genetics | Genetic influences on the human metabolome | Bing Yu | 2017 Fall | Ongoing |
| Exposures and Genetics | The metabolome of overweight and obesity | Rachel Kelly | 2017 Fall | Ongoing |
| Health Outcomes |
Metabolomics of blood pressure regulation |
Christina Menni | 2017 Fall | Complete |
| Health Outcomes | Metabolomic profiles of dietary factors implicated in cancer etiology | Mary Playdon and Steven Moore | 2018 Spring | Ongoing |
| Exposures and Genetics | Genetics, metabolomics, and cardiovascular disease risk | Bing Yu and Christina Menni | 2018 Spring | Ongoing |
| Health Outcomes | Metabolomic profile of type 2 diabetes: the COnsortium of METabolomics Studies (COMETS) | Nicholette Allred and Meghana Gadgil | 2018 Spring | Ongoing |
| Exposures and Genetics | Genetic analysis and causal inference for untargeted signals from MS-based metabolite profiles | Joel Hirschhorn | 2018 Spring | Ongoing |
| Metabolite(s) - Focused | Genes, environment, and metabolic disease - convergence on ceramides | Scott Summers and Mary Playdon | 2018 Spring | Ongoing |
| Health Outcomes | Metabolomic profiles and pancreatic cancer risk | Rachael Z. Stolzenberg-Solomon | 2018 Spring | Ongoing |
| Health Outcomes | Metabolomic profiles of inflammatory and insulinemic dietary patterns and colorectal cancer risk | Fred Tabung | 2019 Winter | Ongoing |
| Health Outcomes | Blood metabolomics and lung cancer risk | Wei Jie Seow | 2019 Winter | Ongoing |
| Exposures and Genetics | Blood metabolites and their association with age: A COMETS Study | Steve Moore | 2019 Spring | Ongoing |
| Metabolite(s) - Focused | Metabolomic profiles of circulating micronutrients and vitamin/nutritional supplements | Demetrius Albanes | 2019 Summer | Ongoing |
| Methods | Genetic imputation of metabolomics data | Burcu Darst | 2019 Summer | Ongoing |
| Exposures and genetics | Biomarkers of exposure and response to coffee intake | Marc Gunter | 2019 Summer | Ongoing |
| Health Outcomes | Metabolomic health and obesity-relevant diseases | Mary Playdon | 2019 Summer | Ongoing |
| Health Outcomes | Genetic metabolite scores for prediction of incident and prevalent cardiometabolic and pulmonary disease | Nasa Sinnott-Armstrong | 2019 Summer | Ongoing |
| Health Outcomes | Sex differences in the metabolome | Raji Balasubramanian | 2020 Winter | Ongoing |
| Exposures and genetics | A metabolomic characterization of APOE genotype using the COnsortium of METabolomics Studies | Megan Marron | 2020 Winter | Ongoing |
| Health Outcomes | Metabolomic profiles of subclinical atherosclerosis | Bing Yu | 2020 Spring | Ongoing |
| Health Outcomes | Metabolomic profiles of colorectal cancer | Jennifer Ose | 2020 Summer | Ongoing |
| Health outcomes | Prospective metabolomics study of gastric cancer | Xiang Shu | 2020 Summer |
Ongoing |
| Health Outcomes | Consequences of air quality on cardiometabolic and pulmonary disease | Nasa Sinnott-Armstrong | 2020 Summer | Ongoing |
| Health Outcomes | Novel metabolomic pathways for hyperuricemia and gout | Hyon K. Choi | 2021 Winter | Ongoing |
| Health Outcomes | Metabolomics of asthma, chronic obstructive pulmonary disease, lung function, and allergy phenotypes | Jessica Lasky-Su, Rachel Kelly, and Bo Chawes on behalf of the COMETS Lung IG | 2021 Winter | Ongoing |
| Health Outcomes | Adulthood weight change, blood metabolomic profiles, and lung function | Hyung-Suk Yoon | 2021 Winter | Ongoing |
| Health Outcomes | Magnesium-modifiable microbial metabolites in association with diet, type 2 diabetes, and coronary heart disease | Danxia Yu | 2021 Winter | Ongoing |
| Metabolite(s) - Focused | Examination of vitamin D-associated and other metabolites in relation to cancer risk and mortality by race and ethnicity | Wayne R. Lawrence and Gieira S. Jones | 2021 Summer | Ongoing |
| Metabolite(s) - Focused | Dietary metabolomics in the COnsortium of METabolomics Studies | Mary Playdon on behalf of the COMETS Diet IG | 2021 Summer | Ongoing |
| Health Outcomes | Metabolome profile associated with interstitial lung abnormalities | Scott Matson | 2022 Winter | Ongoing |
| Health Outcomes | Impact of Caloric Restriction on Metabolomic Aging | Waylon Hastings | 2023 Winter | Ongoing |
| Health Outcomes | Predicting common infectious diseases and their risk on developing new diseases | Ewy Mathé and Jessica Lasky-Su | 2023 Winter | Ongoing |
| Health Outcomes | Metabolomic analysis of breast cancer risk | Vicky Stevens and Steve Moore | 2023 Spring | Ongoing |
| * Projects are classified according to the following focus areas: (1) Health outcomes projects are focused on associations between metabolites and diseases/other health outcomes; (2) Exposures and genetics projects are focused on the interrelationships among exposures, or genetics and metabolites; (3) Metabolite(s)-focused projects will assess the interrelationships between exposures or genetics and specific metabolites (or classes of metabolites) and their role on health outcomes; (4) Methods projects will address analytical, platform, harmonization, statistical or other methodologic topics. | ||||
Guidelines on publishing a COMETS project
COMETS members should follow these guidelines when publishing or presenting on a COMETS projects. Including COMETS in the authorship would enable "COMETS" to be part of the PubMed index, thereby facilitating finding related publications.
Goal
To facilitate searching and tracking of COMETS publications, members should consider including COMETS as part of the authors or title of COMETS-related publications.
Guidelines
- For publications or conference abstracts that address a project or topic related to the entire COMETS consortium (e.g. description of COMETS consortium, COMETS Analytics, Interest Group, etc.), the term "COMETS" or the name of the COMETS Interest Group (e.g. "COMETS Statistics Interest Group") should be included in the authorship and appear in the title.
- For publications or abstracts that arise from COMETS projects (e.g. meta-analyses or analyses using COMETS cohort data), members should include a suffix containing the word COMETS in their title. Suggestions of suffixes include ": a COMETS Project" or ": a Report from COMETS" or ": a COMETS Study."
- For publications or abstracts arising from collaborations with COMETS (e.g. collaboration using COMETS resources), "COMETS" or the specific COMETS IG should be included in the acknowledgements.
Examples of previous COMETS publications
-
Playdon MC, Joshi AD, Tabung FK, Cheng S, Henglin M, Kim A, Lin T, va Roekel EH, Huang J, Krumsiek J, Wang Y, Mathé E, Temprosa M, Moore S, Chawes B, Eliassen AH, Gsur A, Gunter MJ, Harada S, Langenberg C, Orešič M, Perng W, Seow WJ, Zeleznik OA. Metabolomics Analytics Workflow for Epidemiological Research: Perspectives from the Consortium of Metabolomics Studies (COMETS). Metabolites. 2019 Jul 17; 9(7).
- Temprosa M, Moore SC, Zanetti KA, Appel N, Ruggieri D, Mazzilli KM, Chen K, Kelly RS, Lasky-Su JA, Loftfield E, McClain K, Park B, Trijsburg L, Zeleznik OA, Mathé E. COMETS Analytics: An Online Tool for Analyzing and Meta-Analyzing Metabolomics Data in Large Research Consortia. American Journal of Epidemiology. 2021 Apr 22; 191(1).
Example of planned publication
-
COMETS Analytics v2.0 Implements Generalized Linear Models: Findings from the COMETS Lung Disease Interest Group. Rachel S Kelly.
Developed by the COMETS Data Infrastructure and Lung Interest Groups in January 2023.