|Phase III||Biomarker/Laboratory analysis, Treatment||Closed||18 and over||NCI, Other||CDR0000258787|
U10CA031946, CALGB-80101, NCCTG-CALGB-80101, ECOG-CALGB-80101, NCT00052910
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy after surgery may kill any remaining tumor cells following surgery. It is not yet known which chemotherapy and radiation therapy regimen is more effective in treating stomach or esophageal cancer.
PURPOSE: Randomized phase III trial to compare two different chemotherapy and radiation therapy regimens in treating patients who have undergone surgery for stomach or esophageal cancer.
Further Study Information
- Compare overall survival in patients with resected gastric adenocarcinoma treated with epirubicin, cisplatin, and infusional fluorouracil (5-FU) vs 5-FU bolus and leucovorin calcium before and after 5-FU plus radiotherapy.
- Compare disease-free survival and local and distant recurrence rates in these patients treated with these regimens.
- Correlate the expression of putative prognostic markers (including TS, ERCC-1, MSI, E-cadherin, EGFR, p27, COX-2, and c-erbB-2) with overall survival of patients treated with these regimens.
- Correlate specific germline polymorphisms related to chemotherapy metabolism and resistance (including UGT2B7 [epirubicin], GST [cisplatin], ERCCI [cisplatin], XRCC1 [cisplatin], TS [5-FU], DPD [5-FU], and EGFR polymorphisms) with treatment-related toxicity and overall survival of these patients.
- Correlate serum levels of insulin-like growth factor-1 (IGF-1), IGF-2, and IGF-binding protein 3 with overall survival of patients treated with these regimens.
OUTLINE: This is a randomized, multicenter study. Patients are stratified according to depth of tumor penetration (T1 or T2 vs T3 vs T4), lymph node involvement (0 vs 1-3), and extent of lymphadenectomy (D1 or D2 vs D0 or unknown). Patients are randomized to 1 of 2 treatment arms.
- Arm I: Patients receive leucovorin calcium IV and fluorouracil (5-FU) IV on days 1-5 of courses 1, 3, and 4. Courses repeat every 28 days. During course 2, patients undergo radiotherapy 5 days a week and receive 5-FU IV continuously for 5 weeks. Patients rest for 28-35 days between course 2 and 3.
- Arm II: Patients receive epirubicin IV over 3-15 minutes and cisplatin IV over 1 hour on day 1 and 5-FU IV continuously on days 1-21 during course 1. Beginning 1 week later, patients undergo radiotherapy 5 days a week and receive 5-FU IV continuously for 5 weeks. Patients rest for 28-35 days before beginning course 2 of chemotherapy. Patients then receive epirubicin, cisplatin, and 5-FU as in course 1. Treatment repeats every 21 days for 2 courses.
Patients are followed every 3 months for 2 years, every 4 months for 2 years, and then annually for 3 years.
PROJECTED ACCRUAL: A total of 824 patients will be accrued for this study.
- Histologically confirmed adenocarcinoma of the stomach or gastroesophageal junction (adenocarcinoma of the esophagus must involve the gastroesophageal junction) meeting the following criteria:
- Tumor extension beyond muscularis propria and/or nodal involvement without evidence of M1 disease
- Stage II, IIIA, IIIB, or IV (T2, N2, M0)
- Stage IB (T1, N1, M0; T2, N0, M0 allowed if extension beyond muscularis propia)
- Prior en bloc resection, with curative intent, of all known tumor
- No microscopic evidence of tumor at the line of resection
- No noncontiguous resection
- No known unresected or recurrent disease at the distal or proximal line of stomach resection
- No metastatic disease
- 18 and over
- ECOG 0-2
- Not specified
- Granulocyte count at least 1,500/mm^3
- Platelet count at least 100,000/mm^3
- Bilirubin no greater than 2.0 mg/dL
- AST no greater than 3 times upper limit of normal
- Creatinine no greater than 1.5 mg/dL
- No unilateral renal function
- No myocardial infarction within the past 6 months
- No uncontrolled high blood pressure
- No unstable angina
- No symptomatic congestive heart failure
- No serious uncontrolled cardiac arrhythmia
- No New York Heart Association class III or IV heart disease
- No cardiac disease resulting in marked limitation or inability of physical activity
- Stable weight for at least one week before study
- Not pregnant or nursing
- Fertile patients must use effective contraception
- No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or fully resected noninvasive carcinoma in situ
- No other uncontrolled serious medical condition or psychiatric illness that would preclude study entry
- No active infection
- No peripheral neuropathy grade 2 or greater
- All patients must be evaluated by a radiation oncologist prior to enrollment to ensure patient is appropriate for radiotherapy
PRIOR CONCURRENT THERAPY:
- Prior biologic therapy allowed
- No prior chemotherapy
- No other concurrent chemotherapy
- Prior hormonal therapy allowed
- No concurrent hormonal therapy except the following:
- Steroids for adrenal failure
- Hormones for non-disease-related conditions (e.g., insulin for diabetes)
- Intermittent dexamethasone as an antiemetic
- No prior radiotherapy
- See Disease Characteristics
- At least 3 weeks since prior surgery
- No more than 12 weeks since prior surgery
Trial Lead Organizations/Sponsors
Cancer and Leukemia Group BNational Cancer Institute
North Central Cancer Treatment Group
Eastern Cooperative Oncology Group
|Charles S. Fuchs||Study Chair|
|Steven R. Alberts||Study Chair|
|Daniel G. Haller||Study Chair|
Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00052910
Information obtained from ClinicalTrials.gov on December 18, 2012
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