December 2024 - Cancer Currents Blog
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A “Living Medicine:” Engineered E. coli Shrink Tumors in MiceTwo researcher teams have engineered a probiotic strain of E. coli called Nissle 1917 so it can help the immune system attack tumors. Although the E. coli were altered in different ways, resulting in two different immune-based treatment strategies, both were effective in mice.
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Treatment Strategy for ecDNA-Driven Tumors Shows PotentialResearchers have found that cancer cells containing extrachromosomal DNAs (ecDNAs) have a weakness that can be exploited by a drug that targets the CHK1 protein. In mice, combining the drug with another targeted therapy kept cancer at bay for long periods.