Early-Onset Cancer Initiative

The Early-Onset Cancer Initiative is an NCI effort to better understand and address the observed increase in cancers that were historically diagnosed in older adults. Cancers once primarily seen in people over 50 years old, including colorectal, breast, uterine, kidney, and pancreatic are now increasingly affecting younger adults.

Approach

The Early-Onset Cancer Initiative is dedicated to advancing the pace of scientific discovery, incorporating the patient experience, and improving survivorship. This includes:

interdisciplinary risk factors
novel scientific methods
survivorship care

Select NCI-Supported Activities

Cancer Grand Challenges
Team PROSPECT, funded by NCI as part of the Cancer Grand Challenges program, aims to use advanced approaches like precision nutrition to study the biology and physiology involved in the development of early-onset colorectal cancer.
Early-Onset Endometrial (Uterine) Cancer Study
This study was launched as part of NCI's Provocative Questions Initiative to better understand how a specific protein may contribute to the development of endometrial tumors in early-onset cancer patients with obesity.
CISNET-Colon Modeling Group
The U.S. Preventive Services Task Force (USPSTF) commissioned this group to generate data that informed USPSTF’s updated 2021 recommendation that all adults at average risk begin colorectal cancer screening at age 45, instead of age 50.
Breast Cancer Family Registry Cohort
An international database that supports a wide range of studies on gene discovery, cancer prevention, and behavioral interventions. The cohort facilitates collaborative research on breast cancer, including early-onset breast cancer.