Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

Trial Description

Summary

RATIONALE: Radiation therapy uses high-energy x rays to kill tumor cells. Radiation therapy may cause skin reactions when patients are exposed to high-energy x rays. Studying the genetic pattern of patients before and after radiation therapy may help doctors prevent toxicity and plan the best treatment.

PURPOSE: This clinical trial studies genetic susceptibility to radiation-induced skin reactions in racial/ethnic groups of patients with breast cancer.

Further Study Information

OBJECTIVES:

• To develop and validate prediction biomarkers for radiation therapy (RT)-induced acute and chronic skin reactions and quality of life in five racial/ethnic groups of breast cancer patients, Whites*, Black/African Americans, Hispanic/Latinos, Asians/Native Hawaiians/Pacific Islanders, and American Indians/Alaskan Natives. NOTE: *This stratum is closed as of April 25, 2012.

• To develop polygenic models of RT-induced skin reactions with a comprehensive evaluation of genome-wide nonsynonymous single nucleotide polymorphisms (nsSNPs).

• To evaluate the levels of DNA damage (Comet assay) and radiosensitivity (Cell Cycle G2 Delay assay) in lymphocytes before and after RT.

• To test the effect of gene-gene and gene-smoking interactions on RT-induced skin reactions.

• To assess race-ethnic differences in RT-induced skin reactions, DNA damage, and radiosensitivity and to determine if the gene effects are consistent across race-ethnicity (gene-race/ethnic interactions).

OUTLINE: This is a multicenter study. Patients are stratified according to race/ethnicity (Whites* vs Black/African Americans vs Hispanic/Latinos vs Asians/Native Hawaiians/Pacific Islanders vs American Indians/Alaskan Natives). NOTE: *This stratum is closed as of April 25, 2012.

Patients undergo adjuvant radiotherapy after breast-conserving surgery.

Blood and urine samples are collected at baseline and last day of radiotherapy for genotyping, DNA damage, cell cycle assays, urine cotinine, inflammatory immune response biomarkers, and tumor-killing activity by BeadArray System, Comet assay, flow cytometry-based assay, Cell-Cycle G2 Delay Assay, Oxygen Radical Absorbance Capacity (ORAC) assay, and ELISA.

Patients are assessed for acute toxicity by research staff using the ONS Criteria for Radiation-Induced Acute Skin Toxicity at baseline, week 3, and at 1 and 2 months after radiotherapy. Patients are also assessed for chronic toxicity by research staff using the Chronic skin toxicity questionnaire (RTOG SOMA Criteria for RT- Induced Breast/Chest Wall Late Skin Toxicity) at 6 and 12 months after completion of radiotherapy. Photographs of the breast, chest wall, and contralateral breast are also taken at baseline, week 3, last day of radiotherapy, and at 1, 2, 6, and 12 months after completion of radiotherapy.

Patients complete the Breast Cancer Risk Study Questionnaire, the Functional Assessment of Cancer Therapy Breast (FACT-B), the Modified Skindex, and the B39 Quality-of-Life (QOL) Questionnaire at baseline, last day of radiotherapy, and at 1, 2, 6, and 12 months after radiotherapy.

Eligibility Criteria

DISEASE CHARACTERISTICS:

• Female patients newly diagnosed with breast carcinoma including ductal carcinoma in situ (DCIS)

• Stage 0-IIIA disease

• Status post-lumpectomy, -quadrantectomy, or -mastectomy

• Plan to receive adjuvant radiation to the whole breast or chest wall and/or regional lymph nodes

• No sites that cannot send blood/urine specimens to Wake Forest by overnight (next day) express shipping

PATIENT CHARACTERISTICS:

• *This stratum is closed as of April 25, 2012.

• No patients who do not understand English and are unable to complete form with assistance

PRIOR CONCURRENT THERAPY:

• Total dose > 40 Gy, dose per fraction > 1.8 - 2.0 Gy, use of 2D, 3D-conformal, or intensity-modulated radiation therapy (IMRT) treatment techniques allowed; a daily fraction of 2.7 Gy to the whole breast is suggested for hypofractionated regimens

• Concurrent and sequential boost techniques are allowed for both standard and hypofractionated regimens

• Adjuvant hormonal therapy will be allowed prior to, during, and/or after radiotherapy (RT) at the discretion of a medical oncologist

• Targeted therapies, such as Herceptin, will be allowed prior to, during, and/or after RT at the discretion of the medical oncologist

• No prior radiation to the involved breast or chest wall

• No concurrent chemotherapy

• No patients who underwent breast reconstruction following mastectomy

• Placement of tissue expanders and implants are not allowed

• No patients who have undergone MammoSite® or any other form of brachytherapy as well as those who will be treated with skin-sparing IMRT

• Patients may not be concurrently enrolled in a protocol that involves treatment of the skin, i.e., applying lotions/moisturizers

• Protocols that do not involve treatment of the skin are allowed

Trial Contact Information

Trial Lead Organizations/Sponsors

Wake Forest University CCOP Research Base

James J. Urbanic

Principal Investigator

Robin Rosdhal, RN

Ph: (336) 713-6519

U.S.A.
Alaska
	Anchorage
	Providence Cancer Center
		John B Halligan	Ph: 907-261-3109
California
	Castro Valley
	East Bay Radiation Oncology Center
		James H. Feusner	Ph: 510-450-7600
	Martinez
	Contra Costa Regional Medical Center
		James H. Feusner	Ph: 510-450-7600
	Mountain View
	El Camino Hospital Cancer Center
		James H. Feusner	Ph: 510-450-7600
	Palo Alto Medical Foundation
		Peter P. Yu	Ph: 650-934-7000
	Oakland
	Alta Bates Summit Medical Center - Summit Campus
		James H. Feusner	Ph: 510-450-7600
	CCOP - Bay Area Tumor Institute
		James H. Feusner	Ph: 510-450-7600
	Orange
	St. Joseph Hospital Regional Cancer Center - Orange
		Afshin Forouzannia	Ph: 714-734-6220
	Palo Alto
	Palo Alto Medical Foundation
		David S Leibowitz	Ph: 650-853-2906
			Email: waldorj@pamf.org
	San Pablo
	Doctors Medical Center - San Pablo Campus
		James H. Feusner	Ph: 510-450-7600
Delaware
	Newark
	Helen F. Graham Cancer Center at Christiana Hospital
		Stephen Scott Grubbs	Ph: 302-733-6227
Florida
	Fort Lauderdale
	Broward General Medical Center Cancer Center
		Archana Maini	Ph: 954-355-5346
	Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
		Patrick T Reynolds	Ph: 305-674-2625
			Email: info@msccop.com
	Jacksonville
	St. Vincent's Medical Center
		Paul B Ossi	Ph: 904-308-8634
	Jupiter
	Ella Milbank Foshay Cancer Center at Jupiter Medical Center
		Patrick T Reynolds	Ph: 305-674-2625
			Email: info@msccop.com
	Lakeland
	Lakeland Regional Cancer Center at Lakeland Regional Medical Center
		Arvind B Soni	Ph: 863-904-1900
	Miami
	University of Miami Sylvester Comprehensive Cancer Center - Miami
		Cristiane Takita	Ph: 866-574-5124
			Email: Sylvester@emergingmed.com
	Miami Beach
	CCOP - Mount Sinai Medical Center
		Patrick T Reynolds	Ph: 305-674-2625
			Email: info@msccop.com
	Orlando
	Florida Hospital Cancer Institute at Florida Hospital Orlando
		Lee M. Zehngebot	Ph: 407-303-5623
	Pensacola
	Sacred Heart Cancer Center at Sacred Heart Hospital
		Gerald C Lowrey	Ph: 850-416-4611
	Sacred Heart Medical Oncology Group
		Gerald C Lowrey	Ph: 850-416-4611
Georgia
	Savannah
	Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
		Harvey C. Lebos	Ph: 912-350-8568
Hawaii
	Aiea
	Kapiolani Medical Center at Pali Momi
		Jeffrey L. Berenberg	Ph: 808-586-2979
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Ewa Beach
	Leeward Radiation Oncology
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Honolulu
	Cancer Research Center of Hawaii
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Hawaii Medical Center - East
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Kapiolani Medical Center for Women and Children
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Kuakini Medical Center
		Jeffrey L. Berenberg	Ph: 808-586-2979
	OnCare Hawaii, Incorporated - Kuakini
		Jeffrey L. Berenberg	Ph: 808-586-2979
		Jeffrey L. Berenberg	Ph: 808-586-2979
	OnCare Hawaii, Incorporated - Lusitana
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Queen's Cancer Institute at Queen's Medical Center
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Straub Clinic and Hospital, Incorporated
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Tripler Army Medical Center
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Kailua
	Castle Medical Center
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Lihue
	Kauai Medical Clinic
		Jeffrey L. Berenberg	Ph: 808-586-2979
Illinois
	Aurora
	Rush-Copley Cancer Care Center
		Ronald A Sapiente	Ph: 800-446-5532
	Berwyn
	MacNeal Cancer Center at MacNeal Hospital
		Keith L. Shulman	Ph: 773-564-5044
	Chicago
	Louis A. Weiss Memorial Hospital
		Keith L. Shulman	Ph: 773-564-5044
	River Forest
	West Suburban Center for Cancer Care
		Isoken Koko	Ph: 708-488-0882
	Springfield
	Regional Cancer Center at Memorial Medical Center
		James L. Wade	Ph: 217-876-4740
			Email: kcheek@dmhhs.org
	Urbana
	Carle Cancer Center at Carle Foundation Hospital
		Ronald A Sapiente	Ph: 800-446-5532
Indiana
	Bloomington
	Bloomington Hospital Regional Cancer Institute
		David Y. Lee	Ph: 812-353-2831
	Indianapolis
	St. Francis Hospital Cancer Care Services
		Howard M. Gross	Ph: 765-983-3000
	Michigan City
	Saint Anthony Memorial Health Centers
		Ronald A Sapiente	Ph: 800-446-5532
	Richmond
	Reid Hospital & Health Care Services
		Howard M. Gross	Ph: 317-783-8918
Iowa
	Ames
	McFarland Clinic, PC
		Joseph James Merchant	Ph: 515-239-2621
	Mason City
	Mercy Cancer Center at Mercy Medical Center - North Iowa
		Arvind Y Vemula	Ph: 800-433-3883
	Ottumwa
	South Iowa Radiation Oncology Center at Ottumwa Regional Health Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Sioux City
	Mercy Medical Center - Sioux City
		Donald Bruce Wender	Ph: 712-252-0088
	Siouxland Hematology-Oncology Associates, LLP
		Donald Bruce Wender	Ph: 712-252-0088
	St. Luke's Regional Medical Center
		Donald Bruce Wender	Ph: 712-252-0088
Kansas
	Dodge City
	Cancer Center of Kansas, PA - Dodge City
		Shaker R. Dakhil	Ph: 316-262-4467
	El Dorado
	Cancer Center of Kansas, PA - El Dorado
		Shaker R. Dakhil	Ph: 316-262-4467
	Lawrence
	Lawrence Memorial Hospital
		Shaker R. Dakhil	Ph: 316-262-4467
	Prairie Village
	CCOP - Kansas City
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Salina
	Cancer Center of Kansas, PA - Salina
		Shaker R. Dakhil	Ph: 316-262-4467
	Wellington
	Cancer Center of Kansas, PA - Wellington
		Shaker R. Dakhil	Ph: 316-262-4467
	Wichita
	Associates in Women's Health, PA - North Hillside
		Shaker R. Dakhil	Ph: 316-262-4467
	Cancer Center of Kansas, PA - Medical Arts Tower
		Shaker R. Dakhil	Ph: 316-262-4467
	Cancer Center of Kansas, PA - Wichita
		Shaker R. Dakhil	Ph: 316-262-4467
	CCOP - Wichita
		Shaker R. Dakhil	Ph: 316-262-4467
	Via Christi Cancer Center at Via Christi Regional Medical Center
		Shaker R. Dakhil	Ph: 316-262-4467
	Winfield
	Cancer Center of Kansas, PA - Winfield
		Shaker R. Dakhil	Ph: 316-262-4467
Louisiana
	Baton Rouge
	Mary Bird Perkins Cancer Center - Baton Rouge
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
	New Orleans
	Medical Center of Louisiana - New Orleans
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
	Stanley S. Scott Cancer Center at Louisiana State University Medical Center - New Orleans
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
Massachusetts
	Boston
	Boston University Cancer Research Center
		Ariel E Hirsch	Ph: 617-638-8265
	Lowell
	Lowell General Hospital
		Jeffrey D Goldstein	Ph: 972-353-0594
			Email: ghincks@lowellgeneral.org
Michigan
	Kalamazoo
	Borgess Medical Center
		Raymond Sterling Lord	Ph: 269-373-7458
	Bronson Methodist Hospital
		Raymond Sterling Lord	Ph: 269-373-7458
	West Michigan Cancer Center
		Raymond Sterling Lord	Ph: 269-373-7458
	Mount Clemens
	Clemens Regional Medical Center
		Arthur J Frazier	Ph: 586-493-3426
	Royal Oak
	William Beaumont Hospital - Royal Oak Campus
		Peter Y. Chen	Ph: 248-551-7695
Minnesota
	Bemidji
	MeritCare Bemidji
		Preston D. Steen	Ph: 701-234-6161
	Burnsville
	Fairview Ridges Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Duluth
	CCOP - Duluth
		Daniel Nikcevich	Ph: 888-203-7267
	Essentia Health - Duluth Clinic
		Daniel Nikcevich	Ph: 888-203-7267
	Miller - Dwan Medical Center
		Daniel Nikcevich	Ph: 888-203-7267
	Edina
	Fairview Southdale Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Fridley
	Mercy and Unity Cancer Center at Unity Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Maplewood
	HealthEast Cancer Care at St. John's Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minnesota Oncology - Maplewood
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minneapolis
	Hennepin County Medical Center - Minneapolis
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Robbinsdale
	Humphrey Cancer Center at North Memorial Outpatient Center
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Louis Park
	CCOP - Metro-Minnesota
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Park Nicollet Cancer Center
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Paul
	Regions Hospital Cancer Care Center
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	United Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Shakopee
	St. Francis Cancer Center at St. Francis Medical Center
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Waconia
	Ridgeview Medical Center
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Willmar
	Willmar Cancer Center at Rice Memorial Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Woodbury
	Minnesota Oncology - Woodbury
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
Missouri
	Cape Girardeau
	Southeast Cancer Center
		Bryan A Faller	Ph: 800-392-0936
	Jefferson City
	Goldschmidt Cancer Center
		Bryan A Faller	Ph: 800-392-0936
	Kansas City
	Research Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Luke's Hospital
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Joseph
	Heartland Regional Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Joseph Oncology, Incorporated
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Louis
	Missouri Baptist Cancer Center
		Bryan A Faller	Ph: 800-392-0936
Montana
	Great Falls
	Benefis Sletten Cancer Institute
		Grant William Harrer	Ph: 406-731-8217
Nebraska
	Lincoln
	Cancer Resource Center - Lincoln
		Gamini S. Soori	Ph: 800-253-4368
	Omaha
	Alegant Health Cancer Center at Bergan Mercy Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	CCOP - Missouri Valley Cancer Consortium
		Gamini S. Soori	Ph: 800-253-4368
	Creighton University Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	Immanuel Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	Lakeside Hospital
		Gamini S. Soori	Ph: 800-253-4368
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		John Allan Ellerton	Ph: 702-731-8274
	Reno
	Saint Mary's Regional Medical Center
		Kathleen (Katie) B Legarza	Ph: 775-770-7410
New Jersey
	Camden
	Cancer Institute of New Jersey at Cooper University Hospital - Camden
		Stephen Scott Grubbs	Ph: 302-733-6227
	Livingston
	St. Barnabas Medical Center Cancer Center
		Alison Grann	Ph: 973-322-2470
New Mexico
	Albuquerque
	Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital
		Melanie E. Royce	Ph: 505-727-8000
	University of New Mexico Cancer Center
		Melanie E. Royce	Ph: 505-727-8000
New York
	Brooklyn
	Maimonides Cancer Center at Maimonides Medical Center
		Amy V Young	Ph: 718-765-2500
	Elmhurst
	Elmhurst Hospital Center
		Mary Margaret Kemeny	Ph: 718-883-3000
	Jamaica
	Queens Cancer Center of Queens Hospital
		Mary Margaret Kemeny	Ph: 718-883-3000
	White Plains
	Dickstein Cancer Treatment Center at White Plains Hospital Center
		Randy E Stevens	Ph: 914-681-2290
North Carolina
	Asheboro
	Randolph Hospital
		Stacy Wentworth	Ph: 336-832-0821
	Greensboro
	Moses Cone Regional Cancer Center at Wesley Long Community Hospital
		Stacy Wentworth	Ph: 336-832-0821
	Pinehurst
	FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
		Stephen C King	Ph: 910-715-2200
	Reidsville
	Annie Penn Cancer Center
		Stacy Wentworth	Ph: 336-832-0821
	Winston-Salem
	Forsyth Regional Cancer Center at Forsyth Medical Center
		Lisa S Evans	Ph: 336-277-8887
	Wake Forest University Comprehensive Cancer Center
		James J Urbanic	Ph: 336-713-6542
			Email: jurbanic@wfubmc.edu
North Dakota
	Fargo
	Roger Maris Cancer Center at MeritCare Hospital
		Preston D. Steen	Ph: 701-234-6161
		Preston D. Steen	Ph: 701-234-6161
	Sanford Clinic North-Fargo
		Preston D. Steen	Ph: 701-234-6161
	Minot
	Trinity CancerCare Center
		Kevin Basil Collins	Ph: 800-862-0005
Ohio
	Canton
	Mercy Cancer Center at Mercy Medical Center
		Mitchell Haut	Ph: 888-293-4673
	Chillicothe
	Adena Regional Medical Center
		J. Philip Kuebler	Ph: 502-361-8496
	Columbus
	CCOP - Columbus
		J. Philip Kuebler	Ph: 502-361-8496
	Doctors Hospital at Ohio Health
		J. Philip Kuebler	Ph: 502-361-8496
	Grant Medical Center Cancer Care
		J. Philip Kuebler	Ph: 502-361-8496
	Mount Carmel Health - West Hospital
		J. Philip Kuebler	Ph: 502-361-8496
	Riverside Methodist Hospital Cancer Care
		J. Philip Kuebler	Ph: 502-361-8496
	Zangmeister Center
		J. Philip Kuebler	Ph: 502-361-8496
	Dayton
	David L. Rike Cancer Center at Miami Valley Hospital
		Howard M. Gross	Ph: 317-783-8918
	Good Samaritan Hospital
		Howard M. Gross	Ph: 317-783-8918
	Samaritan North Cancer Care Center
		Howard M. Gross	Ph: 317-783-8918
	Delaware
	Grady Memorial Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Findlay
	Blanchard Valley Regional Cancer Center
		Howard M. Gross	Ph: 317-783-8918
	Franklin
	Atrium Medical Center
		Howard M. Gross	Ph: 317-783-8918
	Kettering
	Charles F. Kettering Memorial Hospital
		Howard M. Gross	Ph: 317-783-8918
	Mansfield
	MedCentral - Mansfield Hospital
		Dung B Nguyen	Ph: 419-526-8018
	Marietta
	Strecker Cancer Center at Marietta Memorial Hospital
		J. Philip Kuebler	Ph: 502-361-8496
	Newark
	Licking Memorial Cancer Care Program at Licking Memorial Hospital
		J. Philip Kuebler	Ph: 502-361-8496
	Portsmouth
	Southern Ohio Medical Center Cancer Center
		J. Philip Kuebler	Ph: 502-361-8496
	Springfield
	Community Hospital of Springfield and Clark County
		J. Philip Kuebler	Ph: 502-361-8496
	Troy
	UVMC Cancer Care Center at Upper Valley Medical Center
		Howard M. Gross	Ph: 317-783-8918
	Westerville
	Mount Carmel St. Ann's Cancer Center
		J. Philip Kuebler	Ph: 502-361-8496
	Zanesville
	Genesis - Good Samaritan Hospital
		J. Philip Kuebler	Ph: 502-361-8496
Oregon
	Clackamas
	Clackamas Radiation Oncology Center
		Alison K Conlin	Ph: 503-215-6412
	Portland
	Providence Cancer Center at Providence Portland Medical Center
		Alison K Conlin	Ph: 503-215-6412
	Providence St. Vincent Medical Center
		Alison K Conlin	Ph: 503-215-6412
Pennsylvania
	Erie
	Regional Cancer Center - Erie
		Andrew T Figura	Ph: 814-838-0448
			Email: mhaynes@trcc.org
	Lancaster
	Lancaster General Hospital
		Jeffery S Eshleman	Ph: 717-544-5511
	Phoenixville
	Cancer Center at Phoenixville Hospital
		Carl W. Sharer	Ph: 610-983-1908
	West Chester
	Cancer Center of Chester County
		William E. Luginbuhl	Ph: 610-431-5297
	Williamsport
	Susquehanna Cancer Center at Divine Providence Hospital
		Warren L Robinson	Ph: 800-598-4282
South Carolina
	Beaufort
	Keyserling Cancer Center at Beaufort Memorial Hospital
		Majd Chahin	Ph: 843-522-7819
	Greenwood
	Self Regional Cancer Center at Self Regional Medical Center
		Joanna K Metzner-Sadurski	Ph: 864-725-4771
South Dakota
	Rapid City
	Rapid City Regional Hospital
		Michael J Swartz	Ph: 605-716-3982
			Email: research@rcrh.org
	Sioux Falls
	Sanford Cancer Center at Sanford USD Medical Center
		Miroslaw A Mazurczak	Ph: 605-328-1367
		Miroslaw A Mazurczak	Ph: 605-328-1367
Texas
	Laredo
	Doctor's Hospital of Laredo
		Gary W. Unzeitig	Ph: 888-823-5923
			Email: ctsucontact@westat.com
Virginia
	Richmond
	Virginia Commonwealth University Massey Cancer Center
		Mary H Hackney	Ph: 804-628-1939
Washington
	Vancouver
	Northwest Cancer Specialists at Vancouver Cancer Center
		Alison K Conlin	Ph: 503-215-6412
	Southwest Washington Medical Center Cancer Center
		Alison K Conlin	Ph: 503-215-6412
West Virginia
	Parkersburg
	Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital
		Nik M. Shah	Ph: 304-424-2585

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01407770
Information obtained from ClinicalTrials.gov on April 04, 2013