Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

Trial Description

Summary

RATIONALE: Early surgery may have fewer side effects and improve recovery. Palliative surgery or radiation therapy may help patients with advanced breast cancer live more comfortably. It is not yet known whether early surgery is more effective than palliative therapy for advanced breast cancer.

PURPOSE: This randomized phase III trial is studying early surgery to see how well it works compared to standard palliative therapy in treating patients with stage IV breast cancer.

Further Study Information

OBJECTIVES:

Primary

• To evaluate whether early local therapy comprising surgery of intact primary disease compared to local palliative therapy only in patients with stage IV breast cancer, whose disease does not progress during initial optimal systemic therapy, will result in prolonged survival.

Secondary

• To compare the time to uncontrolled chest wall disease between patients treated with these regimens.

• To determine whether there is a difference in health-related quality-of-life (HRQOL) between patients treated with these regimens.

• To determine whether the absolute value of circulating tumor cells (CTC) burden at 6 months following randomization (time +6) will be lower in the palliative therapy arm than in early local therapy arm, and whether this value is inversely related to survival (lower CTC, longer survival).

• To collect tumor and blood specimens for future exploration of the biological interactions between the primary tumor and metastatic lesions and the effect of primary tumor resection.

OUTLINE: This is a multicenter study. Patients are stratified according to hormone receptor and treatment plan (ER+ or PR+, HER2-, endocrine therapy alone vs ER+ or PR+, and HER2-, chemotherapy and/or endocrine therapy vs ER- or PR-, and HER2- vs HER2+), and number of involved organ systems with distant disease (regional nodes in the axillary, supraclavicular, and internal mammary locations are not considered distant sites) (1 vs > 1). Patients are randomized to 1 of 2 treatment arms.

• Arm I: Patients receive standard palliative therapy, if needed, to address symptoms such as tumor ulceration, pain, bulky adenopathy causing arm symptoms, and other similar situations. Therapy may consist of radiotherapy alone, surgery alone, or a combination of both.

• Arm II: Patients undergo surgery comprising breast-conserving therapy (BCT) or total mastectomy according to patient and treating physician preference. Surgery is to occur no later than 10 weeks after completion of 32 weeks of systemic therapy. Free surgical margins must be achieved with re-excision or mastectomy for patients undergoing BCT. After completion of BCT, patients undergo radiotherapy once a day, 5 days per week. Patients who had mastectomy undergo radiotherapy at the discretion of treating physician.

Patients may undergo blood and tumor tissue sample collection for circulating tumor cells (CTC) burden and future studies.

Patients complete the Functional Assessment of Cancer Therapy - Breast Trial Outcome Index (FACT- TOI) and FACT - General (22) and the Breast Cancer Subscale (FACT-B) quality-of-life questionnaires at baseline and periodically during study.

After completion of study therapy, patients are followed up periodically for 5 years.

Eligibility Criteria

DISEASE CHARACTERISTICS:

• Diagnosis of intact primary (not recurrent) invasive carcinoma of the breast

• Stage IV disease

• Confirmation of the primary tumor should be by needle biopsy (preferred)

• Incisional surgical biopsy allowed as long as there is residual palpable or tumor image in the breast

• Patients must be judged to be candidates for complete resection with free margins followed by radiation therapy (if radiation therapy is indicated)

• For women not undergoing axillary dissection, sentinel node biopsy should document an axillary nodal burden of 1-2 involved lymph nodes (i.e., ACOSOG Z-11 criteria may be applied)

• Prior non-invasive (DCIS) cancer allowed provided there has been no recurrence

• Prior ipsilateral invasive cancer allowed if more than 5 years previous

• No synchronous contralateral breast cancer

• Patients should have at least one organ system involved with distant metastatic disease

• If patient has only one metastatic lesion/focus, this must be proven by biopsy and the pathology report confirming the diagnosis of primary breast cancer, as well as the metastatic site, must be available

• Must have available radiologic reports documenting disease status within the past 6 weeks prior to initiating systemic therapy

• CNS metastases allowed provided projected survival > 6 months

• Patients must have completed at least 16 weeks of optimal systemic therapy (appropriate to the tumor biological profile and the patient's age and menopausal status)

• If systemic therapy is discontinued for toxicity, but there is no distant progression and at least 12 weeks of therapy have been delivered, then the patient remains eligible

• Radiation therapy (if indicated) must begin within 12 weeks of final therapeutic surgical procedure (including re-excision for free margins and completion of axillary dissection)

• Patients may register at any time from the time of diagnosis of stage IV breast cancer (if eligibility criteria met) to the time when a maximum of 30 weeks of induction systemic therapy has been completed

• Patients must be randomized within 16-32 weeks after the start of systemic therapy

• Patients must not have experienced disease progression since the start of systemic therapy, as evidenced by radiographic documentation of disease status before treatment and within 4 weeks +/- 2 weeks prior to randomization, including:

• No new sites of disease

• No enlargement of existing sites by 20% or more in longest diameter

• No symptomatic deterioration

• Patients who require radiotherapy to bone metastases during induction systemic therapy are eligible

• Local disease at the primary site must be asymptomatic

• Hormone receptor status known

PATIENT CHARACTERISTICS:

• See Disease Characteristics

• Menopausal status not specified

• Patients must have adequate organ function to undergo local therapy 4 weeks +/- 2 weeks prior to randomization per investigator discretion and institutional guidelines

• More than 5 years since other primary cancers that were curatively treated

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use an accepted and effective contraception method

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics

Trial Contact Information

Trial Lead Organizations/Sponsors

Eastern Cooperative Oncology Group

Seema A. Khan

Principal Investigator

U.S.A.
Alabama
	Mobile
	University of South Alabama Mitchell Cancer Institute
		Windy Dean-Colomb	Ph: 251-460-6993
Alaska
	Anchorage
	Providence Cancer Center
		Clinical Trials Office - Providence Cancer Center	Ph: 907-261-3109
Arizona
	Scottsdale
	Mayo Clinic Scottsdale
		Clinical Trials Office - All Mayo Clinic Locations	Ph: 507-538-7623
Arkansas
	Little Rock
	Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
		Clinical Trial Office - Arkansas Cancer Research Center at Uni	Ph: 501-686-8274
California
	Castro Valley
	East Bay Radiation Oncology Center
		James H. Feusner, MD	Ph: 510-428-3689
	Chico
	Enloe Cancer Center at Enloe Medical Center
		Clinical Trials Office - Enloe Cancer Center at Enloe Medical	Ph: 530-332-3808
	Fairfield
	North Bay Cancer Center
		Clinical Trials Office - North Bay Cancer Center	Ph: 707-429-6976
	Greenbrae
	California Cancer Care, Incorporated - Greenbrae
		Peter D. Eisenberg, MD	Ph: 415-925-5000
	Long Beach
	Todd Cancer Institute at Long Beach Memorial Medical Center
		Jessica Rayhanabad	Ph: 562-933-0900
	Martinez
	Contra Costa Regional Medical Center
		James H. Feusner, MD	Ph: 510-428-3689
	Monterey
	Community Hospital of the Monterey Peninsula Comprehensive Cancer Center
		John Hausdorff, MD, FACP	Ph: 831-375-4105
	Mountain View
	El Camino Hospital Cancer Center
		Clinical Trials Office - El Camino Hospital Cancer Center	Ph: 650-988-7623
	Oakland
	Alta Bates Summit Medical Center - Summit Campus
		Clinical Trials Office - Alta Bates Summit Medical Center - Su	Ph: 510-204-1414
	CCOP - Bay Area Tumor Institute
		James H. Feusner, MD	Ph: 510-428-3689
	Orange
	Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
		Clinical Trials Office - Chao Family Comprehensive Cancer Cent	Ph: 877-UC-STUDY
			Email: ucstudy@uci.edu
	St. Joseph Hospital Regional Cancer Center - Orange
		Michele M. Carpenter	Ph: 714-771-8999
	San Pablo
	Doctors Medical Center - San Pablo Campus
		James H. Feusner, MD	Ph: 510-428-3689
	Stanford
	Stanford Cancer Center
		Clinical Trials Office - Stanford Cancer Center	Ph: 650-498-7061
			Email: cctoffice@stanford.edu
Colorado
	Aurora
	Aurora Presbyterian Hospital
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	Boulder
	Boulder Community Hospital
		Clinical Trials Office - Boulder Community Hospital	Ph: 303-938-5253
	Colorado Springs
	Penrose Cancer Center at Penrose Hospital
		Clinical Trials Office - Penrose Cancer Center	Ph: 719-776-5275
	Denver
	CCOP - Colorado Cancer Research Program
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	Porter Adventist Hospital
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	Presbyterian - St. Luke's Medical Center
		Clinical Trials Office - Presbyterian - St. Luke's Medical Cen	Ph: 303-839-6000
	Rose Medical Center
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	St. Anthony Central Hospital
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	St. Joseph Hospital
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	Englewood
	Swedish Medical Center
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	Greeley
	North Colorado Medical Center
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	Littleton
	Littleton Adventist Hospital
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	Lone Tree
	Sky Ridge Medical Center
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	Longmont
	Hope Cancer Care Center at Longmont United Hospital
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	Loveland
	McKee Medical Center
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	Parker
	Parker Adventist Hospital
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	Pueblo
	St. Mary - Corwin Regional Medical Center
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	Thornton
	North Suburban Medical Center
		Eduardo R. Pajon, MD	Ph: 303-399-8020ext2261
	Wheat Ridge
	Exempla Lutheran Medical Center
		Clinical Trials Office - Exempla Lutheran Medical Center	Ph: 303-403-3605
Connecticut
	Hartford
	Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
		Christopher M. Reynolds	Ph: 860-714-4680
	Norwalk
	Norwalk Hospital
		Richard C. Frank, MD	Ph: 203-845-2132
	Norwich
	Eastern Connecticut Hematology and Oncology Associates
		Dennis E. Slater, MD	Ph: 860-886-8362
Delaware
	Lewes
	Tunnell Cancer Center at Beebe Medical Center
		Clinical Trials Office - Tunnell Cancer Center	Ph: 302-645-3171
	Newark
	CCOP - Christiana Care Health Services
		Clinical Trial Office - CCOP - Christiana Care Health Services	Ph: 302-623-4450
Florida
	Daytona Beach
	Herbert D. Kerman Regional Oncology Center - Daytona Beach
		Ruby Anne E. Deveras	Ph: 386-254-4211
	Jacksonville
	Mayo Clinic - Jacksonville
		Clinical Trials Office - All Mayo Clinic Locations	Ph: 507-538-7623
	Orlando
	Florida Hospital Cancer Institute at Florida Hospital Orlando
		Clinical Trials Office - Florida Hospital Cancer Institute	Ph: 407-303-5623
	M.D. Anderson Cancer Center at Orlando
		Nikita C. Shah	Ph: 321-841-1075
	Tampa
	H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
		Clinical Trials Office - H. Lee Moffitt Cancer Center and Rese	Ph: 800-456-7121
			Email: canceranswers@moffitt.org
Georgia
	Atlanta
	Emory Crawford Long Hospital
		Ruth M. O'Regan, MD	Ph: 404-778-2208
	Georgia Cancer Center for Excellence at Grady Memorial Hospital
		Ruth M. O'Regan, MD	Ph: 404-778-2208
	Northside Hospital Cancer Center
		Clinical Trials Office - Northside Hospital Cancer Center	Ph: 404-303-3355
	Piedmont Hospital
		Thomas E. Seay, MD, PhD	Ph: 404-851-2340
	Saint Joseph's Hospital of Atlanta
		Clinical Trials Office - Saint Joseph's Hospital of Atlanta	Ph: 404-851-7115
	Winship Cancer Institute of Emory University
		Clinical Trials Office - Winship Cancer Institute	Ph: 404-778-1900
	Columbus
	John B. Amos Cancer Center
		Clinical Trials Office - John B. Amos Cancer Center	Ph: 706-660-6404
	Decatur
	Charles B. Eberhart Cancer Center at DeKalb Medical Center
		Thomas E. Seay, MD, PhD	Ph: 404-851-2340
	Marietta
	Kennestone Cancer Center at Wellstar Kennestone Hospital
		Clinical Trials Office - Kennestone Cancer Center	Ph: 770-793-5980
	Riverdale
	Southern Regional Medical Center
		Clinical Trials Office - Southern Regional Medical Center	Ph: 770-991-8611
	Savannah
	Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
		Grant C. Lewis	Ph: 912-819-6000
Hawaii
	Aiea
	Kapiolani Medical Center at Pali Momi
		Jeffrey L. Berenberg, MD	Ph: 808-433-4089
	Ewa Beach
	Leeward Radiation Oncology
		Jeffrey L. Berenberg, MD	Ph: 808-433-4089
	Honolulu
	Cancer Research Center of Hawaii
		Clinical Trials Office - Cancer Research Center of Hawaii	Ph: 808-586-2979
	Hawaii Medical Center - East
		Jeffrey L. Berenberg, MD	Ph: 808-433-4089
	Kuakini Medical Center
		Jeffrey L. Berenberg, MD	Ph: 808-433-4089
	Queen's Cancer Institute at Queen's Medical Center
		Jeffrey L. Berenberg, MD	Ph: 808-433-4089
	Straub Clinic and Hospital, Incorporated
		Jeffrey L. Berenberg, MD	Ph: 808-433-4089
Idaho
	Boise
	Mountain States Tumor Institute at St. Luke's Regional Medical Center
		Paul G. Montgomery, MD	Ph: 208-381-2711
	Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
		Clinical Trials Office - Saint Alphonsus Cancer Care Center	Ph: 208-367-7954
	Fruitland
	Saint Luke's Mountain States Tumor Institute - Fruitland
		Paul G. Montgomery, MD	Ph: 208-381-2711
	Meridian
	Mountain States Tumor Institute - Meridian
		Paul G. Montgomery, MD	Ph: 208-381-2711
	Nampa
	Saint Luke's Mountain States Tumor Institute
		Paul G. Montgomery, MD	Ph: 208-381-2711
	Twin Falls
	Mountain States Tumor Institute at St. Luke's
		Paul G. Montgomery, MD	Ph: 208-381-2711
Illinois
	Bloomington
	St. Joseph Medical Center
		Nguyet A. Le-Lindqwister	Ph: 309-662-3311
	Canton
	Graham Hospital
		Nguyet A. Le-Lindqwister	Ph: 309-647-5240
	Carthage
	Memorial Hospital
		Nguyet A. Le-Lindqwister	Ph: 217-357-3131
	Chicago
	Hematology-Oncology Associates of Illinois
		Clinical Trails Office - Hematology and Oncology Associates	Ph: 312-695-1301
	John H. Stroger, Jr. Hospital of Cook County
		Thomas E. Lad, MD	Ph: 312-864-3200
	Louis A. Weiss Memorial Hospital
		Clinical Trials Office - Louis A. Weiss Memorial Hospital	Ph: 773-564-5044
	Resurrection Medical Center
		Christopher G. Rose, MD	Ph: 847-965-3200
	Robert H. Lurie Comprehensive Cancer Center at Northwestern University
		Clinical Trials Office - Robert H. Lurie Comprehensive Cancer	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	University of Chicago Cancer Research Center
		Clinical Trials Office - University of Chicago Cancer Research	Ph: 773-834-7424
	University of Illinois Cancer Center
		Clinical Trial Office - University of Illinois Cancer Center	Ph: 312-355-3046
	Decatur
	Decatur Memorial Hospital Cancer Care Institute
		Clinical Trials Office - Decatur Memorial Hospital Cancer Care	Ph: 217-876-4750
	Elmhurst
	Elmhurst Memorial Hospital
		Lucio Di Nunno, MD	Ph: 806-725-8000
	Eureka
	Eureka Community Hospital
		Nguyet A. Le-Lindqwister	Ph: 309-467-2371
	Galesburg
	Galesburg Clinic, PC
		Nguyet A. Le-Lindqwister	Ph: 309-344-1000
	Harvey
	Ingalls Cancer Care Center at Ingalls Memorial Hospital
		Clinical Trials Office - Ingalls Cancer Care Center at Ingalls	Ph: 708-915-4673
	Highland Park
	Kellogg Cancer Care Center
		Seema A. Khan, MD	Ph: 312-503-2112
	Hines
	Veterans Affairs Medical Center - Hines
		Abdul M. Choudhury, MD	Ph: 708-202-8387exts21426
	Hinsdale
	Hinsdale Hematology Oncology Associates
		Elyse C. Schneiderman, MD	Ph: 630-654-1790
	Kankakee
	Provena St. Mary's Regional Cancer Center - Kankakee
		Seema A. Khan, MD	Ph: 312-503-2112
	Libertyville
	North Shore Oncology and Hematology Associates, Limited - Libertyville
		Seema A. Khan, MD	Ph: 312-503-2112
	Macomb
	McDonough District Hospital
		Nguyet A. Le-Lindqwister	Ph: 309-833-4101
	Maywood
	Cardinal Bernardin Cancer Center at Loyola University Medical Center
		Clinical Trials Office - Cardinal Bernardin Cancer Center	Ph: 708-226-4357
	Moline
	Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
		Costas L. Constantinou, MD	Ph: 563-359-9876
	Niles
	Cancer Care and Hematology Specialists of Chicagoland - Niles
		Seema A. Khan, MD	Ph: 312-503-2112
	Normal
	BroMenn Regional Medical Center
		Nguyet A. Le-Lindqwister	Ph: 309-454-1400
	Community Cancer Center
		Nguyet A. Le-Lindqwister	Ph: 309-451-8500
	Oak Lawn
	Advocate Christ Medical Center
		Renee H. Jacobs, MD	Ph: 708-346-9935
	Ottawa
	Community Hospital of Ottawa
		Nguyet A. Le-Lindqwister	Ph: 815-433-3100
	Oncology Hematology Associates of Central Illinois, PC - Ottawa
		Nguyet A. Le-Lindqwister	Ph: 815-431-9270
	Pekin
	Cancer Treatment Center at Pekin Hospital
		Nguyet A. Le-Lindqwister	Ph: 309-353-0512
	Peoria
	CCOP - Illinois Oncology Research Association
		Nguyet A. Le-Lindqwister	Ph: 309-243-3605
	Methodist Medical Center of Illinois
		Clinical Trials Office - Methodist Medical Center of Illinois	Ph: 309-243-3000
	Oncology Hematology Associates of Central Illinois, PC - Peoria
		Nguyet A. Le-Lindqwister	Ph: 309-243-3000
	OSF St. Francis Medical Center
		Nguyet A. Le-Lindqwister	Ph: 309-655-2000
	Proctor Hospital
		Nguyet A. Le-Lindqwister	Ph: 309-691-1000
	Peru
	Illinois Valley Community Hospital
		Nguyet A. Le-Lindqwister	Ph: 815-223-3000
	River Forest
	West Suburban Center for Cancer Care
		Isoken Koko	Ph: 708-763-2700
	Rockford
	Swedish-American Regional Cancer Center
		Clinical Trials Office - Swedish-American Regional Cancer Cent	Ph: 815-489-4413
	Skokie
	Hematology Oncology Associates - Skokie
		Seema A. Khan, MD	Ph: 312-503-2112
	Springfield
	Regional Cancer Center at Memorial Medical Center
		Clinical Trials Office - Regional Cancer Center at Memorial Me	Ph: 217-788-4233
Indiana
	Beech Grove
	St. Francis Hospital and Health Centers - Beech Grove Campus
		Howard M. Gross, MD	Ph: 937-832-1093
	Elkhart
	Elkhart General Hospital
		Jose A. Bufill, MD, FACP	Ph: 574-234-5123
	Goshen
	Center for Cancer Care at Goshen General Hospital
		Clinical Trials Office - Center for Cancer Care at Goshen Gene	Ph: 574-535-2858
	Indianapolis
	Indiana University Melvin and Bren Simon Cancer Center
		Clinical Trials Office - Indiana University Cancer Center	Ph: 317-274-2552
	William N. Wishard Memorial Hospital
		Kathy Miller, MD	Ph: 317-274-1690
	Kokomo
	Howard Community Hospital
		Jose A. Bufill, MD, FACP	Ph: 574-234-5123
	La Porte
	Center for Cancer Therapy at LaPorte Hospital and Health Services
		Jose A. Bufill, MD, FACP	Ph: 574-234-5123
	Mishawaka
	Michiana Hematology-Oncology, PC - Mishawaka
		Jose A. Bufill, MD, FACP	Ph: 574-234-5123
	Saint Joseph Regional Medical Center - Mishawaka
		Jose A. Bufill, MD, FACP	Ph: 574-234-5123
	Richmond
	Reid Hospital & Health Care Services
		Howard M. Gross, MD	Ph: 937-832-1093
	South Bend
	CCOP - Northern Indiana CR Consortium
		Jose A. Bufill, MD, FACP	Ph: 574-234-5123
	Memorial Hospital of South Bend
		Clinical Trials Office - Memorial Hospital of South Bend	Ph: 800-284-7370
Iowa
	Ames
	McFarland Clinic, PC
		Clinical Trials Office - McFarland Clinic, PC	Ph: 515-239-2621
	Clive
	Medical Oncology and Hematology Associates - West Des Moines
		Robert J. Behrens	Ph: 515-875-9713
	Des Moines
	CCOP - Iowa Oncology Research Association
		Robert J. Behrens	Ph: 515-244-7586
	John Stoddard Cancer Center at Iowa Lutheran Hospital
		Clinical Trials Office - John Stoddard Cancer Center at Iowa L	Ph: 515-241-8704
	John Stoddard Cancer Center at Iowa Methodist Medical Center
		Clinical Trials Office - John Stoddard Cancer Center at Iowa M	Ph: 515-241-6727
	Medical Oncology and Hematology Associates at John Stoddard Cancer Center
		Robert J. Behrens	Ph: 515-282-2921
	Medical Oncology and Hematology Associates at Mercy Cancer Center
		Robert J. Behrens	Ph: 515-643-8740
	Mercy Cancer Center at Mercy Medical Center - Des Moines
		Robert J. Behrens	Ph: 515-643-8206
	Ottumwa
	McCreery Cancer Center at Ottumwa Regional
		Robert J. Behrens	Ph: 641-684-2946
	Sioux City
	Mercy Medical Center - Sioux City
		Donald B. Wender, MD, PhD	Ph: 712-252-0088
	Siouxland Hematology-Oncology Associates, LLP
		Donald B. Wender, MD, PhD	Ph: 712-252-0088
	St. Luke's Regional Medical Center
		Donald B. Wender, MD, PhD	Ph: 712-252-0088
Kansas
	Chanute
	Cancer Center of Kansas, PA - Chanute
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Dodge City
	Cancer Center of Kansas, PA - Dodge City
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	El Dorado
	Cancer Center of Kansas, PA - El Dorado
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Fort Scott
	Cancer Center of Kansas - Fort Scott
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Independence
	Cancer Center of Kansas-Independence
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Kingman
	Cancer Center of Kansas, PA - Kingman
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Lawrence
	Lawrence Memorial Hospital
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Liberal
	Cancer Center of Kansas, PA - Liberal
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	McPherson
	Cancer Center of Kansas, PA - McPherson
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Newton
	Cancer Center of Kansas, PA - Newton
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Parsons
	Cancer Center of Kansas, PA - Parsons
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Prairie Village
	CCOP - Kansas City
		Rakesh Gaur, MD	Ph: 913-948-5588
	Pratt
	Cancer Center of Kansas, PA - Pratt
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Salina
	Cancer Center of Kansas, PA - Salina
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Wellington
	Cancer Center of Kansas, PA - Wellington
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Wichita
	Associates in Womens Health, PA - North Review
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Cancer Center of Kansas, PA - Medical Arts Tower
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Cancer Center of Kansas, PA - Wichita
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	CCOP - Wichita
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Via Christi Cancer Center at Via Christi Regional Medical Center
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
	Winfield
	Cancer Center of Kansas, PA - Winfield
		Shaker R. Dakhil, MD, FACP	Ph: 316-262-4467
Kentucky
	Edgewood
	St. Elizabeth Medical Center
		Clinical Trials Office - St. Elizabeth Medical Center	Ph: 859-301-2237
	Lexington
	Lucille P. Markey Cancer Center at University of Kentucky
		Clinical Trials Office - Markey Cancer Center at University of	Ph: 859-257-3379
Louisiana
	Alexandria
	Tulane Cancer Center Office of Clinical Research
		Clinical Trials Office - Tulane Cancer Center	Ph: 504-988-6121
Maryland
	Annapolis
	DeCesaris Cancer Institute at Anne Arundel Medical Center
		Robert R. Buras	Ph: 443-481-5800
	Baltimore
	Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
		Mayer Gorbaty	Ph: 410-601-4734
	Greater Baltimore Medical Center Cancer Center
		Clinical Trials Office - Greater Baltimore Medical Center Canc	Ph: 443-849-3706
	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
		Clinical Trials Office - Sidney Kimmel Comprehensive Cancer Ce	Ph: 410-955-8804
			Email: jhcccro@jhmi.edu
	St. Agnes Hospital Cancer Center
		Richard S. Hudes, MD	Ph: 410-368-2965
	Easton
	Shore Regional Cancer Center at Memorial Hospital - Easton
		Mary S. DeShields, MD	Ph: 410-819-3332
	Elkton MD
	Union Hospital of Cecil County
		Gregory A. Masters, MD	Ph: 302-366-1200
Michigan
	Adrian
	Hickman Cancer Center at Bixby Medical Center
		Clinical Trials Office - Hickman Cancer Center at Bixby Medica	Ph: 517-265-0116
	Ann Arbor
	CCOP - Michigan Cancer Research Consortium
		Christopher M. Reynolds	Ph: 877-590-5995
	Saint Joseph Mercy Cancer Center
		Christopher M. Reynolds	Ph: 734-712-5658
	Dearborn
	Oakwood Cancer Center at Oakwood Hospital and Medical Center
		Clinical Trials Office - Oakwood Cancer Center at Oakwood Hosp	Ph: 313-593-8090
	Detroit
	Barbara Ann Karmanos Cancer Institute
		Clinical Trials Office - Barbara Ann Karmanos Cancer Institute	Ph: 313-576-9363
	Escanaba
	Green Bay Oncology, Limited - Escanaba
		Gerald K. Bayer, MD	Ph: 920-432-6049
	Flint
	Genesys Hurley Cancer Institute
		Clinical Trials Office - Genesys Hurley Cancer Institute	Ph: 810-762-8057
	Hurley Medical Center
		Clinical Trials Office - Hurley Medical Center	Ph: 810-762-8057
	Grand Rapids
	Butterworth Hospital at Spectrum Health
		Gilbert D.A. Padula	Ph: 616-391-2799
	Grosse Pointe Woods
	Van Elslander Cancer Center at St. John Hospital and Medical Center
		Clincial Trials Office - Van Elslander Cancer Center at St. Jo	Ph: 313-343-3166
	Iron Mountain
	Dickinson County Healthcare System
		Gerald K. Bayer, MD	Ph: 920-432-6049
	Jackson
	Foote Memorial Hospital
		Christopher M. Reynolds	Ph: 517-788-4800
	Kalamazoo
	Borgess Medical Center
		Raymond S. Lord, MD	Ph: 269-373-7458
	Bronson Methodist Hospital
		Raymond S. Lord, MD	Ph: 269-373-7458
	West Michigan Cancer Center
		Clinical Trials Office - West Michigan Cancer Center	Ph: 269-373-7458
	Lansing
	Sparrow Regional Cancer Center
		Clinical Trials Office - Sparrow Regional Cancer Center	Ph: 517-364-2890
	Livonia
	St. Mary Mercy Hospital
		Christopher M. Reynolds	Ph: 734-464-4800
	Midland
	MidMichigan Medical Center - Midland
		Clinical Trials Office - MidMichigan Medical Center - Midland	Ph: 989-839-3377
	Monroe
	Community Cancer Center of Monroe
		Rex B. Mowat	Ph: 734-242-7902
	Mercy Memorial Hospital - Monroe
		Rex B. Mowat	Ph: 734-240-8400
	Muskegon
	Mercy General Health Partners
		Gilbert D.A. Padula	Ph: 231-672-2000
	Pontiac
	St. Joseph Mercy Oakland
		Christopher M. Reynolds	Ph: 248-858-3612
	Port Huron
	Mercy Regional Cancer Center at Mercy Hospital
		Christopher M. Reynolds	Ph: 810-985-1484
	Reed City
	Spectrum Health Reed City Hospital
		Gilbert D.A. Padula	Ph: 231-832-3271
	Royal Oak
	William Beaumont Hospital - Royal Oak Campus
		Clinical Trials Office - William Beaumont Hospital - Royal Oak	Ph: 248-551-7695
	Saginaw
	Seton Cancer Institute at Saint Mary's - Saginaw
		Clinical Trials Office - Seton Cancer Institute - Saginaw	Ph: 989-776-8411
	Saint Joseph
	Lakeland Regional Cancer Care Center - St. Joseph
		Jose A. Bufill, MD, FACP	Ph: 574-234-5123
	Lakeside Cancer Specialists, PLLC
		Jose A. Bufill, MD, FACP	Ph: 574-234-5123
	Southfield
	Providence Cancer Institute at Providence Hospital - Southfield Campus
		Anibal Drelichman, MD, MPH, FACP	Ph: 313-552-0620
	Traverse City
	Munson Medical Center
		Gilbert D.A. Padula	Ph: 231-935-6202
	Warren
	St. John Macomb Hospital
		Christopher M. Reynolds	Ph: 586-573-5757
Minnesota
	Burnsville
	Fairview Ridges Hospital
		Joseph W. Leach	Ph: 952-892-2000
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Joseph W. Leach	Ph: 763-236-6000
	Edina
	Fairview Southdale Hospital
		Clinical Trials Office - Fairview Southdale Hospital	Ph: 612-625-3650
	Fridley
	Mercy and Unity Cancer Center at Unity Hospital
		Joseph W. Leach	Ph: 763-236-5000
	Hutchinson
	Hutchinson Area Health Care
		Joseph W. Leach	Ph: 320-234-5000
	Mankato
	Immanuel St. Joseph's
		Mohmmad J. Ranginwala	Ph: 507-625-4031
	Maplewood
	HealthEast Cancer Care at St. John's Hospital
		Joseph W. Leach	Ph: 651-232-7970
	Minnesota Oncology - Maplewood
		Joseph W. Leach	Ph: 651-779-7978
	Minneapolis
	Hennepin County Medical Center - Minneapolis
		Clinical Trials Office - Hennepin County Medical Center - Minn	Ph: 612-873-5911
	Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
		Clinical Trials Office - Virginia Piper Cancer Institute	Ph: 612-863-5654
	New Ulm
	New Ulm Medical Center
		Joseph W. Leach	Ph: 507-217-5000
	Robbinsdale
	Humphrey Cancer Center at North Memorial Outpatient Center
		Clinical Trials Office - Humphrey Cancer Center at North Memor	Ph: 763-520-1893
	Rochester
	Mayo Clinic Cancer Center
		Clinical Trials Office - All Mayo Clinic Locations	Ph: 507-538-7623
	Saint Louis Park
	CCOP - Metro-Minnesota
		Joseph W. Leach	Ph: 952-993-1517
	Park Nicollet Cancer Center
		Joseph W. Leach	Ph: 952-993-3248
	Saint Paul
	United Hospital
		Joseph W. Leach	Ph: 651-241-8000
	Shakopee
	St. Francis Cancer Center at St. Francis Medical Center
		Joseph W. Leach	Ph: 952-403-2031
	St. Paul
	Regions Hospital Cancer Care Center
		Clinical Trials Office - Regions Hospital Cancer Care Center	Ph: 651-254-1517
	Stillwater
	Lakeview Hospital
		Joseph W. Leach	Ph: 651-439-5330
	Waconia
	Ridgeview Medical Center
		Joseph W. Leach	Ph: 952-442-2191
	Willmar
	Willmar Cancer Center at Rice Memorial Hospital
		Joseph W. Leach	Ph: 320-231-4650
	Woodbury
	Minnesota Oncology - Woodbury
		Joseph W. Leach	Ph: 651-735-7414
Mississippi
	Jackson
	University of Mississippi Cancer Clinic
		Barbara S. Craft	Ph: 601-984-5590
	Pascagoula
	Regional Cancer Center at Singing River Hospital
		James E. Clarkson, MD	Ph: 228-374-6296
Missouri
	Cape Girardeau
	Saint Francis Medical Center
		Bethany G. Sleckman, MD	Ph: 314-251-7057
	Kansas City
	Research Medical Center
		Rakesh Gaur, MD	Ph: 913-948-5588
	Saint Luke's Cancer Institute at Saint Luke's Hospital
		Rakesh Gaur, MD	Ph: 913-948-5588
	Rolla
	Mercy Clinic Cancer and Hematology - Rolla
		Robert L. Carolla	Ph: 573-458-6379
	Saint Joseph
	Heartland Regional Medical Center
		Rakesh Gaur, MD	Ph: 913-948-5588
	Saint Joseph Oncology, Incorporated
		Rakesh Gaur, MD	Ph: 913-948-5588
	Saint Louis
	David C. Pratt Cancer Center at St. John's Mercy
		Clinical Trials Office - David C. Pratt Cancer Center at St. J	Ph: 314-251-6770
	St. Anthony's Cancer Center
		Minxiang (Michael) Gu	Ph: 314-525-4063
	Springfield
	Hulston Cancer Center at Cox Medical Center South
		Robert L. Carolla	Ph: 417-269-5257
	St. John's Regional Health Center
		Robert L. Carolla	Ph: 417-820-2000
Montana
	Billings
	Billings Clinic - Downtown
		Clinical Trials Office - Billings Clinic - Downtown	Ph: 800-996-2663
			Email: research@billingsclinic.org
	CCOP - Montana Cancer Consortium
		Benjamin T. Marchello, MD	Ph: 406-238-6290
	Great Falls
	Benefis Sletten Cancer Institute
		Grant W. Harrer, MD, FACP, CCTI	Ph: 406-731-8100
	Big Sky Oncology
		Clinical Trial Office - Big Sky Oncology	Ph: 406-731-8217
	Great Falls Clinic - Main Facility
		Benjamin T. Marchello, MD	Ph: 406-238-6290
Nebraska
	Lincoln
	Cancer Resource Center - Lincoln
		Gamini S. Soori, MD, FACP, FRCP, MBA	Ph: 402-393-3110
	Omaha
	Alegant Health Cancer Center at Bergan Mercy Medical Center
		Clinical Trials Office - Alegant Health Cancer Center at Berge	Ph: 402-398-6060
	CCOP - Missouri Valley Cancer Consortium
		Gamini S. Soori, MD, FACP, FRCP, MBA	Ph: 402-393-3110
	Creighton University Medical Center
		Clinical Trials Office - Creighton University Medical Center	Ph: 402-280-4100
	Immanuel Medical Center
		Gamini S. Soori, MD, FACP, FRCP, MBA	Ph: 402-393-3110
	Lakeside Hospital
		Gamini S. Soori, MD, FACP, FRCP, MBA	Ph: 402-393-3110
New Hampshire
	Lebanon
	Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
		Clinical Trials Office - Norris Cotton Cancer Center	Ph: 603-650-7609
			Email: cancerhelp@dartmouth.edu
	Manchester
	Norris Cotton Cancer Center at Catholic Medical Center
		Gary N. Schwartz	Ph: 603-629-1828
New Jersey
	Flemington
	Hunterdon Regional Cancer Center at Hunterdon Medical Center
		Kenneth B. Blankstein, MD	Ph: 908-788-6100
	Marlton
	Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
		Clinical Trials Office - Fox Chase Virtua Health Cancer Progra	Ph: 888-847-8823
	Newark
	Newark Beth Israel Medical Center
		Clinical Trials Office - Newark Beth Israel Medical Center	Ph: 973-926-3136
	Sewell
	Radiation Oncology Center at Kennedy Health System - Sewell
		Trina A. Poretta	Ph: 856-582-3008
	Toms River
	J. Phillip Citta Regional Cancer Center at Community Medical Center
		Clinical Trials Office - J. Phillip Citta Regional Cancer Cent	Ph: 732-818-3882
	Voorhees
	Cancer Institute of New Jersey at Cooper - Voorhees
		Clinical Trials Office - Cancer Institute of New Jersey at Coo	Ph: 856-325-6757
	Fox Chase Virtua Health Cancer Program at Virtua West Jersey
		Michael S. Entmacher, MD	Ph: 609-702-1900
New Mexico
	Albuquerque
	Lovelace Medical Center - Downtown
		Zoneddy R. Dayao	Ph: 505-727-8000
	University of New Mexico Cancer Center
		Clinical Trials Office - University of New Mexico Cancer Cente	Ph: 505-272-6972
	Las Cruces
	University of New Mexico Cancer Center - South
		Zoneddy R. Dayao	Ph: 505-521-1554
New York
	Bronx
	Albert Einstein Cancer Center at Albert Einstein College of Medicine
		Clinical Trials Office - Albert Einstein Cancer Center at Albe	Ph: 718-904-2730
			Email: aecc@aecom.yu.edu
	Buffalo
	Roswell Park Cancer Institute
		Clinical Trials Office - Roswell Park Cancer Institute	Ph: 877-275-7724
	Cooperstown
	Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital
		Eric Bravin, MD	Ph: 607-547-3336
	Mineola
	Winthrop University Hospital
		Nina D'Abreo	Ph: 516-663-9500
	New York
	Beth Israel Medical Center - Petrie Division
		Clinical Trials Office - Beth Israel Medical Center - Petrie D	Ph: 212-844-6286
	Memorial Sloan-Kettering Cancer Center
		Tari A. King	Ph: 212-639-8895
	Mount Sinai Medical Center
		Paul H. Schmidt, III	Ph: 212-241-6500
	St. Luke's - Roosevelt Hospital Center - St.Luke's Division
		Paula Klein, MD	Ph: 212-604-6021
	Poughkeepsie
	Dyson Center for Cancer Care at Vassar Brothers Medical Center
		Clinical Trials Office - Dyson Center for Cancer Care at Vassa	Ph: 845-483-6483
	Rochester
	Highland Hospital of Rochester
		Jonathan W. Friedberg	Ph: 585-473-2200
	James P. Wilmot Cancer Center at University of Rochester Medical Center
		Jonathan W. Friedberg	Ph: 585-275-5345
	Staten Island
	Nalitt Cancer Institute at Staten Island University Hospital
		Meekoo Dhar	Ph: 718-226-6400
	White Plains
	Dickstein Cancer Treatment Center at White Plains Hospital Center
		Clinical Trials Office - Dickstein Cancer Treatment Center	Ph: 914-681-2290
North Carolina
	Charlotte
	Blumenthal Cancer Center at Carolinas Medical Center
		Clinical Trials Office - Blumenthal Cancer Center at Carolinas	Ph: 704-355-2884
	Concord
	Batte Cancer Center at Northeast Medical Center
		Teresa Flippo-Morton	Ph: 704-783-1322
	Statesville
	Iredell Memorial Hospital
		Ruby A. Grimm, MD	Ph: 704-873-2219
	Wilmington
	Zimmer Cancer Center at New Hanover Regional Medical Center
		Cyrus A. Kotwall, MD	Ph: 910-763-4630
	Winston-Salem
	Wake Forest University Comprehensive Cancer Center
		Clinical Trials Office - Wake Forest University Comprehensive	Ph: 336-713-6771
North Dakota
	Bismarck
	Medcenter One Hospital Cancer Care Center
		John T. Reynolds	Ph: 701-323-5741
	Mid Dakota Clinic, PC
		Clinical Trials Office - Mid Dakota Clinic, PC	Ph: 701-530-6950
	St. Alexius Medical Center Cancer Center
		Clinical Trials Office - St. Alexius Medical Center Cancer Cen	Ph: 701-530-6950
	Fargo
	CCOP - MeritCare Hospital
		Preston D. Steen, MD	Ph: 701-234-2397
	Grand Forks
	Altru Cancer Center at Altru Hospital
		Clinical Trails Office - Altru Cancer Center at Altru Hospital	Ph: 701-780-6520
	Minot
	Trinity CancerCare Center
		Patanit Watanaboonyakhet, DO	Ph: 701-857-3535
Ohio
	Akron
	McDowell Cancer Center at Akron General Medical Center
		Esther H. Rehmus, MD	Ph: 330-344-6505
	Summa Center for Cancer Care at Akron City Hospital
		Clinical Trials Office - Akron City Hospital	Ph: 330-375-6101
	Bowling Green
	Wood County Oncology Center
		Rex B. Mowat	Ph: 419-352-9498
	Canton
	Aultman Cancer Center at Aultman Hospital
		Clinical Trials Office - Aultman Cancer Center at Aultman Hosp	Ph: 330-363-6891
	Chillicothe
	Adena Regional Medical Center
		Clinical Trials Office - Adena Regional Medical Center	Ph: 877-779-7585
	Cleveland
	Case Comprehensive Cancer Center
		Clinical Trials Office - Case Comprehensive Cancer Center	Ph: 800-641-2422
	Columbus
	Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
		Ohio State University Cancer Clinical Trial Matching Service	Ph: 866-627-7616
			Email: Jamesline@osumc.edu
	CCOP - Columbus
		J. Philip Kuebler, MD, PhD	Ph: 614-442-3130
	Doctors Hospital at Ohio Health
		Clinical Trials Office - Doctors Hospital at Ohio Health	Ph: 614-566-3275
	Grant Medical Center Cancer Care
		Clinical Trials Office - Grant Medical Center Cancer Care	Ph: 614-566-4475
	Mount Carmel Health - West Hospital
		J. Philip Kuebler, MD, PhD	Ph: 614-442-3130
	Riverside Methodist Hospital Cancer Care
		Clinical Trials Office - Riverside Methodist Hospital Cancer C	Ph: 614-566-4475
	Dayton
	David L. Rike Cancer Center at Miami Valley Hospital
		Clinical Trials Office - David L. Rike Cancer Center at Miami	Ph: 937-208-2079
	Good Samaritan Hospital
		Howard M. Gross, MD	Ph: 937-832-1093
	Samaritan North Cancer Care Center
		Howard M. Gross, MD	Ph: 937-832-1093
	Delaware
	Grady Memorial Hospital
		J. Philip Kuebler, MD, PhD	Ph: 614-442-3130
	Elyria
	Community Cancer Center
		Rex B. Mowat	Ph: 440-324-0400
	Hematology Oncology Center
		Rex B. Mowat	Ph: 440-324-0401
	Findlay
	Blanchard Valley Medical Associates
		Howard M. Gross, MD	Ph: 937-832-1093
	Franklin
	Middletown Regional Hospital
		Howard M. Gross, MD	Ph: 937-832-1093
	Kettering
	Charles F. Kettering Memorial Hospital
		Clinical Trials Office - Charles F. Kettering Memorial Hospita	Ph: 937-298-3399 ext. 57556
	Lancaster
	Fairfield Medical Center
		J. Philip Kuebler, MD, PhD	Ph: 614-442-3130
	Lima
	Lima Memorial Hospital
		Rex B. Mowat	Ph: 419-228-3335
	Marietta
	Strecker Cancer Center at Marietta Memorial Hospital
		J. Philip Kuebler, MD, PhD	Ph: 614-442-3130
	Maumee
	Northwest Ohio Oncology Center
		Rex B. Mowat	Ph: 419-891-5600
	Mount Vernon
	Knox Community Hospital
		J. Philip Kuebler, MD, PhD	Ph: 614-442-3130
	Newark
	Licking Memorial Cancer Care Program at Licking Memorial Hospital
		J. Philip Kuebler, MD, PhD	Ph: 614-442-3130
	Oregon
	St. Charles Mercy Hospital
		Rex B. Mowat	Ph: 419-696-7200
	Toledo Clinic - Oregon
		Rex B. Mowat	Ph: 419-691-4235
	Portsmouth
	Southern Ohio Medical Center Cancer Center
		J. Philip Kuebler, MD, PhD	Ph: 614-442-3130
	Springfield
	Community Hospital of Springfield and Clark County
		J. Philip Kuebler, MD, PhD	Ph: 614-442-3130
	Sylvania
	Flower Hospital Cancer Center
		Clinical Trials Office - Flower Hospital Cancer Center	Ph: 419-824-1842
	Tiffin
	Mercy Hospital of Tiffin
		Rex B. Mowat	Ph: 419-447-3130
	Toledo
	CCOP - Toledo Community Hospital
		Rex B. Mowat	Ph: 419-843-6147
	Medical University of Ohio Cancer Center
		Clinical Trials Office - Medical University of Ohio Cancer Cen	Ph: 419-383-6583
	St. Anne Mercy Hospital
		Rex B. Mowat	Ph: 419-407-2663
	St. Vincent Mercy Medical Center
		Rex B. Mowat	Ph: 419-251-4515
	Toledo Clinic, Incorporated - Main Clinic
		Rex B. Mowat	Ph: 419-479-5605
	Toledo Hospital
		Clinical Trials Office - Toledo Hospital	Ph: 419-824-1842
	Troy
	UVMC Cancer Care Center at Upper Valley Medical Center
		Clinical Trials Office - UVMC Cancer Care Center at Upper Vall	Ph: 937-440-4842
	Wauseon
	Fulton County Health Center
		Clinical Trials Office - Fulton County Health Center	Ph: 419-330-2708
	Westerville
	Mount Carmel St. Ann's Cancer Center
		J. Philip Kuebler, MD, PhD	Ph: 614-442-3130
	Zanesville
	Genesis - Good Samaritan Hospital
		Clinical Trials Office - Genesis - Good Samaritan Hospital	Ph: 740-454-5232
Oklahoma
	Oklahoma City
	Oklahoma University Cancer Institute
		Shubham Pant	Ph: 405-271-6822
Pennsylvania
	Bethlehem
	St. Luke's Cancer Network at St. Luke's Hospital
		Sanjiv S. Agarwala, MD	Ph: 610-954-2145
	Easton
	Easton Regional Cancer Center at Easton Hospital
		Rajen P. Oza	Ph: 610-250-4567
	Gettysburg
	Adams Cancer Center
		Amir Tabatabai, MD	Ph: 717-741-9229
	Hanover
	Cherry Tree Cancer Center
		Amir Tabatabai, MD	Ph: 717-741-9229
	Hershey
	Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
		Clinical Trials Office - Penn State Hershey Cancer Institute a	Ph: 717-531-3779
			Email: CTO@hmc.psu.edu
	Lancaster
	Lancaster Cancer Center
		Elizabeth Horenkamp	Ph: 717-544-5511
	Langhorne
	St. Mary Regional Cancer Center
		Clinical Trials Office - St. Mary Regional Cancer Center	Ph: 215-710-4585
	Lewistown
	Lewistown Hospital
		J. S. Smith, MD	Ph: 717-531-4488
	Meadowbrook
	Charles A. & Betty Bott Cancer Center at Holy Redeemer Hospital
		Pallav Mehta	Ph: 215-938-3555
	Philadelphia
	Abramson Cancer Center of the University of Pennsylvania
		Clinical Trials Office - Abramson Cancer Center of the Univers	Ph: 800-474-9892
	Fox Chase Cancer Center - Philadelphia
		Clinical Trials Office - Fox Chase Cancer Center - Philadelphi	Ph: 215-728-4790
	Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
		Clinical Trials Office - Kimmel Cancer Center at Thomas Jeffer	Ph: 215-955-6084
	Pittsburgh
	UPMC Cancer Centers
		Clinical Trials Office - UPMC Cancer Centers	Ph: 412-647-8073
	State College
	Mount Nittany Medical Center
		J. S. Smith, MD	Ph: 717-531-4488
	Williamsport
	Susquehanna Cancer Center at Divine Providence Hospital
		Warren L. Robinson, Jr.	Ph: 570-326-8000
	York
	York Cancer Center at Apple Hill Medical Center
		Amir Tabatabai, MD	Ph: 717-741-9229
South Carolina
	Charleston
	Hollings Cancer Center at Medical University of South Carolina
		Clinical Trials Office - Hollings Cancer Center at Medical Uni	Ph: 843-792-9321
	Roper St. Francis Cancer Center at Roper Hospital
		James M. Orcutt, MD	Ph: 843-577-2276
	Spartanburg
	CCOP - Upstate Carolina
		Clinical Trials Office - CCOP - Upstate Carolina	Ph: 800-486-5941
	Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
		Clinical Trials Office - Gibbs Regional Cancer Center	Ph: 800-486-5941
South Dakota
	Sioux Falls
	Avera Cancer Institute
		Addison R. Tolentino	Ph: 605-322-3000
	Sanford Cancer Center at Sanford USD Medical Center
		Clinical Trials Office - Sanford Cancer Center	Ph: 605-328-1367
Tennessee
	Jackson
	West Tennessee Cancer Center at Jackson-Madison County General Hospital
		Clinical Trials Office - West Tennessee Cancer Center	Ph: 731-425-6865
Texas
	Dallas
	Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
		Clinical Trials Office - Simmons Comprehensive Cancer Center a	Ph: 866-460-4673; 214-648-7097
	Galveston
	University of Texas Medical Branch
		Clinical Trials Office - University of Texas Medical Branch	Ph: 409-772-1950
	Houston
	M. D. Anderson Cancer Center at University of Texas
		Clinical Trials Office - M. D. Anderson Cancer Center at the U	Ph: 713-792-3245
	Methodist Hospital
		Jenny Chee Ning Chang	Ph: 713-441-1010
	Irving
	Baylor Medical Center at Irving
		Sarju Waghela	Ph: 972-579-8113
	Laredo
	Doctor's Hospital of Laredo
		Gary W. Unzeitig, MD	Ph: 956-726-3691
	Temple
	CCOP - Scott and White Hospital
		Lucas Wong, MD	Ph: 254-724-1053
Utah
	Salt Lake City
	Huntsman Cancer Institute at University of Utah
		Clinical Trials Office - Huntsman Cancer Institute at Universi	Ph: 801-581-4477
			Email: clinical.trials@hci.utah.edu
Virginia
	Fredericksburg
	Fredericksburg Oncology, Incorporated
		Rex B. Mowat	Ph: 540-368-0500
	Richmond
	Virginia Commonwealth University Massey Cancer Center
		Clinical Trials Office -Virginia Commonwealth University Masse	Ph: 804-628-1939
Washington
	Bellingham
	St. Joseph Cancer Center
		Saul E. Rivkin, MD	Ph: 206-386-2441
	Bremerton
	Harrison Medical Center
		Stephen C. Springate	Ph: 360-792-6605
	Seattle
	Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
		Saul E. Rivkin, MD	Ph: 206-386-2441
	University Cancer Center at University of Washington Medical Center
		Saul E. Rivkin, MD	Ph: 206-386-2441
	Walla Walla
	St. Mary Regional Cancer Center at St. Mary Medical Center
		James R. Cunningham	Ph: 509-525-3320
West Virginia
	Huntington
	St. Mary's Regional Cancer Center at St. Mary's Medical Center
		Arvinder S. Bir	Ph: 304-526-1856
Wisconsin
	Antigo
	Langlade Memorial Hospital
		Hamied R. Rezazadeh, MD	Ph: 715-847-2121
	Appleton
	Fox Valley Hematology and Oncology - East Grant Street
		Honnie R. Bermas	Ph: 920-749-1171
	Fox Valley Surgical Associates at Appleton Medical Center
		Honnie R. Bermas	Ph: 920-731-8131
	Theda Care Cancer Institute
		Clinical Trials Office - Theda Care Cancer Institute	Ph: 920-380-1500
	Chippewa Falls
	Marshfield Clinic - Chippewa Center
		Matthias Weiss, MD	Ph: 715-358-1266
	Eau Claire
	Center for Cancer Treatment & Prevention at Sacred Heart Hospital
		Matthias Weiss, MD	Ph: 715-358-1266
	Marshfield Clinic Cancer Care at Regional Cancer Center
		Matthias Weiss, MD	Ph: 715-358-1266
	Green Bay
	Green Bay Oncology, Limited at St. Mary's Hospital
		Gerald K. Bayer, MD	Ph: 920-432-6049
	Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
		Gerald K. Bayer, MD	Ph: 920-432-6049
	St. Mary's Hospital Medical Center - Green Bay
		Gerald K. Bayer, MD	Ph: 920-432-6049
	St. Vincent Hospital Regional Cancer Center
		Clinical Trials Office - St. Vincent Hospital Regional Cancer	Ph: 920-433-8889
	Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
		Clinical Trials Office - Vince Lombardi Cancer Clinic - Green	Ph: 414-649-5717
	Johnson Creek
	UW Cancer Center Johnson Creek
		Amye J. Tevaarwerk	Ph: 920-699-3500
	La Crosse
	Gundersen Lutheran Center for Cancer and Blood
		Clinical Trials Office - Gundersen Lutheran Cancer Center	Ph: 608-775-2385
			Email: cancerctr@gundluth.org
	Madison
	University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
		Clinical Trials Office - University of Wisconsin Paul P. Carbo	Ph: 608-262-5223
	Manitowoc
	Holy Family Memorial Medical Center Cancer Care Center
		Clinical Trials Office - Holy Family Memorial Medical Center C	Ph: 920-320-2749
	Marinette
	Bay Area Cancer Care Center at Bay Area Medical Center
		Gerald K. Bayer, MD	Ph: 920-432-6049
	Vince Lombardi Cancer Clinic - Marinette
		Dhimant R. Patel, MD	Ph: 920-288-4180
	Marshfield
	Marshfield Clinic - Marshfield Center
		Clinical Trials Office - Marshfield Clinic - Marshfield Center	Ph: 800-782-1581 ext. 94457
	Saint Joseph's Hospital
		Matthias Weiss, MD	Ph: 715-358-1266
	Milwaukee
	Medical College of Wisconsin Cancer Center
		Clinical Trials Office - Medical College of Wisconsin Cancer C	Ph: 414-805-4380
	Minocqua
	Marshfield Clinic - Lakeland Center
		Matthias Weiss, MD	Ph: 715-358-1266
	Oconomowoc
	Regional Cancer Center at Oconomowoc Memorial Hospital
		Clinical Trials Office - Regional Cancer Center at Oconomowoc	Ph: 262-928-7878
	Oconto Falls
	Green Bay Oncology, Limited - Oconto Falls
		Gerald K. Bayer, MD	Ph: 920-432-6049
	Oshkosh
	Vince Lombardi Cancer Clinic - Oshkosh
		Dhimant R. Patel, MD	Ph: 920-288-4180
	Rhinelander
	Ministry Medical Group at Saint Mary's Hospital
		Matthias Weiss, MD	Ph: 715-358-1266
	Rice Lake
	Marshfield Clinic - Indianhead Center
		Matthias Weiss, MD	Ph: 715-358-1266
	Sheboygan
	St. Nicholas Hospital
		Gerald K. Bayer, MD	Ph: 920-432-6049
	Vince Lombardi Cancer Clinic - Sheboygan
		Clinical Trials Office - Vince Lombardi Cancer Clinic - Sheboy	Ph: 414-649-7200
	Stevens Point
	Marshfield Clinic at Saint Michael's Hospital
		Matthias Weiss, MD	Ph: 715-358-1266
	Saint Michael's Hospital Cancer Center
		Matthias Weiss, MD	Ph: 715-358-1266
	Sturgeon Bay
	Green Bay Oncology, Limited - Sturgeon Bay
		Gerald K. Bayer, MD	Ph: 920-432-6049
	Summit
	Aurora Medical Center
		Dhimant R. Patel, MD	Ph: 920-288-4180
	Two Rivers
	Vince Lombardi Cancer Clinic - Two Rivers
		Dhimant R. Patel, MD	Ph: 920-288-4180
	Waukesha
	Waukesha Memorial Hospital Regional Cancer Center
		Clinical Trials Office - Waukesha Memorial Hospital Regional C	Ph: 262-928-7632
	Wausau
	Marshfield Clinic - Wausau Center
		Matthias Weiss, MD	Ph: 715-358-1266
	University of Wisconcin Cancer Center at Aspirus Wausau Hospital
		Clinical Trials Office - University of Wisconsin Cancer Center	Ph: 608-262-5223
	Wauwatosa
	Oncology Alliance, SC - Milwaukee - West
		Rubina Qamar	Ph: 414-476-8450
	Weston
	Diagnostic and Treatment Center
		Matthias Weiss, MD	Ph: 715-358-1266
	Marshfield Clinic - Weston Center
		Matthias Weiss, MD	Ph: 715-358-1266
	Wisconsin Rapids
	Marshfield Clinic - Wisconsin Rapids Center
		Matthias Weiss, MD	Ph: 715-358-1266
	Riverview UW Cancer Center at Riverview Hospital
		Ron J. Kirschling, MD, FACP	Ph: 715-421-7442
Canada
	Saint John
	Saint John Regional Hospital
		Margot J. Burnell, MD	Ph: 506-648-6884
Alberta
	Edmonton
	Cross Cancer Institute at University of Alberta
		Zsolt Gabos	Ph: 780-432-8771
Manitoba
	Winnipeg
	CancerCare Manitoba
		Ethel L. MacIntosh	Ph: 204-787-2241
Ontario
	London
	London Regional Cancer Program at London Health Sciences Centre
		Steven Latosinsky, MD	Ph: 204-787-2673
Quebec
	Montreal
	McGill Cancer Centre at McGill University
		Mark Basik	Ph: 514-398-1444
Israel
	Tel Aviv
	Tel-Aviv Sourasky Medical Center
		Tehillah S. Menes	Ph: 972-3-697-4444
Republic of South Africa
	Pretoria
	Pretoria Academic Hospital
		Lydia M. Dreosti	Ph: 27-12-354-1000
Saudi Arabia
	Riyadh
	King Faisal Specialist Hospital and Research Center
		Kausar Suleman	Ph: 966-3-464-7272 ext. 23940