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pan-FGFR tyrosine kinase inhibitor JNJ-42756493
An orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral administration, JNJ-42756493 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells. FGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Code name: | | JNJ-42756493 | |
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