deferasirox
A synthetic, orally bioavailable, achiral, tridentate triazole derived from salicylic acid with iron-chelating activity. Deferasirox chelates iron at a 2:1 (ligand:iron) ratio. Because of its oral availablity,and long plasma half-life, this agent may be superior to desferrioxamine (desferal, DFO), which is orally inactive and has a short plasma half-life.
| US brand name: | Exjade Jadenu |
|---|---|
| Chemical structure: | 4-(3,5-bis-(hydroxy-phenyl)-1,2,4-triazol-1-yl)-benzoic acid |