2024 Alliance for Nanotechnology in Cancer Principal Investigators’ Meeting

Agenda

DAY 1: October 24, 2024

9:00 am – 9:20 am      Welcome and Introduction

Lalitha K. Shankar, MD, PhD, Acting Associate Director, Cancer Imaging Program (CIP), DCTD, NCI

Piotr Grodzinski, PhD, Branch Chief, NSDB, CIP, DCTD, NCI

Session I          Advances in Extracellular Vesicle Nanotechnology for Cancer Care

Moderator: Yicong Wu, PhD, Program Director, NSDB, CIP, DCTD, NCI

9:20 am – 9:40 am      High throughput nanoplasmonic exosome testing of immunotherapies in bladder cancer

Cesar M. Castro, MD, Massachusetts General Hospital

9:40 am – 10:00 am    Designer extracellular vesicles for cancer therapy

Xiaowei Xu, MD, PhD, University of Pennsylvania

10:00 am – 10:20 am  Mechanism and approach to inactivate mutant KRAS of lung metastatic colon cancer by RNA-ligand-displaying exosome to co-deliver dCas9--gRNA ribonucleoprotein complex and KRAS siRNA

Peixuan Guo, PhD, Ohio State University

10:20 am – 10:40 am Engineering in vivo chimeric antigen receptor macrophages (CARMs) using mRNA-exosomes for cancer immunotherapy

Wen Jiang, MD, PhD, University of Texas MD Anderson Cancer Center

10:40 am – 11:00 am  TNBC ligand-displaying exosomes using RNA nanotechnology for targeted cytosol delivery of RNAi without endosome entrapment

Daniel Binzel, PhD, Ohio State University

11:00 am – 11:20 am Break

Session II         Panel Discussion: What Extracellular Vesicles are Good for – therapy, diagnostics, or both?

Moderator: Wen Jiang, MD, PhD, University of Texas MD Anderson Cancer Center

11:20 am – 12:30 pm

1. Xiaowei Xu, MD, PhD, University of Pennsylvania

2. Cesar Castro, MD, Massachusetts General Hospital

3. Wen Jiang, MD, PhD, University of Texas MD Anderson Cancer Center

4. Kyung Sung, PhD, Center for Biologics Evaluation and Research, FDA

5. Toumy Guettouche, PhD, Mercy BioAnalytics

12:30 pm – 2:00 pm    Lunch Break

Plenary presentation

2:00 pm – 2:40 pm      Regenerative medicine in cancer research

Jennifer Elisseeff, PhD, Johns Hopkins University

 

Session III        Tumor Sensing and Imaging Driven by Nanotechnology

Moderator: Piotr Grodzinski, PhD, Program Director, NSDB, CIP, DCTD, NCI

2:40 pm – 3:00 pm      Rapid and affordable magneto-nanosensors for ctDNA-guided lung cancer management 

                                    Shan X. Wang, PhD, Stanford University

3:00 pm – 3:20 pm      Development of a new multiplexed imaging strategy for immunoprofiling using Raman-active nanoparticles

                                    Cristina Zavaleta, PhD, University of Southern California

3:20 pm – 3:40 pm      Chip-scale intraoperative optical navigation with immunotargeted upconverting nanoparticles

                                    Mekhail Anwar, MD, PhD, University of California, San Francisco

3:40 pm – 4:00 pm      Break

4:00 pm – 6:00 pm      Poster Session

DAY 2: October 25, 2024

8:30 am – 8:40 am      Day 1 recap

Piotr Grodzinski, PhD, Branch Chief, NSDB, CIP, DCTD, NCI

Session IV       Efficient Nanotherapies via Stimulation of Tumor Microenvironment

Moderator: Leela Rani Avula, PhD, Program Director, NSDB, CIP, DCTD, NCI

8:40 am – 9:00 am      Targeting tumor microenvironment by nanoimmunodrugs for glioma treatment

Alexander V. Ljubimov, PhD, Cedars-Sinai Medical Center

9:00 am – 9:20 am      Targeting tumor and its microenvironment using nanotherapeutics for pancreatic cancer

Satyanarayana Rachagani, DVM, PhD, University of Missouri - Columbia

9:20 am – 9:40 am      Development of novel nanotherapeutics to overcome therapy resistance using canine brain tumor as a spontaneous model

Yuanpei Li, PhD, University of California at Davis

9:40 am – 10:00 am    Stimuli-responsive mucin1-specific nanoparticles for efficacious combinatorial chemotherapy of pancreatic ductal adenocarcinoma

Juan Luis Vivero-Escoto, PhD, University of North Carolina at Charlotte

10:00 am – 10:20 am  Design of a novel nanocarrier technology to drug-load CAR T cells

David Akhavan, MD, PhD, University of Kansas Medical Center

10:20 am – 10:40 am  Presentation of Poster Awards/Break

• Jade Miller, Sarah Hall, Richard D’Arcy, Emily Jaremba, Natalie Bennett, Julie Rhoades, and Craig Duvall, Vanderbilt University, “Development of targeted nanoparticle delivery for skeletal metastases of breast cancer”
• Debasmita Paul, Declan Dahlberg, Freddys F. Rodriguez, Abhishek Kulkarni, Lakmal Rozumalski, and Carston R. Wagner, University of Minnesota, “EGFR+ Solid Tumor Targeting by Cytotoxic T-cells with Chemically Self-Assembled Nanorings (CSANs) composed of a-T-cell Receptor Nanobody”
• Aaron S. Schwartz-Duval, Yuri Mackeyev, Iqbal Mahmud, Philip L. Lorenzi, Mihai Gagea, Sunil Krishnan, and Konstantin V. Sokolov, University of Texas MD Anderson Cancer Center, “In situ cancer cell specific biomineralization to overcome nanoparticle delivery barriers and sensitize pancreatic cancer to radiotherapy”

10:40 am – 11:00 am  Towards translation of MU-CN29: new therapeutic nanoparticle for drug-resistant NSCLC

Raghuraman Kannan, PhD, University of Missouri - Columbia

11:00 am – 11:20 am  Nanodelivery of FP polymers to improve treatment of metastatic colorectal cancer

William H. Gmeiner, PhD, Wake Forest University Health Sciences

11:20 am – 11:40 am  Cyanine lipid library for mechanistic understanding of structure-tumor accumulation relationship 

Dmitri Simberg, PhD, University of Colorado-Denver

11:40 am – 12:00 pm  Toward translation of an immunotherapeutic nanomedicine for neuroblastoma

John T. Wilson, PhD, Vanderbilt University

Session V        Combination Therapies

Moderator: Yicong Wu, PhD, Program Director, NSDB, CIP, DCTD, NCI

12:00 pm – 12:20 pm  Development of a novel biodegradable inorganic nanoparticle therapeutic for cancer

Jin Xie, PhD, University of Georgia

12:20 pm – 12:40 pm  Translational combinations of nanocarriers and blockers for metastatic breast cancer

Andrew M. Smith, PhD, University of Illinois at Urbana-Champaign

12:40 pm – 1:00 pm    Toward translation of nanformulated paclitaxel-platinum combination Alexander V. Kabanov, PhD, University of North Carolina at Chapel Hill

1:00 pm – 1:05 pm      Closing remarks

                                        Yicong Wu, PhD, Program Director, NSDB, CIP, DCTD, NCI