Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf
This targeted therapy combination consists of two monoclonal antibodies, pertuzumab and trastuzumab, and hyaluronidase-zzxf, a recombinant form of a naturally occurring enzyme. Pertuzumab and trastuzumab bind to different parts of the HER2 protein on the surface of some cancer cells, causing the cells to stop growing and die. Both also trigger a type of immune reaction that kills cells that have a lot of HER2. Hyaluronidase-zzxf makes it easier for the body to absorb these targeted therapies.
FDA label information for this drug is available at DailyMed.
Use in Cancer
Pertuzumab, trastuzumab, and hyaluronidase-zzxf is approved to be given with docetaxel or other chemotherapy to treat:
- Breast cancer that is HER2 positive. It is used:
- with chemotherapy as neoadjuvant therapy (to shrink the tumor before surgery) in adults with locally advanced, inflammatory, or early-stage breast cancer
- with chemotherapy as adjuvant therapy in adults with early-stage breast cancer who have a high risk that their cancer will recur (come back)
- with the chemotherapy drug docetaxel in adults with metastatic breast cancer that has not been treated with anti-HER2 therapy or chemotherapy
Pertuzumab, trastuzumab, and hyaluronidase-zzxf is a fixed-dose combination of pertuzumab and trastuzumab that is given as a subcutaneous injection. It can be given in less time than pertuzumab or trastuzumab, which are given as infusions. For more information about pertuzumab and trastuzumab that may apply to pertuzumab, trastuzumab, and hyaluronidase-zzxf, see the Drug Information Summaries for Pertuzumab and Trastuzumab.
More About Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf
Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.
MedlinePlus Information on Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf - A lay language summary of important information about this drug that may include the following:
- warnings about this drug,
- what this drug is used for and how it is used,
- what you should tell your doctor before using this drug,
- what you should know about this drug before using it,
- other drugs that may interact with this drug, and
- possible side effects.
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
Research Results and Related Resources
Targeted Therapy to Treat Cancer
Clinical Trials Accepting Patients
Find Clinical Trials for Pertuzumab, Trastuzumab, And Hyaluronidase-zzxf - Check for trials from NCI's list of cancer clinical trials now accepting patients.