PET-Directed Therapy in Treating Patients With Limited-Stage Diffuse Large B-Cell Lymphoma
Trial Sites
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Basic Trial Information
Trial Description
Summary
Further Trial Information
Eligibility Criteria
Trial Contact Information
| Phase | Type | Status | Age | Sponsor | Protocol IDs |
|---|---|---|---|---|---|
| Phase II | Biomarker/Laboratory analysis, Treatment | Active | 18 and over | NCI, Other | CDR0000700624 SWOG-S1001, S1001, NCT01359592 |
Summary
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop cancer cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill cancer cells. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Radiolabeled monoclonal antibodies, such as yttrium Y 90 ibritumomab tiuxetan, can find cancer cells and carry cancer-killing substances to them without harming normal cells. Comparing results of diagnostic procedures, such as PET scan and CT scan, done before, during, and after chemotherapy may help doctors predict a patient's response to treatment and help plan the best treatment.
PURPOSE: This phase II trial studies how well PET-directed chemotherapy works in treating patients with limited-stage diffuse large B-cell lymphoma.
Further Study Information
OBJECTIVES:
Primary
- To assess the 5-year progression-free survival (PFS) rate in patients with newly diagnosed limited-stage diffuse, large B-cell lymphoma (DLBCL) using positron emission tomography (PET)/CT scan to direct therapy after 3 courses of rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone (R-CHOP).
Secondary
- To evaluate PFS within the PET-positive (+) and PET-negative (-) subgroups of patients with newly diagnosed limited-stage DLBCL.
- To evaluate toxicity of the protocol treatments in this patient population.
- To evaluate the response probability in this patient population.
- To evaluate overall survival in the overall population, and within the PET+ and PET- subgroups.
- To estimate the rate of upstaging at baseline by PET/CT at baseline among patients newly diagnosed with limited-stage DLBCL by CT imaging and to describe outcomes in patients upstaged by PET/CT at baseline to advanced DLBCL.
- To describe outcomes in the subgroup of patients upstaged by PET/CT.
- To evaluate the association of germinal center B-cell subtype (GCB) vs stromal-1 vs stromal-2 gene expression signatures with PFS or overall survival.
OUTLINE: This is a multicenter study. Patients are stratified according to whether the patient was upstaged to advanced stage DLBCL, based on local review of the baseline PET/CT (yes vs no).
Chemotherapy: Patients receive R-CHOP comprising rituximab IV, cyclophosphamide IV over 30-60 minutes, vincristine sulfate IV, and doxorubicin hydrochloride IV on day 1, and prednisone orally on days 1-5. Treatment repeats every 21 days for 3* courses. NOTE: *Patients found to have advanced stage DLBCL based on local review of the baseline PET scan receive 6 courses of R-CHOP.
FDG/PET - Radiotherapy: Patients undergo fludeoxyglucose F 18 positron emission tomography (FDG-PET)/CT scan at baseline, on days 15-18 of course 3, and at 12 weeks after completion of course 3. Patients with complete response (PET scan negative) receive one additional course of R-CHOP as above. Patients with partial response (PET scan positive) undergo involved-field radiotherapy (IFRT) 5 days a week for approximately 4-5 weeks.
Monoclonal antibody: Beginning 3-6 weeks after completion of IFRT, patients receive yttrium Y 90 ibritumomab tiuxetan IV over 10 minutes and rituximab IV on day 1 and on day 7, 8, or 9.
Patients may undergo blood sample collection at baseline for correlative studies. Bone marrow tissue samples may be also collected for correlative studies.
After completion of study therapy, patients are followed up every 6 months for 2 years and then yearly for 5 years.
Eligibility Criteria
DISEASE CHARACTERISTICS:
- Patients must have biopsy-proven diffuse large B-cell lymphoma (DLBCL)
- Adequate sections or a paraffin block from the original diagnostic specimen must be submitted for review by the lymphoma pathology group
- Lymphoma must express CD20 antigen by either flow cytometry using anti-CD20 antibodies or by immunoperoxidase staining of paraffin sections
- Patients with primary mediastinal lymphoma or testicular lymphoma are not eligible
- Patients must have non-bulky stage I or II disease by Ann Arbor classification
- This staging excludes FDG-PET evaluation
- Patients who have stage I or II non-bulky disease on diagnostic CT scan, but are upstaged to stage III or IV based on FDG-PET evaluation, are also eligible
- Patients must have a diagnostic quality contrast-enhanced CT scan of the chest, abdomen, and pelvis AND baseline FDG-PET scan performed within 28 days prior to registration
- Low-resolution "localization" CT scans performed as part of a combined PET/CT scan are not adequate for enrollment or response determination on this protocol
- If a patient has an allergy to CT contrast, then a non-enhanced CT will be acceptable
- Patients must not have clinical evidence of central nervous system (CNS) involvement by lymphoma
- Any laboratory or radiographic tests performed to assess CNS involvement must be negative and must be performed within 42 days prior to registration
- Patients may have either measurable or evaluable limited-stage DLBCL
- Patients rendered free of measurable or evaluable disease by virtue of biopsy (resection) are also eligible
- If patient has measurable disease it must be documented on the Lymphoma Baseline Tumor Assessment Form (Form #15187)
- All measurable disease must be assessed within 28 days prior to registration
- Patients with non-measurable disease in addition to measurable disease must have all non-measurable disease assessed within 42 days prior to registration
- Patients must have a unilateral or bilateral bone marrow biopsy performed within 42 days prior to registration
PATIENT CHARACTERISTICS:
- Zubrod performance status 0-2
- ANC ≥ 1,000/mm³
- Platelet count ≥ 100,000/mm³
- Total bilirubin ≤ 2 times upper limit of normal (ULN) (unless due to Gilbert syndrome)
- Patients must not be pregnant or nursing
- Women/men of reproductive potential must have agreed to use an effective contraceptive method during the study period
- Patients must not be known to be HIV-positive
- No other prior malignancy is allowed except for the following:
- Adequately treated basal cell or squamous cell skin cancer
- In situ cervical cancer
- Adequately treated stage I or II cancer from which the patient is currently in complete remission
- Any other cancer from which the patient has been disease-free for 5 years
PRIOR CONCURRENT THERAPY:
- Patients must not have received prior chemotherapy, radiotherapy, or antibody therapy for lymphoma
Trial Lead Organizations/Sponsors
Southwest Oncology Group
National Cancer Institute| Daniel O. Persky |  | Principal Investigator |
Trial Sites
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| U.S.A. | |||
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| Alaska | |||
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| Anchorage | |||
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| Providence Cancer Center | |||
| Jeanne E. Anderson | Ph: 907-261-3109 | ||
| Arizona | |||
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| Tucson | |||
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| Arizona Cancer Center at University Medical Center North | |||
| Thomas P. Miller | Ph: 520-626-9008 | ||
| Arizona Cancer Center at University of Arizona Health Sciences Center | |||
| Thomas P. Miller | Ph: 520-626-9008 | ||
| Colorado | |||
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| Aurora | |||
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| Medical Center of Aurora - South Campus | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Boulder | |||
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| Boulder Community Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Colorado Springs | |||
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| Penrose Cancer Center at Penrose Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Denver | |||
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| CCOP - Colorado Cancer Research Program | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Kaiser Permanente of Colorado | |||
| Alexander Menter | Ph: 303-614-1300 | ||
| Porter Adventist Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Presbyterian - St. Luke's Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Rose Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| St. Anthony Central Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| St. Joseph Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Englewood | |||
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| Swedish Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Greeley | |||
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| North Colorado Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Lafayette | |||
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| Kaiser Permanente - Lafayette | |||
| Alexander Menter | Ph: 303-614-1300 | ||
| Littleton | |||
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| Littleton Adventist Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Lone Tree | |||
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| Sky Ridge Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Longmont | |||
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| Hope Cancer Care Center at Longmont United Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Loveland | |||
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| McKee Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Parker | |||
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| Parker Adventist Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Pueblo | |||
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| St. Mary - Corwin Regional Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Wheat Ridge | |||
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| Exempla Lutheran Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Connecticut | |||
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| Hartford | |||
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| Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| New Haven | |||
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| Yale Cancer Center | |||
| Iris Isufi | Ph: 203-785-5702 | ||
| Georgia | |||
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| Atlanta | |||
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| CCOP - Atlanta Regional | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Northside Hospital Cancer Center | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Piedmont Hospital | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Saint Joseph's Hospital of Atlanta | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Austell | |||
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| WellStar Cobb Hospital | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Columbus | |||
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| John B. Amos Cancer Center | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Decatur | |||
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| Charles B. Eberhart Cancer Center at DeKalb Medical Center | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Fayetteville | |||
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| Piedmont Fayette Hospital | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Lawrenceville | |||
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| Gwinnett Medical Center | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Marietta | |||
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| Kennestone Cancer Center at Wellstar Kennestone Hospital | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Riverdale | |||
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| Southern Regional Medical Center | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Rome | |||
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| Harbin Clinic Cancer Center - Medical Oncology | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Hawaii | |||
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| Aiea | |||
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| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| Kapiolani Medical Center at Pali Momi | |||
| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| Ewa Beach | |||
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| Leeward Radiation Oncology | |||
| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| Honolulu | |||
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| Cancer Research Center of Hawaii | |||
| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| Hawaii Medical Center - East | |||
| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| Kapiolani Medical Center for Women and Children | |||
| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| Kuakini Medical Center | |||
| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| OnCare Hawaii, Incorporated - Kuakini | |||
| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| OnCare Hawaii, Incorporated - Lusitana | |||
| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| Queen's Cancer Institute at Queen's Medical Center | |||
| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| Straub Clinic and Hospital, Incorporated | |||
| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| Kailua | |||
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| Castle Medical Center | |||
| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| Lihue | |||
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| Kauai Medical Clinic | |||
| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| Idaho | |||
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| Boise | |||
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| Mountain States Tumor Institute at St. Luke's Regional Medical Center | |||
| Theodore A. Walters | Ph: 800-845-4624 | ||
| Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Fruitland | |||
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| Saint Luke's Mountain States Tumor Institute - Fruitland | |||
| Paul G. Montgomery | Ph: 800-845-4624 | ||
| Meridian | |||
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| Mountain States Tumor Institute - Meridian | |||
| Paul G. Montgomery | Ph: 800-845-4624 | ||
| Nampa | |||
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| Saint Luke's Mountain States Tumor Institute | |||
| Paul G. Montgomery | Ph: 800-845-4624 | ||
| Twin Falls | |||
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| Mountain States Tumor Institute at St. Luke's | |||
| Paul G. Montgomery | Ph: 800-845-4624 | ||
| Illinois | |||
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| Bloomington | |||
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| Illinois CancerCare - Bloomington | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| St. Joseph Medical Center | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Canton | |||
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| Illinois CancerCare - Canton | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Carthage | |||
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| Illinois CancerCare - Carthage | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Chicago | |||
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| Robert H. Lurie Comprehensive Cancer Center at Northwestern University | |||
| Adam M Petrich | Ph: 312-695-1301 | ||
| Email: cancer@northwestern.edu | |||
| Eureka | |||
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| Eureka Community Hospital | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Illinois CancerCare - Eureka | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Galesburg | |||
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| Galesburg Clinic, PC | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Havana | |||
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| Illinois CancerCare - Havana | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Highland Park | |||
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| Hematology Oncology Associates of Illinois-Highland Park | |||
| Adam M Petrich | Ph: 312-695-1301 | ||
| Email: cancer@northwestern.edu | |||
| Kankakee | |||
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| Provena St. Mary's Regional Cancer Center - Kankakee | |||
| Adam M Petrich | Ph: 312-695-1301 | ||
| Email: cancer@northwestern.edu | |||
| Kewanee | |||
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| Illinois CancerCare - Kewanee Clinic | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Libertyville | |||
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| North Shore Oncology and Hematology Associates, Limited - Libertyville | |||
| Adam M Petrich | Ph: 312-695-1301 | ||
| Email: cancer@northwestern.edu | |||
| Macomb | |||
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| Illinois CancerCare - Macomb | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Maywood | |||
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| Cardinal Bernardin Cancer Center at Loyola University Medical Center | |||
| Scott E. Smith | Ph: 708-226-4357 | ||
| Monmouth | |||
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| Illinois CancerCare - Monmouth | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| OSF Holy Family Medical Center | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Niles | |||
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| Cancer Care and Hematology Specialists of Chicagoland - Niles | |||
| Adam M Petrich | Ph: 312-695-1301 | ||
| Email: cancer@northwestern.edu | |||
| Normal | |||
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| BroMenn Regional Medical Center | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Community Cancer Center | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Illinois CancerCare - Community Cancer Center | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Ottawa | |||
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| Community Hospital of Ottawa | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Illinois CancerCare - Ottawa | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Pekin | |||
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| Cancer Treatment Center at Pekin Hospital | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Illinois CancerCare - Pekin | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Peoria | |||
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| CCOP - Illinois Oncology Research Association | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Illinois CancerCare - Peoria | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Methodist Medical Center of Illinois | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| OSF St. Francis Medical Center | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Proctor Hospital | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Peru | |||
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| Illinois CancerCare - Princeton | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Illinois Valley Community Hospital | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Princeton | |||
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| Illinois CancerCare - Princeton | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Skokie | |||
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| Hematology Oncology Associates - Skokie | |||
| Adam M Petrich | Ph: 312-695-1301 | ||
| Email: cancer@northwestern.edu | |||
| Spring Valley | |||
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| Illinois CancerCare - Spring Valley | |||
| Nguyet A Le-Lindqwister | Ph: 800-793-2262 | ||
| Urbana | |||
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| Carle Cancer Center at Carle Foundation Hospital | |||
| Kalika P. Sarma | Ph: 800-446-5532 | ||
| Indiana | |||
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| Beech Grove | |||
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| St. Francis Hospital and Health Centers - Beech Grove Campus | |||
| Howard M. Gross | Ph: 765-983-3000 | ||
| Indianapolis | |||
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| St. Francis Hospital Cancer Care Services | |||
| Howard M. Gross | Ph: 765-983-3000 | ||
| Richmond | |||
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| Reid Hospital & Health Care Services | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Iowa | |||
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| Sioux City | |||
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| Mercy Medical Center - Sioux City | |||
| Donald Bruce Wender | Ph: 712-252-0088 | ||
| Siouxland Hematology-Oncology Associates, LLP | |||
| Donald Bruce Wender | Ph: 712-252-0088 | ||
| St. Luke's Regional Medical Center | |||
| Donald Bruce Wender | Ph: 712-252-0088 | ||
| Kansas | |||
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| Chanute | |||
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| Cancer Center of Kansas, PA - Chanute | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Dodge City | |||
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| Cancer Center of Kansas, PA - Dodge City | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| El Dorado | |||
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| Cancer Center of Kansas, PA - El Dorado | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Fort Scott | |||
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| Cancer Center of Kansas - Fort Scott | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Independence | |||
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| Cancer Center of Kansas-Independence | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Kingman | |||
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| Cancer Center of Kansas, PA - Kingman | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Lawrence | |||
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| Lawrence Memorial Hospital | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Liberal | |||
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| Cancer Center of Kansas, PA - Liberal | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| McPherson | |||
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| Cancer Center of Kansas, PA - McPherson | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Newton | |||
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| Cancer Center of Kansas, PA - Newton | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Parsons | |||
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| Cancer Center of Kansas, PA - Parsons | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Prairie Village | |||
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| CCOP - Kansas City | |||
| Rakesh Gaur | Ph: 913-948-5588 | ||
| Email: amy.krushelniski@hcahealthcare.com | |||
| Pratt | |||
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| Cancer Center of Kansas, PA - Pratt | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Salina | |||
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| Cancer Center of Kansas, PA - Salina | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Wellington | |||
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| Cancer Center of Kansas, PA - Wellington | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Wichita | |||
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| Associates in Women's Health, PA - North Hillside | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Cancer Center of Kansas, PA - Medical Arts Tower | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Cancer Center of Kansas, PA - Wichita | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| CCOP - Wichita | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Via Christi Cancer Center at Via Christi Regional Medical Center | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Winfield | |||
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| Cancer Center of Kansas, PA - Winfield | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Kentucky | |||
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| Lexington | |||
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| University of Kentucky Chandler Medical Center | |||
| John W Hayslip | Ph: 859-257-3379 | ||
| Maryland | |||
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| Baltimore | |||
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| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | |||
| Lode J. Swinnen | Ph: 410-955-8804 | ||
| Email: jhcccro@jhmi.edu | |||
| Massachusetts | |||
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| Brighton | |||
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| Caritas St. Elizabeth's Medical Center | |||
| Uma Narayanasami | Ph: 617-789-2903 | ||
| Michigan | |||
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| Ann Arbor | |||
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| CCOP - Michigan Cancer Research Consortium | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Saint Joseph Mercy Cancer Center | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Dearborn | |||
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| Oakwood Cancer Center at Oakwood Hospital and Medical Center | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Detroit | |||
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| Josephine Ford Cancer Center at Henry Ford Hospital | |||
| Robert Anthony Chapman | Ph: 313-916-1784 | ||
| Van Elslander Cancer Center at St. John Hospital and Medical Center | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Flint | |||
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| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Genesys Hurley Cancer Institute | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Hurley Medical Center | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Grand Blanc | |||
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| Genesys Regional Medical Center | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Jackson | |||
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| Gayle M. Jacob Cancer Center at Allegiance Health | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Kalamazoo | |||
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| Borgess Medical Center | |||
| Raymond Sterling Lord | Ph: 269-373-7458 | ||
| Bronson Methodist Hospital | |||
| Raymond Sterling Lord | Ph: 269-373-7458 | ||
| West Michigan Cancer Center | |||
| Raymond Sterling Lord | Ph: 269-373-7458 | ||
| Lansing | |||
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| Sparrow Regional Cancer Center | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Livonia | |||
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| St. Mary Mercy Hospital | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Pontiac | |||
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| St. Joseph Mercy Oakland | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Port Huron | |||
|
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| Mercy Regional Cancer Center at Mercy Hospital | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Saginaw | |||
|
|||
| Seton Cancer Institute at Saint Mary's - Saginaw | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Warren | |||
|
|||
| St. John Macomb Hospital | |||
| Christopher M Reynolds | Ph: 734-712-3456 | ||
| Minnesota | |||
|
|||
| Burnsville | |||
|
|||
| Fairview Ridges Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Coon Rapids | |||
|
|||
| Mercy and Unity Cancer Center at Mercy Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Duluth | |||
|
|||
| CCOP - Duluth | |||
| Daniel Nikcevich | Ph: 888-203-7267 | ||
| Essentia Health - Duluth Clinic | |||
| Daniel Nikcevich | Ph: 888-203-7267 | ||
| Miller - Dwan Medical Center | |||
| Daniel Nikcevich | Ph: 888-203-7267 | ||
| Edina | |||
|
|||
| Fairview Southdale Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Fridley | |||
|
|||
| Mercy and Unity Cancer Center at Unity Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Hutchinson | |||
|
|||
| Hutchinson Area Health Care | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Maplewood | |||
|
|||
| HealthEast Cancer Care at St. John's Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Minnesota Oncology - Maplewood | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Minneapolis | |||
|
|||
| Hennepin County Medical Center - Minneapolis | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| New Ulm | |||
|
|||
| New Ulm Medical Center | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Robbinsdale | |||
|
|||
| Humphrey Cancer Center at North Memorial Outpatient Center | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Saint Louis Park | |||
|
|||
| CCOP - Metro-Minnesota | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Park Nicollet Cancer Center | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Saint Paul | |||
|
|||
| Regions Hospital Cancer Care Center | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| United Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Shakopee | |||
|
|||
| St. Francis Cancer Center at St. Francis Medical Center | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Stillwater | |||
|
|||
| Lakeview Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Waconia | |||
|
|||
| Ridgeview Medical Center | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Willmar | |||
|
|||
| Willmar Cancer Center at Rice Memorial Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Woodbury | |||
|
|||
| Minnesota Oncology - Woodbury | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Missouri | |||
|
|||
| Saint Louis | |||
|
|||
| Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | |||
| Nancy L. Bartlett | Ph: 800-600-3606 | ||
| Email: info@siteman.wustl.edu | |||
| Montana | |||
|
|||
| Billings | |||
|
|||
| Billings Clinic Cancer Center - 801 N 29th Street | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| CCOP - Montana Cancer Consortium | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Hematology-Oncology Centers of the Northern Rockies - Billings | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| St. Vincent Healthcare Cancer Care Services | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Bozeman | |||
|
|||
| Bozeman Deaconess Cancer Center | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Butte | |||
|
|||
| St. James Healthcare Cancer Care | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Great Falls | |||
|
|||
| Benefis Sletten Cancer Institute | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Great Falls Clinic - Main Facility | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Helena | |||
|
|||
| St. Peter's Hospital | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Kalispell | |||
|
|||
| Kalispell Regional Medical Center | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Missoula | |||
|
|||
| Montana Cancer Center at St. Patrick Hospital and Health Sciences Center | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Montana Cancer Specialists at Montana Cancer Center | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| New York | |||
|
|||
| Middletown | |||
|
|||
| Tucker Center for Cancer Care at Orange Regional Medical Center | |||
| Jeffrey M. Stewart | Ph: 845-342-7609 | ||
| Rochester | |||
|
|||
| James P. Wilmot Cancer Center at University of Rochester Medical Center | |||
| Jonathan W Friedberg | Ph: 585-275-5830 | ||
| North Carolina | |||
|
|||
| Chapel Hill | |||
|
|||
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | |||
| Steven I Park | Ph: 877-668-0683 | ||
| Goldsboro | |||
|
|||
| Wayne Memorial Hospital, Incorporated | |||
| James N. Atkins | Ph: 919-580-0000 | ||
| Hendersonville | |||
|
|||
| Park Ridge Hospital Breast Health Center | |||
| James Dewitt Bearden | Ph: 800-486-5941 | ||
| Raleigh | |||
|
|||
| Rex Cancer Center at Rex Hospital | |||
| Jeffrey Major Crane | Ph: 919-784-7209 | ||
| Statesville | |||
|
|||
| Iredell Memorial Hospital | |||
| Ruby A. Grimm | Ph: 704-873-5661 | ||
| North Dakota | |||
|
|||
| Fargo | |||
|
|||
| Preston D. Steen | Ph: 701-234-6161 | ||
| Roger Maris Cancer Center at MeritCare Hospital | |||
| Preston D. Steen | Ph: 701-234-6161 | ||
| Sanford Clinic North-Fargo | |||
| Preston D. Steen | Ph: 701-234-6161 | ||
| Ohio | |||
|
|||
| Canton | |||
|
|||
| Mercy Cancer Center at Mercy Medical Center | |||
| Mitchell Haut | Ph: 888-293-4673 | ||
| Dayton | |||
|
|||
| CCOP - Dayton | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| David L. Rike Cancer Center at Miami Valley Hospital | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Good Samaritan Hospital | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Grandview Hospital | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Samaritan North Cancer Care Center | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Findlay | |||
|
|||
| Blanchard Valley Regional Cancer Center | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Franklin | |||
|
|||
| Atrium Medical Center | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Greenville | |||
|
|||
| Wayne Hospital | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Kettering | |||
|
|||
| Charles F. Kettering Memorial Hospital | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Troy | |||
|
|||
| UVMC Cancer Care Center at Upper Valley Medical Center | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Xenia | |||
|
|||
| Ruth G. McMillan Cancer Center at Greene Memorial Hospital | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Oklahoma | |||
|
|||
| Tulsa | |||
|
|||
| Natalie Warren Bryant Cancer Center at St. Francis Hospital | |||
| Joseph P. Lynch | Ph: 918-494-2200 | ||
| Pennsylvania | |||
|
|||
| Danville | |||
|
|||
| Geisinger Cancer Institute at Geisinger Health | |||
| Edward J Gorak | Ph: 570-271-5251 | ||
| South Carolina | |||
|
|||
| Greenville | |||
|
|||
| Bon Secours St. Francis Health System | |||
| James Dewitt Bearden | Ph: 800-486-5941 | ||
| Cancer Centers of the Carolinas - Faris Road | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| Cancer Centers of the Carolinas - Grove Commons | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| CCOP - Greenville | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| Greenville Memorial Hospital | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| Greer | |||
|
|||
| Cancer Centers of the Carolinas - Greer Medical Oncology | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| Seneca | |||
|
|||
| Cancer Centers of the Carolinas - Seneca | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| Spartanburg | |||
|
|||
| Cancer Centers of the Carolinas - Spartanburg | |||
| Jeffrey Kent Giguere | Ph: 864-241-6251 | ||
| CCOP - Upstate Carolina | |||
| James Dewitt Bearden | Ph: 800-486-5941 | ||
| Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | |||
| James Dewitt Bearden | Ph: 800-486-5941 | ||
| South Dakota | |||
|
|||
| Sioux Falls | |||
|
|||
| Miroslaw A Mazurczak | Ph: 605-328-1367 | ||
| Sanford Cancer Center at Sanford USD Medical Center | |||
| Miroslaw A Mazurczak | Ph: 605-328-1367 | ||
| Texas | |||
|
|||
| San Antonio | |||
|
|||
| Cancer Therapy and Research Center | |||
| Kevin R Kelly | Ph: 210-616-5798 | ||
| University Hospital - San Antonio | |||
| Kevin R Kelly | Ph: 210-616-5798 | ||
| University of Texas Health Science Center at San Antonio | |||
| Kevin R Kelly | Ph: 210-616-5798 | ||
| Washington | |||
|
|||
| Anacortes | |||
|
|||
| Cancer Care Center at Island Hogs | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Bellingham | |||
|
|||
| St. Joseph Cancer Center | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Bremerton | |||
|
|||
| Olympic Hematology and Oncology | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Burien | |||
|
|||
| Highline Medical Center Cancer Center | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Issaquah | |||
|
|||
| Swedish Medical Center - Issaquah Campus | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Kennewick | |||
|
|||
| Columbia Basin Hematology | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Mount Vernon | |||
|
|||
| Skagit Valley Hospital Cancer Care Center | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Poulsbo | |||
|
|||
| Harrison Poulsbo Hematology and Onocology | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Seattle | |||
|
|||
| Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Group Health Central Hospital | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Harborview Medical Center | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Swedish Cancer Institute at Swedish Medical Center - First Hill Campus | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| University Cancer Center at University of Washington Medical Center | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Sedro-Woolley | |||
|
|||
| North Puget Oncology at United General Hospital | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Spokane | |||
|
|||
| Cancer Care Northwest - Spokane South | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Evergreen Hematology and Oncology, PS | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| Wenatchee | |||
|
|||
| Wenatchee Valley Medical Center | |||
| Gary E Goodman | Ph: 206-386-2323 | ||
| Email: patra.grevstad@swedish.org | |||
| West Virginia | |||
|
|||
| Morgantown | |||
|
|||
| Mary Babb Randolph Cancer Center at West Virginia University Hospitals | |||
| Sayed M Hamadani | Ph: 304-293-2745 | ||
| Email: sfilburn@hsc.wvu.edu | |||
| Wisconsin | |||
|
|||
| Johnson Creek | |||
|
|||
| UW Cancer Center Johnson Creek | |||
| Brad S. Kahl | Ph: 877-405-6866 | ||
| La Crosse | |||
|
|||
| Gundersen Lutheran Center for Cancer and Blood | |||
| Kurt Oettel | Ph: 608-775-2385 | ||
| Email: cancerctr@gundluth.org | |||
| Madison | |||
|
|||
| University of Wisconsin Paul P. Carbone Comprehensive Cancer Center | |||
| Brad S. Kahl | Ph: 877-405-6866 | ||
| New Richmond | |||
|
|||
| Cancer Center of Western Wisconsin | |||
| Joseph W Leach | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Wyoming | |||
|
|||
| Casper | |||
|
|||
| Rocky Mountain Oncology | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Sheridan | |||
|
|||
| Welch Cancer Center at Sheridan Memorial Hospital | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01359592
Information obtained from ClinicalTrials.gov on November 20, 2012
Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain
the same text. Minor
changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and
contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should
be directed to ClinicalTrials.gov.
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