Tislelizumab-jsgr
Tislelizumab-jsgr works by keeping cancer cells from suppressing the immune system. It binds to the protein PD-1 on the surface of immune cells called T cells, allowing the immune system to recognize and kill the cancer cells. Tislelizumab-jsgr is a type of immunotherapy (immune checkpoint inhibitor) and a type of targeted therapy (monoclonal antibody).
FDA label information for this drug is available at DailyMed.
Use in Cancer
Tislelizumab-jsgr is approved to treat adults with:
- Esophageal cancer that cannot be removed by surgery or has spread to other parts of the body. It is used in patients with squamous cell carcinoma of the esophagus. It is given:
- with platinum-based chemotherapy as the first treatment in patients whose cancer has the PD-L1 protein
- alone in patients whose cancer was treated with systemic chemotherapy that did not include a PD-L1 or PD-1 inhibitor
- Gastric adenocarcinoma or gastroesophageal junction adenocarcinoma that has the PD-L1 protein, is HER2 negative, and cannot be removed by surgery or has spread to other parts of the body. It is given with platinum-based chemotherapy and a fluoropyrimidine as the first treatment.
Tislelizumab-jsgr is also being studied in the treatment of other types of cancer.
More About Tislelizumab-jsgr
Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.
MedlinePlus Information on Tislelizumab-jsgr - A lay language summary of important information about this drug that may include the following:
- warnings about this drug,
- what this drug is used for and how it is used,
- what you should tell your doctor before using this drug,
- what you should know about this drug before using it,
- other drugs that may interact with this drug, and
- possible side effects.
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
Research Results and Related Resources
Targeted Therapy to Treat Cancer
Clinical Trials Accepting Patients
Find Clinical Trials for Tislelizumab-jsgr - Check for trials from NCI's list of cancer clinical trials now accepting patients.