RAS Dialogue Blog
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Message from Dr. LowyA message from Deputy NCI Director, Douglas Lowy, about the progress of the RAS Initiative and its goal to create a virtual network of scientists working collaboratively to solve the RAS problem.
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A Conversation with Allan BalmainDr. Allan Balmain talks about his career path as a pioneer in RAS biology.
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No Magic Bullet for RASKevin Haigis discusses the complicated natural histories of the different RAS genes mutated at different positions in different organs that result in human cancers.
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Targeting RAL-GEF signaling and cytokines in KRAS driven lung cancerDavid Barbie's laboratory seeks to understand how cytokine production stimulated by mutant KRAS influences cancer growth. Inhibitors could improve treatments of cancers driven by mutant KRAS.
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Taking Food Away: Targeting Nutrient Scavenging by RAS-driven CancersCancers driven by mutant KRAS genes are more dependent on scavenging nutrients from the tumor microenvironment, via macropinocytosis, and from internal recycling of cellular components, via autophagy. These differences may be cancer vulnerabilities.