Combining Targeted Therapies for Metastatic Colorectal Cancer
Name of the Trial
Why This Trial Is Important
In this trial, researchers are combining cetuximab with another targeted drug called sorafenib (Nexavar) to treat patients with metastatic colorectal cancer whose tumors show EGFR activity. Sorafenib blocks the activity of two other proteins called vascular endothelial growth factor receptor (VEGFR) and Raf kinase. VEGFR stimulates the growth of blood vessels to tumors (a process called angiogenesis), and Raf kinase is a key molecule in relaying signals from growth factor receptors to the interior of the cell, where the signals are converted into changes in gene activity that lead to cell growth and multiplication.
"The majority of patients with metastatic colorectal cancer have tumors expressing EGFR," said Dr. Kummar. "Cetuximab is approved by the FDA to treat EGFR-expressing metastatic colorectal cancer, but unfortunately, it produces significant tumor shrinkage in only about 10 percent of patients when used as a single agent. With this trial, we hope to see an improved response rate by augmenting the activity of cetuximab with an additional drug that blocks other processes important for tumor growth and cell proliferation."
Who Can Join This Trial
Study Site and Contact Information
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