Genetic Study of Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, or Multiple Myeloma
Trial Sites
Back to Top
Basic Trial Information
Trial Description
Summary
Further Trial Information
Eligibility Criteria
Trial Contact Information
| Phase | Type | Status | Age | Sponsor | Protocol IDs |
|---|---|---|---|---|---|
| No phase specified | Biomarker/Laboratory analysis, Natural history/Epidemiology | Active | 15 and over | NCI, Other | CDR0000256897 CALGB-8461, NCT00048958 |
Summary
RATIONALE: Cytogenetic tests may help predict how cancer will respond to treatment and allow doctors to plan more effective therapy.
PURPOSE: This diagnostic trial is studying genetic differences in patients with treated and untreated acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndromes, or multiple myeloma.
Further Study Information
OBJECTIVES:
- Determine the incidence of chromosomal abnormalities in patients with acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndromes, or multiple myeloma.
- Correlate specific chromosomal abnormalities with clinical and laboratory parameters in these patients.
- Correlate specific karyotype groups with treatment response rates, response duration, survival, and cure in patients treated with various induction and post-induction regimens.
- Correlate specific karyotype groups with multidrug resistance data in these patients.
- Identify new chromosome abnormalities important in leukemogenesis.
- Correlate specific karyotype groups with epidemiological data (toxic exposure and family history) in these patients.
- Determine karyotype changes at relapse and the influence of the type of change (or no change) in karyotype at relapse in subsequent clinical courses in these patients.
- Correlate specific karyotype groups with selected molecular abnormalities as studied in CALGB leukemia protocols.
OUTLINE: This is a multicenter study.
Patients undergo collection of bone marrow and blood specimens for cytogenetic analysis at diagnosis, complete remission, and relapse. Specimens are karyotyped and examined for chromosomal abnormalities.
PROJECTED ACCRUAL: Approximately 6,400 patients will be accrued for this study.
Eligibility Criteria
DISEASE CHARACTERISTICS:
- Must enroll (within 1 month of registration on this study) on a CALGB treatment study for previously untreated acute myeloid leukemia, acute lymphoblastic leukemia, or myelodysplastic syndromes
- Patients enrolled on CLB-100001 (previously treated or untreated multiple myeloma) must enroll on this study
- Simultaneous registration on CLB-9665 (within the continental United States)
PATIENT CHARACTERISTICS:
Age
- 15 and over
Performance status
- Not specified
Life expectancy
- Not specified
Hematopoietic
- Not specified
Hepatic
- Not specified
Renal
- Not specified
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- Not specified
Endocrine therapy
- Not specified
Radiotherapy
- Not specified
Surgery
- Not specified
Trial Lead Organizations/Sponsors
Cancer and Leukemia Group B
National Cancer Institute| Clara D. Bloomfield |  | Study Chair |
Trial Sites
|
|
|
|
| U.S.A. | |||
|
|||
| California | |||
|
|||
| LA Jolla | |||
|
|||
| Rebecca and John Moores UCSD Cancer Center | |||
| Barbara A Parker | Ph: 858-822-5354 | ||
| Email: cancercto@ucsd.edu | |||
| Mountain View | |||
|
|||
| Palo Alto Medical Foundation | |||
| Peter P. Yu | Ph: 650-934-7000 | ||
| San Diego | |||
|
|||
| Naval Medical Center - San Diego | |||
| Preston S. Gable | Ph: 619-532-8712 | ||
| San Francisco | |||
|
|||
| UCSF Helen Diller Family Comprehensive Cancer Center | |||
| Lloyd E Damon | Ph: 877-827-3222 | ||
| Connecticut | |||
|
|||
| Hartford | |||
|
|||
| Helen and Harry Gray Cancer Center at Hartford Hospital | |||
| William J Baker | Ph: 860-545-5363 | ||
| Delaware | |||
|
|||
| Lewes | |||
|
|||
| Tunnell Cancer Center at Beebe Medical Center | |||
| Frank Beardell | Ph: 302-733-6227 | ||
| Newark | |||
|
|||
| Helen F. Graham Cancer Center at Christiana Hospital | |||
| Frank Beardell | Ph: 302-733-6227 | ||
| District of Columbia | |||
|
|||
| Washington | |||
|
|||
| Lombardi Comprehensive Cancer Center at Georgetown University Medical Center | |||
| Catherine M Broome | Ph: 202-444-0381 | ||
| Florida | |||
|
|||
| Fort Lauderdale | |||
|
|||
| Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital | |||
| Rogerio C. Lilenbaum | Ph: 203-785-5702 | ||
| Email: info@msccop.com | |||
| Jupiter | |||
|
|||
| Ella Milbank Foshay Cancer Center at Jupiter Medical Center | |||
| Rogerio C. Lilenbaum | Ph: 203-785-5702 | ||
| Email: info@msccop.com | |||
| Miami Beach | |||
|
|||
| CCOP - Mount Sinai Medical Center | |||
| Rogerio C. Lilenbaum | Ph: 203-785-5702 | ||
| Email: info@msccop.com | |||
| Orlando | |||
|
|||
| Florida Hospital Cancer Institute at Florida Hospital Orlando | |||
| Lee M. Zehngebot | Ph: 407-303-5623 | ||
| Illinois | |||
|
|||
| Bloomington | |||
|
|||
| Illinois CancerCare - Bloomington | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| St. Joseph Medical Center | |||
| John W. Kugler | Ph: 800-793-2262 | ||
| Canton | |||
|
|||
| Illinois CancerCare - Canton | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Chicago | |||
|
|||
| University of Chicago Cancer Research Center | |||
| Richard A. Larson | Ph: 773-834-7424 | ||
| University of Illinois Cancer Center | |||
| David J. Peace | Ph: 312-355-3046 | ||
| Eureka | |||
|
|||
| Illinois CancerCare - Eureka | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Evanston | |||
|
|||
| CCOP - Evanston | |||
| David L. Grinblatt | Ph: 847-570-1381 | ||
| Galesburg | |||
|
|||
| Galesburg Clinic, PC | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Macomb | |||
|
|||
| Illinois CancerCare - Macomb | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Normal | |||
|
|||
| Community Cancer Center | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Ottawa | |||
|
|||
| Community Hospital of Ottawa | |||
| John W. Kugler | Ph: 800-793-2262 | ||
| Illinois CancerCare - Ottawa | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Pekin | |||
|
|||
| Cancer Treatment Center at Pekin Hospital | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Illinois CancerCare - Pekin | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Peoria | |||
|
|||
| CCOP - Illinois Oncology Research Association | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Illinois CancerCare - Peoria | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Methodist Medical Center of Illinois | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| OSF St. Francis Medical Center | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Proctor Hospital | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Peru | |||
|
|||
| Illinois CancerCare - Princeton | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Illinois Valley Community Hospital | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Indiana | |||
|
|||
| Fort Wayne | |||
|
|||
| Fort Wayne Medical Oncology and Hematology | |||
| Sreenivasa Rao Nattam | Ph: 260-484-8830 | ||
| Email: ledgar@fwmoh.com | |||
| Merrillville | |||
|
|||
| Premier Oncology Hematology Associates | |||
| Bharat H. Barai | Ph: 219-736-2800 | ||
| Iowa | |||
|
|||
| Bettendorf | |||
|
|||
| Hematology Oncology Associates of the Quad Cities | |||
| Shobha R. Chitneni | Ph: 563-355-7733 | ||
| Email: kedaprile@rccqc.com | |||
| Cedar Rapids | |||
|
|||
| Iowa Blood and Cancer Care | |||
| David O. Zenk | Ph: 319-297-2900 | ||
| Email: cetscheidt@pcofiowa.com | |||
| Iowa City | |||
|
|||
| Holden Comprehensive Cancer Center at University of Iowa | |||
| Daniel A Vaena | Ph: 800-237-1225 | ||
| Kansas | |||
|
|||
| Overland Park | |||
|
|||
| Menorah Medical Center | |||
| Rakesh Gaur | Ph: 913-948-5588 | ||
| Email: amy.krushelniski@hcahealthcare.com | |||
| Saint Luke's Hospital - South | |||
| Rakesh Gaur | Ph: 913-948-5588 | ||
| Email: amy.krushelniski@hcahealthcare.com | |||
| Prairie Village | |||
|
|||
| CCOP - Kansas City | |||
| Rakesh Gaur | Ph: 913-948-5588 | ||
| Email: amy.krushelniski@hcahealthcare.com | |||
| Maine | |||
|
|||
| Augusta | |||
|
|||
| Harold Alfond Center for Cancer Care | |||
| Thomas Henry Openshaw | Ph: 207-973-4274 | ||
| Bangor | |||
|
|||
| CancerCare of Maine at Eastern Maine Medical Center | |||
| Thomas Henry Openshaw | Ph: 207-973-4274 | ||
| Scarborough | |||
|
|||
| Maine Center for Cancer Medicine and Blood Disorders - Scarborough | |||
| Helen F Ryan | Ph: 207-396-7600 | ||
| Maryland | |||
|
|||
| Baltimore | |||
|
|||
| Greenebaum Cancer Center at University of Maryland Medical Center | |||
| Ivana Gojo | Ph: 410-955-8804 | ||
| Email: jhcccro@jhmi.edu | |||
| Bethesda | |||
|
|||
| National Naval Medical Center | |||
| David C Van Echo | Ph: 301-319-2100 | ||
| Elkton MD | |||
|
|||
| Union Hospital of Cecil County | |||
| Frank Beardell | Ph: 302-733-6227 | ||
| Massachusetts | |||
|
|||
| Boston | |||
|
|||
| Dana-Farber/Brigham and Women's Cancer Center | |||
| Richard Maury Stone | Ph: 866-790-4500 | ||
| Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute | |||
| Richard Maury Stone | Ph: 866-790-4500 | ||
| Massachusetts General Hospital | |||
| Richard Maury Stone | Ph: 866-790-4500 | ||
| Michigan | |||
|
|||
| Battle Creek | |||
|
|||
| Battle Creek Health System Cancer Care Center | |||
| Gilbert D Padula | Ph: 616-685-5225 | ||
| Big Rapids | |||
|
|||
| Mecosta County Medical Center | |||
| Gilbert D Padula | Ph: 616-685-5225 | ||
| Grand Rapids | |||
|
|||
| Butterworth Hospital at Spectrum Health | |||
| Gilbert D Padula | Ph: 616-685-5225 | ||
| CCOP - Grand Rapids | |||
| Gilbert D Padula | Ph: 616-685-5225 | ||
| Lacks Cancer Center at Saint Mary's Health Care | |||
| Gilbert D Padula | Ph: 616-685-5225 | ||
| Muskegon | |||
|
|||
| Mercy General Health Partners | |||
| Gilbert D Padula | Ph: 616-685-5225 | ||
| Reed City | |||
|
|||
| Spectrum Health Reed City Hospital | |||
| Gilbert D Padula | Ph: 616-685-5225 | ||
| Traverse City | |||
|
|||
| Munson Medical Center | |||
| Gilbert D Padula | Ph: 616-685-5225 | ||
| Minnesota | |||
|
|||
| Duluth | |||
|
|||
| St. Luke's Hospital Cancer Care Center | |||
| Tanya L. Repka | |||
| Email: calgbco@calgb.org | |||
| Minneapolis | |||
|
|||
| Masonic Cancer Center at University of Minnesota | |||
| Bruce A. Peterson | Ph: 612-624-2620 | ||
| Veterans Affairs Medical Center - Minneapolis | |||
| Sharon D Luikart | Ph: 612-467-2800 | ||
| Missouri | |||
|
|||
| Cape Girardeau | |||
|
|||
| Southeast Cancer Center | |||
| Alan Philip Lyss | Ph: 800-392-0936 | ||
| Columbia | |||
|
|||
| Ellis Fischel Cancer Center at University of Missouri - Columbia | |||
| Carl E. Freter | Ph: 573-882-7440 | ||
| Jefferson City | |||
|
|||
| Goldschmidt Cancer Center | |||
| Alan Philip Lyss | Ph: 800-392-0936 | ||
| Kansas City | |||
|
|||
| Heartland Hematology Oncology Associates, Incorporated | |||
| Rakesh Gaur | Ph: 913-948-5588 | ||
| Email: amy.krushelniski@hcahealthcare.com | |||
| North Kansas City Hospital | |||
| Rakesh Gaur | Ph: 913-948-5588 | ||
| Email: amy.krushelniski@hcahealthcare.com | |||
| Research Medical Center | |||
| Rakesh Gaur | Ph: 913-948-5588 | ||
| Email: amy.krushelniski@hcahealthcare.com | |||
| Saint Luke's Hospital | |||
| Rakesh Gaur | Ph: 913-948-5588 | ||
| Email: amy.krushelniski@hcahealthcare.com | |||
| Lee's Summit | |||
|
|||
| Saint Luke's East - Lee's Summit | |||
| Rakesh Gaur | Ph: 913-948-5588 | ||
| Email: amy.krushelniski@hcahealthcare.com | |||
| Saint Joseph | |||
|
|||
| Saint Joseph Oncology, Incorporated | |||
| Rakesh Gaur | Ph: 913-948-5588 | ||
| Email: amy.krushelniski@hcahealthcare.com | |||
| Saint Louis | |||
|
|||
| Missouri Baptist Cancer Center | |||
| Alan Philip Lyss | Ph: 800-392-0936 | ||
| Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | |||
| Geoffrey L Uy | Ph: 800-600-3606 | ||
| Email: info@siteman.wustl.edu | |||
| Nebraska | |||
|
|||
| Grand Island | |||
|
|||
| Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center | |||
| Lori J. Maness | Ph: 800-999-5465 | ||
| North Platte | |||
|
|||
| Callahan Cancer Center at Great Plains Regional Medical Center | |||
| Lori J. Maness | Ph: 800-999-5465 | ||
| Omaha | |||
|
|||
| UNMC Eppley Cancer Center at the University of Nebraska Medical Center | |||
| Lori J. Maness | Ph: 800-999-5465 | ||
| Nevada | |||
|
|||
| Las Vegas | |||
|
|||
| CCOP - Nevada Cancer Research Foundation | |||
| John Allan Ellerton | Ph: 702-731-8274 | ||
| Sunrise Hospital and Medical Center | |||
| John Allan Ellerton | Ph: 702-731-8274 | ||
| University Medical Center of Southern Nevada | |||
| John Allan Ellerton | Ph: 702-731-8274 | ||
| New Hampshire | |||
|
|||
| Lebanon | |||
|
|||
| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | |||
| Christopher H Lowrey | Ph: 800-639-6918 | ||
| Email: cancer.research.nurse@dartmouth.edu | |||
| New Jersey | |||
|
|||
| Camden | |||
|
|||
| Cancer Institute of New Jersey at Cooper University Hospital - Camden | |||
| Frank Beardell | Ph: 302-733-6227 | ||
| New York | |||
|
|||
| Buffalo | |||
|
|||
| Roswell Park Cancer Institute | |||
| Meir Wetzler | Ph: 877-275-7724 | ||
| East Syracuse | |||
|
|||
| CCOP - Hematology-Oncology Associates of Central New York | |||
| Jeffrey J. Kirshner | Ph: 315-472-7504 | ||
| Glens Falls | |||
|
|||
| Charles R. Wood Cancer Center at Glens Falls Hospital | |||
| Aqeel A Gillani | Ph: 518-926-6700 | ||
| Lake Success | |||
|
|||
| Monter Cancer Center of the North Shore-LIJ Health System | |||
| Vincent P. Vinciguerra | Ph: 516-562-3467 | ||
| Manhasset | |||
|
|||
| Don Monti Comprehensive Cancer Center at North Shore University Hospital | |||
| Vincent P. Vinciguerra | Ph: 516-562-3467 | ||
| New Hyde Park | |||
|
|||
| Long Island Jewish Medical Center | |||
| Kanti Roop Rai | Ph: 516-562-3467 | ||
| New York | |||
|
|||
| Mount Sinai Medical Center | |||
| Lewis R. Silverman | Ph: 212-824-7320 | ||
| Email: jenny.figueroa@mssm.edu | |||
| New York Weill Cornell Cancer Center at Cornell University | |||
| Eric M Feldman | Ph: 206-287-2900 | ||
| North Carolina | |||
|
|||
| Asheville | |||
|
|||
| Mission Hospitals - Memorial Campus | |||
| Michael Joseph Messino | Ph: 828-213-4150 | ||
| Chapel Hill | |||
|
|||
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | |||
| Thomas C. Shea | Ph: 877-668-0683 | ||
| Charlotte | |||
|
|||
| Blumenthal Cancer Center at Carolinas Medical Center | |||
| James Grier Wall | Ph: 704-355-2884 | ||
| Presbyterian Cancer Center at Presbyterian Hospital | |||
| Justin P Favaro | Ph: 704-384-5369 | ||
| Concord | |||
|
|||
| Batte Cancer Center at Northeast Medical Center | |||
| James Grier Wall | Ph: 704-355-2884 | ||
| Durham | |||
|
|||
| Duke Cancer Institute | |||
| Jeffrey Crawford | Ph: 888-275-3853 | ||
| Goldsboro | |||
|
|||
| Wayne Memorial Hospital, Incorporated | |||
| James N. Atkins | Ph: 919-580-0000 | ||
| Greenville | |||
|
|||
| Leo W. Jenkins Cancer Center at ECU Medical School | |||
| Adam S Asch | Ph: 252-744-2161 | ||
| Hendersonville | |||
|
|||
| Comprehensive Cancer Center at Pardee Hospital | |||
| James E. Radford | Ph: 828-696-4716 | ||
| Kinston | |||
|
|||
| Kinston Medical Specialists | |||
| Peter R. Watson | Ph: 252-559-2200 | ||
| Winston-Salem | |||
|
|||
| Wake Forest University Comprehensive Cancer Center | |||
| Bayard L. Powell | Ph: 336-713-6771 | ||
| Ohio | |||
|
|||
| Columbus | |||
|
|||
| Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center | |||
| Clara D. Bloomfield | Ph: 866-627-7616 | ||
| Email: osu@emergingmed.com | |||
| Oklahoma | |||
|
|||
| Norman | |||
|
|||
| Cancer Care Associates - Norman | |||
| Vikki Ann Canfield | Ph: 405-271-4272 | ||
| Email: julie-traylor@ouhsc.edu | |||
| Oklahoma City | |||
|
|||
| Cancer Care Associates - Mercy Campus | |||
| Vikki Ann Canfield | Ph: 405-271-4272 | ||
| Email: julie-traylor@ouhsc.edu | |||
| Oklahoma University Cancer Institute | |||
| Carla Kurkjian | Ph: 405-271-4272 | ||
| Email: julie-traylor@ouhsc.edu | |||
| Pennsylvania | |||
|
|||
| Pittsburgh | |||
|
|||
| Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital | |||
| John Lister | Ph: 412-578-5000 | ||
| Rhode Island | |||
|
|||
| Providence | |||
|
|||
| Miriam Hospital | |||
| William M. Sikov | Ph: 401-793-2224 | ||
| Rhode Island Hospital Comprehensive Cancer Center | |||
| William M. Sikov | Ph: 401-793-2224 | ||
| South Carolina | |||
|
|||
| Florence | |||
|
|||
| McLeod Regional Medical Center | |||
| Rajesh Bajaj | Ph: 843-679-7256 | ||
| Greenville | |||
|
|||
| Cancer Centers of the Carolinas - Andrews | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| Cancer Centers of the Carolinas - Faris Road | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| Cancer Centers of the Carolinas - Grove Commons | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| CCOP - Greenville | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| Greenville Memorial Hospital | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| Greer | |||
|
|||
| Cancer Centers of the Carolinas - Greer Medical Oncology | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| Seneca | |||
|
|||
| Cancer Centers of the Carolinas - Seneca | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| Spartanburg | |||
|
|||
| Cancer Centers of the Carolinas - Spartanburg | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| Virginia | |||
|
|||
| Danville | |||
|
|||
| Danville Regional Medical Center | |||
| Timothy W. Brotherton | Ph: 434-793-0044 | ||
Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00048958
Information obtained from ClinicalTrials.gov on November 20, 2012
Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain
the same text. Minor
changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and
contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should
be directed to ClinicalTrials.gov.
Back to Top
