RAS Dialogue Blog
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The RASopathies NetworkRASopathies are neurodevelopmental genetic syndromes caused by germline mutations in RAS pathway genes that result in increased MAPK signaling. The RASopathies Network provides an umbrella organization to connect affected families with researchers.
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Intravenous High-Dose Vitamin C in Cancer TherapyPharmacologic levels of vitamin C in plasma can only be achieved by intravenous administration. Vitamin C undermines RAS-mutant cells’ reliance on upregulation of glycolysis and antioxidant activities to support their cancer lifestyle.
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Taking RAS Research to SpaceHigh-quality crystal structures of RAS are essential for developing new drugs for this difficult target. Crystals of RAS protein grown on the International Space Station had improved qualities compared to those grown in earth gravity.
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The Role of Mitochondrial Dynamics in Ras-driven CancersMitochondria are dynamic structures that respond to the metabolic needs of cells. The altered metabolism of cells driven by oncogenic KRAS genes results in mitochondrial fission. Blocking mitochondrial fission limits transformation and tumor growth.
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Covalent Inhibitors of RASA “tethered screening” approach is opening new doors to drugging RAS proteins. The NCI RAS Initiative is developing small molecules that covalently modify cysteine-185 and histidine-95 of KRAS.