Featured Clinical Trials Supported by the National Cancer Institute
Today, thousands of cancer clinical trials are under way in the United States. Clinical trials answer vital research questions that lead to better screening, prevention, diagnosis, and treatment options for all cancers. This section highlights NCI-supported cancer trials and demonstrates the breadth of clinical cancer research supported by the Institute.
To find other cancer trials open to enrollment:
- Call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237) for information about trials all across the country. The call is toll-free and completely confidential.
- Use the clinical trials search form to look online for trials listed on NCI's Cancer.gov Web site. The form has a Help link for tips about searching for clinical trials.
- For information about cancer trials taking place on the National Institutes of Health campus in Bethesda, Maryland, call NCI’s Clinical Trials Referral Office at 1-888-NCI-1937 (1-888-624-1937). The call is toll-free and completely confidential.
(Posted: 08/09/2011) - In this trial, doctors will test the KRAS mutation status of tumors in patients with advanced non-small cell lung cancer whose disease has progressed during or after chemotherapy; they will then randomly assign the patients to either AZD6244 plus erlotinib or either drug alone, depending on KRAS status of their tumors.
Preventing Smoldering Multiple Myeloma from Progressing
(Posted: 07/12/2011) - In this trial, people diagnosed with smoldering myeloma will be treated with an experimental biological agent called IPH2101 that helps immune cells called natural killer cells, or NK cells, attack and destroy myeloma cells.
Adding Targeted Therapy to Treatment for Esophageal Cancer
(Posted: 06/28/2011) - In this phase III clinical trial, people with confirmed HER2-positive locally advanced esophageal cancer will be randomly assigned to receive preoperative radiation therapy and chemotherapy, with or without trastuzumab. Following surgery, patients assigned to the trastuzumab arm of the study will receive maintenance therapy with trastuzumab for 1 year.
Combining Second-Line Targeted Therapies for Advanced Kidney Cancer
(Posted: 06/14/2011) - The goal of this clinical trial is to determine whether using everolimus and bevacizumab in combination will improve the overall survival of patients with renal cell carcinoma (kidney cancer) whose disease has progressed on approved tyrosine kinase inhibitors.
Metformin to Treat Early-Stage Breast Cancer
(Posted: 05/31/2011) - In this trial, nondiabetic women or men younger than age 75 who have been diagnosed with early-stage breast cancer within the previous 12 months and who have undergone surgery to remove their tumor will be randomly assigned to take metformin or placebo pills twice a day for 5 years.