The search textbox has an autosuggest feature. When you enter three or more characters,
a list of up to 10 suggestions will popup under the textbox. Use the arrow keys
to move through the suggestions. To select a suggestion, hit the enter key. Using
the escape key closes the listbox and puts you back at the textbox. The radio buttons
allow you to toggle between having all search items start with or contain the text
you entered in the search box.
teglarinad chloride
A water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, the active drug appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | apoptosis inducer GMX1777 | |
| |||
| Code name: | | GMX1777 | |
| |||
| Chemical structures: | | 4-({N-[6-(4-chlorophenoxy)hexyl]-N'-cyanocarbamimidoyl}amino)-1-(3-oxo- 2,4,7,10,13,16-hexaoxaheptadecan-1-yl)pyridinium chloride pyridinium, 4-[[[[6-(4-chlorophenoxy)hexyl]amino](cyanoamino) methylene]amino]-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-, chloride | |
| |||
