Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Trial Contact Information
Registry Information

Alternate Title

Lisinopril or Carvedilol Phosphate in Reducing Side Effects in Women With HER2-Positive Breast Cancer Receiving Trastuzumab

Basic Trial Information

Objectives

Primary

1. To determine if administration of lisinopril or carvedilol phosphate extended-release (compared to placebo) will reduce the incidence of trastuzumab-induced cardiotoxicity, as measured by LVEF, in women receiving adjuvant or neoadjuvant trastuzumab for HER2-positive breast cancer.

Secondary

1. To determine whether patients randomized to receive lisinopril or carvedilol phosphate extended-release have fewer interruptions in trastuzumab therapy due to cardiomyopathy.
2. To determine changes in quality of life (QOL) in patients treated with these regimens.
3. To determine the long-term effects of lisinopril and/or carvedilol phosphate extended-release on the prevention of cardiomyopathy and their impact on QOL.
4. To compare the predictive value of troponin I and BNP in the identification of trastuzumab-induced cardiotoxicity.

Entry Criteria

Disease Characteristics:

• Diagnosis of HER2-positive breast cancer

• Scheduled to receive adjuvant or neoadjuvant trastuzumab therapy
  • Anthracycline-containing regimens allowed
  • Patients receive trastuzumab with their chemotherapy allowed for eligibility work-up
  • Taxanes are allowed
  • Trastuzumab therapy may be given with or after primary chemotherapy

• Hormone receptor status not specified

Prior/Concurrent Therapy:

• See Disease Characteristics
• No prior trastuzumab or anthracyclines prior to this chemotherapy regimen
• No other concurrent angiotensin-converting enzyme (ACE) inhibitors, β-blockers, or digoxin
• Concurrent participation in other investigational studies allowed

Patient Characteristics:

• Menopausal status not specified
• LVEF ≥ 50% by MUGA or ECHO
• Creatinine ≤ 1.2 mg/dL
• Sitting systolic BP > 90 mm Hg
• Pulse ≥ 60 beats/minute
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• Able to swallow capsules
• No known cardiac history (i.e., heart failure, myocardial infarction, or radiation-induced cardiac dysfunction)
• No known allergy to either ACE inhibitors or β-blockers
• No history of bronchial asthma or related bronchospastic conditions
• No hereditary or idiopathic angioedema
• No history of severe hypersensitivity reactions to drugs or other causes (e.g., bee stings)

Expected Enrollment

Outcomes

Reduction in incidence of trastuzumab-induced cardiotoxicity after 52 weeks of treatment as measured by preservation of LVEF

Number of trastuzumab courses completed without interruption
Quality-of-life changes as assessed by EORTC-QLQ-C30 questionnaire at baseline and at the end of treatment
Long-term effects of study drugs as assessed at 18 and 24 months (or 6 and 12 months after completion of trastuzumab therapy)

Outline

This is a multicenter study. Patients are randomized to 1 of 3 treatment arms.

• Arm I: Patients receive oral lisinopril once daily.

• Arm II: Patients receive oral carvedilol phosphate extended-release once daily.

• Arm III: Patients receive oral placebo once daily.

In all arms, study treatment begins with the first dose of trastuzumab and continues for up to 52 weeks or until the end of trastuzumab therapy.

Quality of life is assessed using the EORTC QLQ-C30 questionnaire at baseline, at 52 weeks (or at the end of trastuzumab therapy), and at 18 and 24 months (or 6 and 12 months after the completion of trastuzumab).

After completion of study treatment, patients are followed up at 3, 6, 9, and 12 months.

Trial Contact Information

Trial Lead Organizations

SunCoast CCOP Research Base at the University of South Florida

Maya Guglin, MD, PhD, Protocol chair		Ph: 813-259-0600; 888-663-3488
Pamela Munster, MD, Protocol co-chair		Ph: 415-885-7810; 800-888-8664 Email: Pmunster@medicine.ucsf.edu

U.S.A.
California
	Grass Valley
	Sierra Nevada Cancer Center at Sierra Nevada Memorial Hospital
		Clinical Trials Research Nurse	Ph:  530-274-6635
	Long Beach
	Todd Cancer Institute at Long Beach Memorial Medical Center
		Bichlien Nguyen	Ph:  562-933-0900
	Salinas
	Salinas Valley Memorial Hospital
		Laura Stampleman, MD	Ph:  831-755-1701
	Sylmar
	Olive View - UCLA Medical Center Foundation
		Jeffrey Miller, MD	Ph:  207-795-2935
Colorado
	Aurora
	Aurora Presbyterian Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Boulder
	Boulder Community Hospital
		Clinical Trials Office - Boulder Community Hospital	Ph:  303-938-5253
	Colorado Springs
	Penrose Cancer Center at Penrose Hospital
		Clinical Trials Office - Penrose Cancer Center	Ph:  719-776-5275
	Denver
	CCOP - Colorado Cancer Research Program
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Porter Adventist Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Presbyterian - St. Luke's Medical Center
		Clinical Trials Office - Presbyterian - St. Luke's Medical Center	Ph:  303-839-6000
	Rose Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	St. Anthony Central Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	St. Joseph Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Englewood
	Swedish Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Greeley
	North Colorado Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Littleton
	Littleton Adventist Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Lone Tree
	Sky Ridge Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Longmont
	Hope Cancer Care Center at Longmont United Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Loveland
	McKee Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Parker
	Parker Adventist Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Pueblo
	St. Mary - Corwin Regional Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Wheat Ridge
	Exempla Lutheran Medical Center
		Clinical Trials Office - Exempla Lutheran Medical Center	Ph:  303-403-3605
Connecticut
	Middletown
	Middlesex Hospital Cancer Center
		Susanna Hong	Ph:  860-358-2050
District of Columbia
	Washington
	Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
		Clinical Trials Office - Lombardi Comprehensive Cancer Center	Ph:  202-444-0381
	Washington Cancer Institute at Washington Hospital Center
		Clinical Trials Office - Washington Cancer Institute	Ph:  202-877-8839
Florida
	Jupiter
	Ella Milbank Foshay Cancer Center at Jupiter Medical Center
		Clinical Trials Office - Ella Milbank Foshay Cancer Center	Ph:  561-745-5768
	Lakeland
	Lakeland Regional Cancer Center at Lakeland Regional Medical Center
		Madhavi Venigalla, MD	Ph:  508-368-3168
	Miami Beach
	CCOP - Mount Sinai Medical Center
		Elisa Krill-Jackson, MD	Ph:  305-535-3300
Georgia
	Augusta
	MBCCOP - Medical College of Georgia Cancer Center
		Randall Roberts	Ph:  818-244-4374
Illinois
	Aurora
	Rush-Copley Cancer Care Center
		Kendrith Rowland, MD	Ph:  217-383-3019
	Bloomington%
	Illinois CancerCare - Bloomington
		Nguyet Le-Lindqwister	Ph:  309-662-2102
	Canton
	Illinois CancerCare - Canton
		Nguyet Le-Lindqwister	Ph:  309-647-5240
	Carthage
	Illinois CancerCare - Carthage
		Nguyet Le-Lindqwister	Ph:  217-357-6877
	Chicago
	Resurrection Medical Center
		Christopher Rose, MD	Ph:  847-965-3200
	Decatur
	Decatur Memorial Hospital Cancer Care Institute
		Clinical Trials Office - Decatur Memorial Hospital Cancer Care Institute	Ph:  217-876-4750
	Eureka
	Illinois CancerCare - Eureka
		Nguyet Le-Lindqwister	Ph:  309-467-2371
	Galesburg
	Illinois CancerCare - Galesburg
		Nguyet Le-Lindqwister	Ph:  309-344-9269
	Havana
	Illinois CancerCare - Havana
		Nguyet Le-Lindqwister	Ph:  309-543-8557
	Kewanee
	Illinois CancerCare - Kewanee Clinic
		Nguyet Le-Lindqwister	Ph:  309-852-0598
	La Grange
	La Grange Memorial Hospital
		Clinical Trials Office - La Grange Memorial Hospital	Ph:  630-856-7526
	Macomb
	Illinois CancerCare - Macomb
		Nguyet Le-Lindqwister	Ph:  309-833-3503
	Monmouth
	Illinois CancerCare - Monmouth
		Nguyet Le-Lindqwister	Ph:  309-734-3141
	Normal
	Illinois CancerCare - Community Cancer Center
		Nguyet Le-Lindqwister	Ph:  309-662-2102
	Oak Lawn
	Advocate Christ Medical Center
		Amar Hamad	Ph:  708-684-8000
	Ottawa
	Oncology Hematology Associates of Central Illinois, PC - Ottawa
		Nguyet Le-Lindqwister	Ph:  815-431-9270
	Pekin
	Illinois CancerCare - Pekin
		Nguyet Le-Lindqwister	Ph:  309-353-0214
	Peoria
	CCOP - Illinois Oncology Research Association
		Nguyet Le-Lindqwister	Ph:  309-243-3605 800-793-2262
	Peru
	Illinois CancerCare - Peru
		Nguyet Le-Lindqwister	Ph:  815-780-3185
	Princeton
	Illinois CancerCare - Princeton
		Nguyet Le-Lindqwister	Ph:  815-875-3010
	Springfield
	Regional Cancer Center at Memorial Medical Center
		Clinical Trials Office - Regional Cancer Center at Memorial Medical Center	Ph:  217-788-4233
	Urbana
	CCOP - Carle Cancer Center
		Clinical Trials Office - CCOP - Carle Cancer Center	Ph:  800-446-5532
Indiana
	Beech Grove
	St. Francis Hospital and Health Centers - Beech Grove Campus
		Howard Gross, MD	Ph:  937-832-1093
	Bloomington
	Bloomington Hospital Regional Cancer Institute
		David Lee, MD	Ph:  812-353-2800
	Elkhart
	Elkhart Clinic, LLC
		Robin Zon, MD	Ph:  574-296-6536
	Elkhart General Hospital
		Robin Zon, MD	Ph:  574-296-6536
	Michiana Hematology-Oncology, PC - Elkhart
		Robin Zon, MD	Ph:  574-296-6536
	Kokomo
	Howard Community Hospital
		Robin Zon, MD	Ph:  574-296-6536
	La Porte
	Center for Cancer Therapy at LaPorte Hospital and Health Services
		Robin Zon, MD	Ph:  574-296-6536
	Michigan City
	Saint Anthony Memorial Health Centers
		Kendrith Rowland, MD	Ph:  217-383-3019
	Mishawaka
	Michiana Hematology-Oncology, PC - South Bend
		Robin Zon, MD	Ph:  574-296-6536
	Saint Joseph Regional Medical Center
		Robin Zon, MD	Ph:  574-296-6536
	Plymouth
	Michiana Hematology Oncology PC - Plymouth
		Robin Zon, MD	Ph:  574-296-6536
	Richmond
	Reid Hospital & Health Care Services
		Howard Gross, MD	Ph:  937-832-1093
	South Bend
	CCOP - Northern Indiana CR Consortium
		Robin Zon, MD	Ph:  574-296-6536
	Memorial Hospital of South Bend
		Clinical Trials Office - Memorial Hospital of South Bend	Ph:  800-284-7370
	Michiana Hematology-Oncology, PC - South Bend
		Robin Zon, MD	Ph:  574-296-6536
	Westville
	Michiana Hematology Oncology PC - La Porte
		Robin Zon, MD	Ph:  574-296-6536
Iowa
	Cedar Rapids
	Cedar Rapids Oncology Associates
		Clinical Trials Office - Cedar Rapids Oncology Associates	Ph:  319-363-2690
	Clive
	Medical Oncology and Hematology Associates - West Des Moines
		Robert Behrens	Ph:  515-875-9713
	Des Moines
	CCOP - Iowa Oncology Research Association
		Robert Behrens	Ph:  515-244-7586 888-244-6061
	Medical Oncology and Hematology Associates at John Stoddard Cancer Center
		Robert Behrens	Ph:  515-282-2921
	Medical Oncology and Hematology Associates at Mercy Cancer Center
		Robert Behrens	Ph:  515-643-8740
	Waterloo
	Covenant Cancer Treatment Center
		Clinical Trials Office - Covenant Cancer Treatment Center	Ph:  319-272-2070
Maine
	Portland
	Mercy Hospital
		Roger Inhorn, MD, PhD	Ph:  207-879-3030
Maryland
	Baltimore
	Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
		Mayer Gorbaty	Ph:  410-601-4734
	Mercy Medical Center
		David Riseberg, MD	Ph:  410-783-5858
Massachusetts
	Plymouth
	Jordan Hospital Club Cancer Center
		James Koomey	Ph:  508-746-2000
Michigan
	Adrian
	Hickman Cancer Center at Bixby Medical Center
		Clinical Trials Office - Hickman Cancer Center at Bixby Medical Center	Ph:  517-265-0116
	Battle Creek
	Battle Creek Health System Cancer Care Center
		Gilbert Padula	Ph:  616-966-8000
	Big Rapids
	Mecosta County Medical Center
		Gilbert Padula	Ph:  231-796-8691
	Detroit
	Barbara Ann Karmanos Cancer Institute
		Clinical Trials Office - Barbara Ann Karmanos Cancer Institute	Ph:  313-576-9363
	Grand Rapids
	Butterworth Hospital at Spectrum Health
		Gilbert Padula	Ph:  616-391-2799
	Lacks Cancer Center at Saint Mary's Health Care
		Gilbert Padula	Ph:  616-752-5222
	Kalamazoo
	West Michigan Cancer Center
		Clinical Trials Office - West Michigan Cancer Center	Ph:  269-373-7458
	Marquette
	Upper Michigan Cancer Center at Marquette General Hospital
		Clinical Trials Office - Upper Michigan Cancer Center at Marquette General Hospital	Ph:  906-225-3467
	Monroe
	Community Cancer Center of Monroe
		Rex Mowat	Ph:  734-242-7902
	Muskegon
	Mercy General Health Partners
		Gilbert Padula	Ph:  231-672-2000
	Saint Joseph
	Lakeside Cancer Specialists, PLLC
		Robin Zon, MD	Ph:  574-296-6536
	Southfield
	Providence Cancer Institute at Providence Hospital - Southfield Campus
		Anibal Drelichman, MD, MPH, FACP	Ph:  313-552-0620
	St. Joseph
	Lakeland Regional Cancer Care Center - St. Joseph
		Robin Zon, MD	Ph:  574-296-6536
	Traverse City
	Munson Medical Center
		Gilbert Padula	Ph:  231-935-6202
Minnesota
	Brainerd
	St. Joseph's Medical Center
		Daniel Nikcevich, MD, PhD	Ph:  218-786-3625
	Burnsville
	Fairview Ridges Hospital
		Joseph Leach	Ph:  952-892-2000
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Joseph Leach	Ph:  763-236-6000
	Duluth
	CCOP - Duluth
		Daniel Nikcevich, MD, PhD	Ph:  218-786-3625
	Edina
	Fairview Southdale Hospital
		Clinical Trials Office - Fairview Southdale Hospital	Ph:  612-625-3650
	Fridley
	Mercy and Unity Cancer Center at Unity Hospital
		Joseph Leach	Ph:  763-236-5000
	Maplewood
	HealthEast Cancer Care at St. John's Hospital
		Joseph Leach	Ph:  651-232-7970
	Minneapolis
	Hennepin County Medical Center - Minneapolis
		Clinical Trials Office - Hennepin County Medical Center - Minneapolis	Ph:  612-873-5911
	Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
		Clinical Trials Office - Virginia Piper Cancer Institute	Ph:  612-863-5654
	Robbinsdale
	Humphrey Cancer Center at North Memorial Outpatient Center
		Clinical Trials Office - Humphrey Cancer Center at North Memorial Outpatient Center	Ph:  763-520-1893
	Saint Louis Park
	CCOP - Metro-Minnesota
		Joseph Leach	Ph:  952-993-1517
	Park Nicollet Cancer Center
		Joseph Leach	Ph:  952-993-3248
	Saint Paul
	United Hospital
		Joseph Leach	Ph:  651-241-8000
	Shakopee
	St. Francis Cancer Center at St. Francis Medical Center
		Joseph Leach	Ph:  952-403-2031
	St. Paul
	Regions Hospital Cancer Care Center
		Clinical Trials Office - Regions Hospital Cancer Care Center	Ph:  651-254-1517
	Stillwater
	Lakeview Hospital
		Joseph Leach	Ph:  651-439-5330 800-423-7212
	Willmar
	Willmar Cancer Center at Rice Memorial Hospital
		Joseph Leach	Ph:  320-231-4650 800-247-1478
	Woodbury
	Minnesota Oncology - Woodbury
		Joseph Leach	Ph:  651-735-7414
Missouri
	Chesterfield
	Saint Luke's Hospital
		Donald Busiek, MD	Ph:  314-205-6737
	Jefferson City
	Goldschmidt Cancer Center
		Alan Lyss, MD	Ph:  314-996-5514
	Saint Louis
	Comprehensive Cancer Care, PC
		Alan Lyss, MD	Ph:  314-996-5514
	Missouri Baptist Cancer Center
		Alan Lyss, MD	Ph:  314-996-5514
Montana
	Billings
	Billings Clinic - Downtown
		Clinical Trials Office - Billings Clinic - Downtown	Ph:  800-996-2663
			Email: research@billingsclinic.org
	CCOP - Montana Cancer Consortium
		Benjamin Marchello, MD	Ph:  406-238-6290
	Hematology-Oncology Centers of the Northern Rockies - Billings
		Benjamin Marchello, MD	Ph:  406-238-6290
	Bozeman
	Bozeman Deaconess Cancer Center
		Benjamin Marchello, MD	Ph:  406-238-6290
	Great Falls
	Big Sky Oncology
		Clinical Trial Office - Big Sky Oncology	Ph:  406-731-8217
	Great Falls Clinic - Main Facility
		Benjamin Marchello, MD	Ph:  406-238-6290
	Sletten Cancer Institute at Benefis Healthcare
		Benjamin Marchello, MD	Ph:  406-238-6290
	Kalispell
	Kalispell Regional Medical Center
		Benjamin Marchello, MD	Ph:  406-238-6290
	Missoula
	Montana Cancer Specialists at Montana Cancer Center
		Clinical Trials Office - Montana Cancer Specialists at Montana Cancer Center	Ph:  406-238-6962
New Hampshire
	Lebanon
	Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
		Clinical Trials Office - Norris Cotton Cancer Center	Ph:  603-650-7609
			Email: cancerhelp@dartmouth.edu
	Nashua
	Foundation Medical Partners
		Marcia Browne, MD	Ph:  781-237-0700
	Oncology Center at St. Joseph Hospital
		Mary Ann Voltz, MD	Ph:  603-880-3408
New Jersey
	Elizabeth
	Trinitas Comprehensive Cancer Center at Trinitas Hospital
		Gerardo Capo	Ph:  908-994-5000
	Long Branch
	Monmouth Medical Center
		Clinical Trials Office - Monmouth Medical Center	Ph:  732-923-7689
	Newark
	UMDNJ University Hospital
		Robert Wieder	Ph:  973-972-4300
	Vineland
	Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
		Clinical Trials Office - Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare	Ph:  856-641-7933
New Mexico
	Albuquerque
	Lovelace Medical Center - Downtown
		Zoneddy Dayao	Ph:  505-727-8000
	University of New Mexico Cancer Center
		Clinical Trials Office - University of New Mexico Cancer Center	Ph:  505-272-6972
New York
	Cooperstown
	Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital
		Eric Bravin, MD	Ph:  607-547-3336
	Glens Falls
	Charles R. Wood Cancer Center at Glens Falls Hospital
		Clinical Trials Office - Charles R. Wood Cancer Center at Glens Falls Hospital	Ph:  518-926-6700
Ohio
	Akron
	McDowell Cancer Center at Akron General Medical Center
		Esther Rehmus, MD	Ph:  330-344-6505
	Summa Center for Cancer Care at Akron City Hospital
		Clinical Trials Office - Akron City Hospital	Ph:  330-375-6101
	Bowling Green
	Wood County Oncology Center
		Rex Mowat	Ph:  419-352-9498
	Canton
	Aultman Cancer Center at Aultman Hospital
		Clinical Trials Office - Aultman Cancer Center at Aultman Hospital	Ph:  330-363-6891
	Dayton
	CCOP - Dayton
		Howard Gross, MD	Ph:  937-832-1093
	David L. Rike Cancer Center at Miami Valley Hospital
		Clinical Trials Office - David L. Rike Cancer Center at Miami Valley Hospital	Ph:  937-208-2079
	Samaritan North Cancer Care Center
		Howard Gross, MD	Ph:  937-832-1093
	Elyria
	Community Cancer Center
		Rex Mowat	Ph:  440-324-0400
	Hematology Oncology Center
		Rex Mowat	Ph:  440-324-0401
	Findlay
	Blanchard Valley Medical Associates
		Howard Gross, MD	Ph:  937-832-1093
	Franklin
	Middletown Regional Hospital
		Howard Gross, MD	Ph:  937-832-1093
	Greenville
	Wayne Hospital
		Howard Gross, MD	Ph:  937-832-1093
	Kettering
	Charles F. Kettering Memorial Hospital
		Clinical Trials Office - Charles F. Kettering Memorial Hospital	Ph:  937-298-3399 ext. 57556
	Lima
	Lima Memorial Hospital
		Rex Mowat	Ph:  419-228-3335
	Maumee
	Northwest Ohio Oncology Center
		Rex Mowat	Ph:  419-891-5600
	Oregon
	St. Charles Mercy Hospital
		Rex Mowat	Ph:  419-696-7200
	Toledo Clinic - Oregon
		Rex Mowat	Ph:  419-691-4235
	Sandusky
	North Coast Cancer Care, Incorporated
		Rex Mowat	Ph:  419-626-9090
	Sylvania
	Flower Hospital Cancer Center
		Clinical Trials Office - Flower Hospital Cancer Center	Ph:  419-824-1842
	Tiffin
	Mercy Hospital of Tiffin
		Rex Mowat	Ph:  419-447-3130
	Toledo
	CCOP - Toledo Community Hospital
		Rex Mowat	Ph:  419-843-6147
	Medical University of Ohio Cancer Center
		Clinical Trials Office - Medical University of Ohio Cancer Center	Ph:  419-383-6583
	St. Anne Mercy Hospital
		Rex Mowat	Ph:  419-407-2663
	Toledo Clinic, Incorporated - Main Clinic
		Rex Mowat	Ph:  419-479-5605
	Troy
	UVMC Cancer Care Center at Upper Valley Medical Center
		Clinical Trials Office - UVMC Cancer Care Center at Upper Valley Medical Center	Ph:  937-440-4842
	Wauseon
	Fulton County Health Center
		Clinical Trials Office - Fulton County Health Center	Ph:  419-330-2708
	Wright-Patterson Afb
	United States Air Force Medical Center - Wright-Patterson
		Brandon Cutler	Ph:  937-257-9133
	Xenia
	Ruth G. McMillan Cancer Center at Greene Memorial Hospital
		Howard Gross, MD	Ph:  937-832-1093
Oklahoma
	Norman
	Cancer Care Associates - Norman
		Vikki Canfield, MD	Ph:  405-751-4343
	Oklahoma City
	Cancer Care Associates - Mercy Campus
		Vikki Canfield, MD	Ph:  405-751-4343
	Tulsa
	Natalie Warren Bryant Cancer Center at St. Francis Hospital
		Jihad Khattab	Ph:  918-494-2273
Pennsylvania
	Danville
	Geisinger Cancer Institute at Geisinger Health
		Clinical Trials Office - Geisinger Cancer Institute	Ph:  570-271-5251
	Hazleton
	Geisinger Hazleton Cancer Center
		Harsh Gandhi	Ph:  570-459-2901
	Philadelphia
	Joan Karnell Cancer Center at Pennsylvania Hospital
		Bernard Mason, MD	Ph:  215-829-6088
	Phoenixville
	Cancer Center at Phoenixville Hospital
		Carl Sharer, DO	Ph:  610-983-1800
	Sayre
	Guthrie Cancer Center at Guthrie Clinic Sayre
		Clinical Trials Office - Guthrie Cancer Center at Guthrie Clinic Sayre	Ph:  800-836-0388
	State College
	Geisinger Medical Group - Scenery Park
		Harsh Gandhi	Ph:  814-231-4560
	Wilkes-Barre
	Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
		Clinical Trials Office - Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center	Ph:  570-271-5251
South Carolina
	Greenville
	CCOP - Greenville
		Jeffrey Giguere, MD, FACP	Ph:  864-987-7000
	Greenwood
	Self Regional Cancer Center at Self Regional Medical Center
		Jeffrey Giguere, MD, FACP	Ph:  864-987-7000
South Dakota
	Rapid City
	Rapid City Regional Hospital
		Richard Tenglin	Ph:  605-719-2360
Virginia
	Fredericksburg
	Fredericksburg Oncology, Incorporated
		Rex Mowat	Ph:  540-368-0500
Wisconsin
	Fond du Lac
	Central Wisconsin Cancer Program at Agnesian HealthCare
		Clinical Trials Office - Central Wisconsin Cancer Program at Agnesian HealthCare	Ph:  800-494-2927
	Green Bay
	Green Bay Oncology, Limited at St. Mary's Hospital
		Anthony Jaslowski, MD, FACP	Ph:  920-884-3135
	Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
		Anthony Jaslowski, MD, FACP	Ph:  920-884-3135
	Janesville
	Mercy Regional Cancer Center
		Robert Delaune, MD	Ph:  952-993-1517
	La Crosse
	Gundersen Lutheran Center for Cancer and Blood
		Clinical Trials Office - Gundersen Lutheran Cancer Center	Ph:  608-775-2385
			Email: cancerctr@gundluth.org
	Mukwonago
	D.N. Greenwald Center
		Michael Thompson
	Oconomowoc
	Regional Cancer Center at Oconomowoc Memorial Hospital
		Clinical Trials Office - Regional Cancer Center at Oconomowoc Memorial Hospital	Ph:  262-928-7878
	Waukesha
	Waukesha Memorial Hospital Regional Cancer Center
		Clinical Trials Office - Waukesha Memorial Hospital Regional Cancer Center	Ph:  262-928-7632

Registry Information
Official Title		Phase II placebo-controlled trial of lisinopril and Coreg CR® to reduce cardiotoxicity in patients with breast cancer receiving (neo)adjuvant chemotherapy with trastuzumab (Herceptin®)
Trial Start Date		2010-03-01
Trial Completion Date		2013-03-01 (estimated)
Registered in ClinicalTrials.gov		NCT01009918
Date Submitted to PDQ		2009-11-04
Information Last Verified		2012-05-19
NCI Grant/Contract Number		CA81920

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