RAS Dialogue Blog
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The Mutational Spectra of Cancer Genes in TCGA DataThe Cancer Genome Atlas has catalogued mutations in more than 30 cancer types. The NCI RAS Initiative uses TCGA data to prioritize and inform its research objectives. The bar graphs show data for KRAS, HRAS, NRAS, BRAF, TP53, EGFR, PIK3CA, and PTEN.
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A Panel of Isogenic RAS-Dependent Cell Lines Developed at the Frederick National LaboratoryMouse embryonic fibroblasts have been engineered to lack all RAS genes on demand. Then individual RAS genes can be introduced. Such cells allow effects of drugs to be tested with more precision.
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RAS Pathway v3.0?Defining the most important elements of RAS signaling is an important objective of the NCI RAS Initiative. In a new RAS Dialogue post, advisor Frank McCormick invites community input on version 3.0 of the RAS Pathway.
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The K-Ras Anchor: Another Twist to the TaleThe specific amino acid sequence of the polybasic domain of K-Ras4B combines with its C-terminal lipid modifications to strongly influence its interactions with the plasma membrane.
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Kras and Cancer Metabolism: A Conversation with Carla MartinsOur cells ordinarily have two copies of each gene, one maternal and one paternal. Cancers in which both KRAS genes are mutated are more aggressive and have different metabolic pathways compared to cancers which have only one mutated KRAS gene.