Clinical Trial Results - Cancer Currents Blog
Reports on findings from cancer clinical trials, with commentary from leading researchers on how the trial results will affect patient care.
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Olanzapine Helps Prevent Nausea and Vomiting Caused by ChemotherapyA drug currently used to treat several psychiatric conditions can help prevent nausea and vomiting in patients receiving chemotherapy, a large clinical trial showed.
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Extended Adjuvant Therapy Beneficial for Some Women with Breast CancerResults from a recent clinical trial showed that extending adjuvant therapy with an aromatase inhibitor to 10 years after initial treatment can have important benefits for postmenopausal women with early-stage hormone receptor–positive breast cancer.
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Early-Stage Cancer Trials Support Promise of Precision Medicine, ImmunotherapyEncouraging findings from several early-stage clinical trials featured at the 2016 American Society of Clinical Oncology annual meeting support the promise of precision medicine and immunotherapy.
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Trials Produce Practice-Changing Results for Brain CancerResults from two clinical trials show that treating patients with the chemotherapy drug temozolomide in addition to radiation therapy increased overall and progression-free survival.
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After Rising for Decades, Thyroid Cancer Incidence StabilizesAfter rising steadily since the 1990s, the incidence of thyroid cancer in the United States may be leveling off, according to an analysis of data from NCI’s SEER program.
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Pembrolizumab Shows Promise in Patients with Rare Form of Skin CancerIn a small clinical trial, more than half of the patients with an aggressive form of skin cancer called Merkel cell carcinoma responded to the immunotherapy drug pembrolizumab.
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Sunitinib and Sorafenib Ineffective as Adjuvant Therapies for Kidney CancerResults from a recent clinical trial show that post-surgical therapy with two anti-angiogenesis drugs does not improve progression-free survival for patients with kidney cancer and may cause serious side effects.
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Drug Combination Shrinks Duodenal Polyps in People with Familial Adenomatous PolyposisIn a small clinical trial of people with an inherited condition that greatly increases gastrointestinal cancer risk, a two-drug combination shrank precancerous lesions in the duodenum.
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Video Intervention Helps Prepare Patients to Participate in Cancer Clinical TrialsPatients who took part in a tailored, video-based educational program had a better understanding of and fewer concerns about participating in clinical trials than patients who received text-based educational.
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Two Drugs Show Efficacy against Common Form of LeukemiaReports from early-stage trials of two new oral drugs provide hope for patients with high-risk chronic lymphocytic leukemia.
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Oncolytic Virus Therapy Shows Benefit in Patients with MelanomaIn a large clinical trial, the oncolytic virus therapy T-VEC improved the durable response rate and median survival in patients with advanced melanoma.
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Study Finds Storytelling Helps Overcome Cervical Cancer Screening DisparitiesUsing a storytelling approach to educate women about cervical cancer screening eliminated disparities in attitudes toward screening and behavior, according to a new study.
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Adjuvant Chemotherapy Modestly Improves Survival in Some Men with Prostate CancerGiving some men with prostate cancer chemotherapy after standard treatment with radiation and hormone therapy modestly improves how long they live, according to results from a new NCI-funded clinical trial.
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The Playing Field for Cancer Checkpoint Inhibitors Is ExpandingThe list of cancers that may be susceptible to checkpoint inhibitors is quickly expanding, according to findings from clinical trials presented at the ASCO annual meeting.
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Whole Brain Radiation for Some Patients with Brain Metastases Worsens Cognitive DeclineIn some patients with cancer that has spread to the brain, whole brain radiation following radiosurgery causes more severe cognitive decline and does not improve survival compared with radiosurgery alone, a new study has found.
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Trial Yields Positive Data on Pembrolizumab for Lung Cancer, Potential Response BiomarkerFindings from an early phase clinical trial may point to a biomarker that identifies patients with advanced non-small cell lung cancer most likely to respond to the immunotherapy drug pembrolizumab (Keytruda®).
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HPV Vaccine Effective Against Infection at Multiple Sites, Provides Partial Protection in Women with Previous InfectionsA new study from NCI researchers finds that the HPV vaccine protects young women from infection with high-risk HPV types at the three primary anatomic sites where persistent HPV infections can cause cancer. The multi-site protection also was observed at lower levels in previously HPV-exposed women.
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Immune-Based Treatment Shows Promise against Metastatic Cervical CancerIn an early phase NCI clinical trial, two patients with metastatic cervical cancer had a complete disappearance of their tumors after receiving treatment with a form of immunotherapy called adoptive cell transfer.
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Treatment Helps Preserve Fertility for Some Women with Breast CancerIn a large clinical trial, giving a hormone-suppressing drug helped some younger women with breast cancer get pregnant after completing cancer treatment.