Study of CD200 Activation Receptor Ligand (CD200AR-L) and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent Glioblastoma

Inclusion Criteria

• Aged 18 years and older.
• Confirmed diagnosis of GBM.
• Radiographically or histologically proven progression or recurrence of disease at any time after standard of care therapy (radiation, temozolomide, with or without a tumor treatment field device).
• Tumor debulking or biopsies may be performed to clinical trial enrollment if indicated and feasible.

Exclusion Criteria

• Bevacizumab or targeted therapy within 45 days of enrollment.
• Intercurrent immune system disorder such as hypoimmunity (marrow failure, HIV) or hyperimmunity (autoimmune disease).
• Unable to complete a standard upfront course of chemoradiotherapy due to disease progression or intolerance of therapy.
• History of Gliadel water, GammaTile or other implanted therapeutic agent.
• Concurrent use of tumor treatment field devices (e.g. Optune).