Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

Trial Description

Summary

This randomized phase III trial is studying sorafenib tosylate and doxorubicin hydrochloride to see how well they work compared with sorafenib tosylate alone in treating patients with locally advanced or metastatic liver cancer. Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving sorafenib tosylate together with doxorubicin hydrochloride is more effective than sorafenib tosylate alone in treating liver cancer.

Further Study Information

PRIMARY OBJECTIVES:

I. To compare the overall survival of patients with locally advanced or metastatic hepatocellular carcinoma treated with sorafenib tosylate with vs without doxorubicin hydrochloride.

SECONDARY OBJECTIVES:

I. To compare the time to progression in patients treated with these regimens. II. To compare the progression-free-survival of patients treated with these regimens.

III. To compare the tumor response using RECIST criteria in patients treated with these regimens.

OUTLINE: This is a multicenter study. Patients are stratified according to extent of disease (locally advanced vs metastatic). Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive doxorubicin hydrochloride IV on day 1 and oral sorafenib tosylate twice daily on days 1-21. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. After 6 courses, patients may continue to receive oral sorafenib tosylate twice daily in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive oral sorafenib tosylate twice daily on days 1-21. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 1 year and then every 6 months for 3 years.

Eligibility Criteria

Inclusion Criteria:

• Patients must have pathologically or cytologically proven hepatocelluar carcinoma; Known mixed histology (e.g. hepatocellular carcinoma plus cholangiocarcinoma) or fibrolamellar variant is not allowed

• Patients must have locally advanced or metastatic disease; Locally advanced disease is defined as disease deemed to be unresectable or non-eligible for transplant without distant metastases

• Lesions must be accurately measurable in at least one dimension (longest diameter to be recorded) as >= 2 cm with conventional techniques or as >= 1 cm with spiral CT scan

• No prior adjuvant sorafenib or other Raf/VEGF inhibitors; Other prior adjuvant therapy is allowed if completed >6 months prior to registration with documented recurrence of HCC

• Patients may have been treated with loco regional therapies provided that they either have:

• 1) a target lesion that has not been subjected to local therapy or

• 2) the target lesion(s) within the field of the local therapy has shown an increase of >= 20% in the size since last treatment.

• Such therapy must be completed at least 4 weeks prior to registration; Patients that have received palliative radiation therapy to the bone need not wait 4 weeks to begin protocol therapy

• Prior therapies allowed include the following:

• A) bland embolization, radiation, radioactive microspheres, etc

• B) chemoembolization using any chemotherapy (except, see "D", below)

• C) chemoembolization drug-eluting beads using doxorubicin

• D) prior therapy with chemoembolization using doxorubicin in the non drug eluting beads form is NOT allowed

• No prior systemic therapy for metastatic disease

• No prior exposure to systemic doxorubicin administered intravenously

• Antiviral treatment is allowed, however interferon therapy must be stopped at least 4 weeks prior to registration

• Allografts are not allowed: No prior history of any allograft, including but not limited to liver and bone marrow transplants

• No known CNS tumors including brain metastases

• No clinically significant gastrointestinal bleeding events requiring intervention, transfusion, or admission to hospital within 30 days prior to registration

• Patients must have completed any major surgery >= 4 weeks from registration

• Concomitant treatment with Rifampin or St John's Wort is not allowed; Patients should discontinue these drugs at least 4 weeks prior to registration

• Patients with a history of hypertension should be well controlled (< 140/90 mmHg) on a regimen of anti-hypertensive therapy

• Significant history of cardiac disease is not allowed:

• Congestive heart failure > Class II New York Heart Assocation (NYHA)

• Myocardial infarction within 6 months prior to registration

• Cardiac arrhythmias requiring anti-arrhythmic therapy other than beta blockers or digoxin

• Serious myocardial dysfunction, defined as scintigraphically (MUGA, myocardial scintigram) determined absolute left ventricular ejection fraction (LVEF) below 45% or an LVEF below the normal limit at the individual institution

• No history of bleeding diathesis

• Patients receiving combination anti-retroviral therapy for human immunodeficiency virus (HIV) are excluded from the study because of possible pharmacokinetic interactions with sorafenib

• ECOG performance status 0-2

• Pregnancy/Nursing Status: The effects of sorafenib on the developing fetus at the recommended therapeutic dose are unknown and may be teratogenic; Thus, women who are pregnant should not go on study. Women should not breastfeed while participating in this study

• Granulocytes ≥ 1,500/μL

• Hemoglobin ≥ 8.5 g/dL

• Platelets ≥ 75,000/μL

• Creatinine ≤ 1.5 times ULN OR creatinine clearance ≥ 60 mL/min

• Child-Pugh score A

• Bilirubin ≤ 3 mg/dL

• ALT and AST ≤ 5 times upper limit of normal (ULN)

• PT/INR ≤ 1.7 (Patients who are being therapeutically anticoagulated with an agent such as coumadin or heparin will be allowed to participate provided that no prior evidence of underlying abnormality in these parameters exists)

Trial Contact Information

Trial Lead Organizations/Sponsors

National Cancer Institute

Ghassan Abou-Alfa

Principal Investigator

U.S.A.
Alabama
	Birmingham
	UAB Comprehensive Cancer Center
		Carla I. Falkson	Ph: 205-934-0309
Alaska
	Anchorage
	Alaska Regional Hospital Cancer Center
		Max J Rabinowitz	Ph: 907-264-2933
California
	Anaheim
	Kaiser Permanente Medical Center - Anaheim/Orange County
		Han A Koh	Ph: 626-564-3455
	Antioch
	Kaiser Permanente - Deer Valley
		Louis Fehrenbacher	Ph: 626-564-3455
	Baldwin Park
	Kaiser Permanente Medical Center - Baldwin Park
		Han A Koh	Ph: 626-564-3455
	Bellflower
	Kaiser Permanente Medical Center - Bellflower
		Han A Koh	Ph: 626-564-3455
	Castro Valley
	East Bay Radiation Oncology Center
		James H. Feusner	Ph: 510-450-7600
	Valley Medical Oncology Consultants - Castro Valley
		James H. Feusner	Ph: 510-450-7600
	Dublin
	Epic Care-Dublin
		James H. Feusner	Ph: 510-450-7600
	Fontana
	Kaiser Permanente Medical Center - Fontana
		Han A Koh	Ph: 626-564-3455
	Fremont
	Kaiser Permanente - Fremont
		Louis Fehrenbacher	Ph: 626-564-3455
	Valley Medical Oncology
		James H. Feusner	Ph: 510-450-7600
	Fresno
	Kaiser Permanente Fresno Medical Center
		Louis Fehrenbacher	Ph: 626-564-3455
	Harbor City
	Kaiser Permanente Medical Center - Harbor City
		Han A Koh	Ph: 626-564-3455
	Hayward
	Kaiser Permanente Medical Center - Hayward
		Louis Fehrenbacher	Ph: 626-564-3455
	Irvine
	Kaiser Permanente - Irvine
		Han A Koh	Ph: 626-564-3455
	Los Angeles
	Kaiser Foundation Hospital - West Los Angeles
		Han A Koh	Ph: 626-564-3455
	Kaiser Permanente Medical Center - Los Angeles
		Han A Koh	Ph: 626-564-3455
	Martinez
	Contra Costa Regional Medical Center
		James H. Feusner	Ph: 510-450-7600
	Modesto
	Kaiser Permanente-Modesto
		Louis Fehrenbacher	Ph: 626-564-3455
	Mountain View
	El Camino Hospital Cancer Center
		James H. Feusner	Ph: 510-450-7600
	Oakland
	Alta Bates Summit Medical Center - Summit Campus
		James H. Feusner	Ph: 510-450-7600
	Bay Area Breast Surgeons, Incorporated
		James H. Feusner	Ph: 510-450-7600
	CCOP - Bay Area Tumor Institute
		James H. Feusner	Ph: 510-450-7600
	Epic Care - Oakland
		James H. Feusner	Ph: 510-450-7600
	Highland General Hospital
		James H. Feusner	Ph: 510-450-7600
	Kaiser Permanente-Oakland
		Louis Fehrenbacher	Ph: 626-564-3455
	Larry G Strieff MD Medical Corporation
		James H. Feusner	Ph: 510-450-7600
	Orange
	Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
		Tara E Seery	Ph: 877-827-8839
			Email: ucstudy@uci.edu
	St. Joseph Hospital Regional Cancer Center - Orange
		Timothy E Byun	Ph: 714-734-6220
	Panorama City
	Kaiser Permanente Medical Group
		Han A Koh	Ph: 626-564-3455
	Pleasant Hill
	East Bay Medical Oncology Hematology Associates - Pleasant Hill
		James H. Feusner	Ph: 510-450-7600
	Redwood City
	Kaiser Permanente Medical Center - Redwood City
		Louis Fehrenbacher	Ph: 626-564-3455
	Richmond
	Kaiser Permanente Medical Center - Richmond
		Louis Fehrenbacher	Ph: 626-564-3455
	Riverside
	Kaiser Permanente Medical Center - Riverside
		Han A Koh	Ph: 626-564-3455
	Roseville
	Kaiser Permanente Medical Center - Roseville
		Louis Fehrenbacher	Ph: 626-564-3455
	Sacramento
	Kaiser Permanente Medical Center - Sacramento
		Louis Fehrenbacher	Ph: 626-564-3455
	South Sacramento Kaiser-Permanente Medical Center
		Louis Fehrenbacher	Ph: 626-564-3455
	San Diego
	Kaiser Permanente Medical Center - Kaiser Foundation Hospital - San Diego
		Han A Koh	Ph: 626-564-3455
	Kaiser Permanente Medical Office -Vandever Medical Office
		Han A Koh	Ph: 626-564-3455
	San Francisco
	Kaiser Permanente Medical Center - San Francisco Geary Campus
		Louis Fehrenbacher	Ph: 626-564-3455
	UCSF Helen Diller Family Comprehensive Cancer Center
		Alan Paul Venook	Ph: 877-827-3222
	San Jose
	Kaiser Permanente Medical Center - Santa Teresa
		Louis Fehrenbacher	Ph: 626-564-3455
	San Marcos
	Kaiser Permanente Health Care
		Han A Koh	Ph: 626-564-3455
	San Pablo
	Doctors Medical Center - San Pablo Campus
		James H. Feusner	Ph: 510-450-7600
	San Rafael
	Kaiser Foundation Hospital - San Rafael
		Louis Fehrenbacher	Ph: 626-564-3455
	Santa Clara
	Kaiser Permanente Medical Center - Santa Clara Homestead Campus
		Louis Fehrenbacher	Ph: 626-564-3455
	Santa Rosa
	Kaiser Permanente Medical Center - Santa Rosa
		Louis Fehrenbacher	Ph: 626-564-3455
	South San Francisco
	Kaiser Permanente Medical Center - South San Francisco
		Louis Fehrenbacher	Ph: 626-564-3455
	Stockton
	Kaiser Permanente Medical Facility - Stockton
		Louis Fehrenbacher	Ph: 626-564-3455
	Vacaville
	Kaiser Permanente Medical Center - Vacaville
		Louis Fehrenbacher	Ph: 626-564-3455
	Vallejo
	Kaiser Permanente Medical Center - Vallejo
		Louis Fehrenbacher	Ph: 626-564-3455
	Walnut Creek
	Kaiser Permanente Medical Center - Walnut Creek
		Louis Fehrenbacher	Ph: 626-564-3455
	Whittier
	Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital
		Jack H. Freimann	Ph: 562-698-0811
			Email: cdelferraro@pih.net
	Woodland Hills
	Kaiser Permanente Medical Cener - Woodland Hills
		Han A Koh	Ph: 626-564-3455
Colorado
	Aurora
	University of Colorado Cancer Center at UC Health Sciences Center
		Wells Messersmith	Ph: 720-848-0650
	Denver
	Kaiser Permanente of Colorado
		Alexander Menter	Ph: 303-614-1300
	Glenwood Springs
	Valley View Hospital Cancer Center
		Wells Messersmith	Ph: 720-848-0650
	Grand Junction
	St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
		Wells Messersmith	Ph: 720-848-0650
	Lafayette
	Kaiser Permanente - Lafayette
		Alexander Menter	Ph: 303-614-1300
	Montrose
	Montrose Memorial Hospital Cancer Center
		Wells Messersmith	Ph: 720-848-0650
Connecticut
	Hartford
	Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Middletown
	Middlesex Hospital Cancer Center
		Susanna Hong	Ph: 860-358-2058
Delaware
	Lewes
	Tunnell Cancer Center at Beebe Medical Center
		Stephen Scott Grubbs	Ph: 302-733-6227
	Newark
	Helen F. Graham Cancer Center at Christiana Hospital
		Stephen Scott Grubbs	Ph: 302-733-6227
Florida
	Lakeland
	Lakeland Regional Cancer Center at Lakeland Regional Medical Center
		Manuel A Molina	Ph: 863-904-1900
	Orlando
	Florida Hospital Cancer Institute at Florida Hospital Orlando
		Lee M. Zehngebot	Ph: 407-303-5623
	Pensacola
	Sacred Heart Cancer Center at Sacred Heart Hospital
		Dee McLeod	Ph: 850-416-4611
	Sacred Heart Medical Oncology Group
		Dee McLeod	Ph: 850-416-4611
Georgia
	Decatur
	Veterans Affairs Medical Center - Atlanta (Decatur)
		Samuel N Chan	Ph: 404-321-6111ext7632
	Macon
	Medical Center of Central Georgia
		Frederick M. Schnell	Ph: 478-633-1226
	Savannah
	Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
		Harvey C. Lebos	Ph: 912-350-8568
	Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
		Grant C Lewis	Ph: 912-350-8568
Hawaii
	Aiea
	Kapiolani Medical Center at Pali Momi
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Honolulu
	Cancer Research Center of Hawaii
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Hawaii Medical Center - East
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Kaiser Permanente - Moanalua Medical Center and Clinic
		Louis Fehrenbacher	Ph: 626-564-3455
	Kapiolani Medical Center for Women and Children
		Jeffrey L. Berenberg	Ph: 808-586-2979
	OnCare Hawaii, Incorporated - Kuakini
		Jeffrey L. Berenberg	Ph: 808-586-2979
	OnCare Hawaii, Incorporated - Lusitana
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Queen's Cancer Institute at Queen's Medical Center
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Straub Clinic and Hospital, Incorporated
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Wailuku
	Maui Memorial Medical Center
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Pacific Cancer Institute - Maui
		Jeffrey L. Berenberg	Ph: 808-586-2979
Idaho
	Boise
	Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Lewiston
	St. Joseph Regional Medical Center
		Yoshio Inoue	Ph: 253-403-2394
Illinois
	Aurora
	Rush-Copley Cancer Care Center
		Kendrith M. Rowland	Ph: 800-446-5532
	Chicago
	Robert H. Lurie Comprehensive Cancer Center at Northwestern University
		Mary Mulcahy	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	University of Chicago Cancer Research Center
		Daniel V Catenacci	Ph: 773-834-7424
	University of Illinois Cancer Center
		Howard Ozer	Ph: 312-355-3046
	Highland Park
	Hematology Oncology Associates of Illinois-Highland Park
		Mary Mulcahy	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Joliet
	Joliet Oncology-Hematology Associates, Limited - West
		Kulumani M Sivarajan	Ph: 815-730-3098
			Email: maureenc@jolietoncology.com
	Kankakee
	Provena St. Mary's Regional Cancer Center - Kankakee
		Mary Mulcahy	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Libertyville
	North Shore Oncology and Hematology Associates, Limited - Libertyville
		Mary Mulcahy	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Niles
	Cancer Care and Hematology Specialists of Chicagoland - Niles
		Mary Mulcahy	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Oak Lawn
	Advocate Christ Medical Center
		Amar Hamad	Ph: 800-323-8622
	Rockford
	Swedish-American Regional Cancer Center
		Harvey Eric Einhorn	Ph: 815-489-4413
	Skokie
	Hematology Oncology Associates - Skokie
		Mary Mulcahy	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Urbana
	Carle Cancer Center at Carle Foundation Hospital
		Kendrith M. Rowland	Ph: 800-446-5532
Indiana
	Elkhart
	Elkhart Clinic, LLC
		Rafat H. Ansari	Ph: 574-234-5123
	Elkhart General Hospital
		Rafat H. Ansari	Ph: 574-234-5123
	Michiana Hematology-Oncology, PC - Elkhart
		Rafat H. Ansari	Ph: 574-234-5123
	Indianapolis
	St. Francis Hospital Cancer Care Services
		Howard M. Gross	Ph: 765-983-3000
	Kokomo
	Community Cancer Care at Howard Regional Health System
		Rafat H. Ansari	Ph: 574-234-5123
	La Porte
	Center for Cancer Therapy at LaPorte Hospital and Health Services
		Rafat H. Ansari	Ph: 574-234-5123
	Michigan City
	Saint Anthony Memorial Health Centers
		Kendrith M. Rowland	Ph: 800-446-5532
	Mishawaka
	Michiana Hematology-Oncology, PC - Mishawaka
		Rafat H. Ansari	Ph: 574-234-5123
	Saint Joseph's Medical Center
		Rafat H. Ansari	Ph: 574-234-5123
	Plymouth
	Michiana Hematology Oncology PC - Plymouth
		Rafat H. Ansari	Ph: 574-234-5123
	Richmond
	Reid Hospital & Health Care Services
		Howard M. Gross	Ph: 317-783-8918
	South Bend
	CCOP - Northern Indiana CR Consortium
		Rafat H. Ansari	Ph: 574-234-5123
	Memorial Hospital of South Bend
		Rafat H. Ansari	Ph: 574-234-5123
	Michiana Hematology-Oncology, PC - South Bend
		Rafat H. Ansari	Ph: 574-234-5123
	Westville
	Michiana Hematology Oncology-PC Westville
		Rafat H. Ansari	Ph: 574-234-5123
Iowa
	Ames
	McFarland Clinic, PC
		Joseph James Merchant	Ph: 515-239-2621
	Bettendorf
	Hematology Oncology Associates of the Quad Cities
		Shobha R. Chitneni	Ph: 563-355-7733
			Email: kedaprile@rccqc.com
	Iowa City
	Holden Comprehensive Cancer Center at University of Iowa
		Daniel A Vaena	Ph: 800-237-1225
	Ottumwa
	South Iowa Radiation Oncology Center at Ottumwa Regional Health Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Sioux City
	Mercy Medical Center - Sioux City
		Donald Bruce Wender	Ph: 712-252-0088
	Siouxland Hematology-Oncology Associates, LLP
		Donald Bruce Wender	Ph: 712-252-0088
	St. Luke's Regional Medical Center
		Donald Bruce Wender	Ph: 712-252-0088
Kansas
	Chanute
	Cancer Center of Kansas, PA - Chanute
		Shaker R. Dakhil	Ph: 316-262-4467
	Dodge City
	Cancer Center of Kansas, PA - Dodge City
		Shaker R. Dakhil	Ph: 316-262-4467
	El Dorado
	Cancer Center of Kansas, PA - El Dorado
		Shaker R. Dakhil	Ph: 316-262-4467
	Fort Scott
	Cancer Center of Kansas - Fort Scott
		Shaker R. Dakhil	Ph: 316-262-4467
	Independence
	Cancer Center of Kansas-Independence
		Shaker R. Dakhil	Ph: 316-262-4467
	Kansas City
	Providence Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Kingman
	Cancer Center of Kansas, PA - Kingman
		Shaker R. Dakhil	Ph: 316-262-4467
	Lawrence
	Lawrence Memorial Hospital
		Shaker R. Dakhil	Ph: 316-262-4467
	Liberal
	Cancer Center of Kansas, PA - Liberal
		Shaker R. Dakhil	Ph: 316-262-4467
	McPherson
	Cancer Center of Kansas, PA - McPherson
		Shaker R. Dakhil	Ph: 316-262-4467
	Newton
	Cancer Center of Kansas, PA - Newton
		Shaker R. Dakhil	Ph: 316-262-4467
	Overland Park
	Menorah Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Luke's Hospital - South
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Parsons
	Cancer Center of Kansas, PA - Parsons
		Shaker R. Dakhil	Ph: 316-262-4467
	Prairie Village
	CCOP - Kansas City
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Pratt
	Cancer Center of Kansas, PA - Pratt
		Shaker R. Dakhil	Ph: 316-262-4467
	Salina
	Cancer Center of Kansas, PA - Salina
		Shaker R. Dakhil	Ph: 316-262-4467
	Wellington
	Cancer Center of Kansas, PA - Wellington
		Shaker R. Dakhil	Ph: 316-262-4467
	Wichita
	Associates in Women's Health, PA - North Hillside
		Shaker R. Dakhil	Ph: 316-262-4467
	Cancer Center of Kansas, PA - Medical Arts Tower
		Shaker R. Dakhil	Ph: 316-262-4467
	Cancer Center of Kansas, PA - Wichita
		Shaker R. Dakhil	Ph: 316-262-4467
	CCOP - Wichita
		Shaker R. Dakhil	Ph: 316-262-4467
	Via Christi Cancer Center at Via Christi Regional Medical Center
		Shaker R. Dakhil	Ph: 316-262-4467
	Winfield
	Cancer Center of Kansas, PA - Winfield
		Shaker R. Dakhil	Ph: 316-262-4467
Louisiana
	Baton Rouge
	Hematology-Oncology Clinic
		Hana F Safah	Ph: 504-988-6121
	Mary Bird Perkins Cancer Center - Baton Rouge
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
	Ochsner Health Center - Bluebonnet
		Jyotsna Fuloria	Ph: 888-562-4763
	Covington
	Ochsner Health Center - Covington
		Jyotsna Fuloria	Ph: 888-562-4763
	New Orleans
	CCOP - Ochsner
		Jyotsna Fuloria	Ph: 888-562-4763
	Medical Center of Louisiana - New Orleans
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
	Ochsner Cancer Institute at Ochsner Clinic Foundation
		Jyotsna Fuloria	Ph: 888-562-4763
	Stanley S. Scott Cancer Center at Louisiana State University Medical Center - New Orleans
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
	Tulane Cancer Center at Tulane University Hospital and Clinic
		Hana F Safah	Ph: 504-988-6121
Maine
	York
	York Hospital's Oncology Treatment Center
		Jonathan D Eneman	Ph: 207-351-3777
Maryland
	Baltimore
	Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
		Mayer Gorbaty	Ph: 800-888-8823
	Greater Baltimore Medical Center Cancer Center
		Paul Celano	Ph: 443-849-3706
	Greenebaum Cancer Center at University of Maryland Medical Center
		Margit N Horiba	Ph: 800-888-8823
	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
		David P Cosgrove	Ph: 410-955-8804
			Email: jhcccro@jhmi.edu
	St. Agnes Hospital Cancer Center
		Carole Miller	Ph: 410-368-2910
	Bethesda
	National Naval Medical Center
		David C Van Echo	Ph: 301-319-2100
	Elkton MD
	Union Hospital of Cecil County
		Stephen Scott Grubbs	Ph: 302-733-6227
Massachusetts
	Boston
	Boston University Cancer Research Center
		Kevan Leighton Hartshorn	Ph: 617-638-8265
Michigan
	Adrian
	Hickman Cancer Center at Bixby Medical Center
		Rex B Mowat	Ph: 517-265-0116
		Rex B Mowat	Ph: 517-265-0116
	Ann Arbor
	CCOP - Michigan Cancer Research Consortium
		Philip J. Stella	Ph: 734-712-3456
	Saint Joseph Mercy Cancer Center
		Philip J. Stella	Ph: 734-712-3456
	Dearborn
	Oakwood Cancer Center at Oakwood Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Detroit
	Van Elslander Cancer Center at St. John Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Escanaba
	Green Bay Oncology, Limited - Escanaba
		Anthony J. Jaslowski	Ph: 800-432-6049
	Flint
	Genesys Hurley Cancer Institute
		Philip J. Stella	Ph: 734-712-3456
	Hurley Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Grand Blanc
	Genesys Regional Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Iron Mountain
	Green Bay Oncology - Iron Mountain
		Anthony J. Jaslowski	Ph: 800-432-6049
	Jackson
	Gayle M. Jacob Cancer Center at Allegiance Health
		Philip J. Stella	Ph: 734-712-3456
	Kalamazoo
	Borgess Medical Center
		Raymond Sterling Lord	Ph: 269-373-7458
	Bronson Methodist Hospital
		Raymond Sterling Lord	Ph: 269-373-7458
	West Michigan Cancer Center
		Raymond Sterling Lord	Ph: 269-373-7458
	Lansing
	Sparrow Regional Cancer Center
		Philip J. Stella	Ph: 734-712-3456
	Livonia
	St. Mary Mercy Hospital
		Philip J. Stella	Ph: 734-712-3456
	Monroe
	Community Cancer Center of Monroe
		Rex B Mowat	Ph: 517-265-0116
	Mercy Memorial Hospital - Monroe
		Rex B Mowat	Ph: 517-265-0116
	Pontiac
	St. Joseph Mercy Oakland
		Philip J. Stella	Ph: 734-712-3456
	Port Huron
	Mercy Regional Cancer Center at Mercy Hospital
		Philip J. Stella	Ph: 734-712-3456
	Saginaw
	Seton Cancer Institute at Saint Mary's - Saginaw
		Philip J. Stella	Ph: 734-712-3456
	Saint Joseph
	Lakeside Cancer Specialists, PLLC
		Rafat H. Ansari	Ph: 574-234-5123
	Southfield
	Providence Hospital - Southfield
		Howard R. Terebelo	Ph: 248-849-5337
			Email: jaswinder.grewal@stjohn.org
	St. Joseph
	Lakeland Regional Cancer Care Center - St. Joseph
		Rafat H. Ansari	Ph: 574-234-5123
	Warren
	St. John Macomb Hospital
		Philip J. Stella	Ph: 734-712-3456
Minnesota
	Brainerd
	St. Joseph's Medical Center
		Daniel Nikcevich	Ph: 888-203-7267
	Burnsville
	Fairview Ridges Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Duluth
	CCOP - Duluth
		Daniel Nikcevich	Ph: 888-203-7267
	Essentia Health - Duluth Clinic
		Daniel Nikcevich	Ph: 888-203-7267
	Miller - Dwan Medical Center
		Daniel Nikcevich	Ph: 888-203-7267
	Edina
	Fairview Southdale Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Fridley
	Mercy and Unity Cancer Center at Unity Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Hutchinson
	Hutchinson Area Health Care
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Maplewood
	HealthEast Cancer Care at St. John's Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minnesota Oncology - Maplewood
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minneapolis
	Hennepin County Medical Center - Minneapolis
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Veterans Affairs Medical Center - Minneapolis
		Sharon D Luikart	Ph: 612-467-2800
	Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	New Ulm
	New Ulm Medical Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Robbinsdale
	Humphrey Cancer Center at North Memorial Outpatient Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Louis Park
	CCOP - Metro-Minnesota
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Park Nicollet Cancer Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Paul
	Regions Hospital Cancer Care Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	United Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Shakopee
	St. Francis Cancer Center at St. Francis Medical Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Stillwater
	Lakeview Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Waconia
	Ridgeview Medical Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Willmar
	Willmar Cancer Center at Rice Memorial Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Woodbury
	Minnesota Oncology - Woodbury
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
Mississippi
	Jackson
	University of Mississippi Cancer Clinic
		Louis V Puneky	Ph: 601-815-6700
Missouri
	Bolivar
	Central Care Cancer Center at Carrie J. Babb Cancer Center
		Robert L Carolla	Ph: 417-269-4520
	Branson
	Skaggs Cancer Center at Skaggs Regional Medical Center
		Robert L Carolla	Ph: 417-269-4520
	Cape Girardeau
	Southeast Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Columbia
	Ellis Fischel Cancer Center at University of Missouri - Columbia
		Carl E. Freter	Ph: 573-882-7440
	Veterans Affairs Medical Center - Columbia (Truman Memorial)
		Shadi M Haddadin
			Email: calgbco@calgb.org
	Jefferson City
	Goldschmidt Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Kansas City
	Heartland Hematology Oncology Associates, Incorporated
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	North Kansas City Hospital
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Parvin Radiation Oncology
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Research Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Luke's Hospital
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Lee's Summit
	Saint Luke's East - Lee's Summit
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Rolla
	Phelps County Regional Medical Center
		Robert L Carolla	Ph: 417-269-4520
	Saint Joseph
	Heartland Regional Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Joseph Oncology, Incorporated
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Louis
	Missouri Baptist Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
		Benjamin R Tan	Ph: 800-600-3606
			Email: info@siteman.wustl.edu
	Springfield
	Cancer Research for the Ozarks
		Robert L Carolla	Ph: 417-269-4520
	Hulston Cancer Center at Cox Medical Center South
		Robert L Carolla	Ph: 417-269-4520
Nebraska
	Grand Island
	Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
		James K Schwarz	Ph: 800-999-5465
	North Platte
	Callahan Cancer Center at Great Plains Regional Medical Center
		James K Schwarz	Ph: 800-999-5465
	Omaha
	Methodist Estabrook Cancer Center
		Robert M. Langdon	Ph: 402-354-5144
	UNMC Eppley Cancer Center at the University of Nebraska Medical Center
		James K Schwarz	Ph: 800-999-5465
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		John Allan Ellerton	Ph: 702-731-8274
	University Medical Center of Southern Nevada
		John Allan Ellerton	Ph: 702-731-8274
	Reno
	Renown Institute for Cancer at Renown Regional Medical Center
		Steven A. Schiff	Ph: 775-982-4400
	Saint Mary's Regional Medical Center
		Vodur S Reddy	Ph: 775-770-3854
New Jersey
	Camden
	Cancer Institute of New Jersey at Cooper University Hospital - Camden
		Stephen Scott Grubbs	Ph: 302-733-6227
	East Orange
	Veterans Affairs Medical Center - East Orange
		Basil S. Kasimis	Ph: 800-475-2336
			Email: patricia.goyer@med.va.gov
	Newark
	UMDNJ University Hospital
		Lillian F. Pliner	Ph: 732-235-8675
New York
	Bronx
	Veterans Affairs Medical Center - Bronx
		Yeun-Hee A Park	Ph: 888-823-5923
			Email: ctsucontact@westat.com
	Brooklyn
	Veterans Affairs Medical Center - Brooklyn
		Andrea Nadine Wiesel Leaf	Ph: 800-877-6976
	Buffalo
	Veterans Affairs Medical Center - Buffalo
		Lynn Marie Steinbrenner	Ph: 716-862-3191
	East Syracuse
	CCOP - Hematology-Oncology Associates of Central New York
		Jeffrey J. Kirshner	Ph: 315-472-7504
	Glens Falls
	Charles R. Wood Cancer Center at Glens Falls Hospital
		Aqeel A Gillani	Ph: 518-926-6700
	Lake Success
	Monter Cancer Center of the North Shore-LIJ Health System
		Bhoomi Mehrotra	Ph: 516-562-3467
	Manhasset
	CCOP - North Shore University Hospital
		Bhoomi Mehrotra	Ph: 516-562-3467
	Don Monti Comprehensive Cancer Center at North Shore University Hospital
		Bhoomi Mehrotra	Ph: 516-562-3467
	Middletown
	Tucker Center for Cancer Care at Orange Regional Medical Center
		Jeffrey M. Stewart	Ph: 845-342-7609
	New Hyde Park
	Long Island Jewish Medical Center
		Bhoomi Mehrotra	Ph: 516-562-3467
	New York
	Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
		Abby Siegel	Ph: 212-305-8615
	Memorial Sloan-Kettering Cancer Center
		Ghassan Abou-Alfa	Ph: 212-639-7202
	Rochester
	James P. Wilmot Cancer Center at University of Rochester Medical Center
		Jonathan W Friedberg	Ph: 585-275-5830
	Syracuse
	SUNY Upstate Medical University Hospital
		Jonathan Wright	Ph: 315-464-5476
North Carolina
	Asheville
	Mission Hospitals - Memorial Campus
		Christopher H Chay	Ph: 828-213-4150
	Charlotte
	Presbyterian Cancer Center at Presbyterian Hospital
		Justin P Favaro	Ph: 704-384-5369
	Goldsboro
	Wayne Memorial Hospital, Incorporated
		James N. Atkins	Ph: 919-580-0000
	Kinston
	Kinston Medical Specialists
		Peter R. Watson	Ph: 252-559-2200
	Rutherfordton
	Rutherford Hospital
		Charles E Bowers	Ph: 800-486-5941
	Statesville
	Iredell Memorial Hospital
		Ruby A. Grimm	Ph: 704-873-5661
North Dakota
	Bismarck
	Medcenter One Hospital Cancer Care Center
		John T Reynolds	Ph: 701-323-5760
			Email: tfischer@mohs.org
	Mid Dakota Clinic, PC
		John T Reynolds	Ph: 701-323-5760
			Email: tfischer@mohs.org
	St. Alexius Medical Center Cancer Center
		John T Reynolds	Ph: 701-323-5760
			Email: tfischer@mohs.org
	Fargo
	Dakota Cancer Institute at Dakota Clinic - South University
		Daniel Nikcevich	Ph: 888-203-7267
Ohio
	Akron
	Summa Center for Cancer Care at Akron City Hospital
		Jennifer E Payne	Ph: 330-375-6101
	Barberton
	Barberton Citizens Hospital
		Jennifer E Payne	Ph: 330-375-6101
	Bowling Green
	Wood County Oncology Center
		Rex B Mowat	Ph: 517-265-0116
	Canton
	Aultman Cancer Center at Aultman Hospital
		Kisa E Weeman	Ph: 330-363-6891
	Chillicothe
	Adena Regional Medical Center
		J. Philip Kuebler	Ph: 502-361-8496
	Cleveland
	MetroHealth Cancer Care Center at MetroHealth Medical Center
		Bruce J. Averbook	Ph: 216-778-8526
			Email: kbauchens@metrohealth.org
	Columbus
	Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
		Tanios Bekaii-Saab	Ph: 866-627-7616
			Email: osu@emergingmed.com
	CCOP - Columbus
		J. Philip Kuebler	Ph: 502-361-8496
	Doctors Hospital at Ohio Health
		J. Philip Kuebler	Ph: 502-361-8496
	Grant Medical Center Cancer Care
		J. Philip Kuebler	Ph: 502-361-8496
	Mount Carmel Health - West Hospital
		J. Philip Kuebler	Ph: 502-361-8496
	Riverside Methodist Hospital Cancer Care
		J. Philip Kuebler	Ph: 502-361-8496
	Zangmeister Center
		J. Philip Kuebler	Ph: 502-361-8496
	Dayton
	CCOP - Dayton
		Howard M. Gross	Ph: 317-783-8918
	David L. Rike Cancer Center at Miami Valley Hospital
		Howard M. Gross	Ph: 765-983-3000
	Good Samaritan Hospital
		Howard M. Gross	Ph: 317-783-8918
	Grandview Hospital
		Howard M. Gross	Ph: 317-783-8918
	Samaritan North Cancer Care Center
		Howard M. Gross	Ph: 317-783-8918
	Veterans Affairs Medical Center - Dayton
		Geetika Kumar	Ph: 937-268-6511
	Delaware
	Grady Memorial Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Elyria
	Hematology Oncology Center
		Rex B Mowat	Ph: 517-265-0116
	Mercy Cancer Center - Elyria
		Rex B Mowat	Ph: 517-265-0116
	Findlay
	Blanchard Valley Regional Cancer Center
		Howard M. Gross	Ph: 317-783-8918
	Franklin
	Atrium Medical Center
		Howard M. Gross	Ph: 317-783-8918
	Greenville
	Wayne Hospital
		Howard M. Gross	Ph: 317-783-8918
	Kettering
	Charles F. Kettering Memorial Hospital
		Howard M. Gross	Ph: 317-783-8918
	Lancaster
	Fairfield Medical Center
		J. Philip Kuebler	Ph: 502-361-8496
	Lima
	Lima Memorial Hospital
		Rex B Mowat	Ph: 517-265-0116
	St. Rita's Medical Center
		Henry Gerad	Ph: 419-226-9617
	Marietta
	Strecker Cancer Center at Marietta Memorial Hospital
		J. Philip Kuebler	Ph: 502-361-8496
	Maumee
	Northwest Ohio Oncology Center
		Rex B Mowat	Ph: 517-265-0116
		Rex B Mowat	Ph: 517-265-0116
	Mount Vernon
	Knox Community Hospital
		J. Philip Kuebler	Ph: 502-361-8496
	Newark
	Licking Memorial Cancer Care Program at Licking Memorial Hospital
		J. Philip Kuebler	Ph: 502-361-8496
	Oregon
	St. Charles Mercy Hospital
		Rex B Mowat	Ph: 517-265-0116
	Toledo Clinic - Oregon
		Rex B Mowat	Ph: 517-265-0116
	Portsmouth
	Southern Ohio Medical Center Cancer Center
		J. Philip Kuebler	Ph: 502-361-8496
	Springfield
	Community Hospital of Springfield and Clark County
		J. Philip Kuebler	Ph: 502-361-8496
	Sylvania
	Flower Hospital Cancer Center
		Rex B Mowat	Ph: 517-265-0116
	Tiffin
	Mercy Hospital of Tiffin
		Rex B Mowat	Ph: 517-265-0116
	Toledo
	CCOP - Toledo Community Hospital
		Rex B Mowat	Ph: 517-265-0116
	St. Anne Mercy Hospital
		Rex B Mowat	Ph: 517-265-0116
	St. Vincent Mercy Medical Center
		Rex B Mowat	Ph: 517-265-0116
	Toledo Clinic, Incorporated - Main Clinic
		Rex B Mowat	Ph: 517-265-0116
	Toledo Hospital
		Rex B Mowat	Ph: 517-265-0116
	University of Toledo Medical Center
		Rex B Mowat	Ph: 517-265-0116
	Troy
	UVMC Cancer Care Center at Upper Valley Medical Center
		Howard M. Gross	Ph: 317-783-8918
	Wauseon
	Fulton County Health Center
		Rex B Mowat	Ph: 517-265-0116
	Westerville
	Mount Carmel St. Ann's Cancer Center
		J. Philip Kuebler	Ph: 502-361-8496
	Xenia
	Ruth G. McMillan Cancer Center at Greene Memorial Hospital
		Howard M. Gross	Ph: 317-783-8918
	Zanesville
	Genesis - Good Samaritan Hospital
		J. Philip Kuebler	Ph: 502-361-8496
Oklahoma
	Norman
	Cancer Care Associates - Norman
		Vikki Ann Canfield
			Email: calgbco@calgb.org
	Oklahoma City
	Cancer Care Associates - Mercy Campus
		Vikki Ann Canfield
			Email: calgbco@calgb.org
	Oklahoma University Cancer Institute
		Carla Kurkjian	Ph: 405-271-4272
			Email: julie-traylor@ouhsc.edu
Oregon
	Portland
	Kaiser Permanente Health Care - Portland
		Nagendra Tirumali	Ph: 503-335-2400
Pennsylvania
	Abington
	Rosenfeld Cancer Center at Abington Memorial Hospital
		Willard G. Andrews	Ph: 215-481-2402
	Pittsburgh
	Veterans Affairs Medical Center - Pittsburgh
		Jocelyn L Tan-Shalaby	Ph: 412-688-6104
	Sayre
	Guthrie Cancer Center at Guthrie Clinic Sayre
		Edward T. O'Brien	Ph: 800-836-0388
South Carolina
	Anderson
	AnMed Cancer Center
		Charles E Bowers	Ph: 800-486-5941
	Greenville
	Bon Secours St. Francis Health System
		Charles E Bowers	Ph: 800-486-5941
	Cancer Centers of the Carolinas - Faris Road
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Cancer Centers of the Carolinas - Grove Commons
		Jeffrey Kent Giguere	Ph: 864-241-6251
	CCOP - Greenville
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Greenville Memorial Hospital
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Greer
	Cancer Centers of the Carolinas - Greer Medical Oncology
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Seneca
	Cancer Centers of the Carolinas - Seneca
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Spartanburg
	Cancer Centers of the Carolinas - Spartanburg
		Jeffrey Kent Giguere	Ph: 864-241-6251
	CCOP - Upstate Carolina
		Charles E Bowers	Ph: 800-486-5941
	Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
		Charles E Bowers	Ph: 800-486-5941
South Dakota
	Rapid City
	Rapid City Regional Hospital
		Mark T Schroeder	Ph: 605-716-3982
			Email: research@rcrh.org
	Sioux Falls
	Avera Cancer Institute
		Addison R Tolentino	Ph: 800-657-4377
			Email: Jan.Healy@avera.org
Tennessee
	Jackson
	West Tennessee Cancer Center at Jackson-Madison County General Hospital
		Brion V Randolph	Ph: 731-425-6865
	Kingsport
	Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
		Asheesh Shipstone	Ph: 423-578-8538
	Knoxville
	U.T. Medical Center Cancer Institute
		Wahid T. Hanna	Ph: 865-544-9773
Texas
	Houston
	Ben Taub General Hospital
		Martha P Mims	Ph: 713-798-1354
			Email: burton@bcm.edu
	Dan L. Duncan Cancer Center at Baylor College of Medicine
		Martha P Mims	Ph: 713-798-1354
			Email: burton@bcm.edu
	St. Luke's Texas Cancer Institute at St. Luke's Episcopal Hospital
		Martha P Mims	Ph: 713-798-1354
			Email: burton@bcm.edu
	Veterans Affairs Medical Center - Houston
		Martha P Mims	Ph: 713-798-1354
			Email: burton@bcm.edu
Vermont
	Berlin
	Mountainview Medical
		Steven Ades	Ph: 802-656-8990
	Burlington
	Vermont Cancer Center at University of Vermont
		Steven Ades	Ph: 802-656-8990
Virginia
	Danville
	Danville Regional Medical Center
		Timothy W. Brotherton	Ph: 434-793-0044
	Fredericksburg
	Fredericksburg Oncology Inc
		Rex B Mowat	Ph: 517-265-0116
	Martinsville
	Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County
		Arthur Sleeper	Ph: 276-666-7827
	Norton
	Southwest Virginia Regional Cancer Center at Wellmonth Health
		Asheesh Shipstone	Ph: 423-578-8538
Washington
	Auburn
	Auburn Regional Center for Cancer Care
		Yoshio Inoue	Ph: 253-403-2394
	Bellevue
	Overlake Cancer Center at Overlake Hospital Medical Center
		Yoshio Inoue	Ph: 253-403-2394
	Centralia
	Providence Centralia Hospital
		Yoshio Inoue	Ph: 253-403-2394
	Everett
	Providence Regional Cancer Partnership
		Yoshio Inoue	Ph: 253-403-2394
	Federal Way
	St. Francis Hospital
		Yoshio Inoue	Ph: 253-403-2394
	Olympia
	Providence St. Peter Hospital Regional Cancer Center
		Yoshio Inoue	Ph: 253-403-2394
	Puyallup
	Good Samaritan Cancer Center
		Yoshio Inoue	Ph: 253-403-2394
	Spokane
	Rockwood Clinic Cancer Treatment Center
		Corliss L. Newman	Ph: 509-755-5800
	Tacoma
	Allenmore Hospital
		Yoshio Inoue	Ph: 253-403-2394
	CCOP - Northwest
		Yoshio Inoue	Ph: 253-403-2394
	Franciscan Cancer Center at St. Joseph Medical Center
		Yoshio Inoue	Ph: 253-403-2394
	MultiCare Regional Cancer Center at Tacoma General Hospital
		Yoshio Inoue	Ph: 253-403-2394
	St. Clare Hospital
		Yoshio Inoue	Ph: 253-403-2394
Wisconsin
	Antigo
	Langlade Memorial Hospital
		Christopher G Peterson	Ph: 877-405-6866
	Green Bay
	Green Bay Oncology, Limited at St. Mary's Hospital
		Anthony J. Jaslowski	Ph: 800-432-6049
	Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
		Anthony J. Jaslowski	Ph: 800-432-6049
	St. Mary's Hospital Medical Center - Green Bay
		Anthony J. Jaslowski	Ph: 800-432-6049
	St. Vincent Hospital Regional Cancer Center
		Anthony J. Jaslowski	Ph: 800-432-6049
	La Crosse
	Gundersen Lutheran Center for Cancer and Blood
		Kurt Oettel	Ph: 608-775-2385
			Email: cancerctr@gundluth.org
	Manitowoc
	Holy Family Memorial Medical Center Cancer Care Center
		Anthony J. Jaslowski	Ph: 800-432-6049
	Marinette
	Bay Area Cancer Care Center at Bay Area Medical Center
		Anthony J. Jaslowski	Ph: 800-432-6049
	Mukwonago
	D.N. Greenwald Center
		Timothy R Wassenaar	Ph: 262-928-7632
	New Richmond
	Cancer Center of Western Wisconsin
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Oconomowoc
	Regional Cancer Center at Oconomowoc Memorial Hospital
		Timothy R Wassenaar	Ph: 262-928-7632
	Oconto Falls
	Green Bay Oncology, Limited - Oconto Falls
		Anthony J. Jaslowski	Ph: 800-432-6049
	Sheboygan
	Saint Nicholas Hospital
		Anthony J. Jaslowski	Ph: 800-432-6049
	Sturgeon Bay
	Green Bay Oncology, Limited - Sturgeon Bay
		Anthony J. Jaslowski	Ph: 800-432-6049
	Waukesha
	Waukesha Memorial Hospital Regional Cancer Center
		Timothy R Wassenaar	Ph: 262-928-7632
	Wausau
	University of Wisconcin Cancer Center at Aspirus Wausau Hospital
		Christopher G Peterson	Ph: 877-405-6866
Canada
Alberta
	Calgary
	Tom Baker Cancer Centre - Calgary
		Vincent C Tam	Ph: 403-521-3433
British Columbia
	Vancouver
	British Columbia Cancer Agency - Vancouver Cancer Centre
		Howard J Lim	Ph: 888-939-3333
Manitoba
	Winnipeg
	CancerCare Manitoba
		Ralph P. W. Wong	Ph: 866-561-1026
			Email: CIO_Web@cancercare.mb.ca
Ontario
	Kitchener
	Grand River Regional Cancer Centre at Grand River Hospital
		Gregory J Knight	Ph: 519-749-4300ext2307
	London
	London Regional Cancer Program at London Health Sciences Centre
		Walter I Kocha	Ph: 519-685-8600
	Ottawa
	Ottawa Hospital Regional Cancer Centre - General Campus
		Rakesh Goel	Ph: 613-761-4395
			Email: info@ohri.ca
	Toronto
	Princess Margaret Hospital
		Jennifer J Knox	Ph: 416-946-4501
			Email: clinical.trials@uhn.on.ca
Quebec
	Montreal
	CHUM - Hopital Saint-Luc
		Moustapha Tehfe	Ph: 514-890-8000ext23611
			Email: sylvie.beaudoin.chum@ssss.gouv.qc.ca
	McGill Cancer Centre at McGill University
		Petr Kavan	Ph: 514-398-1444
			Email: penny.chipman@mcgill.ca
Saskatchewan
	Saskatoon
	Saskatoon Cancer Centre at the University of Saskatchewan
		Shahid Ahmed	Ph: 306-655-2914