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A monoclonal antibody directed against cytotoxic T-lymphocyte-associated antigen-4 (CTLA4), an antigen that is expressed on activated T-cells and exhibits affinity for B7 co-stimulatory molecules. By binding CTLA4, ipilimumab enhances T-cell activation and blocks B7-1 and B7-2 T-cell co-stimulatory pathways. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonyms:||anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody |
monoclonal antibody CTLA-4
|US brand name:||Yervoy|