2023 - RAS Dialogue Blog
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Inhibition of the MAPK pathway induces re-localization of membranous proteins, leading to adaptive resistance to KRAS G12C inhibitor mediated by YAP-induced MRASYuta Adachi and Hiromichi Ebi describe their work uncovering a non-genetic resistance mechanism to KRAS G12C inhibitors involving the mis-localization of scribble, which induces YAP-mediated MRAS expression and reactivates MAPK signaling.
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New type of bifunctional molecules perturb K-Ras interactions with membranesDrs. Johannes Morstein and Kevan Shokat describe their new and unique bifunctional drugs that bind to both KRAS and the plasma membrane.
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KRAS somatic cancer-driver mutations in endometriosis without cancer: towards a molecular classification for endometriosis?Drs. Yong, Orr, and Anglesio discuss how they found KRAS mutations—usually seen in cancer—in endometriosis tissue.
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Oncogene turned bystander - How molecular context shapes KRas oncogenicityOlesja Popow and Kevin Haigis share their insight into the persistent question of why KRAS mutations drive cancers in some tissues and not in others.
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RAS Chat: An Interview with Kevan Shokat and Ziyang ZhangDrs. Kevan Shokat and Ziyang Zhang discuss their work targeting the KRAS G12R and G12S mutations, and give their thoughts on the history and future of RAS research.