A Multilevel Intervention to Increase Colorectal Cancer Screening Tests in Patients with Abnormal Fecal Immunochemical Test Results, PROACT Trial

This clinical trial studies whether an intervention that addresses two or more levels of care (multilevel intervention) increases follow-up of abnormal, non-invasive, colorectal cancer (CRC) screening test results. The fecal immunochemical test (FIT) is a non-invasive, stool-based, CRC screening test. FITs are relatively inexpensive and can be completed at home, for these reasons, it is a preferred method of CRC screening in healthcare settings that care for under-resourced patients or have limited colonoscopy access. For FIT-based CRC screening to be effective, abnormal results must be followed by a colonoscopy, however, many patients fail to complete this recommended follow-up test. The multilevel intervention addresses barriers to follow-up colonoscopy at the patient and health system levels of care through a CRC screening patient navigator, an educational video, and transportation assistance. The navigator provides patient support and assistance with colonoscopy scheduling. The educational video addresses identified patient fears around colonoscopies. Transportation assistance is offered after the colonoscopy through a rideshare program, to address transportation barriers. Therefore, this multilevel intervention may increase follow-up colonoscopy completion in patients with abnormal FIT results.

Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT06822530.

Trial PhaseNo phase specified

Trial Typescreening

Lead OrganizationFred Hutch/University of Washington/Seattle Children's Cancer Consortium

Principal InvestigatorRachel B. Issaka

• Primary IDRG1124701
• Secondary IDsNCI-2024-08639
• ClinicalTrials.gov IDNCT06822530