Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma
Trial Sites
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Basic Trial Information
Trial Description
Summary
Further Trial Information
Eligibility Criteria
Trial Contact Information
| Phase | Type | Status | Age | Sponsor | Protocol IDs |
|---|---|---|---|---|---|
| Phase III | Supportive care, Treatment | Active | 3 to 21 at diagnosis | NCI, Other | CDR0000365506 COG-ACNS0331, ACNS0331, NCT00085735 |
Summary
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy, such as vincristine, cisplatin, lomustine, and cyclophosphamide, work in different ways to stop tumor cells from dividing so they stop growing or die. Giving radiation therapy with chemotherapy after surgery may kill any remaining tumor cells. It is not yet known whether standard-dose radiation therapy combined with chemotherapy after surgery is more effective than reduced-dose craniospinal (head and spine) radiation therapy plus either posterior fossa (back of the brain) boost or tumor bed (site of the tumor) boost radiation therapy combined with chemotherapy in treating medulloblastoma.
PURPOSE: This randomized phase III trial is studying standard-dose radiation therapy to see how well it works compared to reduced-dose craniospinal radiation therapy AND posterior fossa boost radiation therapy to see how well it works compared to tumor bed boost radiation therapy when given together with chemotherapy in treating young patients who have undergone surgery for newly diagnosed standard-risk medulloblastoma.
Further Study Information
OBJECTIVES:
Primary
- Compare event-free and overall survival of pediatric patients (3 to 7 years of age) with newly diagnosed standard-risk medulloblastoma treated with standard-dose vs reduced-dose craniospinal radiotherapy and posterior fossa boost vs tumor bed boost radiotherapy in combination with chemotherapy comprising vincristine, cisplatin, lomustine, and cyclophosphamide.
- Compare event-free and overall survival of these patients (8 to 21 years of age) treated with standard-dose craniospinal radiotherapy and posterior fossa boost vs tumor bed boost radiotherapy in combination with this chemotherapy regimen.
Secondary
- Compare patterns of failure in patients treated with these regimens.
- Compare the cognitive, auditory, and endocrinologic effects of these regimens in these patients.
- Compare the audiologic and endocrinologic toxicity from these regimens in these patients.
- Develop an optimal gene expression medulloblastoma outcome predictor.
- Assess quality of life and functional status in patients treated with these regimens.
OUTLINE: This is a randomized, multicenter study. Patients will undergo radiotherapy on days 1-5, 8-12, 15-19, 22-26, 29-33, 36-40, and 43-47 (weeks 0-6). Patients receive vincristine IV on days 8, 15, 22, 29, 36, and 43 (weeks 1-6) beginning 31 days after surgery.Patients 3 to 7 years of age are randomized to 1 of 2 chemoradiotherapy arms. Patients 8-21 years old are assigned to arm II.
- Chemoradiotherapy:Patients will undergo radiotherapy on days 1-5, 8-12, 15-19, 22-26, 29-33, 36-40, and 43-47 (weeks 0-6). Patients receive vincristine IV on days 8, 15, 22, 29, 36, and 43 (weeks 1-6) beginning 31 days after surgery. Patients 3 to 7 years of age are randomized to 1 of 2 radiotherapy arms (arms I and II). Patients 8-21 years old are assigned to arm II.
- Radiotherapy (first randomization):
- Arm I: Patients undergo reduced-dose craniospinal radiotherapy with boost.
- Arm II: Patients undergo standard-dose craniospinal radiotherapy with boost. All patients are then randomized to 1 of 2 chemoradiotherapy arms (arms III and IV).
- Radiotherapy boost (second randomization):
- Arm III: Patients will undergo radiotherapy boost to the entire posterior fossa.
- Arm IV: Patients will undergo radiotherapy boost to the tumor bed only.
- Maintenance chemotherapy: Beginning 4 weeks after completion of chemoradiotherapy, patients receive 2 different regimens of maintenance chemotherapy for a total of 9 courses. Each course in regimen A is 6 weeks (42 days) in duration. Each course in regimen B is 4 weeks (28 days) in duration.
- Regimen A (courses 1, 2, 4, 5, 7, and 8): Patients receive oral lomustine and cisplatin IV over 6 hours on day 1 and vincristine IV on days 1, 8, and 15 of weeks 11, 17, 27, 33, 43, and 49.
- Regimen B (courses 3, 6, and 9): Patients receive cyclophosphamide IV over 1 hour on days 1 and 2 and vincristine IV on days 1 and 8 of weeks 23, 39, and 55.
Treatment continues in the absence of disease progression or unacceptable toxicity.
Quality of life is assessed at 3-6 months after completion of radiotherapy and at 3-4 years after study entry. Neurocognitive function may also be assessed.
Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter.
Eligibility Criteria
DISEASE CHARACTERISTICS:
- Histologically confirmed medulloblastoma located in the posterior fossa
- Standard-risk disease
- Minimal volume, non-disseminated disease, defined by the following:
- Residual tumor ≤ 1.5 cm^2 confirmed by MRI with contrast imaging within 21 days after surgery
- No metastatic disease in the head, spine, or cerebrospinal fluid (CSF) confirmed by both of the following:
- Enhanced MRI of the spine within 5 days before surgery OR within 28 days after surgery
- Negative cytological examination of CSF after surgery, but before study enrollment
- Brain stem involvement allowed
PATIENT CHARACTERISTICS:
Age
- 3 to 21 at diagnosis
Performance status
- Karnofsky 50-100% (> 16 years of age) OR
- Lansky 30-100% (≤ 16 years of age)
Life expectancy
- Not specified
Hematopoietic
- Absolute neutrophil count > 1,500/mm^3
- Platelet count > 100,000/mm^3 (transfusion independent)
- Hemoglobin > 10 g/dL (transfusions allowed)
Hepatic
- Bilirubin < 1.5 times upper limit of normal (ULN)
- AST or ALT < 1.5 times ULN
Renal
- Creatinine clearance OR radioisotope glomerular filtration rate ≥ 70 mL/min
Other
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- No prior chemotherapy
Endocrine therapy
- Prior corticosteroids allowed
Radiotherapy
- No prior radiotherapy
Surgery
- See Disease Characteristics
Trial Lead Organizations/Sponsors
Children's Oncology Group
National Cancer Institute| Jeff M. Michalski |  | Study Chair |
Trial Sites
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| U.S.A. | |||
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| Alabama | |||
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| Birmingham | |||
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| Children's Hospital of Alabama at University of Alabama at Birmingham | |||
| Alyssa T Reddy | Ph: 205-934-0309 | ||
| Arizona | |||
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| Phoenix | |||
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| Phoenix Children's Hospital | |||
| Jessica Boklan | Ph: 602-546-0920 | ||
| Tucson | |||
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| Arizona Cancer Center at University of Arizona Health Sciences Center | |||
| Brenda J Wittman | Ph: 520-626-9008 | ||
| California | |||
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| Downey | |||
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| Southern California Permanente Medical Group | |||
| Robert M Cooper | Ph: 626-564-3455 | ||
| Loma Linda | |||
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| Loma Linda University Cancer Institute at Loma Linda University Medical Center | |||
| Antranik A Bedros | Ph: 909-558-3375 | ||
| Long Beach | |||
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| Jonathan Jaques Children's Cancer Center at Miller Children's Hospital | |||
| Amanda M Termuhlen | Ph: 562-933-5437 | ||
| Los Angeles | |||
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| Childrens Hospital Los Angeles | |||
| Leo Mascarenhas | Ph: 323-361-4110 | ||
| Madera | |||
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| Children's Hospital Central California | |||
| Vonda L Crouse | Ph: 866-353-5437 | ||
| Oakland | |||
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| Children's Hospital and Research Center Oakland | |||
| Joseph C Torkildson | Ph: 510-450-7600 | ||
| Kaiser Permanente-Oakland | |||
| Vincent A Kiley | Ph: 626-564-3455 | ||
| Orange | |||
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| Children's Hospital of Orange County | |||
| Violet Shen | Ph: 714-997-3000 | ||
| Palo Alto | |||
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| Lucile Packard Children's Hospital at Stanford University Medical Center | |||
| Neyssa M Marina | Ph: 650-498-7061 | ||
| Email: clinicaltrials@med.stanford.edu | |||
| Sacramento | |||
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| University of California Davis Cancer Center | |||
| Jay Michael S Balagtas | Ph: 916-734-3089 | ||
| San Diego | |||
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| Rady Children's Hospital - San Diego | |||
| William D Roberts | Ph: 858-966-5934 | ||
| Colorado | |||
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| Aurora | |||
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| Children's Hospital Colorado Center for Cancer and Blood Disorders | |||
| Kelly W Maloney | Ph: 720-777-6672 | ||
| Connecticut | |||
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| Hartford | |||
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| Connecticut Children's Medical Center | |||
| Michael S Isakoff | Ph: 860-545-9981 | ||
| New Haven | |||
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| Yale Cancer Center | |||
| Nina S Kadan-Lottick | Ph: 203-785-5702 | ||
| Delaware | |||
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| Wilmington | |||
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| Alfred I. duPont Hospital for Children | |||
| Christopher N Frantz | Ph: 302-651-5755 | ||
| District of Columbia | |||
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| Washington | |||
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| Children's National Medical Center | |||
| Jeffrey S Dome | Ph: 202-884-2549 | ||
| Florida | |||
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| Fort Lauderdale | |||
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| Broward General Medical Center Cancer Center | |||
| Hector M Rodriguez-Cortes | Ph: 954-355-5346 | ||
| Fort Myers | |||
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| Lee Cancer Care of Lee Memorial Health System | |||
| Emad K Salman | Ph: 239-343-5333 | ||
| Gainesville | |||
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| University of Florida Shands Cancer Center | |||
| William B Slayton | Ph: 352-273-8675 | ||
| Email: trials@cancer.ufl.edu | |||
| Hollywood | |||
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| Joe DiMaggio Children's Hospital | |||
| Iftikhar Hanif | Ph: 954-265-2234 | ||
| Jacksonville | |||
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| Nemours Children's Clinic | |||
| Eric S Sandler | Ph: 904-697-3529 | ||
| Miami | |||
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| Miami Children's Hospital | |||
| Enrique A Escalon | Ph: 305-662-8360 | ||
| University of Miami Sylvester Comprehensive Cancer Center - Miami | |||
| Julio C Barredo | Ph: 866-574-5124 | ||
| Email: Sylvester@emergingmed.com | |||
| Orlando | |||
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| Florida Hospital Cancer Institute at Florida Hospital Orlando | |||
| Clifford A Selsky | Ph: 407-303-5623 | ||
| M.D. Anderson Cancer Center at Orlando | |||
| Vincent F Giusti | Ph: 321-841-7246 | ||
| Nemours Children's Clinic - Orlando | |||
| Ramamoorthy Nagasubramanian | Ph: 407-650-7150 | ||
| Pensacola | |||
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| Nemours Children's Clinic - Pensacola | |||
| Jeffrey H Schwartz | Ph: 904-697-3529 | ||
| Saint Petersburg | |||
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| All Children's Hospital | |||
| Gregory A Hale | Ph: 727-767-2423 | ||
| Email: HamblinF@allkids.org | |||
| Tampa | |||
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| St. Joseph's Children's Hospital of Tampa | |||
| Hardeo K Panchoosingh | Ph: 800-882-4123 | ||
| Georgia | |||
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| Atlanta | |||
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| AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus | |||
| Howard M Katzenstein | Ph: 888-785-1112 | ||
| Augusta | |||
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| Medical College of Georgia Cancer Center | |||
| Colleen H McDonough | Ph: 706-721-1663 | ||
| Email: cancer@georgiahealth.edu | |||
| Hawaii | |||
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| Honolulu | |||
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| Cancer Research Center of Hawaii | |||
| Robert W Wilkinson | Ph: 808-983-6090 | ||
| Tripler Army Medical Center | |||
| Jeremy V Edwards | Ph: 808-433-6336 | ||
| Illinois | |||
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| Chicago | |||
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| Ann and Robert H. Lurie Children's Hospital of Chicago | |||
| David O Walterhouse | Ph: 773-880-4562 | ||
| University of Chicago Cancer Research Center | |||
| Charles M Rubin | Ph: 773-834-7424 | ||
| Maywood | |||
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| Cardinal Bernardin Cancer Center at Loyola University Medical Center | |||
| Ricarchito B Manera | Ph: 708-226-4357 | ||
| Oak Lawn | |||
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| Keyser Family Cancer Center at Advocate Hope Children's Hospital | |||
| Sharad N Salvi | Ph: 847-723-7570 | ||
| Park Ridge | |||
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| Advocate Lutheran General Cancer Care Center | |||
| Jong H Kwon | Ph: 847-384-3621 | ||
| Peoria | |||
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| Saint Jude Midwest Affiliate | |||
| Pedro A De Alarcon | Ph: 309-655-3258 | ||
| Springfield | |||
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| Simmons Cooper Cancer Institute | |||
| Gregory P Brandt | Ph: 217-545-7929 | ||
| Indiana | |||
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| Indianapolis | |||
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| Riley's Children Cancer Center at Riley Hospital for Children | |||
| Robert J Fallon | Ph: 317-274-2552 | ||
| St. Vincent Indianapolis Hospital | |||
| Bassem I Razzouk | Ph: 317-338-2194 | ||
| Iowa | |||
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| Des Moines | |||
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| Blank Children's Hospital | |||
| Wendy L Woods-Swafford | Ph: 888-823-5923 | ||
| Email: ctsucontact@westat.com | |||
| Iowa City | |||
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| Holden Comprehensive Cancer Center at University of Iowa | |||
| Raymond Tannous | Ph: 800-237-1225 | ||
| Kentucky | |||
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| Lexington | |||
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| University of Kentucky Chandler Medical Center | |||
| Martha F Greenwood | Ph: 859-257-3379 | ||
| Louisville | |||
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| Kosair Children's Hospital | |||
| Salvatore J Bertolone | Ph: 866-530-5516 | ||
| Louisiana | |||
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| New Orleans | |||
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| Children's Hospital of New Orleans | |||
| Lolie C Yu | Ph: 504-894-5377 | ||
| Tulane Cancer Center at Tulane University Hospital and Clinic | |||
| Tammuella C Singleton | Ph: 504-988-6121 | ||
| Maine | |||
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| Bangor | |||
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| CancerCare of Maine at Eastern Maine Medical Center | |||
| Sarah J Fryberger | Ph: 207-973-4274 | ||
| Scarborough | |||
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| Maine Children's Cancer Program at Barbara Bush Children's Hospital | |||
| Eric C Larsen | Ph: 207-396-8090 | ||
| Email: wrighd@mmc.org | |||
| Maryland | |||
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| Baltimore | |||
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| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | |||
| Kenneth J Cohen | Ph: 410-955-8804 | ||
| Email: jhcccro@jhmi.edu | |||
| Bethesda | |||
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| National Naval Medical Center | |||
| Anne B Warwick | Ph: 301-319-2100 | ||
| Massachusetts | |||
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| Boston | |||
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| Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute | |||
| Carlos Rodriguez-Galindo | Ph: 866-790-4500 | ||
| Floating Hospital for Children at Tufts - New England Medical Center | |||
| Johannes E Wolff | Ph: 617-636-5000 | ||
| Email: ContactUsCancerCenter@TuftsMedicalCenter.org | |||
| Michigan | |||
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| Detroit | |||
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| Van Elslander Cancer Center at St. John Hospital and Medical Center | |||
| Hadi Sawaf | Ph: 313-343-3166 | ||
| Grand Rapids | |||
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| Helen DeVos Children's Hospital at Spectrum Health | |||
| David S Dickens | Ph: 616-267-1925 | ||
| Kalamazoo | |||
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| Bronson Methodist Hospital | |||
| Jeffrey S Lobel | Ph: 800-227-2345 | ||
| Lansing | |||
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| Breslin Cancer Center at Ingham Regional Medical Center | |||
| Renuka Gera | Ph: 517-334-2765 | ||
| Minnesota | |||
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| Minneapolis | |||
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| Children's Hospitals and Clinics of Minnesota - Minneapolis | |||
| Bruce C Bostrom | Ph: 612-813-5193 | ||
| Masonic Cancer Center at University of Minnesota | |||
| Christopher L Moertel | Ph: 612-624-2620 | ||
| Rochester | |||
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| Mayo Clinic Cancer Center | |||
| Carola A. S. Arndt | Ph: 507-538-7623 | ||
| Mississippi | |||
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| Jackson | |||
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| University of Mississippi Cancer Clinic | |||
| Gail C Megason | Ph: 601-815-6700 | ||
| Missouri | |||
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| Kansas City | |||
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| Children's Mercy Hospital | |||
| Maxine L Hetherington | Ph: 816-234-3265 | ||
| Saint Louis | |||
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| Cardinal Glennon Children's Hospital | |||
| William S Ferguson | Ph: 314-268-4000 | ||
| Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | |||
| Joshua B Rubin | Ph: 800-600-3606 | ||
| Email: info@siteman.wustl.edu | |||
| Nebraska | |||
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| Omaha | |||
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| Children's Hospital | |||
| Minnie Abromowitch | Ph: 402-955-3949 | ||
| UNMC Eppley Cancer Center at the University of Nebraska Medical Center | |||
| Peter F Coccia | Ph: 800-999-5465 | ||
| Nevada | |||
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| Las Vegas | |||
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| CCOP - Nevada Cancer Research Foundation | |||
| Jonathan Bernstein | Ph: 702-384-0013 | ||
| New Hampshire | |||
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| Lebanon | |||
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| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | |||
| Sara Chaffee | Ph: 800-639-6918 | ||
| Email: cancer.research.nurse@dartmouth.edu | |||
| New Jersey | |||
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| Hackensack | |||
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| Hackensack University Medical Center Cancer Center | |||
| Burton E Appel | Ph: 201-996-2879 | ||
| Morristown | |||
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| Carol G. Simon Cancer Center at Morristown Memorial Hospital | |||
| Steven L Halpern | Ph: 973-971-5900 | ||
| New Brunswick | |||
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| Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School | |||
| Richard A Drachtman | Ph: 732-235-8675 | ||
| Saint Peter's University Hospital | |||
| Stanley Calderwood | Ph: 732-745-8600ext6163 | ||
| Email: kcovert@saintpetersuh.com | |||
| Newark | |||
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| Newark Beth Israel Medical Center | |||
| Peri Kamalakar | Ph: 973-926-7230 | ||
| Paterson | |||
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| St. Joseph's Hospital and Medical Center | |||
| Mary A Bonilla | Ph: 973-754-2909 | ||
| New Mexico | |||
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| Albuquerque | |||
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| University of New Mexico Cancer Center | |||
| Koh B Boayue | Ph: 505-272-6972 | ||
| New York | |||
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| Albany | |||
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| Albany Medical Center Hospital | |||
| Vikramjit S Kanwar | Ph: 518-262-3368 | ||
| Bronx | |||
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| Montefiore Medical Center | |||
| Rosanna J Ricafort | Ph: 718-904-2730 | ||
| Email: aecc@aecom.yu.edu | |||
| Mineola | |||
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| Winthrop University Hospital | |||
| Mark E Weinblatt | Ph: 866-946-8476 | ||
| New Hyde Park | |||
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| Schneider Children's Hospital | |||
| Arlene S Redner | Ph: 718-470-3470 | ||
| New York | |||
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| Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center | |||
| Alice Lee | Ph: 212-305-8615 | ||
| New York University Medical Center | |||
| Jeffrey C Allen | Ph: 212-263-4434 | ||
| Email: prmc.coordinator@nyumc.org | |||
| Rochester | |||
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| James P. Wilmot Cancer Center at University of Rochester Medical Center | |||
| Lisa R Hackney | Ph: 585-275-5830 | ||
| Syracuse | |||
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| SUNY Upstate Medical University Hospital | |||
| Karol H Kerr | Ph: 315-464-5476 | ||
| North Carolina | |||
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| Chapel Hill | |||
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| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | |||
| Stuart H Gold | Ph: 877-668-0683 | ||
| Charlotte | |||
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| Blumenthal Cancer Center at Carolinas Medical Center | |||
| Joel A Kaplan | Ph: 704-355-2884 | ||
| Presbyterian Cancer Center at Presbyterian Hospital | |||
| Paulette C Bryant | Ph: 704-384-5369 | ||
| Winston-Salem | |||
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| Wake Forest University Comprehensive Cancer Center | |||
| Thomas W McLean | Ph: 336-713-6771 | ||
| North Dakota | |||
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| Fargo | |||
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| Roger Maris Cancer Center at MeritCare Hospital | |||
| Nathan L Kobrinsky | Ph: 701-234-6161 | ||
| Ohio | |||
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| Akron | |||
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| Akron Children's Hospital | |||
| Steven J Kuerbitz | Ph: 330-543-3193 | ||
| Cincinnati | |||
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| Cincinnati Children's Hospital Medical Center | |||
| John P Perentesis | Ph: 513-636-2799 | ||
| Cleveland | |||
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| Cleveland Clinic Taussig Cancer Center | |||
| Tanya M Tekautz | Ph: 866-223-8100 | ||
| Seidman Cancer Center at University Hospitals/Case Medical Center | |||
| Yousif (Joe) H Matloub | Ph: 216-844-5437 | ||
| Columbus | |||
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| Nationwide Children's Hospital | |||
| Laura T Martin | Ph: 614-722-2708 | ||
| Dayton | |||
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| Dayton Children's - Dayton | |||
| Emmett H Broxson | Ph: 800-228-4055 | ||
| Toledo | |||
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| Mercy Children's Hospital | |||
| Rama Jasty | Ph: 419-251-8210 | ||
| Toledo Hospital | |||
| Dagmar T Stein | Ph: 419-824-1842 | ||
| Oklahoma | |||
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| Oklahoma City | |||
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| Oklahoma University Cancer Institute | |||
| Rene Y McNall-Knapp | Ph: 405-271-4272 | ||
| Email: julie-traylor@ouhsc.edu | |||
| Oregon | |||
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| Portland | |||
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| Knight Cancer Institute at Oregon Health and Science University | |||
| Linda C. Stork | Ph: 503-494-1080 | ||
| Email: trials@ohsu.edu | |||
| Legacy Emanuel Children's Hospital | |||
| Janice F Olson | Ph: 503-413-2560 | ||
| Pennsylvania | |||
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| Bethlehem | |||
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| Lehigh Valley Hospital - Muhlenberg | |||
| Philip M Monteleone | Ph: 484-884-2201 | ||
| Danville | |||
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| Geisinger Cancer Institute at Geisinger Health | |||
| Jeffrey S Taylor | Ph: 570-271-5251 | ||
| Hershey | |||
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| Penn State Children's Hospital | |||
| John F Kuttesch | Ph: 505-272-6972 | ||
| Email: CTO@hmc.psu.edu | |||
| Philadelphia | |||
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| St. Christopher's Hospital for Children | |||
| Gregory E Halligan | Ph: 215-427-8991 | ||
| Rhode Island | |||
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| Providence | |||
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| Rhode Island Hospital Comprehensive Cancer Center | |||
| Cindy L Schwartz | Ph: 401-444-1488 | ||
| South Carolina | |||
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| Charleston | |||
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| Hollings Cancer Center at Medical University of South Carolina | |||
| Jacqueline M Kraveka | Ph: 843-792-9321 | ||
| Columbia | |||
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| Palmetto Health South Carolina Cancer Center | |||
| Ronnie W. Neuberg | Ph: 803-434-3680 | ||
| Greenville | |||
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| BI-LO Charities Children's Cancer Center | |||
| Cary E Stroud | Ph: 864-241-6251 | ||
| South Dakota | |||
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| Sioux Falls | |||
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| Sanford Cancer Center at Sanford USD Medical Center | |||
| Kayelyn J Wagner | Ph: 605-328-1367 | ||
| Tennessee | |||
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| Nashville | |||
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| Vanderbilt-Ingram Cancer Center | |||
| Haydar A Frangoul | Ph: 800-811-8480 | ||
| Texas | |||
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| Amarillo | |||
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| Texas Tech University Health Sciences Center School of Medicine - Amarillo | |||
| Osvaldo Regueira | Ph: 806-354-5411 | ||
| Austin | |||
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| Dell Children's Medical Center of Central Texas | |||
| Sharon K Lockhart | Ph: 512-324-8022 | ||
| Corpus Christi | |||
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| Driscoll Children's Hospital | |||
| M. Cris Johnson | Ph: 361-694-5311 | ||
| Dallas | |||
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| Medical City Dallas Hospital | |||
| Carl Lenarsky | Ph: 972-566-5588 | ||
| Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas | |||
| Naomi J Winick | Ph: 214-648-7097 | ||
| Fort Worth | |||
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| Cook Children's Medical Center - Fort Worth | |||
| Mary Meaghan P Granger | Ph: 682-885-2103 | ||
| Houston | |||
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| Dan L. Duncan Cancer Center at Baylor College of Medicine | |||
| Lisa R Bomgaars | Ph: 713-798-1354 | ||
| Email: burton@bcm.edu | |||
| Univeristy of Texas M.D. Anderson Cancer Center | |||
| Soumen Khatua | Ph: 713-792-3245 | ||
| Lubbock | |||
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| Covenant Children's Hospital | |||
| Latha Prasannan | Ph: 806-725-8000 | ||
| Email: jaccresearch@covhs.org | |||
| San Antonio | |||
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| Methodist Children's Hospital of South Texas | |||
| Jaime Estrada | Ph: 210-575-7000 | ||
| University of Texas Health Science Center at San Antonio | |||
| Paul J Thomas | Ph: 210-567-0653 | ||
| Email: che@uthscsa.edu | |||
| Temple | |||
|
|||
| Scott and White Cancer Institute | |||
| Guy H Grayson | Ph: 254-724-5407 | ||
| Utah | |||
|
|||
| Salt Lake City | |||
|
|||
| Primary Children's Medical Center | |||
| Phillip E Barnette | Ph: 801-585-5270 | ||
| Vermont | |||
|
|||
| Burlington | |||
|
|||
| Vermont Cancer Center at University of Vermont | |||
| Alan C Homans | Ph: 802-656-8990 | ||
| Virginia | |||
|
|||
| Falls Church | |||
|
|||
| Inova Fairfax Hospital | |||
| Marshall A Schorin | Ph: 703-208-6650 | ||
| Norfolk | |||
|
|||
| Children's Hospital of The King's Daughters | |||
| Eric J Lowe | Ph: 757-668-7243 | ||
| Portsmouth | |||
|
|||
| Naval Medical Center - Portsmouth | |||
| Brian L Feldman | Ph: 757-953-5939 | ||
| Richmond | |||
|
|||
| Virginia Commonwealth University Massey Cancer Center | |||
| Kamar Godder | Ph: 804-628-1939 | ||
| Roanoke | |||
|
|||
| Carilion Medical Center for Children at Roanoke Community Hospital | |||
| Mandy M Atkinson | Ph: 540-981-7376 | ||
| Washington | |||
|
|||
| Seattle | |||
|
|||
| Children's Hospital and Regional Medical Center - Seattle | |||
| Jeffrey R Geyer | Ph: 866-987-2000 | ||
| Spokane | |||
|
|||
| Providence Cancer Center at Sacred Heart Medical Center | |||
| Jeff M. Michalski | Ph: 800-600-3606 | ||
| Email: info@siteman.wustl.edu | |||
| Tacoma | |||
|
|||
| Madigan Army Medical Center - Tacoma | |||
| Melissa A Forouhar | Ph: 253-968-0129 | ||
| Email: mamcdci@amedd.army.mil | |||
| West Virginia | |||
|
|||
| Charleston | |||
|
|||
| West Virginia University Medical School - Charleston | |||
| Allen R Chauvenet | Ph: 304-388-9944 | ||
| Wisconsin | |||
|
|||
| Green Bay | |||
|
|||
| St. Vincent Hospital Regional Cancer Center | |||
| John R Hill | Ph: 920-433-8889 | ||
| Madison | |||
|
|||
| University of Wisconsin Paul P. Carbone Comprehensive Cancer Center | |||
| Kenneth B De Santes | Ph: 608-262-5223 | ||
| Marshfield | |||
|
|||
| Marshfield Clinic - Marshfield Center | |||
| Michael J McManus | Ph: 715-389-4457 | ||
| Milwaukee | |||
|
|||
| Midwest Children's Cancer Center at Children's Hospital of Wisconsin | |||
| Michael E Kelly | Ph: 414-805-4380 | ||
| Australia | |||
|
|||
| South Australia | |||
|
|||
| North Adelaide | |||
|
|||
| Women's and Children's Hospital | |||
| Maria L Kirby | Ph: (08) 8161 7327 | ||
| Email: cywhs.oncsec@health.sa.gov.au | |||
| Western Australia | |||
|
|||
| Perth | |||
|
|||
| Princess Margaret Hospital for Children | |||
| Catherine H Cole | Ph: (08) 9340 8330 | ||
| Email: admin@childcancerresearch.com.au | |||
| Canada | |||
|
|||
| Alberta | |||
|
|||
| Edmonton | |||
|
|||
| University of Alberta Hospital | |||
| Sunil Jayantilal` S Desai | Ph: 780-407-6615 | ||
| Email: val.taylor@albertahealthservices.ca | |||
| British Columbia | |||
|
|||
| Vancouver | |||
|
|||
| Children's and Women's Hospital of British Columbia | |||
| Caron Strahlendorf | Ph: 604-875-2345ext6477 | ||
| Manitoba | |||
|
|||
| Winnipeg | |||
|
|||
| CancerCare Manitoba | |||
| Rochelle A Yanofsky | Ph: 866-561-1026 | ||
| Email: CIO_Web@cancercare.mb.ca | |||
| Newfoundland and Labrador | |||
|
|||
| Saint John's | |||
|
|||
| Janeway Children's Health and Rehabilitation Centre | |||
| Lisa Anne B Goodyear | Ph: 866-722-1126 | ||
| Nova Scotia | |||
|
|||
| Halifax | |||
|
|||
| IWK Health Centre | |||
| Margaret C Yhap | Ph: 902-470-8394 | ||
| Ontario | |||
|
|||
| Hamilton | |||
|
|||
| McMaster Children's Hospital at Hamilton Health Sciences | |||
| Carol Portwine | Ph: 905-521-2100ext74595 | ||
| Kingston | |||
|
|||
| Cancer Centre of Southeastern Ontario at Kingston General Hospital | |||
| Mariana P Silva | Ph: 613-544-2630 | ||
| London | |||
|
|||
| Children's Hospital of Western Ontario | |||
| Anne E Cairney | Ph: 519-685-8306 | ||
| Ottawa | |||
|
|||
| Children's Hospital of Eastern Ontario | |||
| Jacqueline M Halton | Ph: 613-738-3931 | ||
| Toronto | |||
|
|||
| Hospital for Sick Children | |||
| Eric Bouffet | Ph: 416-813-7654ext2027 | ||
| Email: jason.mcguire@sickkids.ca | |||
| Quebec | |||
|
|||
| Montreal | |||
|
|||
| Hopital Sainte Justine | |||
| Yvan Samson | Ph: 514-345-4931 | ||
| Montreal Children's Hospital at McGill University Health Center | |||
| Sharon B Abish | Ph: 514-412-4445 | ||
| Email: info@thechildren.com | |||
| Ste-Foy | |||
|
|||
| Centre de Recherche du Centre Hospitalier de l'Universite Laval | |||
| Bruno Michon | Ph: 418-525-4444 | ||
| Saskatchewan | |||
|
|||
| Saskatoon | |||
|
|||
| Saskatoon Cancer Centre at the University of Saskatchewan | |||
| Christopher Mpofu | Ph: 306-655-2914 | ||
| New Zealand | |||
|
|||
| Christchurch | |||
|
|||
| Christchurch Hospital | |||
| Michael J Sullivan | Ph: 03 364 0640 | ||
| Auckland | |||
|
|||
| Grafton | |||
|
|||
| Starship Children's Health | |||
| Lochie R Teague | Ph: 0800 728 436 | ||
| Switzerland | |||
|
|||
| Bern | |||
|
|||
| Swiss Pediatric Oncology Group Bern | |||
| Roland A Ammann | Ph: 031 389 91 89 | ||
| Geneva | |||
|
|||
| Swiss Pediatric Oncology Group Geneva | |||
| Ayse H Ozsahin | Ph: 031 389 91 89 | ||
| Lausanne | |||
|
|||
| Swiss Pediatric Oncology Group Lausanne | |||
| Maja Beck Popovic | Ph: 31 389 91 89 | ||
Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00085735
Information obtained from ClinicalTrials.gov on November 26, 2012
Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain
the same text. Minor
changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and
contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should
be directed to ClinicalTrials.gov.
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