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talminogene laherparepvec
An oncolytic, recombinant herpes simplex type-1 virus (HSV) encoding thuman cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with potential immunostimulating and antineoplastic activities. Upon administration, talminogene laherparepvec selectively infects and replicates in tumor cells, thereby inducing tumor cell lysis. In addition, expressed GM-CSF may stimulate a cytotoxic T cell response against tumor cells, resulting in immune-mediated tumor cell death in addition to HSV-mediated oncolytic tumor cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | GM-CSF-encoding oncolytic herpes simplex virus | |
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| US brand name: | | OncoVEX GM-CSF | |
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