Table 9. Agents With Selective Activity Against Subtypes of Soft Tissue Tumors
| Agent | Soft Tissue Sarcoma Subtype |
| Sunitinib [11,12] | Alveolar soft part sarcoma |
| Sunitinib [13] | Solitary fibrous tumor |
| Sirolimus [14] | Perivascular epithelioid cell tumor (PEComa) |
| Crizotinib [15] | Inflammatory myofibroblastic tumor |
| Imatinib | Tenosynovial giant cell tumor |
| Imatinib [16] | Chordoma |
| Imatinib [17] | Dermatofibrosarcoma protuberans |
References
- Stacchiotti S, Negri T, Zaffaroni N, et al.: Sunitinib in advanced alveolar soft part sarcoma: evidence of a direct antitumor effect. Ann Oncol 22 (7): 1682-90, 2011. [PUBMED Abstract]
- Stacchiotti S, Tamborini E, Marrari A, et al.: Response to sunitinib malate in advanced alveolar soft part sarcoma. Clin Cancer Res 15 (3): 1096-104, 2009. [PUBMED Abstract]
- Stacchiotti S, Negri T, Libertini M, et al.: Sunitinib malate in solitary fibrous tumor (SFT). Ann Oncol 23 (12): 3171-9, 2012. [PUBMED Abstract]
- Wagner AJ, Malinowska-Kolodziej I, Morgan JA, et al.: Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors. J Clin Oncol 28 (5): 835-40, 2010. [PUBMED Abstract]
- Butrynski JE, D'Adamo DR, Hornick JL, et al.: Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor. N Engl J Med 363 (18): 1727-33, 2010. [PUBMED Abstract]
- Stacchiotti S, Longhi A, Ferraresi V, et al.: Phase II study of imatinib in advanced chordoma. J Clin Oncol 30 (9): 914-20, 2012. [PUBMED Abstract]
- Rutkowski P, Van Glabbeke M, Rankin CJ, et al.: Imatinib mesylate in advanced dermatofibrosarcoma protuberans: pooled analysis of two phase II clinical trials. J Clin Oncol 28 (10): 1772-9, 2010. [PUBMED Abstract]
