Mitoxantrone Hydrochloride

Placeholder slot

(MY-toh-ZAN-trone HY-droh-KLOR-ide)

Mitoxantrone hydrochloride is a type of chemotherapy drug called an anthracycline. It blocks an enzyme called topoisomerase II, which cuts and repairs tangled strands of DNA. This stops or slows the growth of cancer cells and other rapidly dividing cells and causes them to die.

FDA Approved

Yes

FDA label information for this drug is available at DailyMed.

Use in Cancer

Mitoxantrone hydrochloride is approved to be used with other drugs to treat:

Acute non-lymphocytic leukemia in adults.
Prostate cancer. It is used as palliative treatment in patients with advanced disease that is hormone-refractory (does not respond to hormone treatment).

Mitoxantrone hydrochloride is also being studied in the treatment of other types of cancer.

More About Mitoxantrone Hydrochloride

Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.

MedlinePlus Information on Mitoxantrone - A lay language summary of important information about this drug that may include the following:

warnings about this drug,
what this drug is used for and how it is used,
what you should tell your doctor before using this drug,
what you should know about this drug before using it,
other drugs that may interact with this drug, and
possible side effects.

Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.

Clinical Trials Accepting Patients

Find Clinical Trials for Mitoxantrone Hydrochloride - Check for trials from NCI's list of cancer clinical trials now accepting patients.