A critical unmet need in the management of malignancies is the development of minimally invasive methods that predict whether a screen-detected lesion is indolent (i.e., requiring only careful monitoring) or progressive (requiring appropriate intervention).
DCB and the NCI Division of Cancer Prevention (DCP) supported the Molecular Characterization of Screen-Detected Lesions (MCL) consortium, which worked to comprehensively characterize cellular and molecular components of early lesions and identify features that distinguish indolent from aggressive/progressive lesions. Multi-disciplinary MCL teams (that were funded by RFA-CA-14-010 & RFA-CA-14-011) used enabling technologies to inform better predictions of the fate of precancers and early lesions.
About MCL
Information about the initial goals and the 2015 launch of the MCL program can be found in a DCP news article.
MCL Highlight
Using histological, molecular, and immunological profiling approaches in a recent NPJ Breast Cancer study, Nachmanson et al. generated a breast precancer atlas showing the molecular and microenvironmental heterogeneity of ductal carcinoma in situ (DCIS).
Past Projects
| Institution |
Principal Investigator(s) |
Project Title |
| Baylor College of Medicine |
Christopher Amos |
Coordinating Center: Molecular and Cellular Findings of Screen-Detected Lesions |
| Johns Hopkins University |
Kenneth Pienta,
Angelo De Marzo |
Multidiciplinary Integrative Genomic Approach to Distinguish Lethal from Indolent Prostate Cancer in Men of Europena and African Ancestry |
| MD Anderson Cancer Center |
Anirban Maitra |
Imaging and Molecular Correlates of Progression in Cystic Neoplasms of the Pancreas |
| Stanford University |
James Brooks |
Stanford Molecular and Cellular Characterization Laboratory |
| University of California, Los Angeles |
Steven Dubinett,
Denise Aberle,
Fenghai Duan,
Marc Lenburg |
Integrated Molecular, Cellular, and Imaging Characterization of Screen-Detected Lung Cancer |
| University of California, San Francisco |
Laura Esserman,
Alexander Borowsky |
Elucidating the Molecular and Contextual Basis for IDLE Utralow Risk Lesions and the Tumor Immune Microenvironment of High Risk In Situ and Invasive Breast Cancers |
| University of Vermont & State Agricultural College |
Janet Stein,
Brian Sprague,
Donald Weaver |
Vermont Breast Cancer Molecular Characterization Laboratory |
| Vanderbilt University Medical Center |
Pierre Massion,
Fabien Maldonado |
Cellular, Molecular and Quantitative Imaging Analysis of Screening-Detected Lung Adenocarcinoma |
