RAS Dialogue Blog
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Sin1: a novel RAS effector with isoform specificitySin1, a member of the mTORC2 complex, is found to interact preferentially with KRAS4A via an atypical RAS binding domain. This interaction is shown to be dispensable for mTORC2 activity.
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Simulating Ras: 30 years of progressProgress in computational simulations of Ras’s movement within lipid bilayers reveal the membrane’s potential directive role on Ras orientation and signaling.
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RAS Initiative Leadership ChangeThe RAS Initiative welcomes a new Program Officer, Dr. Christopher Kane
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KRAS-related long noncoding RNAs in human cancersA growing body of evidence supports the role of long noncoding RNAs (lncRNAs) in cancer development. Several KRAS-related lncRNAs have been identified, with various mechanisms of cancer promotion
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Tissue Health Prevails: KRAS Mutant Cells are Outcompeted from Adult Pancreas TissuesNot all RAS mutations in pancreatic tissue lead to cancer. Cells that acquire RAS mutations can be outcompeted by healthy, neighbouring cells, with the EphA2 receptor playing an important role in this process