NCI Materials
About SELECT
- NIH-funded study shows increased prostate cancer risk from vitamin E supplements
(Posted: 10/11/2011) - Men who took 400 international units of vitamin E daily had more prostate cancers compared to men who took a placebo, according to an updated review of data from the Selenium and Vitamin E Cancer Prevention Trial (SELECT). The findings showed that, per 1,000 men, there were 76 prostate cancers in men who took only vitamin E supplements, vs. 65 in men on placebo over a seven-year period, or 11 more cases of prostate cancer per 1,000 men. This represents a 17 percent increase in prostate cancers relative to those who took a placebo. This difference was statistically significant and therefore is not likely due to chance. - Selenium and Vitamin E Cancer Prevention Trial (SELECT)
(Posted: 10/31/2008, Updated: 10/11/2011) - SELECT is continuing to evaluate the effects of the supplements, but participants are no longer taking study supplements. The independent Data and Safety Monitoring Committee for the trial found that selenium and vitamin E, taken alone or together for an average of five and one-half years, did not prevent prostate cancer. - Review of Prostate Cancer Prevention Study Shows No Benefit for Use of Selenium and Vitamin E Supplements
(Posted: 10/27/2008, Updated: 12/09/2008) - Initial, independent review of study data from the Selenium and Vitamin E Cancer Prevention Trial (SELECT), funded by the National Cancer Institute (NCI) and other institutes that comprise the National Institutes of Health shows that selenium and vitamin E supplements, taken either alone or together, did not prevent prostate cancer. The data also showed two concerning trends: a small but not statistically significant increase in the number of prostate cancer cases among the over 35,000 men age 50 and older in the trial taking only vitamin E and a small, but not statistically significant increase in the number of cases of adult onset diabetes in men taking only selenium. - Largest-Ever Prostate Cancer Prevention Trial Opens: 32,000 Men Sought to Test Vitamin E and Selenium
(Posted: 07/24/2001) - Healthy men age 55 and older are needed for the largest-ever prostate cancer prevention study, launched today by the NCI and a network of researchers known as the Southwest Oncology Group (SWOG). Questions and Answers - Phase III Randomized Study of Selenium and Vitamin E for the Prevention of Prostate Cancer (SELECT Trial)
A summary of the SELECT protocol statement. - SELECT Data: Enrollment Statistics
(Updated: 09/04/2003) - Enrollment data from SELECT, the Selenium and Vitamin E Cancer Prevention Trial.
About SELECT (Español)
- Estudio financiado por NIH muestra un riesgo mayor de cáncer de próstata debido a complementos de vitamina E
(Publicación: 11 de octubre de 2011 ) - De acuerdo a una revisión ulterior de los datos del Estudio del Selenio y la Vitamina E para Prevenir el Cáncer (SELECT), los hombres que tomaron diariamente 400 unidades internacionales (U.I.) de vitamina E tuvieron más cánceres de próstata que los hombres que tomaron un placebo. Los resultados mostraron que, por cada 1 000 hombres, hubo 76 casos de cáncer de próstata entre hombres que tomaron solamente complementos de vitamina E en comparación con 65 casos de cáncer entre hombres que tomaron un placebo durante un período de 7 años; es decir, 11 casos más de cáncer de próstata por cada 1 000 hombres. Esto representa un aumento de 17% en cánceres de próstata en relación con los que tomaron un placebo. Esta diferencia fue estadísticamente significativa y, por lo tanto, es posible que no se deba a la casualidad. - La revisión del estudio de prevención de cáncer de próstata indica no haber beneficio del uso de suplementos de selenio y de vitamina E
(Publicación: 27 de octubre de 2008 , Actualización: 9 de diciembre de 2008 ) - La revisión inicial, independiente, de los datos del estudio SELECT, sigla en inglés del Estudio del Selenio y la Vitamina E para Prevenir el Cáncer, financiado por el Instituto Nacional del Cáncer (NCI) y otros institutos que comprenden los Institutos Nacionales de la Salud (NIH), indica que los suplementos de selenio y de vitamina E, tomados juntos o por separado, no impiden el cáncer de próstata. Los datos indicaron también dos tendencias preocupantes: un pequeño aumento aunque no significativo estadísticamente en el número de casos de cáncer de próstata entre los más de 35 000 hombres de 50 años y mayores en el estudio que tomaron sólo vitamina E, y un aumento pequeño aunque no significativo estadísticamente en el número de casos de diabetes de aparición en edad adulta en los hombres que tomaron sólo el selenio. - Se inagura estudio de prevención de cáncer de próstata
(Publicación: 24 de julio de 2001 ) - Más de 400 centros en los Estados Unidos, Puerto Rico y Canadá están aceptando participantes para SELECT. Este estudio durará 12 años. SELECT es el primer estudio diseñado para observar directamente los efectos del selenio y la vitamina E, tanto juntos como por separado, para prevenir el cáncer de próstata.
About Prostate Cancer Prevention
- Prostate Cancer Prevention (PDQ®)
[ patient ] [ health professional ]
Expert-reviewed information summary about factors that may influence the risk of developing prostate cancer and about research aimed at the prevention of this disease.
About Other Vitamin E Trials
- HOPE-TOO: NCI Comment on Published Results
(Posted: 03/15/2005) - A report published in the March 16 issue of the Journal of the American Medical Association finds no clear evidence that men and women who had vascular disease or diabetes and who took 400 i.u. of vitamin E daily for 7 years reduced their risk of cancer compared to others with these conditions who took a placebo.
About Other Prostate Cancer Prevention Trials
- The Prostate Cancer Prevention Trial
A collection of material about a study designed to see whether the drug finasteride (trade name Proscar) can prevent prostate cancer in men ages 55 and older. - Dutasteride Decreases Prostate Cancer Risk
(Posted: 04/12/2010) - Results from a large randomized clinical trial indicate that men at an increased risk for prostate cancer reduced their risk with regular use of the drug dutasteride (Avodart). - Prevention of Prostate Cancer
List of open clinical trials investigating ways to prevent to prostate cancer, or to prevent a recurrence or progression of prostate cancer, from NCI's clinical trials list.
