shark cartilage extract AE-941
A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity. Shark cartilage extract AE-941 competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cell receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells.
| Synonym: | Neovastat/AE-941 |
|---|---|
| US brand name: | Neovastat |
| Foreign brand name: | Neovastat |
| Code name: | AE-941 |
| IND number: | 59439 |
| NSC code: | 706456 |