Updates & Insights Blog
This blog features current topics in cancer genomics research and news and updates from CCG. Let's continue the conversation on our Personal Genomics Podcast.
-
Pediatric Genomic Data Inventory: A Valuable Resource of Pediatric Cancer ProjectsEach year, more than 200,000 children and adolescents under the age of 20 are diagnosed with cancer worldwide1.
-
From Ignoring Features to Machine Learning Features: Computational Biology Then and NowDr. John Weinstein discusses progress in computational biology over the 12-year span of TCGA. The field has expanded greatly, with researchers taking on more complex problems and trying different approaches.
-
The Genomic Data Commons Turns 2: Progress in Clinical Tool DevelopmentThe Genomic Data Commons (GDC) launched two years ago with the goal to build a collaborative, interactive knowledge system that anyone can use. Dr. Lou Staudt reflects on milestones reached at the GDC’s two year anniversary and challenges ahead in building clinically relevant tools and advancing precision medicine.
-
After TCGA: Building Clinical Genomic ResourcesThe Center for Cancer Genomics (CCG) continues to build genomic resources with a special focus on clinical features and patient outcome. A new wave of cancer characterization projects will generate data relevant for precision medicine and build on the legacy left by The Cancer Genome Atlas, which officially concluded in April 2018.
-
Office of Cancer Genomics: Integration of Structural, Functional, and Computational Genomic Data Advances Precision OncologyA collaborative study conducted by two Office of Cancer Genomics (OCG) initiatives highlights the importance of integrating structural and functional genomics programs to improve cancer therapies, and more specifically, contribute to precision oncology treatments for children.
-
Understanding the Other Side of ResearchFor over seven years, the Office of Cancer Genomics (OCG) has supported recent doctoral graduates through internship and fellowship programs.
-
Challenging Experiences in Expanding Opportunities: The Burkitt Lymphoma Genome Sequencing Project in BrazilBurkitt Lymphoma (BL) is an aggressive B-cell lymphoma involving dysregulation of the MYC oncogene by chromosomal translocations. It is most common in children but also affects adults and occurs in sporadic, endemic, and HIV-associated forms.
-
Studying Human Cancer Invasion and Metastasis in Real-Time in the LaboratoryA large majority of cancer deaths are attributable to metastasis, the process by which cancer cells spread throughout the body to form new tumors in distant vital organs1. Despite its central importance to patient outcomes, the cellular and molecular basis of metastasis is incompletely understood.
-
Responses to Cancer Therapies are ComplexPatient clinical responses and changes in tumor burden during treatment reflect the cumulative effects of diverse phenomena that occur at the cellular level. Therefore, it is useful to describe treatment responses at the level of patients, tumors and cells.
-
TARGET Reveals the Genomic Characteristics of Multiple Childhood CancersThe Therapeutically Applicable Research to Generate Effective Treatments (TARGET), a large-scale pediatric genomic characterization initiative, continues to demonstrate the importance of integrative analyses using comprehensive data and metadata generated from high-quality