Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Related Publications
Trial Contact Information
Related Information
Registry Information

Alternate Title

Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)

Basic Trial Information

Special Category: NCI Web site featured trial, CTSU trial

Objectives

Primary

1. Compare the disease-free survival of women with previously resected axillary-node negative breast cancer with an Oncotype DX Recurrence Score (ODRS) of 11-25 treated with adjuvant combination chemotherapy and hormonal therapy vs adjuvant hormonal therapy alone.
2. Compare the distant recurrence-free interval, recurrence-free interval, and overall survival of patients with an ODRS of 11-25 treated with these regimens.
3. Create a tissue and specimen bank that includes formalin-fixed, paraffin-embedded tumor specimens, tissue microarrays, plasma, and DNA obtained from peripheral blood of patients enrolled in this trial.

Secondary

1. Determine if adjuvant hormonal therapy alone is sufficient treatment (i.e., 10-year distant disease-free survival of at least 95%) for patients with an ODRS of ≤ 10.
2. Determine the disease-free survival, distant recurrence-free interval, recurrence-free interval, and overall survival of patients with ODRS of ≤ 10.
3. Compare the outcomes projected at 10 years using classical pathologic information, including tumor size, hormone receptor status, and histologic grade, with those made by the Genomic Health Oncotype DX test in patients treated with these regimens.
4. Estimate failure rates as a function of ODRS separately in patients treated with combination chemotherapy (group 2/arm II and group 3) and in patients treated with no chemotherapy (group 1 and group 2/arm I).
5. Determine the prognostic significance of the ODRS and of the individual recurrent score gene groups (proliferation gene group, HER2 gene group, estrogen receptor gene group, invasion gene group, and other genes) in patients treated with these regimens.

Tertiary

1. To evaluate the effects of chemotherapy and hormonal therapy vs hormonal therapy alone on perceived cognitive impairment, fatigue, fear of recurrence among pre-menopausal patients, endocrine symptoms and sexual dysfunction, and overall health-related quality of life (HRQL).
2. To determine whether perceived cognitive impairment, fatigue, fear of recurrence, endocrine symptoms, and overall HRQL are similar for patients receiving chemotherapy plus hormonal therapy in secondary study group 2 as for those in the primary study group (arm D vs C).
3. To determine whether perceived cognitive impairment, fatigue, fear of recurrence, endocrine symptoms, and overall HRQL are similar for patients receiving hormonal therapy alone in secondary study group 1 as for those in the primary study group (arms A vs B).
4. To determine whether age will be inversely associated with a fear of recurrence, independent of treatment assignment.
5. Among participants receiving hormonal treatment alone on arm A and arm B, to determine whether ODRS will be inversely correlated with fear of recurrence.

Entry Criteria

Disease Characteristics:

• Histologically confirmed adenocarcinoma of the breast

• Hormone receptor status: estrogen and/or progesterone receptor positive tumor

• Her2/neu negative tumor by either fluorescent in situ hybridization (FISH) or immunohistochemistry (e.g., 0 or 1+ by DAKO Herceptest)

• Must have undergone surgery to remove the primary tumor by either a mastectomy or local excision plus an acceptable axillary procedure (i.e., sentinel lymph node biopsy and/or axillary dissection) within the past 84 days
  • Must have adequate (i.e., ≥ 1 mm, if margin width specified) tumor-free margins of resection for invasive and ductal carcinoma in situ
    • Lobular carcinoma in situ involving the resection margins are allowed
  • Negative axillary nodes as determined by a sentinel lymph node biopsy and/or axillary dissection as defined by the American Joint Committee on Cancer sixth edition staging system

• Tumor size 1.1-5.0 cm
  • Tumors that measure 5 mm-1.0 cm are allowed provided there are unfavorable histological features, defined as intermediate or poor nuclear and/or histologic grade or lymphovascular invasion
  • Pathologic tumor size should be used
    • If microscopic measurement is used and tumor includes ductal carcinoma in situ, the measurement should include only the invasive component of the tumor

• Tissue specimen from the primary tumor available for diagnostic testing with Oncotype DX to determine Oncotype Recurrence Score
  • No prior Oncotype DX Assay unless patient has a recurrence score of 11-25

• Patients who develop breast cancer while receiving a selective estrogen-receptor modulator (SERM) (e.g., tamoxifen, toremifene, or raloxifene) or an aromatase inhibitor (e.g., anastrazole, letrozole, or exemestane) for breast cancer prevention or a SERM for other indications (e.g., raloxifene for osteoporosis) are ineligible

• No prior ipsilateral or contralateral invasive breast cancer, bilateral synchronous cancers, or prior ipsilateral or contralateral ductal carcinoma in situ

Prior/Concurrent Therapy:

• See Disease Characteristics
• No prior chemotherapy or radiotherapy (including MammoSite^® brachytherapy radiotherapy) for this cancer
• Prior SERM or aromatase inhibitor therapy that was administered for up to 8 weeks for this cancer is allowed
• No concurrent radiotherapy with chemotherapy
• Concurrent enrollment on another CTSU study allowed provided patient is already enrolled on ECOG-PACCT-1 and the treatment options in the other study are consistent with PACCT-1-specified treatment assignment (i.e., chemohormonal therapy or hormonal therapy alone)

Patient Characteristics:

• Female only
• Any menopausal status allowed
• WBC count ≥ 3,500/mm³
• Platelet count ≥ 100,000/mm³
• Creatinine ≤ 1.5 mg/dL
• AST ≤ 3 times upper limit of normal
• Life expectancy ≥ 10 years
• No chronic obstructive pulmonary disease requiring treatment
• No chronic liver disease (e.g., cirrhosis or chronic active hepatitis)
• No history of cerebrovascular accident
• No history of congestive heart failure or other cardiac disease that would contradict the use of an anthracycline (e.g., doxorubicin hydrochloride or epirubicin)
• No chronic psychiatric condition or other condition that would preclude study compliance
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective nonhormonal contraception (e.g., intrauterine device, condoms, diaphragm, abstinence)
• No other invasive malignancies within the past 5 years except curatively treated basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix

Expected Enrollment

A total of 11,248 patients will be accrued for this study.

Outcomes

Disease-free survival
Distant recurrence-free interval
Recurrence-free interval
Overall survival
Comparison of FACT-Cog perceived cognitive impairment scores between participants on arm B and arm at 3 months

Comparison of FACT-Cog scores between arms B and C at 3, 12, 18, 24, and 36 months
Differences in FACT-Cog change scores from randomization to 3, 6, 12, 18, 24, and 36 months
Differences between arms B and C on other patient-reported outcomes measures
Differences between participants receiving hormonal treatment alone (arm B vs arm A) on patient-reported outcomes measures
Differences between participants receiving chemotherapy followed by hormonal treatment (arm C vs arm D) on patient-reported outcomes measures

Outline

This is a multicenter, partially randomized study. Patients are assigned to 1 of 3 treatment groups based on their risk of distant recurrence determined by Oncotype DX Breast Cancer Assay.

• Group 1 (Secondary study group 1; Oncotype DX recurrence score [ODRS] < 11): Patients receive standard hormonal therapy (e.g., oral tamoxifen alone, oral aromatase inhibitor [e.g., anastrozole, letrozole, or exemestane] alone, or oral tamoxifen followed by oral aromatase inhibitor) at the discretion of the treating physician for 5 or 10 years.

• Group 2 (Primary study group; ODRS 11-25): Patients are stratified according to tumor size (≤ 2.0 cm vs ≥ 2.1 cm), menopausal status (postmenopausal vs premenopausal vs perimenopausal), planned chemotherapy (taxane-containing [i.e., paclitaxel, docetaxel] vs nontaxane-containing), planned radiotherapy (whole breast with no boost planned vs whole breast with boost planned vs partial breast irradiation planned vs no planned radiation therapy [for patients who have had a mastectomy]) and Oncotype DX Recurrence Score (11-15 vs 16-20 vs 21-25). Patients are then randomized to receive either hormonal therapy alone or combination chemotherapy and hormonal therapy.
  • Arm I (experimental): Patients receive hormonal therapy as in group 1 at the discretion of the treating physician.

  • Arm II (standard): Patients receive standard combination chemotherapy at the discretion of the treating physician. Within 4 weeks after the last dose of chemotherapy, patients receive hormonal therapy as in group 1 at the discretion of the treating physician.

• Group 3 (Secondary study group 2; ODRS > 25): Patients receive combination chemotherapy as in group 2, arm II followed by hormonal therapy as in group 1.

Patients in all groups who have had breast-conservation surgery are also treated with radiotherapy. Radiotherapy should begin within 4 weeks of registration for patients receiving hormonal therapy alone or within 8 weeks after completion of chemotherapy. Patients participating in NSABP and/or RTOG partial irradiation trial(s) may receive partial breast radiation.

Tissue obtained at surgery (performed prior to study entry) is examined by the Oncotype DX Recurrence Score Assay and other assays to correlate response with various biomarkers.

Patients may complete quality-of-life assessments at baseline and at 3, 6, 12, 24, and 36 months.

After completion of study treatment, patients are followed up periodically for up to 20 years.

Zujewski JA, Kamin L: Trial assessing individualized options for treatment for breast cancer: the TAILORx trial. Future Oncol 4 (5): 603-10, 2008.[PUBMED Abstract]

Trial Contact Information

Trial Lead Organizations

Eastern Cooperative Oncology Group

Joseph Sparano, MD, Protocol chair		Ph: 718-920-4826 Email: jsparano@montefiore.org

Southwest Oncology Group

Daniel Hayes, MD, Protocol chair		Ph: 734-615-6725; 800-865-1125 Email: hayesdf@umich.edu

Cancer and Leukemia Group B

Elizabeth Dees, MD, Protocol chair		Ph: 919-966-4431

American College of Surgeons Oncology Group

John Olson, MD, PhD, Protocol chair		Ph: 919-668-1767 Email: jaomd@duke.edu

North Central Cancer Treatment Group

Edith Perez, MD, Protocol chair		Ph: 507-284-1159 Email: perez.edith@mayo.edu

NCIC-Clinical Trials Group

Kathleen Pritchard, MD, Protocol chair		Ph: 416-480-4616 Email: kathy.pritchard@sunnybrook.ca

National Surgical Adjuvant Breast and Bowel Project

Charles Geyer, FACP, MD, Protocol chair		Ph: 412-359-8353; 866-680-0004

U.S.A.
Alabama
	Mobile
	University of South Alabama Mitchell Cancer Institute
		Hung Khong	Ph:  251-460-6993
Arkansas
	Little Rock
	Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
		Clinical Trial Office - Arkansas Cancer Research Center at University of Arkansas for Medical Sciences	Ph:  501-686-8274
California
	Berkeley
	Alta Bates Summit Comprehensive Cancer Center
		Clinical Trials Office - Alta Bates Summit Comprehensive Cancer Center	Ph:  510-204-3428
	Burbank
	Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center
		Clinical Trials Office - Providence Saint Joseph Medical Center - Burbank	Ph:  818-847-3220
	Burlingame
	Peninsula Medical Center
		David Irwin, MD	Ph:  510-204-1591
	La Jolla
	Scripps Cancer Center - San Diego
		Joan Kroener, MD	Ph:  858-554-8629
	Loma Linda
	Loma Linda University Cancer Institute at Loma Linda University Medical Center
		Clinical Trials Office - Loma Linda University Cancer Institute	Ph:  909-558-3375
	Los Angeles
	Jonsson Comprehensive Cancer Center at UCLA
		Clinical Trials Office - Jonsson Comprehensive Cancer Center at UCLA	Ph:  888-798-0719
	USC/Norris Comprehensive Cancer Center and Hospital
		Clinical Trials Office - USC/Norris Comprehensive Cancer Center and Hospital	Ph:  323-865-0451
	Marysville
	Tibotec Therapeutics - Division of Ortho Biotech Products, LP
		Helen Chew, MD	Ph:  916-734-3771
	Mission Hills
	Providence Holy Cross Cancer Center
		Shamel Sanani, MD	Ph:  818-365-3099
	Modesto
	Memorial Medical Center
		Clinical Trials Office - Memorial Medical Center	Ph:  209-572-7116
	Orange
	Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
		Clinical Trials Office - Chao Family Comprehensive Cancer Center	Ph:  877-UC-STUDY
			Email: ucstudy@uci.edu
	Pleasanton
	Valley Medical Oncology Consultants - Pleasanton
		Helen Chew, MD	Ph:  916-734-3771
	Sacramento
	University of California Davis Cancer Center
		Clinical Trials Office - University of California Davis Cancer Center	Ph:  916-734-3089
	San Diego
	Naval Medical Center - San Diego
		Jarrod Holmes	Ph:  619-532-7303
	Sharp Memorial Hospital Cancer Center
		Clinical Trials Office - Sharp Memorial Hospital Cancer Center	Ph:  858-939-5015
	San Francisco
	California Pacific Medical Center - California Campus
		David Irwin, MD	Ph:  510-204-1591
	San Rafael
	Sutter Health - Western Division Cancer Research Group
		David Irwin, MD	Ph:  510-204-1591
	Vallejo
	Sutter Solano Medical Center
		David Irwin, MD	Ph:  510-204-1591
Colorado
	Boulder
	Boulder Community Hospital
		Clinical Trials Office - Boulder Community Hospital	Ph:  303-938-5253
	Colorado Springs
	Penrose Cancer Center at Penrose Hospital
		Clinical Trials Office - Penrose Cancer Center	Ph:  719-776-5275
	Denver
	CCOP - Colorado Cancer Research Program
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Porter Adventist Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	St. Joseph Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Grand Junction
	St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Greeley
	North Colorado Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Longmont
	Hope Cancer Care Center at Longmont United Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Wheat Ridge
	Exempla Lutheran Medical Center
		Clinical Trials Office - Exempla Lutheran Medical Center	Ph:  303-403-3605
Connecticut
	Greenwich
	Bendheim Cancer Center at Greenwich Hospital
		Clinical Trials Office - Bendheim Cancer Center	Ph:  203-863-3698
	Hartford
	Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
		Philip Stella, MD	Ph:  734-712-1000
	Norwich
	Eastern Connecticut Hematology and Oncology Associates
		Dennis Slater, MD	Ph:  860-886-8362
District of Columbia
	Washington
	Walter Reed Army Medical Center
		Clinical Trials Office - Walter Reed Army Medical Center	Ph:  202-782-7840
Florida
	Fort Lauderdale
	Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
		Clinical Trials Office - Michael and Dianne Bienes Comprehensive Cancer Center	Ph:  954-776-3239
	Gainesville
	University of Florida Shands Cancer Center
		Clinical Trials Office - University of Florida Shands Cancer Center	Ph:  888-254-7581
	Jupiter
	Ella Milbank Foshay Cancer Center at Jupiter Medical Center
		Clinical Trials Office - Ella Milbank Foshay Cancer Center	Ph:  561-745-5768
	Miami Beach
	CCOP - Mount Sinai Medical Center
		Rogerio Lilenbaum, MD	Ph:  305-535-3310
	Weston
	Cleveland Clinic Florida - Weston
		Clinical Trials Office - Cleveland Clinic Florida - Weston	Ph:  954-659-5705
Georgia
	Augusta
	Augusta Oncology Associates - Walton Way
		Alice David	Ph:  706-821-2944
Idaho
	Boise
	Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
		Clinical Trials Office - Saint Alphonsus Cancer Care Center	Ph:  208-367-7954
Illinois
	Chicago
	John H. Stroger, Jr. Hospital of Cook County
		Thomas Lad, MD	Ph:  312-864-3200
	Elmhurst
	Elmhurst Memorial Hospital
		Robert Eisner	Ph:  630-833-1400
	Moline
	Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
		Costas Constantinou, MD	Ph:  563-359-9876
	Normal
	Mid-Illinois Hematology-Oncology Associates at Community Cancer Center
		John Migas, MD	Ph:  309-451-2207
	Olympia Fields
	Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields
		Clinical Trials Office - Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields	Ph:  708-679-2217
	Rockford
	Swedish-American Regional Cancer Center
		Clinical Trials Office - Swedish-American Regional Cancer Center	Ph:  815-489-4413
Indiana
	Indianapolis
	Community Regional Cancer Care at Community Hospital East
		Sumeet Bhatia	Ph:  317-355-5347
	Community Regional Cancer Care at Community Hospital North
		Sumeet Bhatia	Ph:  317-621-4300
	Munster
	Community Hospital
		Erwin Robin, MD	Ph:  219-836-2860
Iowa
	Bettendorf
	Hematology Oncology Associates of the Quad Cities
		Shobha Chitneni, MD, MBBS	Ph:  563-355-7733
	Ottumwa
	McCreery Cancer Center at Ottumwa Regional
		Robert Behrens	Ph:  641-684-2946
	Waterloo
	Covenant Cancer Treatment Center
		Clinical Trials Office - Covenant Cancer Treatment Center	Ph:  319-272-2070
Louisiana
	Alexandria
	Tulane Cancer Center Office of Clinical Research
		Clinical Trials Office - Tulane Cancer Center	Ph:  504-988-6121
	Baton Rouge
	Mary Bird Perkins Cancer Center - Baton Rouge
		Robert Veith	Ph:  225-767-0847
	Ochsner Health Center - Bluebonnet
		Jyotsna Fuloria	Ph:  225-761-5200
	Covington
	Ochsner Health Center - Covington
		Jyotsna Fuloria	Ph:  985-875-2828 866-624-7637
	New Orleans
	CCOP - Ochsner
		Jyotsna Fuloria	Ph:  504-842-3910
	MBCCOP - LSU Health Sciences Center
		Robert Veith	Ph:  504-568-5151
	Ochsner Cancer Institute at Ochsner Clinic Foundation
		Jyotsna Fuloria	Ph:  504-842-4360 888-624-7637
	Shreveport
	Christus Schumpert Cancer Treatment Center
		Clinical Trials Office - Christus Schumpert Cancer Treatment Center	Ph:  318-681-4763
	Feist-Weiller Cancer Center at Louisiana State University Health Sciences
		Clinical Trials Office - Feist-Weiller Cancer Center at Louisiana State University Health Sciences	Ph:  318-813-1412
Maine
	Augusta
	Harold Alfond Center for Cancer Care
		Donald Magioncalda, MD	Ph:  207-626-1000
	Scarborough
	Maine Center for Cancer Medicine and Blood Disorders - Scarborough
		Tracey Weisberg, MD	Ph:  207-885-7634
	York
	York Hospital's Oncology Treatment Center
		Jonathan Eneman	Ph:  207-351-3777
Maryland
	Cumberland
	Regional Cancer Center at Western Maryland Health System - Sacred Heart Campus
		Alida Podrumar	Ph:  301-723-5536
	Easton
	Shore Regional Cancer Center at Memorial Hospital - Easton
		Mary DeShields, MD	Ph:  410-819-3332
	Frederick
	Frederick Memorial Hospital Regional Cancer Therapy Center
		Brian O'Connor, MD	Ph:  301-662-8477
	Silver Spring
	Holy Cross Hospital
		Clinical Trials Office - Holy Cross Hospital	Ph:  310-754-7552
	Towson
	Cancer Institute at St. Joseph Medical Center
		Hector Silva	Ph:  410-337-1000
Massachusetts
	Attleboro
	Sturdy Memorial Hospital
		Michael Vasconcelles, MD	Ph:  617-632-5301
	Boston
	Tufts Medical Center Cancer Center
		John Nystrom	Ph:  617-636-6100
	Burlington
	Lahey Clinic Medical Center - Burlington
		Clinical Trials Office - Lahey Clinic Medical Center - Burlington	Ph:  781-744-8027
	Pittsfield
	Berkshire Hematology Oncology, PC
		Harvey Zimbler, MD	Ph:  413-496-8205
	Quincy
	Commonwealth Hematology-Oncology, PC - Quincy
		Susan Sajer, MD	Ph:  978-287-3436
	Worcester
	Saint Vincent Hospital at Worcester Medical Center
		Clinical Trials Office - Saint Vincent Hospital at Worcester Medical Center	Ph:  508-363-7018
	UMASS Memorial Cancer Center - University Campus
		Kathryn Edmiston, MD	Ph:  508-334-5141
Michigan
	Adrian
	Hickman Cancer Center at Bixby Medical Center
		Clinical Trials Office - Hickman Cancer Center at Bixby Medical Center	Ph:  517-265-0116
	Ann Arbor
	CCOP - Michigan Cancer Research Consortium
		Philip Stella, MD	Ph:  734-712-1000
	Saint Joseph Mercy Cancer Center
		Philip Stella, MD	Ph:  734-712-1000
	Dearborn
	Oakwood Cancer Center at Oakwood Hospital and Medical Center
		Clinical Trials Office - Oakwood Cancer Center at Oakwood Hospital and Medical Center	Ph:  313-593-8090
	Detroit
	Josephine Ford Cancer Center at Henry Ford Hospital
		Robert Chapman, MD	Ph:  313-916-1332
	Flint
	Genesys Hurley Cancer Institute
		Clinical Trials Office - Genesys Hurley Cancer Institute	Ph:  810-762-8057
	Grosse Pointe Woods
	Van Elslander Cancer Center at St. John Hospital and Medical Center
		Clincial Trials Office - Van Elslander Cancer Center at St. John Hospital and Medical Center	Ph:  313-343-3166
	Lansing
	Sparrow Regional Cancer Center
		Clinical Trials Office - Sparrow Regional Cancer Center	Ph:  517-364-2890
	Livonia
	St. Mary Mercy Hospital
		Philip Stella, MD	Ph:  734-712-1000
	Monroe
	Community Cancer Center of Monroe
		Paul Schaefer, MD	Ph:  419-479-5605
	Mercy Memorial Hospital - Monroe
		Paul Schaefer, MD	Ph:  419-479-5605
	Mount Clemens
	Clemens Regional Medical Center
		Clinical Trials Office - Ted B. Wahby Cancer Center at Mount Clemens General Hospital	Ph:  586-493-3426
	Pontiac
	St. Joseph Mercy Oakland
		Philip Stella, MD	Ph:  734-712-1000
	Port Huron
	Mercy Regional Cancer Center at Mercy Hospital
		Philip Stella, MD	Ph:  734-712-1000
	Royal Oak
	William Beaumont Hospital - Royal Oak Campus
		Clinical Trials Office - William Beaumont Hospital - Royal Oak Campus	Ph:  248-551-7695
	Saginaw
	Seton Cancer Institute at Saint Mary's - Saginaw
		Clinical Trials Office - Seton Cancer Institute - Saginaw	Ph:  989-776-8411
	Warren
	St. John Macomb Hospital
		Philip Stella, MD	Ph:  734-712-1000
Minnesota
	Duluth
	CCOP - Duluth
		Daniel Nikcevich, MD, PhD	Ph:  218-786-3625
	Duluth Clinic Cancer Center - Duluth
		Clinical Trials Office - Duluth Clinic Cancer Center - Duluth	Ph:  218-786-3308
	Miller - Dwan Medical Center
		Daniel Nikcevich, MD, PhD	Ph:  218-786-3625
Mississippi
	Jackson
	Jackson Oncology Associates, PLLC
		Jyotsna Fuloria	Ph:  601-355-2485
	Pascagoula
	Regional Cancer Center at Singing River Hospital
		James Clarkson, MD	Ph:  228-374-6296
Missouri
	Cape Girardeau
	Saint Francis Medical Center
		Bethany Sleckman, MD	Ph:  314-251-7057
	Columbia
	Ellis Fischel Cancer Center at University of Missouri - Columbia
		Clinical Trial Office - Ellis Fischel Cancer Center	Ph:  573-882-7440
	Saint Louis
	David C. Pratt Cancer Center at St. John's Mercy
		Clinical Trials Office - David C. Pratt Cancer Center at St. John's Mercy	Ph:  314-251-6770
	Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
		Michael Naughton, MD	Ph:  314-996-8872
	Springfield
	CCOP - Cancer Research for the Ozarks
		Robert Carolla	Ph:  417-269-4520
	Hulston Cancer Center at Cox Medical Center South
		Robert Carolla	Ph:  417-269-5257
Montana
	Billings
	Billings Clinic - Downtown
		Clinical Trials Office - Billings Clinic - Downtown	Ph:  800-996-2663
			Email: research@billingsclinic.org
	CCOP - Montana Cancer Consortium
		Benjamin Marchello, MD	Ph:  406-238-6290
	Hematology-Oncology Centers of the Northern Rockies - Billings
		Benjamin Marchello, MD	Ph:  406-238-6290
	St. Vincent Healthcare Cancer Care Services
		Benjamin Marchello, MD	Ph:  406-238-6290
	Bozeman
	Bozeman Deaconess Cancer Center
		Benjamin Marchello, MD	Ph:  406-238-6290
	Butte
	St. James Healthcare Cancer Care
		Benjamin Marchello, MD	Ph:  406-238-6290
	Great Falls
	Great Falls Clinic - Main Facility
		Benjamin Marchello, MD	Ph:  406-238-6290
	Sletten Cancer Institute at Benefis Healthcare
		Benjamin Marchello, MD	Ph:  406-238-6290
	Havre
	Northern Montana Hospital
		Benjamin Marchello, MD	Ph:  406-238-6290
	Helena
	St. Peter's Hospital
		Benjamin Marchello, MD	Ph:  406-238-6290
	Kalispell
	Glacier Oncology, PLLC
		Benjamin Marchello, MD	Ph:  406-238-6290
	Kalispell Medical Oncology at KRMC
		Benjamin Marchello, MD	Ph:  406-238-6290
	Kalispell Regional Medical Center
		Benjamin Marchello, MD	Ph:  406-238-6290
	Missoula
	Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
		Clinical Trials Office - Montana Cancer Center at St. Patrick Hospital and Health Sciences Center	Ph:  406-329-7029
	Montana Cancer Specialists at Montana Cancer Center
		Clinical Trials Office - Montana Cancer Specialists at Montana Cancer Center	Ph:  406-238-6962
Nebraska
	Grand Island
	Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
		Elizabeth Reed, MD	Ph:  402-559-5388
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		John Ellerton, MD, CM	Ph:  702-384-0013
	Reno
	Renown Institute for Cancer at Renown Regional Medical Center
		Steven Schiff, MD	Ph:  775-329-0873
New Hampshire
	Exeter
	Center for Cancer Care at Exeter Hospital
		Michael Buff	Ph:  603-580-6636
	Keene
	Kingsbury Center for Cancer Care at Cheshire Medical Center
		Steven Larmon	Ph:  603-354-5400
	Nashua
	Foundation Medical Partners
		Marcia Browne, MD	Ph:  781-237-0700
New Jersey
	Freehold
	CentraState Medical Center
		Jeffrey Silberberg, MD	Ph:  732-431-8400
	Ridgewood
	Valley Hospital - Ridgewood
		Thomas Rakowski, MD	Ph:  201-444-4526
	Sparta
	Frederick R. and Betty M. Smith Cancer Treatment Center
		Allison Zibelli, MD	Ph:  215-923-5676
	Summit
	Overlook Hospital
		Bonni Guerin	Ph:  908-522-2000
New Mexico
	Albuquerque
	Hematology Oncology Associates, PC
		Melanie Royce, MD, PhD	Ph:  505-272-6057
	Lovelace Medical Center - Downtown
		Melanie Royce, MD, PhD	Ph:  505-272-6057
	Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital
		Melanie Royce, MD, PhD	Ph:  505-272-6057
	University of New Mexico Cancer Center
		Clinical Trials Office - University of New Mexico Cancer Center	Ph:  505-272-6972
	Santa Fe
	New Mexico Cancer Care Associates
		Clinical Trials Office - New Mexico Cancer Care Associates	Ph:  505-955-7910
New York
	Plattsburgh
	Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center
		Jan Duus, MD	Ph:  518-562-7110
	Rochester
	Highland Hospital of Rochester
		Richard Fisher, MD	Ph:  585-275-0842
	James P. Wilmot Cancer Center at University of Rochester Medical Center
		Richard Fisher, MD	Ph:  585-275-0842
	Lipson Cancer and Blood Center at Rochester General Hospital
		Peter Bushunow, MD	Ph:  585-922-4020
North Carolina
	Charlotte
	Blumenthal Cancer Center at Carolinas Medical Center
		Clinical Trials Office - Blumenthal Cancer Center at Carolinas Medical Center	Ph:  704-355-2884
	Durham
	Duke Cancer Institute
		Clinical Trials Office - Duke Cancer Institute	Ph:  888-275-3853
	Fayetteville
	Cape Fear Valley Medical Center Cancer Center
		Clinical Trial Office - Cape Fear Valley Medical Center Cancer Center	Ph:  910-609-4561
	Greenville
	Leo W. Jenkins Cancer Center at ECU Medical School
		Clinical Trials Office - Leo W. Jenkins Cancer Center at ECU Medical School	Ph:  252-744-2391
	Henderson
	Maria Parham Medical Center
		Jeffrey Crawford, MD	Ph:  919-681-9509
	Lumberton
	Southeastern Regional Medical Center
		Jeffrey Crawford, MD	Ph:  919-681-9509
	Oxford
	Granville Medical Center
		Jeffrey Crawford, MD	Ph:  919-681-9509
	Pinehurst
	FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
		Clinical Trials Office - FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center	Ph:  910-715-2200
	Raleigh
	Duke Health Raleigh Hospital
		Jeffrey Crawford, MD	Ph:  919-681-9509
	Rex Cancer Center at Rex Hospital
		Clinical Trials Office - Rex Cancer Center	Ph:  919-784-7209
	Roxboro
	Person Memorial Hospital
		Jeffrey Crawford, MD	Ph:  919-681-9509
	Statesville
	Iredell Memorial Hospital
		Ruby Grimm, MD	Ph:  704-873-2219
	Winston-Salem
	Wake Forest University Comprehensive Cancer Center
		Clinical Trials Office - Wake Forest University Comprehensive Cancer Center	Ph:  336-713-6771
Ohio
	Bowling Green
	Wood County Oncology Center
		Paul Schaefer, MD	Ph:  419-479-5605
	Canton
	Aultman Cancer Center at Aultman Hospital
		Clinical Trials Office - Aultman Cancer Center at Aultman Hospital	Ph:  330-363-6891
	Chillicothe
	Adena Regional Medical Center
		Clinical Trials Office - Adena Regional Medical Center	Ph:  877-779-7585
	Cincinnati
	Charles M. Barrett Cancer Center at University Hospital
		Elizabeth Shaughnessy, MD	Ph:  513-584-8900
	Christ Hospital Cancer Center
		Robert Cody, MD	Ph:  513-321-4333
	Cleveland
	Case Comprehensive Cancer Center
		Clinical Trials Office - Case Comprehensive Cancer Center	Ph:  800-641-2422
	Clyde
	North Coast Cancer Care - Clyde
		Paul Schaefer, MD	Ph:  419-479-5605
	Columbus
	Doctors Hospital at Ohio Health
		Clinical Trials Office - Doctors Hospital at Ohio Health	Ph:  614-566-3275
	Grant Medical Center Cancer Care
		Clinical Trials Office - Grant Medical Center Cancer Care	Ph:  614-566-4475
	Mount Carmel Health - West Hospital
		J. Philip Kuebler, MD, PhD	Ph:  614-442-3130
	Riverside Methodist Hospital Cancer Care
		Clinical Trials Office - Riverside Methodist Hospital Cancer Care	Ph:  614-566-4475
	Delaware
	Grady Memorial Hospital
		J. Philip Kuebler, MD, PhD	Ph:  614-442-3130
	Lima
	Lima Memorial Hospital
		Paul Schaefer, MD	Ph:  419-479-5605
	St. Rita's Medical Center
		Clinical Trials Office - St. Rita's Medical Center	Ph:  419-226-9617
	Marietta
	Strecker Cancer Center at Marietta Memorial Hospital
		J. Philip Kuebler, MD, PhD	Ph:  614-442-3130
	Maumee
	Northwest Ohio Oncology Center
		Paul Schaefer, MD	Ph:  419-479-5605
		Paul Schaefer, MD	Ph:  419-479-5605
	Newark
	Licking Memorial Cancer Care Program at Licking Memorial Hospital
		J. Philip Kuebler, MD, PhD	Ph:  614-442-3130
	Norwalk
	Fisher-Titus Medical Center
		Paul Schaefer, MD	Ph:  419-479-5605
	Oregon
	St. Charles Mercy Hospital
		Paul Schaefer, MD	Ph:  419-479-5605
	Toledo Clinic - Oregon
		Paul Schaefer, MD	Ph:  419-479-5605
	Sandusky
	North Coast Cancer Care, Incorporated
		Paul Schaefer, MD	Ph:  419-479-5605
	Springfield
	Community Hospital of Springfield and Clark County
		J. Philip Kuebler, MD, PhD	Ph:  614-442-3130
	Sylvania
	Flower Hospital Cancer Center
		Clinical Trials Office - Flower Hospital Cancer Center	Ph:  419-824-1842
	Tiffin
	Mercy Hospital of Tiffin
		Paul Schaefer, MD	Ph:  419-479-5605
	Toledo
	CCOP - Toledo Community Hospital
		Paul Schaefer, MD	Ph:  419-479-5605
	Medical University of Ohio Cancer Center
		Clinical Trials Office - Medical University of Ohio Cancer Center	Ph:  419-383-6583
	St. Anne Mercy Hospital
		Paul Schaefer, MD	Ph:  419-479-5605
	St. Vincent Mercy Medical Center
		Paul Schaefer, MD	Ph:  419-479-5605
	Toledo Clinic, Incorporated - Main Clinic
		Paul Schaefer, MD	Ph:  419-479-5605
	Toledo Hospital
		Clinical Trials Office - Toledo Hospital	Ph:  419-824-1842
	Wauseon
	Fulton County Health Center
		Clinical Trials Office - Fulton County Health Center	Ph:  419-330-2708
	Westerville
	Mount Carmel St. Ann's Cancer Center
		J. Philip Kuebler, MD, PhD	Ph:  614-442-3130
	Wright-Patterson Afb
	United States Air Force Medical Center - Wright-Patterson
		Roger Wood	Ph:  937-257-9133
	Zanesville
	Genesis - Good Samaritan Hospital
		Clinical Trials Office - Genesis - Good Samaritan Hospital	Ph:  740-454-5232
Oklahoma
	Lawton
	Cancer Centers of Southwest Oklahoma, LLC - Lawton
		Nadim Nimeh, MD	Ph:  580-536-2121ext.113
	Norman
	Cancer Care Associates - Norman
		Vikki Canfield, MD	Ph:  405-751-4343
	Oklahoma City
	Cancer Care Associates - Mercy Campus
		Vikki Canfield, MD	Ph:  405-751-4343
	Cancer Care Associates at Troy and Dollie Smith Cancer Center
		Vikki Canfield, MD	Ph:  405-751-4343
	Tulsa
	Natalie Warren Bryant Cancer Center at St. Francis Hospital
		Joseph Lynch, MD	Ph:  918-494-8275
Oregon
	Milwaukie
	Providence Milwaukie Hospital
		Janet Ruzich	Ph:  503-513-8300
	Portland
	Adventist Medical Center
		Janet Ruzich	Ph:  503-257-2500
	CCOP - Columbia River Oncology Program
		Janet Ruzich	Ph:  503-216-6260
	Providence Cancer Center at Providence Portland Medical Center
		Clinical Trials Office - Providence Cancer Center at Providence Portland Medical Center	Ph:  503-215-6412
	Providence St. Vincent Medical Center
		Clinical Trials Office - Providence St. Vincent Medical Center	Ph:  503-215-6412
Pennsylvania
	Abington
	Rosenfeld Cancer Center at Abington Memorial Hospital
		Clinical Trials Office - Rosenfeld Cancer Center at Abington Memorial Hospital	Ph:  215-481-2402
	Doylestown
	Doylestown Hospital Cancer Center
		Mitchell Alden, DO	Ph:  215-345-8444
	East Stroudsburg
	Dale and Frances Hughes Cancer Center at Pocono Medical Center
		Allison Zibelli, MD	Ph:  215-923-5676
	Ephrata
	Ephrata Cancer Center at Ephrata Community Hospital
		Allison Zibelli, MD	Ph:  215-923-5676
	Erie
	Regional Cancer Center - Erie
		Carmen Pisc	Ph:  814-838-9000
	Hershey
	Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
		Clinical Trials Office - Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center	Ph:  717-531-3779
			Email: CTO@hmc.psu.edu
	Langhorne
	St. Mary Regional Cancer Center
		Clinical Trials Office - St. Mary Regional Cancer Center	Ph:  215-710-4585
	Meadowbrook
	Charles A. & Betty Bott Cancer Center at Holy Redeemer Hospital
		Joseph Potz	Ph:  215-938-3555
	Media
	Riddle Memorial Hospital Cancer Center
		Allison Zibelli, MD	Ph:  215-923-5676
	Philadelphia
	Fox Chase Cancer Center - Philadelphia
		Clinical Trials Office - Fox Chase Cancer Center - Philadelphia	Ph:  215-728-4790
	Frankford Hospital Cancer Center - Torresdale Campus
		Allen Terzian, MD	Ph:  215-612-5250
	Pittsburgh
	Allegheny Cancer Center at Allegheny General Hospital
		Thomas Julian	Ph:  412-359-3336 866-680-0004
	Pottstown
	Pottstown Memorial Regional Cancer Center
		Wei Song, MD, PhD	Ph:  610-327-7555
	Reading
	McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
		Clinical Trials Office - McGlinn Family Regional Cancer Center	Ph:  610-988-9323
	Sayre
	Guthrie Cancer Center at Guthrie Clinic Sayre
		Clinical Trials Office - Guthrie Cancer Center at Guthrie Clinic Sayre	Ph:  800-836-0388
	Upland
	Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center
		Allison Zibelli, MD	Ph:  215-923-5676
	West Grove
	Jennersville Regional Hospital
		Clinical Trials Office - Jennersville Regional Hospital	Ph:  610-869-1396
	Williamsport
	Susquehanna Cancer Center at Divine Providence Hospital
		Warren Robinson, Jr.	Ph:  570-326-8000
	York
	York Cancer Center at Apple Hill Medical Center
		Amir Tabatabai, MD	Ph:  717-741-9229
Rhode Island
	Pawtucket
	Memorial Hospital of Rhode Island
		Anthony Thomas, DO	Ph:  401-729-2700
South Carolina
	Anderson
	AnMed Cancer Center
		Clinical Trials Office - AnMed Cancer Center	Ph:  864-512-1000
	Charleston
	Hollings Cancer Center at Medical University of South Carolina
		Clinical Trials Office - Hollings Cancer Center at Medical University of South Carolina	Ph:  843-792-9321
	Roper St. Francis Cancer Center at Roper Hospital
		James Orcutt, MD	Ph:  843-577-2276
	Columbia
	South Carolina Oncology Associates, PA
		William Babcock	Ph:  803-461-3000
	Spartanburg
	CCOP - Upstate Carolina
		Clinical Trials Office - CCOP - Upstate Carolina	Ph:  800-486-5941
	Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
		Clinical Trials Office - Gibbs Regional Cancer Center	Ph:  800-486-5941
South Dakota
	Sioux Falls
	Sanford Cancer Center at Sanford USD Medical Center
		Clinical Trials Office - Sanford Cancer Center	Ph:  605-328-1367
Tennessee
	Franklin
	Vanderbilt-Ingram Cancer Center - Cool Springs
		Ingrid Mayer, MD	Ph:  615-322-4967
	Jackson
	West Tennessee Cancer Center at Jackson-Madison County General Hospital
		Clinical Trials Office - West Tennessee Cancer Center	Ph:  731-425-6865
	Memphis
	University of Tennessee Cancer Institute - Memphis
		Clinical Trials Office - University of Tennessee Cancer Institute	Ph:  901-448-3303
	Nashville
	Vanderbilt Breast Center at One Hundred Oaks
		Ingrid Mayer, MD	Ph:  615-322-4967
	Vanderbilt-Ingram Cancer Center
		Clinical Trials Office - Vanderbilt-Ingram Cancer Center	Ph:  800-811-8480
Texas
	Fort Sam Houston
	Brooke Army Medical Center
		Clinical Trials Office - Brooke Army Medical Center	Ph:  210-916-4837
	Lackland AFB
	Wilford Hall Medical Center
		John Renshaw	Ph:  210-292-7100
	Laredo
	Doctor's Hospital of Laredo
		Gary Unzeitig, MD	Ph:  956-726-3691
	San Antonio
	University of Texas Health Science Center at San Antonio
		Anand Karnad, MD	Ph:  210-567-4777
Virginia
	Charlottesville
	Martha Jefferson Hospital Cancer Care Center
		Robert Pritchard, MD	Ph:  434-982-8390
	Fredericksburg
	Fredericksburg Oncology, Incorporated
		Paul Schaefer, MD	Ph:  419-479-5605
	Lynchburg
	Lynchburg Hematology-Oncology Clinic
		John Leach MacNeill, MD	Ph:  434-947-5925
	Newport News
	Peninsula Cancer Institute - Newport News Office
		Guy Tillinghast	Ph:  757-534-5555
Washington
	Spokane
	Rockwood Clinic Cancer Treatment Center
		Clinical Trials Office - Rockwood Clinic Cancer Treatment Center	Ph:  509-838-2531 ext. 6880
	Tacoma
	Madigan Army Medical Center - Tacoma
		Richard Reed	Ph:  206-968-1110
	Vancouver
	Northwest Cancer Specialists at Vancouver Cancer Center
		Janet Ruzich	Ph:  360-944-9889
West Virginia
	Charleston
	West Virginia University Health Sciences Center - Charleston
		Steven Jubelirer, MD	Ph:  304-388-8380
	Morgantown
	Mary Babb Randolph Cancer Center at West Virginia University Hospitals
		Jame Abraham, MD	Ph:  304-293-4229
Wisconsin
	Elkhorn
	Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn
		Dhimant Patel, MD	Ph:  920-288-4180
	Fond du Lac
	Central Wisconsin Cancer Program at Agnesian HealthCare
		Clinical Trials Office - Central Wisconsin Cancer Program at Agnesian HealthCare	Ph:  800-494-2927
	Franklin
	Oncology Alliance - Franklin
		Rubina Qamar	Ph:  414-529-3210
	Glendale
	Oncology Alliance, SC - Milwaukee - East
		Clinical Trials Office - Oncology Alliance, SC - Milwaukee - East	Ph:  414-906-4480
	Green Bay
	St. Vincent Hospital Regional Cancer Center
		Clinical Trials Office - St. Vincent Hospital Regional Cancer Center	Ph:  920-433-8889
	Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
		Clinical Trials Office - Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center	Ph:  414-649-5717
	Kenosha
	Oncology Alliance - Kenosha South
		Rubina Qamar	Ph:  262-942-9644
	La Crosse
	Franciscan Skemp Healthcare - La Crosse Campus
		Paula Gill	Ph:  608-785-0940
	Gundersen Lutheran Center for Cancer and Blood
		Clinical Trials Office - Gundersen Lutheran Cancer Center	Ph:  608-775-2385
			Email: cancerctr@gundluth.org
	Manitowoc
	Holy Family Memorial Medical Center Cancer Care Center
		Clinical Trials Office - Holy Family Memorial Medical Center Cancer Care Center	Ph:  920-320-2749
	Marinette
	Vince Lombardi Cancer Clinic - Marinette
		Dhimant Patel, MD	Ph:  920-288-4180
	Mequon
	Columbia Saint Mary's Hospital - Ozaukee
		Carl Olson, MD	Ph:  414-291-1556
	Milwaukee
	Aurora Sinai Medical Center
		Clinical Trials Office - Aurora Sinai Medical Center	Ph:  414-649-5717
	Columbia-Saint Mary's Cancer Care Center
		Clinical Trials Office - Columbia-St. Mary's Cancer Care Center	Ph:  414-326-1739
	Medical Consultants, Limited
		Jonathan Treisman, MD	Ph:  414-385-3086
	Oncology Alliance, SC - Milwaukee - South
		Rubina Qamar	Ph:  414- 384-5111
	Wheaton Franciscan Cancer Care - St. Joseph
		Norwood Anderson, MD	Ph:  414-874-1100
	Oconomowoc
	Regional Cancer Center at Oconomowoc Memorial Hospital
		Clinical Trials Office - Regional Cancer Center at Oconomowoc Memorial Hospital	Ph:  262-928-7878
	Oshkosh
	Vince Lombardi Cancer Clinic - Oshkosh
		Magdalena Flejsierowicz	Ph:  920-303-8700
	Summit
	Aurora Medical Center
		Dhimant Patel, MD	Ph:  920-288-4180
	Two Rivers
	Vince Lombardi Cancer Clinic - Two Rivers
		Dhimant Patel, MD	Ph:  920-288-4180
	Waukesha
	Waukesha Memorial Hospital Regional Cancer Center
		Clinical Trials Office - Waukesha Memorial Hospital Regional Cancer Center	Ph:  262-928-7632
	Wauwatosa
	Oncology Alliance, SC - Milwaukee - West
		Rubina Qamar	Ph:  414-476-8450
	West Allis
	Aurora Women's Pavilion of West Allis Memorial Hospital
		Magdalena Flejsierowicz	Ph:  414-978-3000
Wyoming
	Casper
	Rocky Mountain Oncology
		Benjamin Marchello, MD	Ph:  406-238-6290
	Sheridan
	Welch Cancer Center at Sheridan Memorial Hospital
		Benjamin Marchello, MD	Ph:  406-238-6290
Australia
New South Wales
	Coffs Harbour
	Coffs Harbour Health Campus
		John Forbes	Ph:  61-2-6656-7820
	Waratah
	Newcastle Mater Misericordiae Hospital
		John Forbes	Ph:  61-2-4921-1211
Canada
British Columbia
	Kelowna
	British Columbia Cancer Agency - Centre for the Southern Interior
		Barbara Czerkawski	Ph:  250-712-3900
	Penticton
	Penticton Regional Hospital
		Deepu Mirchandani, MD, MS	Ph:  306-655-2690
	Surrey
	BCCA - Fraser Valley Cancer Centre
		Lee Ann Martin	Ph:  604-930-2098 800-587-2885
	Vancouver
	British Columbia Cancer Agency - Vancouver Cancer Centre
		Stephen Chia	Ph:  604-877-6000 800-663-3333
	Victoria
	British Columbia Cancer Agency - Vancouver Island Centre
		Andrew Attwell	Ph:  250-519-5500
Manitoba
	Winnipeg
	CancerCare Manitoba
		Debjani Grenier, MD	Ph:  204-235-3394
New Brunswick
	Saint John
	Saint John Regional Hospital
		Margot Burnell, MD	Ph:  506-648-6884
Ontario
	Sudbury
	Northeastern Ontario Regional Cancer Centre
		Pedro Lopez, MD	Ph:  705-522-6237ext.2320
Quebec
	Montreal
	CHUM - Hotel Dieu Hospital
		Andre Robidoux, MD	Ph:  514-890-8000ext.15535
	Hopital Notre-Dame du CHUM
		Andre Robidoux, MD	Ph:  514-890-8000ext.15535
Saskatchewan
	Regina
	Allan Blair Cancer Centre at Pasqua Hospital
		Muhammad Salim, MD	Ph:  306-766-2203
Peru
	Lima
	Instituto Nacional de Enfermedades Neoplasicas
		Carlos Vallejos-Sologuren, MD, FACP	Ph:  511-620-4995