Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outline
Published Results
Trial Contact Information
Registry Information

Alternate Title

Radiolabeled Monoclonal Antibody in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

Basic Trial Information

Phase Type Status Age Sponsor Protocol IDs Phase I Treatment Closed 19 and over NCI UAB-0127 UAB-F010806018, NCI-G02-2053, NCT00033423

Objectives

1. Determine the maximum tolerated dose of yttrium Y 90 ibritumomab tiuxetan when administered in combination with rituximab in patients with relapsed or refractory low-grade, follicular, or transformed CD20-positive B-cell non-Hodgkin's lymphoma (NHL).
2. Determine the toxicity of different doses of yttrium Y 90 ibritumomab tiuxetan in patients treated with this regimen.
3. Determine the frequency of reversal of bone marrow involvement with NHL in patients treated with this regimen.
4. Determine the antitumor response in patients treated with this regimen.

Entry Criteria

Disease Characteristics:

• Histologically confirmed low-grade, follicular, or transformed CD20-positive B-cell non-Hodgkin's lymphoma (NHL)



• Relapsed after prior chemotherapy OR chemotherapy-resistant disease



• Failed at least 1 prior chemotherapy regimen



• CD20-positive B-cell population in lymph nodes or bone marrow for International Working Formulation A (small lymphocytic lymphoma) and transformed NHL



• Bone marrow involvement with lymphoma less than 25% bilaterally



• No impaired bone marrow reserve defined as at least 1 of the following criteria:
  • Prior myeloablative therapies with bone marrow transplantation or peripheral blood stem cell rescue
  • Platelet count less than 100,000/mm3
  • Bone marrow cellularity no greater than 15%
  • Marked reduction in bone marrow precursors of one or more cell lines (e.g., granulocytic, megakaryocytic, or erythroid)
  • Failed prior stem cell collection



• No CNS lymphoma, chronic lymphocytic lymphoma, or HIV or AIDS-related lymphoma



• No diffuse small lymphocytic/marginal zone lymphoma with lymphocyte count greater than 5,000/mm³



• No pleural effusion

 [Note: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology.]

Prior/Concurrent Therapy:

Biologic therapy:

• See Disease Characteristics
• No prior radioimmunotherapy
• Prior rituximab allowed if more than 6 months to progression after an objective response
• At least 6 weeks since prior rituximab
• At least 3 weeks since prior filgrastim (G-CSF) or sargramostim (GM-CSF)
• Recovered from prior immunotherapy

Chemotherapy:

• See Disease Characteristics
• No prior fludarabine
• At least 3 weeks since prior anticancer chemotherapy (6 weeks for nitrosoureas or mitomycin) and recovered
• No concurrent chemotherapy

Endocrine therapy:

• At least 3 weeks since prior anticancer endocrine therapy
• No concurrent high-dose systemic corticosteroids (e.g., 50 mg or more of prednisone as a single dose or 50 mg or less of prednisone for more than 6 doses)

Radiotherapy:

• No prior radiotherapy to more than 25% of active bone marrow (involved field or regional)
• At least 3 weeks since prior anticancer radiotherapy and recovered

Surgery:

• At least 4 weeks since prior surgery (except diagnostic surgery) and recovered

Other:

• No other concurrent anticancer therapy
• Concurrent oral anticoagulant therapy allowed if platelet count is at least 30,000/mm3

Patient Characteristics:

Age:

• 19 and over

Performance status:

• WHO 0-2

Life expectancy:

• At least 6 months

Hematopoietic:

• See Disease Characteristics
• Absolute neutrophil count at least 1,500/mm³
• Platelet count at least 100,000/mm³
• Hematocrit greater than 30%
• Hemoglobin greater than 9.0 g/dL

Hepatic:

• Bilirubin no greater than 1.5 mg/dL

Renal:

• Creatinine no greater than 1.5 mg/dL

Other:

• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 6 months after study participation
• No anti-murine antibody reactivity if prior exposure to murine antibodies or proteins
• No other primary malignancy
• No other serious nonmalignant disease or infection that would preclude study participation

Expected Enrollment

Approximately 6-30 patients will be accrued for this study.

Outline

This is a multicenter, dose-escalation study of yttrium Y 90 ibritumomab tiuxetan.

Patients receive rituximab IV once weekly on weeks 1-4. After 4 doses of rituximab, patients without bone marrow involvement and cellularity greater than 50% expected receive rituximab IV once weekly on weeks 6 and 7 and yttrium Y 90 ibritumomab tiuxetan IV over 10 minutes with the final dose of rituximab (day 43).

Cohorts of 5-6 patients receive escalating dose of yttrium Y 90 ibritumomab tiuxetan until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 4 of 5 or 3 of 6 patients experience dose-limiting toxicity.

Patients are followed at 6 and 12 weeks, every 2-3 months for 2 years, and then every 6 months for 2 years.

Forero-Torres A, Besh S, Knox S, et al.: Higher doses of Rituxan alter pharmacokinetics and biodistribution of Zevalin but may increase responses; a preliminary report of a phase I study of Zevalin using a modified treatment regimen for relapsed or refractory CD20+ B-Cell follicular/transformed non-Hodgkins lymphoma. [Abstract] Blood 102 (11 Pt 1): A-1483, 2003.

Trial Contact Information

Trial Lead Organizations

Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham

Andres Forero-Torres, MD, CSU, Protocol chair		Ph: 205-934-7167 Email: andres.forero@ccc.uab.edu

Registry Information
Official Title		Phase I, Multicenter, Open Label, Dose Escalation Of 90Y-Zevalin Radioimmunotherapy Using A Modified Treatment Regimen For Relapsed Or Refractory CD20+ B-Cell (Follicular/Transformed) Non-Hodgkin's Lymphoma
Trial Start Date		2002-02-01
Registered in ClinicalTrials.gov		NCT00033423
Date Submitted to PDQ		2002-02-07
Information Last Verified		2006-11-28
NCI Grant/Contract Number		P30-CA13148

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