cisplatin
View Patient InformationAn alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition.
| Synonym: | cis-diamminedichloridoplatinum cis-diamminedichloro platinum (II) cis-diamminedichloroplatinum Cis-dichloroammine Platinum (II) cis-platinous diamine dichloride cis-platinum cis-platinum II cis-platinum II diamine dichloride Cismaplat Cisplatina Cysplatyna DDP Peyrone's Chloride Peyrone's Salt Platinoxan platinum platinum diamminodichloride |
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| Foreign brand name: | Abiplatin Blastolem Briplatin Cisplatyl Citoplatino Citosin Lederplatin Metaplatin Neoplatin Placis Platamine Platiblastin Platiblastin-S Platinex Platinol- AQ Platinol-AQ VHA Plus Platiran Platistin Platosin |
| Abbreviation: | CDDP DDP |
| Chemical structure: | (SP-4-2)-diamminedichloroplatinum platinum, diaminedichloro-, cis- (8CI) |