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Early Surgery or Standard Palliative Therapy in Treating Patients With Stage IV Breast Cancer

Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IIIBiomarker/Laboratory analysis, TreatmentActive18 and overNCI, OtherCDR0000688097
ECOG-E2108, E2108, NCT01242800

Trial Description

Summary

RATIONALE: Early surgery may have fewer side effects and improve recovery. Palliative surgery or radiation therapy may help patients with advanced breast cancer live more comfortably. It is not yet known whether early surgery is more effective than palliative therapy for advanced breast cancer.

PURPOSE: This randomized phase III trial is studying early surgery to see how well it works compared to standard palliative therapy in treating patients with stage IV breast cancer.

Further Study Information

OBJECTIVES:

Primary

  • To evaluate whether early local therapy comprising surgery of intact primary disease compared to local palliative therapy only in patients with stage IV breast cancer, whose disease does not progress during initial optimal systemic therapy, will result in prolonged survival.

Secondary

  • To compare the time to uncontrolled chest wall disease between patients treated with these regimens.
  • To determine whether there is a difference in health-related quality-of-life (HRQOL) between patients treated with these regimens.
  • To determine whether the absolute value of circulating tumor cells (CTC) burden at 6 months following randomization (time +6) will be lower in the palliative therapy arm than in early local therapy arm, and whether this value is inversely related to survival (lower CTC, longer survival).
  • To collect tumor and blood specimens for future exploration of the biological interactions between the primary tumor and metastatic lesions and the effect of primary tumor resection.

OUTLINE: This is a multicenter study. Patients are stratified according to hormone receptor and treatment plan (ER+ or PR+, HER2-, endocrine therapy alone vs ER+ or PR+, and HER2-, chemotherapy and/or endocrine therapy vs ER- or PR-, and HER2- vs HER2+), and number of involved organ systems with distant disease (regional nodes in the axillary, supraclavicular, and internal mammary locations are not considered distant sites) (1 vs > 1). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive standard palliative therapy, if needed, to address symptoms such as tumor ulceration, pain, bulky adenopathy causing arm symptoms, and other similar situations. Therapy may consist of radiotherapy alone, surgery alone, or a combination of both.
  • Arm II: Patients undergo surgery comprising breast-conserving therapy (BCT) or total mastectomy according to patient and treating physician preference. Surgery is to occur no later than 10 weeks after completion of 32 weeks of systemic therapy. Free surgical margins must be achieved with re-excision or mastectomy for patients undergoing BCT. After completion of BCT, patients undergo radiotherapy once a day, 5 days per week. Patients who had mastectomy undergo radiotherapy at the discretion of treating physician.

Patients may undergo blood and tumor tissue sample collection for circulating tumor cells (CTC) burden and future studies.

Patients complete the Functional Assessment of Cancer Therapy - Breast Trial Outcome Index (FACT- TOI) and FACT - General (22) and the Breast Cancer Subscale (FACT-B) quality-of-life questionnaires at baseline and periodically during study.

After completion of study therapy, patients are followed up periodically for 5 years.

Eligibility Criteria

DISEASE CHARACTERISTICS:

  • Diagnosis of intact primary (not recurrent) invasive carcinoma of the breast
  • Stage IV disease
  • Confirmation of the primary tumor should be by needle biopsy (preferred)
  • Incisional surgical biopsy allowed as long as there is residual palpable or tumor image in the breast
  • Patients must be judged to be candidates for complete resection with free margins followed by radiation therapy (if radiation therapy is indicated)
  • For women not undergoing axillary dissection, sentinel node biopsy should document an axillary nodal burden of 1-2 involved lymph nodes (i.e., ACOSOG Z-11 criteria may be applied)
  • Prior non-invasive (DCIS) cancer allowed provided there has been no recurrence
  • Prior ipsilateral invasive cancer allowed if more than 5 years previous
  • No synchronous contralateral breast cancer
  • Patients should have at least one organ system involved with distant metastatic disease
  • If patient has only one metastatic lesion/focus, this must be proven by biopsy and the pathology report confirming the diagnosis of primary breast cancer, as well as the metastatic site, must be available
  • Must have available radiologic reports documenting disease status within the past 6 weeks prior to initiating systemic therapy
  • CNS metastases allowed provided projected survival > 6 months
  • Patients must have completed at least 16 weeks of optimal systemic therapy (appropriate to the tumor biological profile and the patient's age and menopausal status)
  • If systemic therapy is discontinued for toxicity, but there is no distant progression and at least 12 weeks of therapy have been delivered, then the patient remains eligible
  • Radiation therapy (if indicated) must begin within 12 weeks of final therapeutic surgical procedure (including re-excision for free margins and completion of axillary dissection)
  • Patients may register at any time from the time of diagnosis of stage IV breast cancer (if eligibility criteria met) to the time when a maximum of 30 weeks of induction systemic therapy has been completed
  • Patients must be randomized within 16-32 weeks after the start of systemic therapy
  • Patients must not have experienced disease progression since the start of systemic therapy, as evidenced by radiographic documentation of disease status before treatment and within 4 weeks +/- 2 weeks prior to randomization, including:
  • No new sites of disease
  • No enlargement of existing sites by 20% or more in longest diameter
  • No symptomatic deterioration
  • Patients who require radiotherapy to bone metastases during induction systemic therapy are eligible
  • Local disease at the primary site must be asymptomatic
  • Hormone receptor status known

PATIENT CHARACTERISTICS:

  • See Disease Characteristics
  • Menopausal status not specified
  • Patients must have adequate organ function to undergo local therapy 4 weeks +/- 2 weeks prior to randomization per investigator discretion and institutional guidelines
  • More than 5 years since other primary cancers that were curatively treated
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use an accepted and effective contraception method

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics

Trial Contact Information

Trial Lead Organizations/Sponsors

Eastern Cooperative Oncology Group

National Cancer Institute

Seema A. KhanPrincipal Investigator

Trial Sites

U.S.A.
Alabama
  Mobile
 University of South Alabama Mitchell Cancer Institute
 Windy Dean-Colomb Ph: 251-445-9870
  Email: pfrancisco@usouthal.edu
Alaska
  Anchorage
 Providence Cancer Center
 Jeanne E. Anderson Ph: 907-261-3109
Arizona
  Scottsdale
 21st Century Oncology - Scottsdale
 Steven E Finkelstein Ph: 888-823-5923
  Email: ctsucontact@westat.com
 Mayo Clinic Scottsdale
 Barbara A. Pockaj Ph: 507-538-7623
  Tucson
 Arizona Cancer Center at UMC Orange Grove
 Pavani Chalasani Ph: 520-626-9008
 Arizona Cancer Center at University Medical Center North
 Pavani Chalasani Ph: 520-626-9008
Arkansas
  Little Rock
 Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
 Rangaswamy Govindarajan Ph: 501-686-8274
California
  Castro Valley
 East Bay Radiation Oncology Center
 James H. Feusner Ph: 510-450-7600
  Chico
 Enloe Cancer Center at Enloe Medical Center
 William E Bonis Ph: 530-332-3808
  Duarte
 City of Hope Comprehensive Cancer Center
 Laura L Kruper Ph: 800-826-4673
  Email: becomingapatient@coh.org
  El Segundo
 21st Century Oncology - El Segundo
 David Khan Ph: 888-326-9729
  Fairfield
 North Bay Cancer Center
 Brian G Vikstrom Ph: 707-646-4016
  Fresno
 California Cancer Center - Woodward Park Office
 Brent L. Kane Ph: 559-447-4050
  Greenbrae
 Marin Cancer Institute at Marin General Hospital
 Peter D. Eisenberg Ph: 415-925-5000
  Email: info@marinspecialtycare.com
  Long Beach
 Todd Cancer Institute at Long Beach Memorial Medical Center
 Jessica Rayhanabad Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Martinez
 Contra Costa Regional Medical Center
 James H. Feusner Ph: 510-450-7600
  Monterey
 Community Hospital of the Monterey Peninsula Comprehensive Cancer Center
 John Hausdorff Ph: 831-625-4753
  Mountain View
 El Camino Hospital Cancer Center
 James H. Feusner Ph: 510-450-7600
  Oakland
 Alta Bates Summit Medical Center - Summit Campus
 James H. Feusner Ph: 510-450-7600
 CCOP - Bay Area Tumor Institute
 James H. Feusner Ph: 510-450-7600
  Orange
 Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
 Rita S. Mehta Ph: 877-827-8839
  Email: ucstudy@uci.edu
 St. Joseph Hospital Regional Cancer Center - Orange
 Michele M Carpenter Ph: 714-734-6220
  San Pablo
 Doctors Medical Center - San Pablo Campus
 James H. Feusner Ph: 510-450-7600
  Stanford
 Stanford Cancer Center
 Frederick M Dirbas Ph: 650-498-7061
  Email: ccto-office@stanford.edu
Colorado
  Aurora
 Medical Center of Aurora - South Campus
 Eduardo R. Pajon Ph: 888-785-6789
  Boulder
 Boulder Community Hospital
 Eduardo R. Pajon Ph: 888-785-6789
  Colorado Springs
 Penrose Cancer Center at Penrose Hospital
 Eduardo R. Pajon Ph: 888-785-6789
  Denver
 CCOP - Colorado Cancer Research Program
 Eduardo R. Pajon Ph: 888-785-6789
 Porter Adventist Hospital
 Eduardo R. Pajon Ph: 888-785-6789
 Presbyterian - St. Luke's Medical Center
 Eduardo R. Pajon Ph: 888-785-6789
 Rose Medical Center
 Eduardo R. Pajon Ph: 888-785-6789
 St. Anthony Central Hospital
 Eduardo R. Pajon Ph: 888-785-6789
 St. Joseph Hospital
 Eduardo R. Pajon Ph: 888-785-6789
  Englewood
 Swedish Medical Center
 Eduardo R. Pajon Ph: 888-785-6789
  Greeley
 North Colorado Medical Center
 Eduardo R. Pajon Ph: 888-785-6789
  Littleton
 Littleton Adventist Hospital
 Eduardo R. Pajon Ph: 888-785-6789
  Lone Tree
 Sky Ridge Medical Center
 Eduardo R. Pajon Ph: 888-785-6789
  Longmont
 Hope Cancer Care Center at Longmont United Hospital
 Eduardo R. Pajon Ph: 888-785-6789
  Loveland
 McKee Medical Center
 Eduardo R. Pajon Ph: 888-785-6789
  Parker
 Parker Adventist Hospital
 Eduardo R. Pajon Ph: 888-785-6789
  Pueblo
 St. Mary - Corwin Regional Medical Center
 Eduardo R. Pajon Ph: 888-785-6789
  Thornton
 North Suburban Medical Center
 Eduardo R. Pajon Ph: 888-785-6789
  Wheat Ridge
 Exempla Lutheran Medical Center
 Eduardo R. Pajon Ph: 888-785-6789
Connecticut
  Hartford
 Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
 Christopher M Reynolds Ph: 734-712-3456
  Norwalk
 Norwalk Hospital
 Richard C. Frank Ph: 203-852-2996
  Email: jennifer.long@norwalkhealth.org
  Norwich
 Eastern Connecticut Hematology and Oncology Associates
 Dennis E. Slater Ph: 860-886-8362
Delaware
  Lewes
 Tunnell Cancer Center at Beebe Medical Center
 Gregory A. Masters Ph: 302-733-6227
  Newark
 Helen F. Graham Cancer Center at Christiana Hospital
 Gregory A. Masters Ph: 302-733-6227
District of Columbia
  Washington
 Sibley Memorial Hospital
 Frederick Pearson Smith Ph: 202-243-2373
Florida
  Bradenton
 21st Century Oncology - Lakewood Ranch Oncology
 Dwight L Fitch Ph: 888-823-5923
  Email: ctsucontact@westat.com
 21st Century Oncology - Bradenton
 Dwight L Fitch Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Daytona Beach
 Herbert D. Kerman Regional Oncology Center - Daytona Beach
 Ruby Anne E Deveras Ph: 386-254-4211
  Fort Lauderdale
 Broward General Medical Center Cancer Center
 Barry S Berman Ph: 954-355-5346
  Fort Walton Beach
 21st Century Oncology - Fort Walton Beach
 James H Stevens Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Jacksonville
 Mayo Clinic - Jacksonville
 Barbara A. Pockaj Ph: 507-538-7623
  Orlando
 Florida Hospital Cancer Institute at Florida Hospital Orlando
 Lee M. Zehngebot Ph: 407-303-5623
 M.D. Anderson Cancer Center at Orlando
 Nikita C. Shah Ph: 321-841-7246
  Tampa
 H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
 Roohi Ismail-Khan Ph: 800-456-7121
  Email: canceranswers@moffitt.org
Georgia
  Atlanta
 Emory Crawford Long Hospital
 Ruth M. O'Regan Ph: 404-778-1868
 Georgia Cancer Center for Excellence at Grady Memorial Hospital
 Ruth M. O'Regan Ph: 404-778-1868
 Winship Cancer Institute of Emory University
 Ruth M. O'Regan Ph: 404-778-1868
  Decatur
 Charles B. Eberhart Cancer Center at DeKalb Medical Center
 Jayanthi Srinivasiah Ph: 404-501-3279
  Savannah
 Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
 Grant C Lewis Ph: 912-350-8568
Hawaii
  Aiea
 Kapiolani Medical Center at Pali Momi
 Jeffrey L. Berenberg Ph: 808-586-2979
 Jeffrey L. Berenberg Ph: 808-586-2979
  Honolulu
 Cancer Research Center of Hawaii
 Jeffrey L. Berenberg Ph: 808-586-2979
 Kapiolani Medical Center for Women and Children
 Jeffrey L. Berenberg Ph: 808-586-2979
 Kuakini Medical Center
 Jeffrey L. Berenberg Ph: 808-586-2979
 OnCare Hawaii, Incorporated - Kuakini
 Jeffrey L. Berenberg Ph: 808-586-2979
 Jeffrey L. Berenberg Ph: 808-586-2979
 OnCare Hawaii, Incorporated - Lusitana
 Jeffrey L. Berenberg Ph: 808-586-2979
 Queen's Cancer Institute at Queen's Medical Center
 Jeffrey L. Berenberg Ph: 808-586-2979
 Straub Clinic and Hospital, Incorporated
 Jeffrey L. Berenberg Ph: 808-586-2979
  Kailua
 Castle Medical Center
 Jeffrey L. Berenberg Ph: 808-586-2979
  Lihue
 Kauai Medical Clinic
 Jeffrey L. Berenberg Ph: 808-586-2979
Idaho
  Boise
 Mountain States Tumor Institute at St. Luke's Regional Medical Center
 Paul G. Montgomery Ph: 800-845-4624
 Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
 Christopher M Reynolds Ph: 734-712-3456
  Fruitland
 Saint Luke's Mountain States Tumor Institute - Fruitland
 Paul G. Montgomery Ph: 800-845-4624
  Meridian
 Mountain States Tumor Institute - Meridian
 Paul G. Montgomery Ph: 800-845-4624
  Nampa
 Saint Luke's Mountain States Tumor Institute
 Paul G. Montgomery Ph: 800-845-4624
  Twin Falls
 Mountain States Tumor Institute at St. Luke's
 Paul G. Montgomery Ph: 800-845-4624
Illinois
  Bloomington
 St. Joseph Medical Center
 John W. Kugler Ph: 800-793-2262
  Chicago
 John H. Stroger, Jr. Hospital of Cook County
 Thomas E. Lad Ph: 312-864-6000
 Louis A. Weiss Memorial Hospital
 Keith L. Shulman Ph: 773-564-5044
 Resurrection Medical Center
 Christopher G. Rose Ph: 773-792-5116
 Robert H. Lurie Comprehensive Cancer Center at Northwestern University
 Seema A. Khan Ph: 312-695-1301
  Email: cancer@northwestern.edu
 University of Chicago Cancer Research Center
 Rita Nanda Ph: 773-834-7424
 University of Illinois Cancer Center
 Lucy F Chen Ph: 312-355-3046
  Decatur
 Decatur Memorial Hospital Cancer Care Institute
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Elmhurst
 Elmhurst Memorial Hospital
 Lucio Di Nunno Ph: 630-782-7900
  Eureka
 Eureka Community Hospital
 John W. Kugler Ph: 800-793-2262
  Galesburg
 Galesburg Clinic, PC
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Harvey
 Ingalls Cancer Care Center at Ingalls Memorial Hospital
 Mark F. Kozloff Ph: 708-915-4673
  Email: clinicaltrials@ingalls.org
  Highland Park
 Hematology Oncology Associates of Illinois-Highland Park
 Seema A. Khan Ph: 312-695-1301
  Email: cancer@northwestern.edu
  Hines
 Veterans Affairs Medical Center - Hines
 Abdul M. Choudhury Ph: 708-202-8387
  Hinsdale
 Hinsdale Hematology Oncology Associates
 Elyse Cheryl Schneiderman Ph: 630-654-1790
  Email: info@hhoaltd.com
  Kankakee
 Provena St. Mary's Regional Cancer Center - Kankakee
 Seema A. Khan Ph: 312-695-1301
  Email: cancer@northwestern.edu
  Libertyville
 North Shore Oncology and Hematology Associates, Limited - Libertyville
 Seema A. Khan Ph: 312-695-1301
  Email: cancer@northwestern.edu
  Maywood
 Cardinal Bernardin Cancer Center at Loyola University Medical Center
 Constantine V Godellas Ph: 708-226-4357
  Email: clinical_trials@rush.edu
  Moline
 Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
 Costas L. Constantinou Ph: 319-363-2690
  Niles
 Cancer Care and Hematology Specialists of Chicagoland - Niles
 Seema A. Khan Ph: 312-695-1301
  Email: cancer@northwestern.edu
  Normal
 BroMenn Regional Medical Center
 John W. Kugler Ph: 800-793-2262
 Community Cancer Center
 John W. Kugler Ph: 800-793-2262
  Oak Lawn
 Advocate Christ Medical Center
 Renee H. Jacobs Ph: 630-856-7526
  Ottawa
 Community Hospital of Ottawa
 John W. Kugler Ph: 800-793-2262
 Illinois CancerCare - Ottawa
 John W. Kugler Ph: 800-793-2262
  Pekin
 Cancer Treatment Center at Pekin Hospital
 John W. Kugler Ph: 800-793-2262
  Peoria
 CCOP - Illinois Oncology Research Association
 John W. Kugler Ph: 800-793-2262
 Illinois CancerCare - Peoria
 John W. Kugler Ph: 800-793-2262
 Methodist Medical Center of Illinois
 John W. Kugler Ph: 800-793-2262
 OSF St. Francis Medical Center
 John W. Kugler Ph: 800-793-2262
 Proctor Hospital
 John W. Kugler Ph: 800-793-2262
  River Forest
 West Suburban Center for Cancer Care
 Isoken Koko Ph: 708-488-0882
  Rockford
 Swedish-American Regional Cancer Center
 Harvey Eric Einhorn Ph: 815-489-4413
  Skokie
 Hematology Oncology Associates - Skokie
 Seema A. Khan Ph: 312-695-1301
  Email: cancer@northwestern.edu
  Springfield
 Regional Cancer Center at Memorial Medical Center
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
Indiana
  Elkhart
 Elkhart General Hospital
 Jose A. Bufill Ph: 574-237-1328
  Goshen
 Center for Cancer Care at Goshen General Hospital
 Laura L. Morris Ph: 574-535-2858
  Indianapolis
 St. Francis Hospital Cancer Care Services
 Howard M. Gross Ph: 765-983-3000
  Kokomo
 Community Cancer Care at Howard Regional Health System
 Jose A. Bufill Ph: 574-237-1328
  La Porte
 Center for Cancer Therapy at LaPorte Hospital and Health Services
 Jose A. Bufill Ph: 574-237-1328
  Mishawaka
 Michiana Hematology-Oncology, PC - Mishawaka
 Jose A. Bufill Ph: 574-237-1328
 Saint Joseph's Medical Center
 Jose A. Bufill Ph: 574-237-1328
  Richmond
 Reid Hospital & Health Care Services
 Howard M. Gross Ph: 317-783-8918
  South Bend
 CCOP - Northern Indiana CR Consortium
 Jose A. Bufill Ph: 574-237-1328
 Memorial Hospital of South Bend
 Jose A. Bufill Ph: 574-237-1328
Iowa
  Ames
 McFarland Clinic, PC
 Joseph James Merchant Ph: 515-239-2621
  Clive
 Medical Oncology and Hematology Associates-West Des Moines
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 Mercy Cancer Center - West Lakes
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
  Des Moines
 CCOP - Iowa Oncology Research Association
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 John Stoddard Cancer Center at Iowa Lutheran Hospital
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 John Stoddard Cancer Center at Iowa Methodist Medical Center
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 Medical Oncology and Hematology Associates at John Stoddard Cancer Center
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 Medical Oncology and Hematology Associates at Mercy Cancer Center
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 Mercy Cancer Center at Mercy Medical Center - Des Moines
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
  Ottumwa
 South Iowa Radiation Oncology Center at Ottumwa Regional Health Center
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
  Sioux City
 Mercy Medical Center - Sioux City
 Donald Bruce Wender Ph: 712-252-0088
 Siouxland Hematology-Oncology Associates, LLP
 Donald Bruce Wender Ph: 712-252-0088
 St. Luke's Regional Medical Center
 Donald Bruce Wender Ph: 712-252-0088
  West Des Moines
 Methodist West Hospital
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
Kansas
  Chanute
 Cancer Center of Kansas, PA - Chanute
 Shaker R. Dakhil Ph: 316-262-4467
  Dodge City
 Cancer Center of Kansas, PA - Dodge City
 Shaker R. Dakhil Ph: 316-262-4467
  El Dorado
 Cancer Center of Kansas, PA - El Dorado
 Shaker R. Dakhil Ph: 316-262-4467
  Fort Scott
 Cancer Center of Kansas - Fort Scott
 Shaker R. Dakhil Ph: 316-262-4467
  Independence
 Cancer Center of Kansas-Independence
 Shaker R. Dakhil Ph: 316-262-4467
  Kingman
 Cancer Center of Kansas, PA - Kingman
 Shaker R. Dakhil Ph: 316-262-4467
  Lawrence
 Lawrence Memorial Hospital
 Shaker R. Dakhil Ph: 316-262-4467
  Liberal
 Cancer Center of Kansas, PA - Liberal
 Shaker R. Dakhil Ph: 316-262-4467
  McPherson
 Cancer Center of Kansas, PA - McPherson
 Shaker R. Dakhil Ph: 316-262-4467
  Newton
 Cancer Center of Kansas, PA - Newton
 Shaker R. Dakhil Ph: 316-262-4467
  Parsons
 Cancer Center of Kansas, PA - Parsons
 Shaker R. Dakhil Ph: 316-262-4467
  Prairie Village
 CCOP - Kansas City
 Rakesh Gaur Ph: 913-948-5588
  Email: amy.krushelniski@hcahealthcare.com
  Pratt
 Cancer Center of Kansas, PA - Pratt
 Shaker R. Dakhil Ph: 316-262-4467
  Salina
 Cancer Center of Kansas, PA - Salina
 Shaker R. Dakhil Ph: 316-262-4467
  Wellington
 Cancer Center of Kansas, PA - Wellington
 Shaker R. Dakhil Ph: 316-262-4467
  Wichita
 Associates in Women's Health, PA - North Hillside
 Shaker R. Dakhil Ph: 316-262-4467
 Cancer Center of Kansas, PA - Medical Arts Tower
 Shaker R. Dakhil Ph: 316-262-4467
 Cancer Center of Kansas, PA - Wichita
 Shaker R. Dakhil Ph: 316-262-4467
 CCOP - Wichita
 Shaker R. Dakhil Ph: 316-262-4467
 Via Christi Cancer Center at Via Christi Regional Medical Center
 Shaker R. Dakhil Ph: 316-262-4467
  Winfield
 Cancer Center of Kansas, PA - Winfield
 Shaker R. Dakhil Ph: 316-262-4467
Kentucky
  Edgewood
 St. Elizabeth Medical Center
 Joseph Michael Guenther Ph: 859-301-5473
  Email: darla.hehman@stelizabeth.com
  Lexington
 University of Kentucky Chandler Medical Center
 Suleiman A Massarweh Ph: 859-257-3379
  Louisville
 University of Louisville School of Medicine
 Elizabeth C Riley Ph: 866-530-5516
Louisiana
  New Orleans
 Medical Center of Louisiana - New Orleans
 Robert W Veith Ph: 504-568-3410
  Email: aconne1@lsuhsc.edu
 Stanley S. Scott Cancer Center at Louisiana State University Medical Center - New Orleans
 Robert W Veith Ph: 504-568-3410
  Email: aconne1@lsuhsc.edu
 Tulane Cancer Center at Tulane University Hospital and Clinic
 Hana F Safah Ph: 504-988-6121
Maryland
  Annapolis
 DeCesaris Cancer Institute at Anne Arundel Medical Center
 Robert R Buras Ph: 443-481-1320
  Email: kbodenhorn@aahs.org
  Baltimore
 Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
 Mayer Gorbaty Ph: 800-888-8823
 Greater Baltimore Medical Center Cancer Center
 Robert B Donegan Ph: 443-849-3706
 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 Mehran Habibi Ph: 410-955-8804
  Email: jhcccro@jhmi.edu
 St. Agnes Hospital Cancer Center
 Richard S. Hudes Ph: 410-368-2910
  Easton
 Shore Regional Cancer Center at Memorial Hospital - Easton
 Mary S. DeShields Ph: 410-820-6800ext108
  Email: srichter@shorehealth.org
  Elkton MD
 Union Hospital of Cecil County
 Gregory A. Masters Ph: 302-733-6227
  Salisbury
 Peninsula Regional Medical Center
 Paul E Zorsky Ph: 410-543-7017
  Email: sandra.heineken@peninsula.org
Massachusetts
  Boston
 Dana-Farber/Brigham and Women's Cancer Center
 Mehra Golshan Ph: 617-724-5200
 Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
 Mehra Golshan Ph: 617-724-5200
  Brighton
 Caritas St. Elizabeth's Medical Center
 Dorcas Chi Ph: 617-789-2903
  Fall River
 Hudner Oncology Center at Saint Anne's Hospital - Fall River
 John L Yang Ph: 508-674-5600
Michigan
  Adrian
 Hickman Cancer Center at Bixby Medical Center
 Rex B Mowat Ph: 517-265-0116
 Rex B Mowat Ph: 517-265-0116
  Ann Arbor
 CCOP - Michigan Cancer Research Consortium
 Christopher M Reynolds Ph: 734-712-3456
 Saint Joseph Mercy Cancer Center
 Christopher M Reynolds Ph: 734-712-3456
  Clarkston
 21st Century Oncology-Clarkston
 Jeffrey D. Forman Ph: 248-858-6215
  Dearborn
 Oakwood Cancer Center at Oakwood Hospital and Medical Center
 Christopher M Reynolds Ph: 734-712-3456
  Detroit
 Van Elslander Cancer Center at St. John Hospital and Medical Center
 Christopher M Reynolds Ph: 734-712-3456
 Wayne State University
 Lydia W Choi Ph: 313-576-9363
  Escanaba
 Green Bay Oncology, Limited - Escanaba
 Gerald K. Bayer Ph: 800-432-6049
  Farmington Hills
 21st Century Oncology-Farmington Hills
 Jeffrey D. Forman Ph: 248-858-6215
  Flint
 Genesys Hurley Cancer Institute
 Christopher M Reynolds Ph: 734-712-3456
 Hurley Medical Center
 Christopher M Reynolds Ph: 734-712-3456
  Grand Rapids
 Butterworth Hospital at Spectrum Health
 Gilbert D Padula Ph: 616-685-5225
 Lacks Cancer Center at Saint Mary's Health Care
 Gilbert D Padula Ph: 616-685-5225
  Iron Mountain
 Green Bay Oncology - Iron Mountain
 Gerald K. Bayer Ph: 800-432-6049
  Jackson
 Gayle M. Jacob Cancer Center at Allegiance Health
 Christopher M Reynolds Ph: 734-712-3456
  Kalamazoo
 Borgess Medical Center
 Raymond Sterling Lord Ph: 269-373-7458
 Bronson Methodist Hospital
 Raymond Sterling Lord Ph: 269-373-7458
 West Michigan Cancer Center
 Raymond Sterling Lord Ph: 269-373-7458
  Lansing
 Sparrow Regional Cancer Center
 Christopher M Reynolds Ph: 734-712-3456
  Livonia
 St. Mary Mercy Hospital
 Christopher M Reynolds Ph: 734-712-3456
  Midland
 MidMichigan Medical Center - Midland
 Michel R. Hurtubise Ph: 989-839-3377
  Monroe
 Community Cancer Center of Monroe
 Rex B Mowat Ph: 517-265-0116
 Mercy Memorial Hospital - Monroe
 Rex B Mowat Ph: 517-265-0116
  Muskegon
 Mercy General Health Partners
 Gilbert D Padula Ph: 616-685-5225
  Pontiac
 St. Joseph Mercy Oakland
 Christopher M Reynolds Ph: 734-712-3456
  Port Huron
 Mercy Regional Cancer Center at Mercy Hospital
 Christopher M Reynolds Ph: 734-712-3456
  Reed City
 Spectrum Health Reed City Hospital
 Gilbert D Padula Ph: 616-685-5225
  Royal Oak
 William Beaumont Hospital - Royal Oak Campus
 Jannifer S Stromberg Ph: 248-551-7695
  Saginaw
 Seton Cancer Institute at Saint Mary's - Saginaw
 Christopher M Reynolds Ph: 734-712-3456
  Saint Joseph
 Lakeside Cancer Specialists, PLLC
 Jose A. Bufill Ph: 574-237-1328
  Southfield
 Providence Hospital - Southfield
 Anibal Drelichman Ph: 248-849-5337
  Email: jaswinder.grewal@stjohn.org
  St. Joseph
 Lakeland Regional Cancer Care Center - St. Joseph
 Jose A. Bufill Ph: 574-237-1328
  Traverse City
 Munson Medical Center
 Gilbert D Padula Ph: 616-685-5225
  Warren
 St. John Macomb Hospital
 Christopher M Reynolds Ph: 734-712-3456
Minnesota
  Bemidji
 MeritCare Bemidji
 Preston D. Steen Ph: 701-234-6161
  Burnsville
 Fairview Ridges Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Coon Rapids
 Mercy and Unity Cancer Center at Mercy Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Edina
 Fairview Southdale Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Fridley
 Mercy and Unity Cancer Center at Unity Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Hutchinson
 Hutchinson Area Health Care
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Mankato
 Immanuel St. Joseph's
 Mohmmad J Ranginwala Ph: 507-385-2929
  Maplewood
 HealthEast Cancer Care at St. John's Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 Minnesota Oncology - Maplewood
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Minneapolis
 Hennepin County Medical Center - Minneapolis
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  New Ulm
 New Ulm Medical Center
 Patrick J. Flynn Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Robbinsdale
 Humphrey Cancer Center at North Memorial Outpatient Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Rochester
 Mayo Clinic Cancer Center
 Barbara A. Pockaj Ph: 507-538-7623
  Saint Louis Park
 CCOP - Metro-Minnesota
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 Park Nicollet Cancer Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Saint Paul
 Regions Hospital Cancer Care Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 United Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Shakopee
 St. Francis Cancer Center at St. Francis Medical Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Stillwater
 Lakeview Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Waconia
 Ridgeview Medical Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Willmar
 Willmar Cancer Center at Rice Memorial Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Woodbury
 Minnesota Oncology - Woodbury
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
Mississippi
  Jackson
 University of Mississippi Cancer Clinic
 Barbara S Craft Ph: 601-815-6700
  Pascagoula
 Regional Cancer Center at Singing River Hospital
 James E. Clarkson Ph: 228-809-5292
Missouri
  Cape Girardeau
 Saint Francis Medical Center
 Bethany G. Sleckman Ph: 913-948-5588
  Columbia
 Ellis Fischel Cancer Center at University of Missouri - Columbia
 Rashmi Ramasubbaiah Ph: 573-882-7440
  Rolla
 Mercy Clinic Cancer and Hematology - Rolla
 Robert L Carolla Ph: 417-269-4520
  Saint Louis
 David C. Pratt Cancer Center at St. John's Mercy
 Bethany G. Sleckman Ph: 913-948-5588
 Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
 Julie A Margenthaler Ph: 800-600-3606
  Email: info@siteman.wustl.edu
 St. Anthony's Cancer Center
 Minxiang (Michael) Gu Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Springfield
 Hulston Cancer Center at Cox Medical Center South
 Robert L Carolla Ph: 417-269-4520
 St. John's Regional Health Center
 Robert L Carolla Ph: 417-269-4520
Montana
  Billings
 Billings Clinic Cancer Center - 801 N 29th Street
 Benjamin Thomas Marchello Ph: 800-648-6274
 CCOP - Montana Cancer Consortium
 Benjamin Thomas Marchello Ph: 800-648-6274
  Great Falls
 Benefis Sletten Cancer Institute
 Grant William Harrer Ph: 406-731-8217
Nebraska
  Lincoln
 Cancer Resource Center - Lincoln
 Gamini S. Soori Ph: 800-253-4368
  Omaha
 Alegant Health Cancer Center at Bergan Mercy Medical Center
 Gamini S. Soori Ph: 800-253-4368
 CCOP - Missouri Valley Cancer Consortium
 Gamini S. Soori Ph: 800-253-4368
 Creighton University Medical Center
 Gamini S. Soori Ph: 800-253-4368
 Immanuel Medical Center
 Gamini S. Soori Ph: 800-253-4368
 Lakeside Hospital
 Gamini S. Soori Ph: 800-253-4368
Nevada
  Reno
 Saint Mary's Regional Medical Center
 Kathleen (Katie) B Legarza Ph: 775-770-7410
New Hampshire
  Concord
 New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
 Douglas Jay Weckstein Ph: 603-224-2556
  Hooksett
 New Hampshire Oncology - Hematology, PA - Hooksett
 Douglas Jay Weckstein Ph: 603-224-2556
  Laconia
 Lakes Region General Hospital
 Douglas Jay Weckstein Ph: 603-224-2556
  Lebanon
 Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
 Gary N Schwartz Ph: 800-639-6918
  Email: cancer.research.nurse@dartmouth.edu
  Manchester
 Norris Cotton Cancer Center at Catholic Medical Center
 Gary N Schwartz Ph: 800-639-6918
  Email: cancer.research.nurse@dartmouth.edu
New Jersey
  Camden
 Cancer Institute of New Jersey at Cooper University Hospital - Camden
 Gregory A. Masters Ph: 302-733-6227
  Mount Holly
 Virtua Fox Chase Health Cancer Program at Virtua Memorial Hospital Burlington County
 Michael S. Entmacher Ph: 888-847-8823
  Newark
 Newark Beth Israel Medical Center
 Lori Schleicher Ph: 973-926-7230
  Sewell
 Radiation Oncology Center at Kennedy Health System - Sewell
 Trina A Poretta Ph: 888-847-8823
  Voorhees
 Fox Chase Virtua Health Cancer Program at Virtua West Jersey
 Michael S. Entmacher Ph: 888-847-8823
New Mexico
  Albuquerque
 Lovelace Medical Center - Downtown
 Zoneddy R Dayao Ph: 505-272-6972
 University of New Mexico Cancer Center
 Zoneddy R Dayao Ph: 505-272-6972
  Las Cruces
 Memorial Medical Center
 Zoneddy R Dayao Ph: 505-272-6972
New York
  Bronx
 Jack D. Weiler Hospital at Montefiore Medical Center - East Campus
 Lisa Wiechmann Ph: 718-904-2730
  Email: aecc@aecom.yu.edu
 Montefiore Medical Center
 Lisa Wiechmann Ph: 718-904-2730
  Email: aecc@aecom.yu.edu
  Brooklyn
 Maimonides Cancer Center at Maimonides Medical Center
 Susan Burdette-Radoux Ph: 718-765-2500
  Buffalo
 Roswell Park Cancer Institute
 Shicha Kumar Ph: 877-275-7724
  Cooperstown
 Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital
 Eric Bravin Ph: 607-547-6965
  Email: jennifer.victory@bassett.org
  Mineola
 Winthrop University Hospital
 Nina D'Abreo Ph: 866-946-8476
  New York
 Memorial Sloan-Kettering Cancer Center
 Tari A King Ph: 212-639-7202
 Mount Sinai Medical Center
 Paul H Schmidt Ph: 212-824-7320
  Email: jenny.figueroa@mssm.edu
  Poughkeepsie
 Dyson Center for Cancer Care at Vassar Brothers Medical Center
 Angela J. Keleher Ph: 845-483-6483
  Rochester
 Daisy Marquis Jones Radiation Oncology Center at Highland Hospital of Rochester
 Jonathan W Friedberg Ph: 585-275-5830
 James P. Wilmot Cancer Center at University of Rochester Medical Center
 Jonathan W Friedberg Ph: 585-275-5830
  Staten Island
 Nalitt Cancer Institute at Staten Island University Hospital
 Meekoo Dhar Ph: 718-226-8888
  White Plains
 Dickstein Cancer Treatment Center at White Plains Hospital Center
 Julie A Monroe Ph: 914-681-2290
North Carolina
  Charlotte
 Blumenthal Cancer Center at Carolinas Medical Center
 Teresa Flippo-Morton Ph: 704-355-2884
  Concord
 Batte Cancer Center at Northeast Medical Center
 Teresa Flippo-Morton Ph: 704-355-2884
  Greenville
 Carolina Radiation Medicine, PA
 Ron R. Allison Ph: 252-744-2161
  Monroe
 Edwards Cancer Center at Union Regional Medical Center
 Teresa Flippo-Morton Ph: 704-355-2884
  Statesville
 Iredell Memorial Hospital
 Ruby A. Grimm Ph: 704-873-5661
  Wilmington
 Zimmer Cancer Center at New Hanover Regional Medical Center
 Cyrus A. Kotwall Ph: 910-342-3000
  Email: cancer.research@nhrmc.org
  Winston-Salem
 Wake Forest University Comprehensive Cancer Center
 Marissa M Howard-McNatt Ph: 336-713-6771
North Dakota
  Bismarck
 Medcenter One Hospital Cancer Care Center
 John T Reynolds Ph: 701-323-5760
  Email: tfischer@mohs.org
 Mid Dakota Clinic, PC
 John T Reynolds Ph: 701-323-5760
  Email: tfischer@mohs.org
 St. Alexius Medical Center Cancer Center
 John T Reynolds Ph: 701-323-5760
  Email: tfischer@mohs.org
  Fargo
 Roger Maris Cancer Center at MeritCare Hospital
 Preston D. Steen Ph: 701-234-6161
 Preston D. Steen Ph: 701-234-6161
 Sanford Clinic North-Fargo
 Preston D. Steen Ph: 701-234-6161
  Grand Forks
 Altru Cancer Center at Altru Hospital
 Grant R Seeger Ph: 701-780-6520
  Minot
 Trinity CancerCare Center
 Patanit Watanaboonyakhet Ph: 800-862-0005
Ohio
  Akron
 McDowell Cancer Center at Akron General Medical Center
 Esther H. Rehmus Ph: 330-344-6348
 Summa Center for Cancer Care at Akron City Hospital
 Jennifer E Payne Ph: 330-375-6101
  Bowling Green
 Wood County Oncology Center
 Rex B Mowat Ph: 517-265-0116
  Canton
 Aultman Cancer Center at Aultman Hospital
 Kisa E Weeman Ph: 330-363-6891
  Chillicothe
 Adena Regional Medical Center
 J. Philip Kuebler Ph: 502-361-8496
  Cincinnati
 Bethesda North Hospital
 Ching Ho Ph: 513-862-2230
 Good Samaritan Hospital Cancer Treatment Center
 Kevin J. Grannan Ph: 513-862-2230
  Cleveland
 Case Comprehensive Cancer Center
 Janice Lyons Ph: 800-641-2422
  Columbus
 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
 Stephen P Povoski Ph: 866-627-7616
  Email: osu@emergingmed.com
 CCOP - Columbus
 J. Philip Kuebler Ph: 502-361-8496
 Doctors Hospital at Ohio Health
 J. Philip Kuebler Ph: 502-361-8496
 Grant Medical Center Cancer Care
 J. Philip Kuebler Ph: 502-361-8496
 Mount Carmel Health - West Hospital
 J. Philip Kuebler Ph: 502-361-8496
 Riverside Methodist Hospital Cancer Care
 J. Philip Kuebler Ph: 502-361-8496
 Zangmeister Center
 J. Philip Kuebler Ph: 614-566-3275
  Dayton
 David L. Rike Cancer Center at Miami Valley Hospital
 Howard M. Gross Ph: 317-783-8918
 Good Samaritan Hospital
 Howard M. Gross Ph: 317-783-8918
 Samaritan North Cancer Care Center
 Howard M. Gross Ph: 317-783-8918
  Delaware
 Grady Memorial Hospital
 J. Philip Kuebler Ph: 614-566-3275
  Elyria
 Hematology Oncology Center
 Rex B Mowat Ph: 517-265-0116
 Mercy Cancer Center - Elyria
 Rex B Mowat Ph: 517-265-0116
  Findlay
 Blanchard Valley Regional Cancer Center
 Howard M. Gross Ph: 317-783-8918
  Franklin
 Atrium Medical Center
 Howard M. Gross Ph: 317-783-8918
  Kettering
 Charles F. Kettering Memorial Hospital
 Howard M. Gross Ph: 317-783-8918
  Lancaster
 Fairfield Medical Center
 J. Philip Kuebler Ph: 502-361-8496
  Lima
 Lima Memorial Hospital
 Rex B Mowat Ph: 517-265-0116
  Marietta
 Strecker Cancer Center at Marietta Memorial Hospital
 J. Philip Kuebler Ph: 502-361-8496
  Maumee
 Northwest Ohio Oncology Center
 Rex B Mowat Ph: 517-265-0116
  Mount Vernon
 Knox Community Hospital
 J. Philip Kuebler Ph: 502-361-8496
  Newark
 Licking Memorial Cancer Care Program at Licking Memorial Hospital
 J. Philip Kuebler Ph: 502-361-8496
  Oregon
 St. Charles Mercy Hospital
 Rex B Mowat Ph: 517-265-0116
 Toledo Clinic - Oregon
 Rex B Mowat Ph: 517-265-0116
  Portsmouth
 Southern Ohio Medical Center Cancer Center
 J. Philip Kuebler Ph: 502-361-8496
  Springfield
 Community Hospital of Springfield and Clark County
 J. Philip Kuebler Ph: 502-361-8496
  Sylvania
 Flower Hospital Cancer Center
 Rex B Mowat Ph: 517-265-0116
  Tiffin
 Mercy Hospital of Tiffin
 Rex B Mowat Ph: 517-265-0116
  Toledo
 CCOP - Toledo Community Hospital
 Rex B Mowat Ph: 517-265-0116
 St. Anne Mercy Hospital
 Rex B Mowat Ph: 517-265-0116
 St. Vincent Mercy Medical Center
 Rex B Mowat Ph: 517-265-0116
 Toledo Clinic, Incorporated - Main Clinic
 Rex B Mowat Ph: 517-265-0116
 Toledo Hospital
 Rex B Mowat Ph: 517-265-0116
 University of Toledo Medical Center
 Rex B Mowat Ph: 517-265-0116
  Troy
 UVMC Cancer Care Center at Upper Valley Medical Center
 Howard M. Gross Ph: 317-783-8918
  Wauseon
 Fulton County Health Center
 Rex B Mowat Ph: 517-265-0116
  Westerville
 Mount Carmel St. Ann's Cancer Center
 J. Philip Kuebler Ph: 502-361-8496
  Zanesville
 Genesis - Good Samaritan Hospital
 J. Philip Kuebler Ph: 502-361-8496
Oklahoma
  Oklahoma City
 Oklahoma University Cancer Institute
 Carla Kurkjian Ph: 405-271-4272
  Email: julie-traylor@ouhsc.edu
Pennsylvania
  Bethlehem
 St. Luke's Cancer Network at St. Luke's Hospital
 Sanjiv S. Agarwala Ph: 610-954-3582
  Email: infolink@slhn.org
  Easton
 Easton Regional Cancer Center at Easton Hospital
 Rajen P Oza Ph: 610-250-4000
  Gettysburg
 Adams Cancer Center
 Amir Tabatabai Ph: 877-441-7957
  Hanover
 Cherry Tree Cancer Center
 Amir Tabatabai Ph: 877-441-7957
  Hershey
 Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
 J. Stanley Smith Ph: 717-531-3779
  Email: CTO@hmc.psu.edu
  Lancaster
 Lancaster General Hospital
 Elizabeth Horenkamp Ph: 717-544-5511
  Langhorne
 St. Mary Regional Cancer Center
 Robert C. Reilly Ph: 215-710-4585
  Lewistown
 Lewistown Hospital
 J. Stanley Smith Ph: 717-531-3779
  Email: CTO@hmc.psu.edu
  Meadowbrook
 Charles A. & Betty Bott Cancer Center at Holy Redeemer Hospital
 Pallav Mehta Ph: 215-938-3551
  Philadelphia
 Abramson Cancer Center of the University of Pennsylvania
 Carla S Fisher Ph: 215-746-7406
 Albert Einstein Cancer Center
 Mark S Morginstin Ph: 215-456-3880
 Fox Chase Cancer Center - Philadelphia
 Lori J. Goldstein Ph: 215-728-4790
 Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
 Rebecca J Jaslow Ph: 215-955-6084
  Pittsburgh
 UPMC Cancer Centers
 Kandace P McGuire Ph: 412-647-2811
  State College
 Mount Nittany Medical Center
 J. Stanley Smith Ph: 717-531-3779
  Email: CTO@hmc.psu.edu
  Williamsport
 Susquehanna Cancer Center at Divine Providence Hospital
 Warren L Robinson Ph: 800-598-4282
  York
 WellSpan Health
 Amir Tabatabai Ph: 877-441-7957
South Carolina
  Charleston
 Hollings Cancer Center at Medical University of South Carolina
 Megan K Baker Ruppel Ph: 843-792-9321
 Roper St. Francis Cancer Center at Roper Hospital
 James Michael Orcutt Ph: 843-720-8386
  Email: elizabeth.strojny@roperstfrancis.com
South Dakota
  Sioux Falls
 Avera Cancer Institute
 Addison R Tolentino Ph: 800-657-4377
  Email: Jan.Healy@avera.org
 Sanford Cancer Center at Sanford USD Medical Center
 Miroslaw A Mazurczak Ph: 605-328-1367
 Miroslaw A Mazurczak Ph: 605-328-1367
Tennessee
  Jackson
 West Tennessee Cancer Center at Jackson-Madison County General Hospital
 Brion V Randolph Ph: 731-425-6865
Texas
  Dallas
 Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
 Ann E. Spangler Ph: 214-648-7097
  Galveston
 University of Texas Medical Branch
 Sandra S. Hatch Ph: 409-772-1950
  Email: clinical.research@utmb.edu
  Houston
 Methodist Hospital
 Jenny Chee Ning Chang Ph: 713-790-2700
  Email: burton@bcm.edu
 Univeristy of Texas M.D. Anderson Cancer Center
 Gildy V. Babiera Ph: 713-792-3245
  Irving
 Baylor Medical Center at Irving
 Sarju Waghela Ph: 800-422-9567
  Laredo
 Doctor's Hospital of Laredo
 Gary W. Unzeitig Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Temple
 Scott and White Cancer Institute
 Lucas Wong Ph: 254-724-5407
Utah
  Salt Lake City
 Huntsman Cancer Institute at University of Utah
 Matthew M Poppe Ph: 801-581-4477
  Email: clinical.trials@hci.utah.edu
Virginia
  Fredericksburg
 Fredericksburg Oncology Inc
 Rex B Mowat Ph: 517-265-0116
Washington
  Bellevue
 Overlake Cancer Center at Overlake Hospital Medical Center
 Yoshio Inoue Ph: 253-403-2394
  Bellingham
 St. Joseph Cancer Center
 Gary E Goodman Ph: 206-386-2323
  Email: patra.grevstad@swedish.org
  Bremerton
 Harrison Medical Center
 Stephen C Springate Ph: 866-844-9355
 Olympic Hematology and Oncology
 Gary E Goodman Ph: 206-386-2323
  Email: patra.grevstad@swedish.org
  Everett
 Providence Regional Cancer Partnership
 Yoshio Inoue Ph: 253-403-2394
  Issaquah
 Swedish Medical Center - Issaquah Campus
 Gary E Goodman Ph: 206-386-2323
  Email: patra.grevstad@swedish.org
  Puyallup
 Good Samaritan Cancer Center
 Yoshio Inoue Ph: 253-403-2394
  Seattle
 Group Health Central Hospital
 Gary E Goodman Ph: 206-386-2323
  Email: patra.grevstad@swedish.org
 Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
 Gary E Goodman Ph: 206-386-2323
  Email: patra.grevstad@swedish.org
 University Cancer Center at University of Washington Medical Center
 Gary E Goodman Ph: 206-386-2323
  Email: patra.grevstad@swedish.org
  Spokane
 Cancer Care Northwest - Spokane South
 Gary E Goodman Ph: 206-386-2323
  Email: patra.grevstad@swedish.org
  Tacoma
 CCOP - Northwest
 Yoshio Inoue Ph: 253-403-2394
 Franciscan Cancer Center at St. Joseph Medical Center
 Yoshio Inoue Ph: 253-403-2394
 Madigan Army Medical Center - Tacoma
 Anthony J Fadell Ph: 253-968-0129
  Email: mamcdci@amedd.army.mil
 MultiCare Regional Cancer Center at Tacoma General Hospital
 Yoshio Inoue Ph: 253-403-2394
  Walla Walla
 St. Mary Regional Cancer Center at St. Mary Medical Center
 James R Cunningham Ph: 800-422-6237
  Wenatchee
 Wenatchee Valley Medical Center
 Gary E Goodman Ph: 206-386-2323
  Email: patra.grevstad@swedish.org
West Virginia
  Huntington
 Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
 Maria-Rosalia B. Tria Tirona Ph: 304-399-6617
 St. Mary's Regional Cancer Center at St. Mary's Medical Center
 Arvinder S Bir Ph: 888-823-5923
  Email: ctsucontact@westat.com
Wisconsin
  Antigo
 Langlade Memorial Hospital
 Hamied R. Rezazadeh Ph: 877-405-6866
  Appleton
 Fox Valley Surgical Associates at Appleton Medical Center
 Honnie R Bermas Ph: 800-574-3872
  Chippewa Falls
 Marshfield Clinic - Chippewa Center
 Matthias Weiss Ph: 800-347-0673
  Eau Claire
 Center for Cancer Treatment & Prevention at Sacred Heart Hospital
 Matthias Weiss Ph: 800-347-0673
 Marshfield Clinic Cancer Care at Regional Cancer Center
 Matthias Weiss Ph: 800-347-0673
  Green Bay
 Green Bay Oncology, Limited at St. Mary's Hospital
 Gerald K. Bayer Ph: 800-432-6049
 Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
 Gerald K. Bayer Ph: 800-432-6049
 St. Mary's Hospital Medical Center - Green Bay
 Gerald K. Bayer Ph: 800-432-6049
 St. Vincent Hospital Regional Cancer Center
 Gerald K. Bayer Ph: 800-432-6049
 Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
 Dhimant R. Patel Ph: 800-252-2990
  La Crosse
 Gundersen Lutheran Center for Cancer and Blood
 Kurt Oettel Ph: 608-775-2385
  Email: cancerctr@gundluth.org
  Manitowoc
 Holy Family Memorial Medical Center Cancer Care Center
 Gerald K. Bayer Ph: 800-432-6049
  Marinette
 Bay Area Cancer Care Center at Bay Area Medical Center
 Gerald K. Bayer Ph: 800-432-6049
 Vince Lombardi Cancer Clinic - Marinette
 Dhimant R. Patel Ph: 800-252-2990
  Marshfield
 Marshfield Clinic - Marshfield Center
 Matthias Weiss Ph: 800-347-0673
 Saint Joseph's Hospital
 Matthias Weiss Ph: 800-347-0673
  Milwaukee
 Froedtert Hospital and Medical College of Wisconsin
 Yee C Cheng Ph: 414-805-4380
  Minocqua
 Marshfield Clinic - Lakeland Center
 Matthias Weiss Ph: 800-347-0673
  New Richmond
 Cancer Center of Western Wisconsin
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Oconomowoc
 Regional Cancer Center at Oconomowoc Memorial Hospital
 Timothy R Wassenaar Ph: 262-928-7632
  Oconto Falls
 Green Bay Oncology, Limited - Oconto Falls
 Gerald K. Bayer Ph: 800-432-6049
  Oshkosh
 Vince Lombardi Cancer Clinic - Oshkosh
 Dhimant R. Patel Ph: 800-252-2990
  Rhinelander
 Ministry Medical Group at Saint Mary's Hospital
 Matthias Weiss Ph: 800-347-0673
 Matthias Weiss Ph: 800-347-0673
  Rice Lake
 Marshfield Clinic - Indianhead Center
 Matthias Weiss Ph: 800-347-0673
  Sheboygan
 Saint Nicholas Hospital
 Gerald K. Bayer Ph: 800-432-6049
 Vince Lombardi Cancer Clinic - Sheboygan
 Dhimant R. Patel Ph: 800-252-2990
  Stevens Point
 Marshfield Clinic at Saint Michael's Hospital
 Matthias Weiss Ph: 800-347-0673
 Saint Michael's Hospital Cancer Center
 Matthias Weiss Ph: 800-347-0673
  Sturgeon Bay
 Green Bay Oncology, Limited - Sturgeon Bay
 Gerald K. Bayer Ph: 800-432-6049
  Summit
 Aurora Medical Center
 Dhimant R. Patel Ph: 800-252-2990
  Two Rivers
 Vince Lombardi Cancer Clinic - Two Rivers
 Dhimant R. Patel Ph: 800-252-2990
  Waukesha
 Waukesha Memorial Hospital Regional Cancer Center
 Timothy R Wassenaar Ph: 262-928-7632
  Wausau
 Marshfield Clinic - Wausau Center
 Matthias Weiss Ph: 800-347-0673
 University of Wisconcin Cancer Center at Aspirus Wausau Hospital
 Hamied R. Rezazadeh Ph: 877-405-6866
  Wauwatosa
 Oncology Alliance, SC - Milwaukee - West
 Rubina Qamar Ph: 888-709-2080
  Weston
 Diagnostic and Treatment Center
 Matthias Weiss Ph: 800-347-0673
 Marshfield Clinic - Weston Center
 Matthias Weiss Ph: 800-347-0673
  Wisconsin Rapids
 Marshfield Clinic - Wisconsin Rapids Center
 Matthias Weiss Ph: 800-347-0673
 Riverview UW Cancer Center at Riverview Hospital
 Ron James Kirschling Ph: 877-405-6866
Canada
Alberta
  Edmonton
 Cross Cancer Institute at University of Alberta
 Zsolt Gabos Ph: 780-432-8500
Manitoba
  Winnipeg
 CancerCare Manitoba
 Ethel L MacIntosh Ph: 866-561-1026
  Email: CIO_Web@cancercare.mb.ca
New Brunswick
  Saint John
 Saint John Regional Hospital
 Margot J. Burnell Ph: 506-648-6890
Quebec
  Montreal
 McGill Cancer Centre at McGill University
 Mark Basik Ph: 514-340-8222ext8248
  Email: penny.chipman@mcgill.ca
Israel
  Tel Aviv
 Tel-Aviv Sourasky Medical Center
 Tehillah S Menes Ph: 011-972-3-6974761
  Email: mop@tasmc.health.gov.il
Republic of South Africa
  Pretoria
 University of Pretoria
 Lydia M Dreosti Ph: 27 12 319 2449
Saudi Arabia
  Riyadh
 King Faisal Specialist Hospital and Research Center
 Kausar Suleman Ph: 011-966-1-464-7272 ext 38005

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01242800
Information obtained from ClinicalTrials.gov on April 04, 2013

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.

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