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Onco-Aging Consortium (OAC)

Image of KRAS-driven lung cancer overlayed with "Onco-Aging Consortium"

Onco-Aging Consortium

The OAC is a joint NCI and National Institute on Aging (NIA) program funded through RFA-CA-20-040. It was established to support research addressing key questions regarding how hallmarks of aging lead to impaired cellular activities and alterations in the microenvironment that contribute to the development and outgrowth of cancer-initiating cells (CICs). 

The OAC supports interdisciplinary teams that combine aging and cancer expertise with approaches to decipher the biological pathways during aging that contribute to cancer initiation.  

OAC News and Highlights

OAC Scientist Highlights: Drs. Marcia Haigis and Carla Kim

Dr. Marcia Haigis (a Professor of Cell Biology at Harvard Medical School) and Dr. Carla Kim (a Professor of Pediatrics and Genetics at Boston Children's Hospital) are investigating how molecular changes in alveolar cells contribute to lung cancer initiation during aging.

They recently found that epigenetic regulation that coordinates lung progenitor cells’ regenerative responses becomes dysregulated during aging and may contribute to the development of age-related lung diseases. 

OAC Meetings

OAC Investigators Meeting – Sept. 9 - 10, 2024

OAC Kick-Off Meeting – Feb. 17 - 18, 2022

 

DCB Contact for OAC

For additional information about the OAC, please contact Dr. Margaret Klauzinska. 

Funded Projects

Institution Principal Investigator(s) Project Title
Fred Hutchison Cancer Research Center William M. Grady, Matt Kaeberlein The role of the senescent microenvironment on cancer initiating cells in the colon
Harvard Medical School Marcia Haigis, Carla F. Kim Progenitor cell states contributing to aging and lung cancer
Jackson Laboratory Sheng Li, James V. Degregori Impact of aging and clonal hematopoiesis on epigenetic heterogeneity, evolvability, and leukemogenesis
Jackson Laboratory Jennifer J. Trowbridge, Ross L. Levine Assessing the interplay between inflammatory signaling and epigenetic dysregulation in age-associated clonal hematopoiesis and leukemia initiation
Memorial Sloan Kettering Cancer Center Scott W. Lowe Impact of the aging niche on cancer phenotypes probed using mouse cancer models produced by somatic engineering
Stanford University Monte M. Winslow Dissecting the interplay between aging, genotype and the microenvironment in lung cancer
University of California, San Diego Robert A.J. Signer, Jeffrey A. Magee The influence of proteostasis loss in aging hematopoietic stem cells on leukemia initiation
University of Michigan Gary J. Fisher, Andrej A. Dlugosz, Taihao Quan The aging cutaneous microenvironment and cancer initiation
University of Michigan Megan M. Weivoda, Thomas L.G. Andersen, Matthew T. Drake Role of senescence in multiple myeloma tumorigenesis
University of Pittsburgh Lan Coffman, Ronald J. Buckanovich, Toren Finkel Defining the impact of stromal aging on ovarian cancer initiation
University of Texas Health Science Center Sun Luzhe Aging-associated mammary cancer-initiating cells
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