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Genetic Study of Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, or Multiple Myeloma

Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
No phase specifiedBiomarker/Laboratory analysis, Natural history/EpidemiologyActive15 and overNCI, OtherCDR0000256897
CALGB-8461, NCT00048958

Trial Description

Summary

RATIONALE: Cytogenetic tests may help predict how cancer will respond to treatment and allow doctors to plan more effective therapy.

PURPOSE: This diagnostic trial is studying genetic differences in patients with treated and untreated acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndromes, or multiple myeloma.

Further Study Information

OBJECTIVES:

  • Determine the incidence of chromosomal abnormalities in patients with acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndromes, or multiple myeloma.
  • Correlate specific chromosomal abnormalities with clinical and laboratory parameters in these patients.
  • Correlate specific karyotype groups with treatment response rates, response duration, survival, and cure in patients treated with various induction and post-induction regimens.
  • Correlate specific karyotype groups with multidrug resistance data in these patients.
  • Identify new chromosome abnormalities important in leukemogenesis.
  • Correlate specific karyotype groups with epidemiological data (toxic exposure and family history) in these patients.
  • Determine karyotype changes at relapse and the influence of the type of change (or no change) in karyotype at relapse in subsequent clinical courses in these patients.
  • Correlate specific karyotype groups with selected molecular abnormalities as studied in CALGB leukemia protocols.

OUTLINE: This is a multicenter study.

Patients undergo collection of bone marrow and blood specimens for cytogenetic analysis at diagnosis, complete remission, and relapse. Specimens are karyotyped and examined for chromosomal abnormalities.

PROJECTED ACCRUAL: Approximately 6,400 patients will be accrued for this study.

Eligibility Criteria

DISEASE CHARACTERISTICS:

  • Must enroll (within 1 month of registration on this study) on a CALGB treatment study for previously untreated acute myeloid leukemia, acute lymphoblastic leukemia, or myelodysplastic syndromes
  • Patients enrolled on CLB-100001 (previously treated or untreated multiple myeloma) must enroll on this study
  • Simultaneous registration on CLB-9665 (within the continental United States)

PATIENT CHARACTERISTICS:

Age

  • 15 and over

Performance status

  • Not specified

Life expectancy

  • Not specified

Hematopoietic

  • Not specified

Hepatic

  • Not specified

Renal

  • Not specified

PRIOR CONCURRENT THERAPY:

Biologic therapy

  • Not specified

Chemotherapy

  • Not specified

Endocrine therapy

  • Not specified

Radiotherapy

  • Not specified

Surgery

  • Not specified

Trial Contact Information

Trial Lead Organizations/Sponsors

Cancer and Leukemia Group B

National Cancer Institute

Clara D. BloomfieldStudy Chair

Trial Sites

U.S.A.
Alabama
  Birmingham
 UAB Comprehensive Cancer Center
 Clinical Trials Office - UAB Comprehensive Cancer Center Ph: 205-934-0309
California
  La Jolla
 Rebecca and John Moores UCSD Cancer Center
 Clinical Trials Office - Rebecca and John Moores UCSD Cancer Ph: 858-822-5354
  Email: cancercto@ucsd.edu
  San Diego
 Kaiser Permanente Medical Office -Vandever Medical Office
 Han A. Koh Ph: 619-528-2596
 Naval Medical Center - San Diego
 Preston S. Gable, MD, FACP Ph: 619-532-7319
  San Francisco
 UCSF Helen Diller Family Comprehensive Cancer Center
 Clinical Trials Office - UCSF Helen Diller Family Comprehensi Ph: 877-827-3222
Delaware
  Lewes
 Tunnell Cancer Center at Beebe Medical Center
 Clinical Trials Office - Tunnell Cancer Center Ph: 302-645-3171
  Newark
 CCOP - Christiana Care Health Services
 Clinical Trial Office - CCOP - Christiana Care Health Services Ph: 302-623-4450
District of Columbia
  Washington
 Walter Reed Army Medical Center
 Clinical Trials Office - Walter Reed Army Medical Center Ph: 202-782-7840
Florida
  Fort Lauderdale
 Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
 Clinical Trials Office - Michael and Dianne Bienes Comprehensi Ph: 954-776-3239
  Jupiter
 Ella Milbank Foshay Cancer Center at Jupiter Medical Center
 Clinical Trials Office - Ella Milbank Foshay Cancer Center Ph: 561-745-5768
  Miami Beach
 CCOP - Mount Sinai Medical Center
 Rogerio C. Lilenbaum, MD Ph: 305-535-3310
  Orlando
 Florida Hospital Cancer Institute at Florida Hospital Orlando
 Clinical Trials Office - Florida Hospital Cancer Institute Ph: 407-303-5623
Illinois
  Bloomington
 St. Joseph Medical Center
 John W. Kugler, MD Ph: 309-243-3605
  Bloomington%
 Illinois CancerCare - Bloomington
 John W. Kugler, MD Ph: 309-243-3605
  Canton
 Graham Hospital
 John W. Kugler, MD Ph: 309-243-3605
 Illinois CancerCare - Canton
 John W. Kugler, MD Ph: 309-243-3605
  Carthage
 Illinois CancerCare - Carthage
 John W. Kugler, MD Ph: 309-243-3605
 Memorial Hospital
 John W. Kugler, MD Ph: 309-243-3605
  Chicago
 University of Chicago Cancer Research Center
 Clinical Trials Office - University of Chicago Cancer Research Ph: 773-834-7424
 University of Illinois Cancer Center
 Clinical Trial Office - University of Illinois Cancer Center Ph: 312-355-3046
  Eureka
 Eureka Community Hospital
 John W. Kugler, MD Ph: 309-243-3605
 Illinois CancerCare - Eureka
 John W. Kugler, MD Ph: 309-243-3605
  Evanston
 Evanston Hospital
 Clinical Trials Office - Evanston Hospital Ph: 847-570-1381
  Galesburg
 Galesburg Clinic, PC
 John W. Kugler, MD Ph: 309-243-3605
 Illinois CancerCare - Galesburg
 John W. Kugler, MD Ph: 309-243-3605
  Havana
 Illinois CancerCare - Havana
 John W. Kugler, MD Ph: 309-243-3605
 Mason District Hospital
 John W. Kugler, MD Ph: 309-243-3605
  Kewanee
 Illinois CancerCare - Kewanee Clinic
 John W. Kugler, MD Ph: 309-243-3605
  Macomb
 Illinois CancerCare - Macomb
 John W. Kugler, MD Ph: 309-243-3605
 McDonough District Hospital
 John W. Kugler, MD Ph: 309-243-3605
  Monmouth
 Illinois CancerCare - Monmouth
 John W. Kugler, MD Ph: 309-243-3605
 OSF Holy Family Medical Center
 John W. Kugler, MD Ph: 309-243-3605
  Normal
 BroMenn Regional Medical Center
 John W. Kugler, MD Ph: 309-243-3605
 Community Cancer Center
 John W. Kugler, MD Ph: 309-243-3605
 Illinois CancerCare - Community Cancer Center
 John W. Kugler, MD Ph: 309-243-3605
  Ottawa
 Community Hospital of Ottawa
 John W. Kugler, MD Ph: 309-243-3605
 Oncology Hematology Associates of Central Illinois, PC - Ottawa
 John W. Kugler, MD Ph: 309-243-3605
  Pekin
 Cancer Treatment Center at Pekin Hospital
 John W. Kugler, MD Ph: 309-243-3605
 Illinois CancerCare - Pekin
 John W. Kugler, MD Ph: 309-243-3605
  Peoria
 CCOP - Illinois Oncology Research Association
 John W. Kugler, MD Ph: 309-243-3605
 Methodist Medical Center of Illinois
 Clinical Trials Office - Methodist Medical Center of Illinois Ph: 309-243-3000
 Oncology Hematology Associates of Central Illinois, PC - Peoria
 John W. Kugler, MD Ph: 309-243-3605
 OSF St. Francis Medical Center
 John W. Kugler, MD Ph: 309-243-3605
 Proctor Hospital
 John W. Kugler, MD Ph: 309-243-3605
  Peru
 Illinois CancerCare - Peru
 John W. Kugler, MD Ph: 309-243-3605
 Illinois Valley Community Hospital
 John W. Kugler, MD Ph: 309-243-3605
  Princeton
 Illinois CancerCare - Princeton
 John W. Kugler, MD Ph: 309-243-3605
 Perry Memorial Hospital
 John W. Kugler, MD Ph: 309-243-3605
  Rockford
 Center for Cancer Care at OSF Saint Anthony Medical Center
 Clinical Trials Office - Center for Cancer Care at OSF Saint Ph: 815-227-2633
  Spring Valley
 Illinois CancerCare - Spring Valley
 John W. Kugler, MD Ph: 309-243-3605
Iowa
  Bettendorf
 Hematology Oncology Associates of the Quad Cities
 Shobha R. Chitneni, MD, MBBS Ph: 563-355-7733
  Cedar Rapids
 Iowa Blood and Cancer Care
 David O. Zenk, MD Ph: 319-369-7091
 Mercy Regional Cancer Center at Mercy Medical Center
 David O. Zenk, MD Ph: 319-369-7091
 St. Luke's Hospital
 David O. Zenk, MD Ph: 319-369-7091
  Iowa City
 Holden Comprehensive Cancer Center at University of Iowa
 Cancer Information Service Ph: 800-237-1225
Kansas
  Overland Park
 Menorah Medical Center
 Rakesh Gaur, MD Ph: 816-823-0555
 Saint Luke's Hospital - South
 Rakesh Gaur, MD Ph: 816-823-0555
  Shawnee Mission
 Shawnee Mission Medical Center
 Rakesh Gaur, MD Ph: 816-823-0555
Maine
  Bangor
 CancerCare of Maine at Eastern Maine Medical Center
 Clinical Trials Office - CancerCare of Maine Ph: 207-973-4274
  Scarborough
 Maine Center for Cancer Medicine and Blood Disorders - Scarborough
 Helen F. Ryan Ph: 207-885-7600
Maryland
  Baltimore
 Greenebaum Cancer Center at University of Maryland Medical Center
 Clinical Trials Office - Greenebaum Cancer Center at Universit Ph: 800-888-8823
  Elkton MD
 Union Hospital of Cecil County
 Frank Beardell, MD Ph: 302-737-7700
Massachusetts
  Boston
 Dana-Farber/Brigham and Women's Cancer Center
 Clinical Trials Office Ph: 617-724-5200
 Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
 Richard M. Stone, MD Ph: 617-632-2214
 Massachusetts General Hospital
 Clinical Trials Office - Massachusetts General Hospital Ph: 877-726-5130
Michigan
  Battle Creek
 Battle Creek Health System Cancer Care Center
 Martin J. Bury Ph: 616-966-8000
  Big Rapids
 Mecosta County Medical Center
 Martin J. Bury Ph: 231-796-8691
  Grand Rapids
 Butterworth Hospital at Spectrum Health
 Martin J. Bury Ph: 616-391-2799
 CCOP - Grand Rapids
 Martin J. Bury Ph: 616-391-1230
 Lacks Cancer Center at Saint Mary's Health Care
 Martin J. Bury Ph: 616-752-5222
  Muskegon
 Mercy General Health Partners
 Martin J. Bury Ph: 231-672-2000
  Traverse City
 Munson Medical Center
 Martin J. Bury Ph: 231-935-6202
  Wyoming
 Metro Health Hospital
 Martin J. Bury Ph: 616-252-7200
Minnesota
  Duluth
 St. Luke's Hospital Cancer Care Center
 Tanya L. Repka, MD, FACP Ph: 218-726-3081
  Minneapolis
 Masonic Cancer Center at University of Minnesota
 Clinical Trials Office - Masonic Cancer Center at University o Ph: 612-624-2620
 Veterans Affairs Medical Center - Minneapolis
 Clinical Trials Office - Veterans Affairs Medical Center - Min Ph: 612-467-2800
Missouri
  Columbia
 Ellis Fischel Cancer Center at University of Missouri - Columbia
 Clinical Trial Office - Ellis Fischel Cancer Center Ph: 573-882-7440
  Kansas City
 CCOP - Kansas City
 Rakesh Gaur, MD Ph: 816-823-0555
 Heartland Hematology Oncology Associates, Incorporated
 Rakesh Gaur, MD Ph: 816-823-0555
 North Kansas City Hospital
 Rakesh Gaur, MD Ph: 816-823-0555
 Research Medical Center
 Rakesh Gaur, MD Ph: 816-823-0555
 Saint Luke's Cancer Institute at Saint Luke's Hospital
 Rakesh Gaur, MD Ph: 816-823-0555
 St. Joseph Medical Center
 Rakesh Gaur, MD Ph: 816-823-0555
 Truman Medical Center - Hospital Hill
 Rakesh Gaur, MD Ph: 816-823-0555
  Lee's Summit
 Saint Luke's East - Lee's Summit
 Rakesh Gaur, MD Ph: 816-823-0555
  Liberty
 Liberty Hospital
 Rakesh Gaur, MD Ph: 816-823-0555
  Saint Joseph
 Heartland Regional Medical Center
 Rakesh Gaur, MD Ph: 816-823-0555
 Saint Joseph Oncology, Incorporated
 Rakesh Gaur, MD Ph: 816-823-0555
  Saint Louis
 Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
 Nancy L. Bartlett, MD Ph: 314-362-5654
Nebraska
  Grand Island
 Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
 Lori J. Maness, MD Ph: 402-559-5520
  North Platte
 Callahan Cancer Center at Great Plains Regional Medical Center
 Clinical Trials Office - Callahan Cancer Center at Great Plain Ph: 308-696-7864
  Omaha
 Methodist Estabrook Cancer Center
 Robert M. Langdon, MD Ph: 402-399-8762
 UNMC Eppley Cancer Center at the University of Nebraska Medical Center
 Clinical Trials Office - UNMC Eppley Cancer Center at the Univ Ph: 800-999-5465
Nevada
  Las Vegas
 CCOP - Nevada Cancer Research Foundation
 John A. Ellerton, MD, CM Ph: 702-384-0013
 University Medical Center of Southern Nevada
 John A. Ellerton, MD, CM Ph: 702-384-0013
New Hampshire
  Lebanon
 Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
 Clinical Trials Office - Norris Cotton Cancer Center Ph: 603-650-7609
  Email: cancerhelp@dartmouth.edu
New Jersey
  Voorhees
 Cancer Institute of New Jersey at Cooper - Voorhees
 Clinical Trials Office - Cancer Institute of New Jersey at Coo Ph: 856-325-6757
New York
  Buffalo
 Roswell Park Cancer Institute
 Clinical Trials Office - Roswell Park Cancer Institute Ph: 877-275-7724
  East Syracuse
 CCOP - Hematology-Oncology Associates of Central New York
 Jeffrey J. Kirshner, MD Ph: 315-472-7504
  Lake Success
 Monter Cancer Center of the North Shore-LIJ Health System
 Vincent P. Vinciguerra, MD Ph: 516-734-8954
  Manhasset
 CCOP - North Shore University Hospital
 Vincent P. Vinciguerra, MD Ph: 516-734-8954
 Don Monti Comprehensive Cancer Center at North Shore University Hospital
 Clinical Trials Office - Don Monti Comprehensive Cancer Center Ph: 516-734-8900
  New Hyde Park
 Long Island Jewish Medical Center
 Kanti R. Rai, MD Ph: 718-470-7135
  New York
 New York Weill Cornell Cancer Center at Cornell University
 Clinical Trials Office - New York Weill Cornell Cancer Center Ph: 212-746-1848
  Syracuse
 SUNY Upstate Medical University Hospital
 Clinical Trials Office - SUNY Upstate Medical University Hospi Ph: 315-464-5476
 Veterans Affairs Medical Center - Syracuse
 Jane M. Hudson Ph: 315-425-4400
North Carolina
  Asheville
 Mission Hospitals - Memorial Campus
 Clinical Trials Office - Mission Hospitals - Memorial Campus Ph: 828-213-4150
  Chapel Hill
 Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
 Clinical Trials Office - Lineberger Comprehensive Cancer Cente Ph: 877-668-0683; 919-966-4432
  Charlotte
 Presbyterian Cancer Center at Presbyterian Hospital
 Clinical Trials Office - Presbyterian Cancer Center at Presbyt Ph: 704-384-5369
  Concord
 Batte Cancer Center at Northeast Medical Center
 James G. Wall, MD Ph: 704-783-1370
  Durham
 Duke Cancer Institute
 Clinical Trials Office - Duke Comprehensive Cancer Center Ph: 888-275-3853
  Goldsboro
 Wayne Memorial Hospital, Incorporated
 James N. Atkins, MD Ph: 919-580-0000
  Greenville
 Leo W. Jenkins Cancer Center at ECU Medical School
 Clinical Trials Office - Leo W. Jenkins Cancer Center at ECU M Ph: 252-744-2391
  Hendersonville
 Pardee Memorial Hospital
 James E. Radford, MD Ph: 828-692-8045
  Kinston
 Kinston Medical Specialists
 Peter R. Watson, MD Ph: 252-559-2200ext.201
  Winston-Salem
 Forsyth Regional Cancer Center at Forsyth Medical Center
 Clinical Trials Office - Forsyth Regional Cancer Center at For Ph: 336-277-8887
 Wake Forest University Comprehensive Cancer Center
 Clinical Trials Office - Wake Forest University Comprehensive Ph: 336-713-6771
Ohio
  Columbus
 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
 Ohio State University Cancer Clinical Trial Matching Service Ph: 866-627-7616
  Email: osu@emergingmed.com
Pennsylvania
  Pittsburgh
 Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
 John Lister Ph: 412-578-5000
Rhode Island
  Pawtucket
 Memorial Hospital of Rhode Island
 Anthony G. Thomas, DO Ph: 401-729-2700
  Providence
 Miriam Hospital
 Clinical Trials Office - Miriam Hospital Ph: 401-793-2224
 Rhode Island Hospital Comprehensive Cancer Center
 Clinical Trials Office - Rhode Island Hospital Comprehensive C Ph: 401-444-1488
South Carolina
  Charleston
 Hollings Cancer Center at Medical University of South Carolina
 Clinical Trials Office - Hollings Cancer Center at Medical Uni Ph: 843-792-9321
  Easley
 Cancer Centers of the Carolinas - Easley
 Clinical Trials Office - Cancer Centers of the Carolinas Ph: 864-241-6251
  Florence
 McLeod Regional Medical Center
 Clinical Trials Office - McLeod Regional Medical Center Ph: 843-679-7256
  Greenville
 Bon Secours St. Francis Health System
 Clinical Trails Office - Bon Secours St. Francis Health System Ph: 864-255-1713
 Cancer Centers of the Carolinas - Eastside
 Clinical Trials Office - Cancer Centers of the Carolinas Ph: 864-241-6251
 Cancer Centers of the Carolinas - Faris Road
 Jeffrey K. Giguere, MD, FACP Ph: 864-987-7000
 Cancer Centers of the Carolinas - Grove Commons
 Clinical Trials Office - Cancer Centers of the Carolinas Ph: 864-241-6251
 CCOP - Greenville
 Jeffrey K. Giguere, MD, FACP Ph: 864-987-7000
 Greenville Hospital Cancer Center
 Clinical Trials Office - Greenville Hospital Cancer Center Ph: 864-241-6251
  Greenwood
 Self Regional Cancer Center at Self Regional Medical Center
 Jeffrey K. Giguere, MD, FACP Ph: 864-987-7000
  Greer
 Cancer Centers of the Carolinas - Greer Medical Oncology
 Jeffrey K. Giguere, MD, FACP Ph: 864-987-7000
 Cancer Centers of the Carolinas - Greer Radiation Oncology
 Jeffrey K. Giguere, MD, FACP Ph: 864-987-7000
  Seneca
 Cancer Centers of the Carolinas - Seneca
 Jeffrey K. Giguere, MD, FACP Ph: 864-987-7000
  Spartanburg
 Cancer Centers of the Carolinas - Spartanburg
 Jeffrey K. Giguere, MD, FACP Ph: 864-987-7000
Vermont
  Berlin
 Mountainview Medical
 Barbara W. Grant, MD Ph: 802-847-8400
  Burlington
 Fletcher Allen Health Care - University Health Center Campus
 Clinical Trials Office - Fletcher Allen Health Care Ph: 802-656-8990
Virginia
  Danville
 Danville Regional Medical Center
 Clinical Trials Office - Danville Regional Medical Center Ph: 434-799-3753
  Richmond
 Virginia Commonwealth University Massey Cancer Center
 Clinical Trials Office -Virginia Commonwealth University Masse Ph: 804-628-1939

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00048958
Information obtained from ClinicalTrials.gov on November 20, 2012

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.

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