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Epstein Barr Virus Associated Lymphoma Consortium (EALC)

Hematoxylin and eosin (HE) staining of the Epstein-Barr virus (EBV).

The Epstein Barr Virus Associated-Lymphoma Consortium (EALC) is advancing the understanding of the role of Epstein Barr virus (EBV) infection on Non-Hodgkin Lymphoma and/or Hodgkin disease development with or without an underlying HIV/AIDS infection. 

The goal of the consortium is to increase knowledge about how EBV promotes Non-Hodgkin Lymphoma and/or Hodgkin disease initiation, progression, and resulting conditions, as well as to provide insights into mechanistic differences in the relationship between EBV infection and lymphoma development in individuals with HIV infection and those without an underlying HIV infection.  

EALC News

Highlights from 2024 EALC Annual Meeting

Mariah Riel et al. with the University of Wisconsin-Madison EALC Project showed that the effects of EBV latent membrane protein 2A (LMP2A) in lymphoblastoid cells are strongly influenced by B cell receptor (BCR) isotype. 

Dr. Rina Xian et al. with the Johns Hopkins University EALC Project found that EBV DNA from tumors is epigenetically modified with unique methylation profiles that may correspond to different virus latency patterns. Additionally, the methods they shared will enable future studies of the EBV methylome in different HIV positive populations for the development of new diagnostic assays.  

DCB Contact for EALC

For additional information about the EALC, please contact Dr. Betsy Read-Connole.

Funded Projects

Institution Principal Investigator(s) Center Title
Duke University  Micah A. Luftig Defining and exploiting EBV-infected cell heterogeneity in non-Hodgkin lymphomas
John Hopkins University Richard F. Ambinder, Rena Xian Investigating the EBV methylome in PLWH: Discovery and development of novel EBV diagnostics in plasma and saliva
Stanford University Olivia Martinez, Sheri M. Krams Epstein Barr virus driven mechanisms of post transplant lymphoproliferative disease
University of Florida  Sumita Bhaduri-McIntosh, Michael McIntosh Synthetic lethal targeting of EBV-positive diffuse large B cell lymphomas in persons living with HIV
University of Wisconsin-Madison Eric C. Johannsen  Role of Epstein-Barr virus LMP2A protein in maintaining oncogenic IgM signaling in EBV+ B cell lymphomas
University of Wisconsin-Madison Shannon C. Kenney Roles of LMP1 and MYC in EBV-induced B-cell tumors
Washington University in St. Louis  Vikas R. Dharnidharka  Understanding the immune response changes to clinical interventions for Epstein-Barr virus infection prior to lymphoma development in children after organ transplants (UNEARTH)
Weill Cornell  Ethel Cesarman, Benjamin E. Gewurz, Lisa G. Roth

B cell determinants of EBV latency

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