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fluciclatide F 18
A radiopharmaceutical compound of a small synthetic cyclic peptide containing an RGD-sequence (Arg-Gly-Asp) labeled with the positron-emitting isotope fluorine F 18 that may be used to selectively image tumor cells and tumor vasculature by PET imaging. The RGD motif of fluciclatide F 18 selectively binds to the alphaVbeta3 integrin receptor, commonly upregulated on the surfaces of tumor cells and endothelial cells of tumor vasculature. This agent may be of use in visualizing and quantifying the development of tumor vascularity in response to antiangiogenic agents. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Chemical structures:||6-N-[(28E)-29-(4-[18F]fluorophenyl)-5,25-dioxo-3,9,12,15,18,21,27-heptaoxa-6,24,28- triazanonacos-28-enoyl]-2-N-(2-sulfanylacetyl)-L-lysyl-L-cysteinyl-L-arginylglycyl-L-α- aspartyl-L-cysteinyl-L-phenylalanyl-1-N-(17-amino-13,17-dioxo-3,6,9,15-tetraoxa-12- azaheptadecyl)-L-cysteinamide cyclic (2→6)-disulfide cyclic (1→8)-thioether |
L-cysteinamide, N6-[29-[4-(fluoro-18F)phenyl]-1,5,25-trioxo-3,9,12,15,18,21,27- heptaoxa-6,24,28-triazanonacos-28-en-1-yl]-N2-(2-mercaptoacetyl)-L-lysyl-L-cysteinyl- L-arginylglycyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-N-(17-amino-13,17-dioxo- 3,6,9,15-tetraoxa-12-azaheptadec-1-yl)-, cyclic (1→8)-thioether, cyclic (2→6)-disulfide