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A purine derivative with antineoplastic and anti-angiogenic properties. 6-methylmercaptopurine riboside (6-MMPR) inhibits amidophosphoribosyltransferase, the first committed step in de novo purine synthesis, and inhibits fibroblast growth factor-2 (FGF2)-induced cell proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Code names:||NCI-C04784 |
|Chemical structures:||6-(methylmercapto)purine ribonucleoside |
6-methyl MP riboside
9H-purine, 6-(methylthio)-9-beta-D-ribofuranosyl- (8CI 9CI)
9H-purine, 6-(methylthio)-9-beta-D-ribofuranosyl-, dihydrate