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2024 Alliance for Nanotechnology in Cancer Principal Investigators’ Meeting

October 24 – October 25, 2024

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Day 1: Thursday, October 24
Time	Session
9:00 – 9:20 a.m.	Welcome and Introduction Janet Eary, M.D., Associate Director, Cancer Imaging Program, DCTD, National Cancer Institute Piotr Grodzinski, Ph.D., Branch Chief, NSDB/CIP/DCTD, National Cancer Institute
9:20 – 10:00 a.m.	Plenary presentation Engineering the stimulation of natural and synthetic T cells for cancer immunotherapy Darrell Irvine, Ph.D., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Session I	NANOTECHNOLOGY-DRIVEN IMMUNOTHERAPY MODERATOR: Piotr Grodzinski, Ph.D., Branch Chief, NSDB, CIP, DCTD, NCI
10:00 – 10:20 a.m.	Nano-optogenetic control of CAR-T cells for precision immunotherapy with enhanced safety Yubin Zhou, Ph.D., TEXAS A&M UNIVERSITY HEALTH CENTER
10:20 – 10:40 a.m.	Use of a nano-enabled platform for pancreatic cancer immunotherapy Andre Nel, M.D., Ph.D., UNIVERSITY OF CALIFORNIA LOS ANGELES
10:40 – 11:00 a.m.	Plant virus nanoparticles for immunotherapy and relapse prevention of ovarian cancer Nicole Steinmetz, Ph.D., UNIVERSITY OF CALIFORNIA, SAN DIEGO
11:00 – 11:20 a.m.	Break
11:20 – 11:40 a.m.	Systemic delivery of siRNA by nanosac for checkpoint blockade immunotherapy of head and neck squamous cell cancer Yoon Yeo, Ph.D., PURDUE UNIVERSITY
11:40 a.m – 12:00 p.m.	Intrapleural immunotherapeutic nanoparticles for MPE treatment Dawen Zhao, M.D., Ph.D., WAKE FOREST UNIVERSITY HEALTH SCIENCES
12:00 – 12:20 p.m.	Dual action immunostimulatory nanoparticles for treatment of aggressive cancers Efstathios Karathanasis, Ph.D., CASE WESTERN RESERVE UNIVERSITY
12:20 – 1:40 p.m.	Lunch Break
Session II	PANEL DISCUSSION: mRNA VACCINES FOR CANCER – LESSONS LEARNED FROM COVID19 MODERATOR: Andre Nel, M.D., Ph.D., UNIVERSITY OF CALIFORNIA LOS ANGELES
1:40 – 3:00 p.m.	Andre Nel, M.D., Ph.D., UNIVERSITY OF CALIFORNIA LOS ANGELES Matthias Stephan, M.D., Ph.D., FRED HUTCHINSON CANCER CENTER Puneet Tyagi, Ph.D., ASTRA ZENECA Yoon Yeo, Ph.D., PURDUE UNIVERSITY
Session III	GENE THERAPIES MODERATOR: Leela Rani Avula, Ph.D., Program Director, NSDB, CIP, DCTD, NCI
3:00 – 3:20 p.m.	Next-gen targeted nanoparticles for inhibiting Gli2 in bone metastatic tumors Julie Rhoades, Ph.D., VANDERBILT UNIVERSITY MEDICAL CENTER
3:20 – 3:40 p.m.	Developing macrophage reprogramming mRNA nanocarriers for initial clinical testing Matthias Stephan M.D., Ph.D., FRED HUTCHINSON CANCER CENTER
3:40 – 4:00 p.m.	Targeted RNA delivery using ribonucleoprotein Xiaohu Gao, Ph.D., UNIVERSITY OF WASHINGTON
4:00 – 6:00 p.m.	POSTER SESSION

Day 2: Wednesday, October 18
Time	Session
8:30 – 8:40 a.m.	Day 1 recap Carolina Salvador Morales, Ph.D., Program Director, NSDB, CIP, DCTD, NCI
Session IV	CANCER INTERVENTIONS ENABLED BY NANOMATERIALS AND DEVICES MODERATOR: Yicong Wu, Ph.D., Program Director, NSDB, CIP, DCTD, NCI
8:40 – 9:00 a.m.	Magnetofluorescent nanoprobe for the image-guided delivery to glioblastoma John Yu, M.D., CEDARS-SINAI MEDICAL CENTER
9:00 – 9:20 a.m.	Customized nanofibers with preferential lung-targeting properties for treating metastatic pulmonary tumors Vanessa Bellat, Ph.D., WEILL MEDICAL COLL OF CORNELL UNIVERSITY
9:20 – 9:40 a.m.	Click Chemistry-Mediated Extracellular Vesicles Enrichment for Characterization of Tumor-Derived Extracellular Vesicles Hsian-Rong Tseng, Ph.D., UNIVERSITY OF CALIFORNIA LOS ANGELES
9:40 – 10:00 a.m.	Tumor-targeting transformable nanotherapeutic platform against cancer Kit Lam, M.D., Ph.D., UNIVERSITY OF CALIFORNIA AT DAVIS
10:00 – 10:10 a.m.	Presentation of Poster Awards Siyao Liu, Lian He, Kai Huang, Gang Han, Yubin Zhou, Institute of Biosciences and Technology, Texas A&M University Nano-optogenetics for precision immunotherapy Anthony O. Omole, Jessica F. A. de Oleveira, Lucas Sutorus, Nicole F. Steinmetz, Institute of Engineering in Medicine, University of California, San Diego Ovarian cancer therapy using plant viral nanoparticles Alina Ringaci, Ting-Yu Shih, Christopher Gromisch, Aladin Hamoud, Samantha M. Berry, Yolonda L. Colson, Mark W. Grinstaff, College of Engineering, Boston University Self-assembled Nano-zip Antibody Drug Conjugate for the treatment of HER2-positive breast cancer James G. Shamul, Xiaoming He, Department of Bioengineering, University of Maryland, College Park A meta-analysis of engineered blood brain barriers in vitro
10:10 – 10:40 a.m.	Break
Session V	NCI RESOURCES – SUPPORT AND AID FOR CURRENT AND FUTURE GRANTEES MODERATOR: Piotr Grodzinski, Ph.D., Branch Chief, NSDB, CIP, DCTD, NCI
10:40 – 11:00 a.m.	Grant policies, beyond R01s Leela Rani Avula, Ph.D., NSDB, CIP, DCTD, NCI
11:00 – 11:20 a.m.	NCL overview Marina Dobrovolskaia, Ph.D., NCL, FNLCR
11:20 – 11:40 a.m.	caNanoLab database overview Weina Ke, Ph.D., FNLCR
Session VI	COMBINATION THERAPIES MODERATOR: Carolina Salvador Morales, Ph.D., Program Director, NSDB, CIP, DCTD, NC
11:40 am – 12:00 p.m.	Pre-IND development of polymeric micelles with dual drug payloads for HCC therapy Chun Li, Ph.D., UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER
12:00 – 12:20 p.m.	Inhibition of iRhom by CD44-targeting Nanocarrier for Improved Cancer Immunochemotherapy Song Li, M.D., Ph.D., UNIVERSITY OF PITTSBURGH AT PITTSBURGH
12:20 – 12:40 p.m.	Nano-beter Paclitaxel by Polymeric Micelles, Prodrug Nanotechnology, and mTOR Inhibition Glen Kwon, Ph.D., UNIVERSITY OF WISCONSIN-MADISON
12:40 – 1:00 p.m.	Nanoscale Metal-Organic Framework for the Treatment of Head and Neck Cancer Wenbin Lin, Ph.D., UNIVERSITY OF CHICAGO
1:00 – 1:20 p.m.	Closing remarks Piotr Grodzinski, Ph.D., Branch Chief, NSDB, CIP, DCTD, NCI