Definition of predisposing mutation

predisposing mutation (PREE-dih-SPOH-zing myoo-TAY-shun): A genetic alteration that increases an individual’s susceptibility or predisposition to a certain disease or disorder. When such a variant (or mutation) is inherited, development of symptoms is more likely, but not certain. Also called deleterious mutation, disease-causing mutation, pathogenic variant, and susceptibility gene mutation.