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An iodinated analogue of deoxyuridine. Idoxuridine incorporates into DNA during the S-phase of the cell cycle, sensitizing cells to ionizing radiation by increasing DNA strand breaks. When this agent contains a radioactive isomer of iodine, the radioactive idoxuridine kills cancer cells directly after preferential incorporation into the DNA of rapidly dividing tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand names:||Dendrid |
|Foreign brand names:||Idexur |
|Code name:||SKF 14287|
|Chemical structures:||1-(2-deoxy-beta-D-ribofuranosyl)-5-iodouracil |