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Sorafenib and Temsirolimus in Treating Patients With Recurrent Glioblastoma
Alternate Title Basic Trial Information Trial Description Purpose Eligibility Treatment/Intervention Trial Contact Information Registry Information
Alternate Title
Phase I/II Study of Sorafenib and Temsirolimus in Patients With Recurrent Glioblastoma (Phase I Closed to Accrual as of 11/21/07)
Basic Trial Information
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Phase
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Protocol IDs
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Phase II, Phase I

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Biomarker/Laboratory analysis, Treatment

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Active

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18 and over

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NCI

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NCCTG-N0572 N0572, NCT00329719

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Trial Description Purpose: Sorafenib may stop the growth of tumor cells by blocking blood flow to the tumor. Drugs used in chemotherapy, such as temsirolimus, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Sorafenib and temsirolimus may also stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving sorafenib together with temsirolimus may kill more tumor cells.
This phase I/II trial is studying the side effects and best dose of temsirolimus when given together with sorafenib and to see how well they work in treating patients with recurrent glioblastoma. Eligibility: Eligibility criteria include the following: Final eligibility for a clinical trial is determined by the health professionals conducting the trial. Treatment/Intervention: Some patients will receive sorafenib by mouth twice a day. They will also receive an infusion of temsirolimus once a week. Treatment may continue for as long as benefit is shown. Other patients will receive sorafenib by mouth twice a day for 8 days and an infusion of temsirolimus on day 1. They will undergo surgery on day 8. After recovering from surgery, patients will receive sorafenib by mouth twice a day and an infusion of temsirolimus once a week for as long as benefit is shown. Patients will undergo blood and tissue sample collection before beginning treatment for laboratory studies. After finishing treatment, patients will be evaluated every 6 months for 5 years and once a year thereafter.
Important: For more details about this trial, refer to the Health Professional version of the trial summary. If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on
NCI's Web site.
Trial Contact Information
Trial Lead Organizations North Central Cancer Treatment Group  |  |  | | Kurt Jaeckle, MD, Protocol chair |  | |  | | David Schiff, MD, Protocol co-chair |  | | Ph: 434-982-4415; 800-223-9173 |
|  | | Bradley Erickson, MD, PhD, Protocol co-chair |  | |  | Trial Sites
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| U.S.A. |
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| Arizona |
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Scottsdale |
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| | | | | | | | | Mayo Clinic Scottsdale |
| | | Clinical Trials Office - All Mayo Clinic Locations | |
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| Colorado |
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Fort Collins |
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| | | | Front Range Cancer Specialists |
| | | Robert Marschke, Jr. | |
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| Florida |
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Jacksonville |
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| | | | Mayo Clinic - Jacksonville |
| | | Clinical Trials Office - All Mayo Clinic Locations | |
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| Illinois |
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Aurora |
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| | | | Rush-Copley Cancer Care Center |
| | | Kendrith Rowland, MD | |
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Bloomington |
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| | | St. Joseph Medical Center |
| | | John Kugler, MD | |
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Canton |
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| | | Graham Hospital |
| | | John Kugler, MD | |
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Carthage |
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| | | Memorial Hospital |
| | | John Kugler, MD | |
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Effingham |
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| | | St. Anthony's Memorial Hospital |
| | | Clinical Trials Office - St. Anthony's Memorial Hospital | |
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Eureka |
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| | | Eureka Community Hospital |
| | | John Kugler, MD | |
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Galesburg |
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| | | Galesburg Clinic, PC |
| | | John Kugler, MD | |
| | | Galesburg Cottage Hospital |
| | | John Kugler, MD | |
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Havana |
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| | | Mason District Hospital |
| | | John Kugler, MD | |
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Hopedale |
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| | | Hopedale Medical Complex |
| | | John Kugler, MD | |
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Joliet |
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| | | Joliet Oncology-Hematology Associates, Limited - West |
| | | Kendrith Rowland, MD | |
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Macomb |
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| | | McDonough District Hospital |
| | | John Kugler, MD | |
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Normal |
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| | | BroMenn Regional Medical Center |
| | | John Kugler, MD | |
| | | Community Cancer Center |
| | | John Kugler, MD | |
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Ottawa |
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| | | Community Hospital of Ottawa |
| | | John Kugler, MD | |
| | | Oncology Hematology Associates of Central Illinois, PC - Ottawa |
| | | John Kugler, MD | |
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Pekin |
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| | | Cancer Treatment Center at Pekin Hospital |
| | | John Kugler, MD | |
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Peoria |
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| | | CCOP - Illinois Oncology Research Association |
| | | John Kugler, MD | |
| | | Methodist Medical Center of Illinois |
| | | Clinical Trials Office - Methodist Medical Center of Illinois | |
| | | Oncology Hematology Associates of Central Illinois, PC - Peoria |
| | | John Kugler, MD | |
| | | OSF St. Francis Medical Center |
| | | John Kugler, MD | |
| | | Proctor Hospital |
| | | John Kugler, MD | |
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Peru |
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| | | Illinois Valley Community Hospital |
| | | John Kugler, MD | |
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Princeton |
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| | | Perry Memorial Hospital |
| | | John Kugler, MD | |
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Spring Valley |
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| | | St. Margaret's Hospital |
| | | John Kugler, MD | |
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Urbana |
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| | | Carle Cancer Center at Carle Foundation Hospital |
| | | Clinical Trials Office - Carle Cancer Center | |
| | | CCOP - Carle Cancer Center |
| | | Clinical Trials Office - CCOP - Carle Cancer Center | |
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| Indiana |
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Michigan City |
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| | | | Saint Anthony Memorial Health Centers |
| | | Kendrith Rowland, MD | |
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| Iowa |
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Ames |
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| | | | McFarland Clinic, PC |
| | | Clinical Trials Office - McFarland Clinic, PC | |
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Cedar Rapids |
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| | | Cedar Rapids Oncology Associates |
| | | Clinical Trials Office - Cedar Rapids Oncology Associates | |
| | | Mercy Regional Cancer Center at Mercy Medical Center |
| | | Martin Wiesenfeld, MD | |
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Des Moines |
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| | | CCOP - Iowa Oncology Research Association |
| | | Roscoe Morton, MD, FACP | |
| | | John Stoddard Cancer Center at Iowa Lutheran Hospital |
| | | Clinical Trials Office - John Stoddard Cancer Center at Iowa Lutheran Hospital | |
| | | John Stoddard Cancer Center at Iowa Methodist Medical Center |
| | | Clinical Trials Office - John Stoddard Cancer Center at Iowa Methodist Medical Center | |
| | | Medical Oncology and Hematology Associates at John Stoddard Cancer Center |
| | | Roscoe Morton, MD, FACP | |
| | | Medical Oncology and Hematology Associates at Mercy Cancer Center |
| | | Roscoe Morton, MD, FACP | |
| | | Mercy Cancer Center at Mercy Medical Center - Des Moines |
| | | Roscoe Morton, MD, FACP | |
| | | Mercy Capitol Hospital |
| | | Roscoe Morton, MD, FACP | |
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Mason City |
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| | | Mercy Cancer Center at Mercy Medical Center - North Iowa |
| | | Clinical Trials Office - Mercy Cancer Center at Mercy Medical Center - North Iowa | |
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Sioux City |
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| | | Mercy Medical Center - Sioux City |
| | | Donald Wender, MD, PhD | |
| | | Siouxland Hematology-Oncology Associates, LLP |
| | | Donald Wender, MD, PhD | |
| | | St. Luke's Regional Medical Center |
| | | Donald Wender, MD, PhD | |
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| Kansas |
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Chanute |
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| | | | Cancer Center of Kansas, PA - Chanute |
| | | Shaker Dakhil, MD, FACP | |
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Dodge City |
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| | | Cancer Center of Kansas, PA - Dodge City |
| | | Shaker Dakhil, MD, FACP | |
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El Dorado |
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| | | Cancer Center of Kansas, PA - El Dorado |
| | | Shaker Dakhil, MD, FACP | |
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Kingman |
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| | | Cancer Center of Kansas, PA - Kingman |
| | | Shaker Dakhil, MD, FACP | |
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Liberal |
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| | | Southwest Medical Center |
| | | Shaker Dakhil, MD, FACP | |
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Newton |
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| | | Cancer Center of Kansas, PA - Newton |
| | | Shaker Dakhil, MD, FACP | |
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Parsons |
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| | | Cancer Center of Kansas, PA - Parsons |
| | | Shaker Dakhil, MD, FACP | |
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Pratt |
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| | | Cancer Center of Kansas, PA - Pratt |
| | | Shaker Dakhil, MD, FACP | |
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Salina |
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| | | Cancer Center of Kansas, PA - Salina |
| | | Shaker Dakhil, MD, FACP | |
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Wellington |
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| | | Cancer Center of Kansas, PA - Wellington |
| | | Shaker Dakhil, MD, FACP | |
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Wichita |
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| | | Associates in Womens Health, PA - North Review |
| | | Shaker Dakhil, MD, FACP | |
| | | Cancer Center of Kansas, PA - Wichita |
| | | Shaker Dakhil, MD, FACP | |
| | | Cancer Center of Kansas, PA - Medical Arts Tower |
| | | Shaker Dakhil, MD, FACP | |
| | | CCOP - Wichita |
| | | Shaker Dakhil, MD, FACP | |
| | | Via Christi Cancer Center at Via Christi Regional Medical Center |
| | | Shaker Dakhil, MD, FACP | |
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Winfield |
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| | | Cancer Center of Kansas, PA - Winfield |
| | | Shaker Dakhil, MD, FACP | |
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| Michigan |
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Escanaba |
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| | | | Green Bay Oncology, Limited - Escanaba |
| | | Anthony Jaslowski, MD, FACP | |
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Iron Mountain |
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| | | Dickinson County Healthcare System |
| | | Anthony Jaslowski, MD, FACP | |
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| Minnesota |
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Alexandria |
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| | | | Harold Windschitl, MD | |
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Bemidji |
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| | | MeritCare Bemidji |
| | | Preston Steen, MD | |
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Burnsville |
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| | | Fairview Ridges Hospital |
| | | Patrick Flynn, MD | |
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Coon Rapids |
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| | | Mercy and Unity Cancer Center at Mercy Hospital |
| | | Patrick Flynn, MD | |
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Duluth |
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| | | CCOP - Duluth |
| | | Daniel Nikcevich, MD, PhD | |
| | | Duluth Clinic Cancer Center - Duluth |
| | | Clinical Trials Office - Duluth Clinic Cancer Center - Duluth | |
| | | Miller - Dwan Medical Center |
| | | Daniel Nikcevich, MD, PhD | |
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Edina |
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| | | Fairview Southdale Hospital |
| | | Clinical Trials Office - Fairview Southdale Hospital | |
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Fergus Falls |
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| | | Harold Windschitl, MD | |
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Fridley |
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| | | Mercy and Unity Cancer Center at Unity Hospital |
| | | Patrick Flynn, MD | |
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Hutchinson |
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| | | Hutchinson Area Health Care |
| | | Daniel Anderson | | Ph: | 320-234-5000 | | 800-454-3903 |
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Lichfield |
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| | | Meeker County Memorial Hospital |
| | | Clinical Trials Office - Meeker County Memorial Hospital | |
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Maplewood |
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| | | HealthEast Cancer Care at St. John's Hospital |
| | | Daniel Anderson | |
| | | Minnesota Oncology Hematology, PA - Maplewood |
| | | Patrick Flynn, MD | |
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Minneapolis |
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| | | Hennepin County Medical Center - Minneapolis |
| | | Clinical Trials Office - Hennepin County Medical Center - Minneapolis | |
| | | Virginia Piper Cancer Institute at Abbott - Northwestern Hospital |
| | | Clinical Trials Office - Virginia Piper Cancer Institute | |
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Robbinsdale |
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| | | Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center |
| | | Clinical Trials Office - Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center | |
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Rochester |
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| | | Mayo Clinic Cancer Center |
| | | Clinical Trials Office - All Mayo Clinic Locations | |
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Saint Cloud |
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| | | CentraCare Clinic - River Campus |
| | | Harold Windschitl, MD | |
| | | Coborn Cancer Center |
| | | Harold Windschitl, MD | |
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Saint Louis Park |
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| | | CCOP - Metro-Minnesota |
| | | Patrick Flynn, MD | |
| | | Park Nicollet Cancer Center |
| | | Patrick Flynn, MD | |
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Saint Paul |
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| | | HealthEast Cancer Care at St. Joseph's Hospital |
| | | Daniel Anderson | |
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