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trifluoperazine hydrochloride
The hydrochloride salt of trifluoperazine, a phenothiazine derivative and a dopamine, alpha-adrenergic, and anticholinergic antagonist with antipsychotic, anxiolytic, and antiemetic activities. Trifluoperazine blocks central dopamine receptors, which may prevent or mitigate delusions and hallucinations caused by an excess of dopamine; dopamine blockade in the chemoreceptor trigger zone (CTZ) may result in an antiemetic effect. This agent binds to central adrenergic receptors, which may result in anxiolytic effects.Trifluoperazine also functions as a calmodulin inhibitor, elevating cytosolic calcium. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand name: | | Stelazine | |
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| Foreign brand names: | | Eskazine Jatroneural Terfluzine | |
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| Code name: | | SKF 5019 | |
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| Chemical structure: | | 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride | |
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